Clinical trials: Free Tissue Flaps, open to volunteers
Breast Reconstruction, Free Flap Reconstruction
ESP Blocks in Breast Free Flaps
This study is a prospective randomized controlled trial to assess the efficacy of erector spinae plane (ESP) blocks in patients undergoing autologous free flap breast reconstruction.
- Trial name
- NCT07891039
- Testing
- Bupivacaine with Epinephrine and Dexamethasone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Carilion Clinic
Carcinomatous Resections, Violent Trauma
Evaluation of the PICO® Negative Pressure Dressing System on the Fibula Free Flap Donor Site's Skin Graft.
A fibula free flap can be used for the reconstruction of a mandible or a maxillar when the lack of bonne exceeds 3cm. This flap is made of the fibula bone, some muscle around, the fibular vascular pedicle and a skin paddle to…
- Trial name
- PICOFLAP (NCT04628416)
- Testing
- PICO dressing, Conventional dressing
- Where
- France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Montpellier
Oral Squamous Cell Carcinoma (OSCC), Postoperative Pain
Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral Cancer
This randomized, double-blind, parallel-group controlled trial evaluates the effectiveness of hydrogen water oral care on acute oral inflammation, oral microbiota, and pain in patients with oral cancer who have undergone free…
- Conditions
- Oral Squamous Cell Carcinoma (OSCC), Postoperative Pain, Postoperative Oral Mucositis, Free Flap Reconstruction
- Trial name
- NCT07306546
- Testing
- Hydrogen Water Oral Care, Water Oral Care
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Breast Neoplasms, Ischemia-Reperfusion Injury
DIEP Flap Breast Reconstruction: Perioperative Biomarkers and Outcomes
Brief Summary This observational study will follow patients who undergo DIEP flap breast reconstruction to better understand a common surgical challenge called ischemia-reperfusion (I/R) injury.
- Conditions
- Breast Neoplasms, Ischemia-Reperfusion Injury, Postoperative Complications, Wound Healing
- Trial name
- NCT07263347
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hubei Cancer Hospital
Breast Reconstruction, Thrombosis, Venous
Bioimpedance Measurement of Abdominal Free Flaps During Arterial and Venous Weaning in Breast Reconstruction
As the occurrence of thrombosis in post surgery is rare, it seemed difficult to study only this one. This is why we decided to test the bioimpedance, temperature and green, red and infrared light absorption measurements of the…
- Conditions
- Breast Reconstruction, Thrombosis, Venous, Bioimpedance Measurement Capacity
- Trial name
- MONITRANS2 (NCT05710705)
- Testing
- portable prototype of bioimpedance measurement
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Oral Cancer, Postoperative Pain Management
Effect of Dezocine Versus Nalbuphine Combined With Sufentanil on Postoperative Analgesia, Complications, and Free Flap Survival in Patients Undergoing Oral Cancer Radical Surgery: A Randomized Controlled Clinical Trial.
Background: Oral cancer radical surgery often requires free flap reconstruction. Postoperative pain is severe, and traditional opioids like sufentanil have side effects and may adversely affect tumor biology.
- Conditions
- Oral Cancer, Postoperative Pain Management, Free Tissue Flaps, Mouth Neoplasms
- Trial name
- NCT07401641
- Testing
- Dezocine and Sufentanil combination, Nalbuphine and Sufentanil combination
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Reconstruction, Breast Cancer
Optimizing Postoperative Recovery After Breast Reconstruction With Autologous Tissue (BestDIEP)
Women who have their breast reconstructed with autologous tissue seem to be more satisfied with their breast. However, autologous breast reconstruction entails a bigger operation, and the usage of more health care resources, than…
- Trial name
- BestDIEP (NCT05363189)
- Testing
- Venous augmentation, Traditional ERAS (enhanced recovery after surgery) protocol, Sahlgrenska recovery protocol
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Vastra Gotaland Region
Reconstructive Surgical Procedures, Free Tissue Flaps
Energy Expenditure Assessment in Head and Neck Cancer Patients Treated With Free Flap Surgery
What is the purpose of this study? Patients with head and neck cancer who undergo surgery with free flap reconstruction often need careful nutritional support during recovery.
- Conditions
- Reconstructive Surgical Procedures, Free Tissue Flaps, Head and Neck Cancer, Perioperative Care
- Trial name
- NCT07759193
- Testing
- Indirect Calorimetry (Diagnostic Test)
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Microvascular Free Flap Transfer, Fibula Flap
Artificial Intelligence-Enabled Skin Perforator Segmentation
Computer-assisted surgery has revolutionized reconstruction with more efficient, accurate, and predictable surgery, as reported in our previous studies.
- Trial name
- NCT06634472
- Testing
- artificial intelligence
- Where
- Hong Kong
- Volunteers
- 49 people
- Sponsor
- The University of Hong Kong
Breast Cancer
Opioid Free Versus Opioid Based Anaesthesia for Free Flap Reconstruction Surgery of the Breast: A Phase III Multicentric Randomized Controlled Study.
This study will compare morphine consumption during the first 48 hours postoperatively between the OFA group and the CA control group.
- Trial name
- OFOBA (NCT05439005)
- Testing
- Dexmedetomidine
- Where
- 3 sites in France
- Volunteers
- 158 people
- Sponsor
- Institut Curie
Modified Free Gingival Graft , Connective Tissue Graft
Efficacy of the Modified Free Gingival Graft Technique
Gingival recessions can be defined as the exposure of the root surface after an apical migration of the gingival margin in relation to the cemento-enamel junction. Gingival recessions affect both younger and older populations.
- Trial name
- FGG (NCT06580821)
- Testing
- mucogingigval surgery
- Where
- Ecuador
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Especialidades Espiritu Santo
Head and Neck Cancer
Assessing Perfusion of Osteotomized Scapula and Lat Flap
The gold standard for reconstruction of the jaw is the utilization of a bone free tissue transfer. Scapula reconstruction is an excellent option for elderly patients, those with significant comorbidities and for complex defects…
- Trial name
- NCT06811532
- Testing
- Blood perfusion analysis using SPY-Q software
- Volunteers
- 30 people
- Sponsor
- Western University, Canada
Body Mass Index Greater Than or Equal to 30, Malignant Breast Neoplasm
Negative Pressure Wound Therapy in Healing Abdominal Incision in Obese Patients Undergoing Breast Reconstruction Surgery
This trial studies the safety and how well negative pressure wound therapy works in healing the abdominal incision in obese patients undergoing free flap breast reconstruction surgery.
- Conditions
- Body Mass Index Greater Than or Equal to 30, Malignant Breast Neoplasm, Mammoplasty Patient, Obesity
- Trial name
- NCT04003038
- Testing
- Negative Pressure Wound Therapy, Wound Care Management
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Head and Neck Cancer, Healthy
Non-invasive Preoperative Tissue Evaluation in Head and Neck Tumor Patients Using Multispectral Optoacoustic Tomography (MSOT)
Multispectral Optoacoustic Tomography (MSOT) is a promising imaging technology that utilizes pulsed laser light. One of the key capabilities of this technology is measuring oxygenation within human tissue.
- Trial name
- msotcmfflap (NCT06716892)
- Testing
- Multispectral Optoacoustic Tomography (MSOT)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School