Clinical trials: Free Tissue Flaps
Pain, Postoperative
Regional Anesthesia for Head and Neck Reconstruction
By utilizing regional anesthesia blocks at the surgery tissue donor sites, it can potentially reduce post-operative pain while also reducing the use of opioids.
- Trial name
- NCT04304716
- Testing
- Regional Anesthesia
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Toe Transfer, Free Tissue Flap
Long Term Follow up of Toe-to-hand Transfers
Toe transfers are perceived to have changed the landscape of the injured hand over the last half century, yet there are limited validated data that unequivocally support the functional role of toe transfers after traumatic…
- Conditions
- Toe Transfer, Free Tissue Flap, Patient Reported Outcome Measures
- Trial name
- NCT06487676
- Testing
- Toe transfer, Replantation
- Volunteers
- 75 people
- Sponsor
- Chang Gung Memorial Hospital
Cancer
Impact of Forearm Free Flap in Orbital Exenteration Reconstruction
Orbital exenteration is the en bloc removal of the entire orbital contents. This mutilating surgical technique is reserved for the management of certain malignant orbito-palpebral tumors or those that secondarily invade the…
- Trial name
- REXOR (NCT05255315)
- Testing
- Comparative analysis comparing the morbidity of the antebrachial free flap to that of the temporal flap flap during exenteration as well as the rate of fitting patients with epithesis.
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Institut Curie
Breast Cancer
Influence of the Superficial Inferior Epigastric System in Deep Inferior Epigastric Perforator (DIEP) Flaps
The purpose of this study is to determine in-vivo the effects the contralateral superficial inferior epigastric vascular system has on the perfusion of Zone IV of deep inferior epigastric perforator flaps.
- Trial name
- NCT01464970
- Testing
- Both Superficial Inferior Artery and Vein Clamped, Superficial Inferior Epigastric Vessels both unclamped, SIE Artery Unclamped, Vein Clamped
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- NHS Greater Glasgow and Clyde
Head and Neck Cancer, Intraoperative Complications
Coagulation and Vitamin K in Head and Neck Microvascular Free Flap Surgery
For patients with large head and neck tumors the recommended treatment, in many cases, is a combination of extensive surgery and postoperative radiotherapy.
- Conditions
- Head and Neck Cancer, Intraoperative Complications, Coagulation Disorder, Blood, Vitamin K Deficiency
- Trial name
- MVL-COAG (NCT04517461)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Free Tissue Flaps
Detection of Flap Ischemia Using Interstitial Glucose Monitor
A simple device that objectively assesses flap perfusion - either as a stand-alone tool or an adjunct to the current monitoring method - would be a tremendous improvement in detection of early postoperative flap ischemia and, in…
- Trial name
- NCT02604069
- Testing
- Continuous Glucose Monitor
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Head and Neck Cancer
Optimising Microsurgical Reconstruction After Advanced Head and Neck Cancers
This study aims to improve the peri- and postoperative care regimen for patients undergoing microvascular reconstruction after head and neck cancer by introducing an enhanced recovery after surgery (ERAS) programme.
- Trial name
- NCT04308525
- Testing
- Early ambulation, Early oral feeding, Multimodal opioid-sparing analgesia
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Carcinomatous Resections, Violent Trauma
Evaluation of the PICO® Negative Pressure Dressing System on the Fibula Free Flap Donor Site's Skin Graft.
A fibula free flap can be used for the reconstruction of a mandible or a maxillar when the lack of bonne exceeds 3cm. This flap is made of the fibula bone, some muscle around, the fibular vascular pedicle and a skin paddle to…
- Trial name
- PICOFLAP (NCT04628416)
- Testing
- PICO dressing, Conventional dressing
- Where
- France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Montpellier
Breast Cancer
Pain Management Following TRAM Flap for Breast Reconstruction
The objective of this pilot study is to examine the efficacy of the ON~Q Pain Relief System plus Intravenous Patient Controlled Analgesia (IVPCA) with Morphine vs IV PCA alone in patients undergoing free transverse rectus…
- Trial name
- NCT00500565
- Testing
- Saline, Bupivicaine
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- M.D. Anderson Cancer Center
Maxillary Neoplasms
Reconstruction of Maxillary and Midfacial Defects Using Latissimus Dorsi Scapular Free Flaps
Bony reconstruction of the midface with free tissue transfer is complex and challenging due to structural considerations such as the need for orbital support, patency of the nasal cavity, restoration of the palate and alveolus…
- Trial name
- NCT04522700
- Testing
- scapular free flap
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- hassan harby mohamed
Keratinized Mucosa Deficiency, Peri-implant Soft Tissue
Apical Flap Repositioning vs. Mucosa Excision With Free Gingival Grafts for Peri-Implant Keratinized Mucosa Augmentation
The goal of this clinical trial is to learn which surgical technique works better to increase the amount of firm gum tissue (called keratinized mucosa) around dental implants in adults.
- Conditions
- Keratinized Mucosa Deficiency, Peri-implant Soft Tissue, Dental Implants
- Trial name
- FGGIF (NCT07772414)
- Testing
- Free gingival graft with apical flap repositioning, Free gingival graft with vestibular mucosa excision
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of Barcelona
Remote Ischemic Preconditioning
Effects of Remote Ischemic Preconditioning During Free Flap Reconstruction
Remote ischemic preconditioning (RIPC) has been revealed organ-protective effect in many previous clinical settings including coronary intervention or cardiovascular surgery.
- Trial name
- NCT03474952
- Testing
- remote ischemic preconditioning (RIPC)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
High Myopia, Macular Holes
High Myopia Macular Hole and Retinal Detachment Treated With Double ILM Flaps
From July 2015 to December 2015, clinical record of 8 consecutive cases of macular hole with retinal detachment in high myopia treated with combined inverted and free ILM flap insertion into the hole were retrospectively…
- Conditions
- High Myopia, Macular Holes, Retinal Detachment
- Trial name
- NCT03174639
- Testing
- Inverted and free ILM insertion
- Volunteers
- 8 people
- Sponsor
- National Taiwan University Hospital
Ischemia-Reperfusion Injury, Free Flap
Non-invasive Remote Ischemic PreConditioning (RIPC) in Free Flaps for Breast Reconstruction
This prospective randomized clinical study investigates the effects of Remote Ischemic Conditioning (RIC) on tissue perfusion and ischemia-reperfusion injury in patients undergoing free flap reconstruction in reconstructive…
- Conditions
- Ischemia-Reperfusion Injury, Free Flap, Conditioning Therapy
- Trial name
- RIPC (NCT07487220)
- Testing
- Remote ischemic preconditiong
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Ruhr University of Bochum
Body Mass Index Greater Than or Equal to 30, Malignant Breast Neoplasm
Negative Pressure Wound Therapy in Healing Abdominal Incision in Obese Patients Undergoing Breast Reconstruction Surgery
This trial studies the safety and how well negative pressure wound therapy works in healing the abdominal incision in obese patients undergoing free flap breast reconstruction surgery.
- Conditions
- Body Mass Index Greater Than or Equal to 30, Malignant Breast Neoplasm, Mammoplasty Patient, Obesity
- Trial name
- NCT04003038
- Testing
- Negative Pressure Wound Therapy, Wound Care Management
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Reconstruction, Anesthesia
Comparing Local Anesthetics for TAP Block During Abdominally-based Free Flap for Breast Reconstruction
This study will compare the efficiency of transversus abominus plane (TAP) block using liposomal bupivacaine versus plain bupivacaine that is administered in the operating room under ultrasound guidance prior to the in patients…
- Conditions
- Breast Reconstruction, Anesthesia, Transverse Abdominis Plane Block
- Trial name
- NCT03700970
- Testing
- Liposomal bupivacaine, Regular bupivacaine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Vascular Thrombosis
Is Red Blood Cell Transfusion a Risk Factor for Vascular Pedicle Thrombosis? The Study Case of a Latin American Cohort
The present cohort was performed between January of 2014 and December of 2019. It included 302 free flaps conducted between January 2006 and December 2019 in the Hospital de San José and Hospital Infantil Universitario de San…
- Trial name
- RBCT (NCT04860544)
- Testing
- RED BLOOD CELLS TRANFUSION
- Volunteers
- 302 people
- Sponsor
- Fundación Universitaria de Ciencias de la Salud
Head and Neck Cancer
Goal Directed Fluid Therapy in Free Flap Reconstructive Surgery
Wide excision of head and neck cancer with microsurgical free flap's reconstruction (FFR) results to a high cancer cure rate and a good functional recovery.
- Trial name
- NCT01129037
- Testing
- Goal directed fluid management based on continuous monitoring of stroke volume
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- University Health Network, Toronto
Oral Squamous Cell Carcinoma (OSCC)
Clinical Outcomes of Thoracodorsal Artery Flap in Oral and Maxillofacial Reconstruction
The goal of this study is to retrospectively compare different types of free flaps to determine the most suitable free flap for functional reconstruction in oral squamous cell carcinoma patients following tumor resection.
- Trial name
- NCT06599801
- Testing
- Thoracodorsal artery perforator flap reconstruction surgery, Forearm flaps reconstruction surgery, Anterolateral thigh flap reconstruction surgery
- Where
- China
- Volunteers
- 217 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sedation Set-up Time, Additional Time Required for Volatile Sedation
Volatiles in Critical Care After Free Flap Surgery
Patients undergoing complex free flap surgery are randomised to volatile or intravenous sedation in terms of subsequent intensive care sedation, based on the in-hospital standard of care.
- Trial name
- NCT05707884
- Testing
- critical care management
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Goethe University