Clinical trials: Frailty/Sarcopenia
Frailty, Sarcopenia
PROfiles of FGF-19 Post-prandial Secretion in Older Adults With Frailty and Without Frailty
Fibroblast Growth Factor 19 (FGF-19) is an intestinal hormone secreted in the post-prandial state, whose primary role is to inhibit bile acid synthesis in the liver.
- Trial name
- PRO-FGF (NCT07893665)
- Testing
- FLEXMEAL : post-prandial blood sampling
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Sarcopenia, Aging
Effects of Polyphenol Supplementation and Exercise on Physical Performance in Older Adults
After approximately age 40 years, individuals experience a natural loss of muscle mass, strength, and physical function that is linked to higher risks of falls, disability, loss of independence, and mortality.
- Conditions
- Sarcopenia, Aging, Frailty
- Trial name
- NCT07441343
- Testing
- Polyphenol Rich-Extract, Resistance Band-Based & Aerobic Stationary Cycling Exercise
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. Chris McGlory, PhD
Cognitive Decline, Sarcopenia
Holistic Integration for Healthy Longevity and Aging in Place
Background: Taiwan is experiencing rapid population aging, with a growing prevalence of chronic diseases and functional impairments among older adults.
- Conditions
- Cognitive Decline, Sarcopenia, Depression Disorders, Nutrition Disorder
- Trial name
- HIHOPE (NCT06882434)
- Testing
- Local intervention program, Referral Process, Telehealth Education & Digital Integration
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Frailty, Sarcopenia
Development of Frailty Prevention Clinic in Geriatric Comprehensive Clinic RSCM:
There is an increasing number of elderly population, not only in Indonesia, but also in the world. With increasing of age, there is also an increasing number of elderly with sarcopenia and frailty.
- Conditions
- Frailty, Sarcopenia, Resistance Training
- Trial name
- NCT05511311
- Testing
- Resistance Training, Standard Therapy
- Where
- Indonesia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Sarcopenia, Kidney Transplantation
Muscle Ultrasound for Sarcopenia Assessment in Kidney Transplant Recipients
This is a single-center prospective observational study designed to evaluate the effectiveness of multimodal muscle ultrasound for the assessment of sarcopenia in kidney transplant recipients.
- Conditions
- Sarcopenia, Kidney Transplantation, Muscle Wasting
- Trial name
- KT-SARC (NCT07607236)
- Testing
- Muscle Ultrasound
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sichuan Provincial People's Hospital
Sarcopenia, Nicotinamide Adenine Dinucleotide Concentration
Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans
Frailty is an age-associated clinical condition of poor physiological reserve that increases risks for falls, hospitalization and mortality.
- Conditions
- Sarcopenia, Nicotinamide Adenine Dinucleotide Concentration, Muscle Quality and NAD+ Content
- Trial name
- NR-VET (NCT04691986)
- Testing
- Nicotinamide Riboside
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Frailty, Sarcopenia
Fit in the Aged by Professional Training
This intervention study tests training methods to stabilize or improve functionality in the high risk group of prefrail elderly persons.
- Trial name
- FiAT (NCT00783159)
- Testing
- Power Training, Strength Training, Control
- Where
- Germany
- Volunteers
- 69 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Sarcopenia, Hypogonadism
TOM: Testosterone in Older Men With Sarcopenia
The purpose of this study is to determine whether testosterone replacement in older men with low testosterone levels will increase muscle strength, improve physical performance and overall sense of well being, and reduce fatigue.
- Conditions
- Sarcopenia, Hypogonadism, Muscular Diseases
- Trial name
- NCT00240981
- Testing
- Topical testosterone gel 1% (active formulation)
- Where
- 2 sites in United States
- Volunteers
- 209 people
- Sponsor
- Boston Medical Center
Frailty, Sarcopenia
A Randomized Control Trial of an Intervention to Reverse Frailty and Enhance Resilience Through Exercise and Education
Resistance training done at home and protein supplementation may be the most effective and easiest to implement interventions to reverse frailty and build resilience.
- Trial name
- REFEREE (NCT04628754)
- Testing
- Exercise and protein
- Where
- Ireland
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Liver Cirrhosis
The Impact of a Dietary Fiber Enriched Diet on the Outcome of Patients with Liver Cirrhosis
The goal of this dietary intervention is to study the impact of a dietary fiber enriched diet on the intestinal dysbiosis, systemic inflammation and cirrhosis-related complications in patients with liver cirrhosis.
- Trial name
- ChainCirr (NCT06634186)
- Testing
- Dietary intervention
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Hannover Medical School
Malnutrition, Sarcopenia
Post - Hospital Syndrome: Profile of Functional Status by Malnutrition
Malnutrition is common problem in hospitalized geriatrics at discharge. Malnutrition is a high risk for functional limitations, impaired muscle strength and reduced quality of life.
- Trial name
- NCT03126500
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Old Age; Debility, Sarcopenia
Effectiveness Multicomponent Exercise Programme in Older Subjects. A Pilot Study.
Sarcopenia can occur or increase due to sedentary lifestyles, physical inactivity or chronic endocrine and inflammatory disorders, this pathology is much more frequent in older people due to the added risk factors and the fact…
- Conditions
- Old Age; Debility, Sarcopenia, Exercise Addiction
- Trial name
- NCT05286723
- Testing
- Multicomponent Training
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Universitat Internacional de Catalunya
Frailty, Sarcopenia
Resistance-Based Multicomponent Training Plus Nutrition Supplementation for Intrinsic Capacity and Disability Risk in Chinese Rural Older Adults
This study is a five-arm, parallel-group, assessor-blinded randomized controlled trial designed to evaluate the effects of resistance-dominant multicomponent training combined with nutritional supplementation on intrinsic…
- Conditions
- Frailty, Sarcopenia, Mobility Limitation, Nutritional Risk
- Trial name
- NCT07660653
- Testing
- Routine Health Education, Leucine-Enriched Whey Protein and Vitamin D Supplementation, Progressive Resistance Training
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Capital University of Physical Education and Sports, China
Cirrhosis, Liver, Sarcopenia
Body Composition Changes After TIPS and Associated Clinical Outcomes
The purpose of this study is to prospectively assess the impact of TIPS creation on muscle mass and physical function in patients with cirrhosis, and to determine whether these changes correlate with improved outcomes in patients…
- Trial name
- NCT05420753
- Testing
- Transjugular Intrahepatic Portosystemic Shunt (TIPS) creation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Oregon Health and Science University
Sarcopenia, Acute Lymphoblastic Leukemia
Physical Activity and Exercise During Early Treatment Phases for Childhood Acute Lymphoblastic Leukaemia to Protect Against Muscle Loss and Improve Frailty Outcomes
This is a small trial testing out a new approach before doing a bigger study. Researchers are observing a group of children/adolescents (ages 5-17) with acute lymphoblastic leukemia (ALL) and testing a physical activity and…
- Trial name
- PROTECT (NCT07325305)
- Testing
- Exercise
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Murdoch Childrens Research Institute
Sarcopenia, Muscle Loss
Counteracting Age-related Loss of Skeletal Muscle Mass
Up to approximately 205 (dependent on drop-out rate) healthy elderly individuals (at least 65 years old) are recruited as subjects.
- Trial name
- CALM (NCT02034760)
- Testing
- Heavy Resistance Training, Light Intensity Training, Protein Whey
- Where
- Denmark
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Sarcopenia in Elderly, Frailty at Older Adults
Effect of Micronized Creatine Monohydrate on Muscle Mass, Strength and Performance in Older Adults Submitted to Total Knee Arthroplasty
Double-blind randomized placebo-controlled clinical trial with two parallel arms. The main objective is to evaluate the efficacy and safety of creatine supplementation in older adults who have been operated on for total knee…
- Conditions
- Sarcopenia in Elderly, Frailty at Older Adults, Functional Capacity, Creatine Supplementation
- Trial name
- CREAR (NCT06925880)
- Testing
- Creatine Monohydrate
- Where
- Spain
- Volunteers
- 262 people
- Sponsor
- Consorci Sanitari del Maresme
Cystic Fibrosis, Sarcopenia
Tele-Rehabilitation in Adults With Cystic Fibrosis
This study is a randomized controlled trial designed to evaluate the effectiveness of an 8-week tele-rehabilitation program in adults with cystic fibrosis.
- Conditions
- Cystic Fibrosis, Sarcopenia, Frailty
- Trial name
- CF-TR (NCT07500493)
- Testing
- Tele-Rehabilitation Exercise Program
- Volunteers
- 76 people
- Sponsor
- King Saud University
Sarcopenia in Elderly, Frailty at Older Adults
Exergaming-based Sitting Tai Chi for Sarcopenia and/or Frailty
This randomized controlled trial will evaluate the effects of an exergaming-based sitting Tai Chi program on muscle strength, physical function, cognition, and psychosocial outcomes in older adults living in residential care…
- Trial name
- NCT07616219
- Testing
- Exergaming-based sitting Tai Chi, General health education
- Where
- Hong Kong
- Volunteers
- 152 people
- Sponsor
- Hong Kong Metropolitan University
Metabolic Syndrome, Aging
Sustainable Exercise and Nutrition Programs for Managing Metabolic Disorders in Older Women
This study aims to evaluate the impact of sustainable diet and exercise programs on metabolic health and quality of life in older women.
- Conditions
- Metabolic Syndrome, Aging, Sarcopenia, Obesity
- Trial name
- NCT07015307
- Testing
- Sustainable Diet Program, Supervised Physical Exercise Program, Combined Sustainable Diet and Exercise Program
- Where
- Spain
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Alicante