Clinical trials: Free Tissue Flaps
Free Flap Reconstruction
The Effect of Dexmedetomidine as an Adjuvant for Lower Limb Nerve Blocks
Peripheral nerve block has been recommended as the technique for postoperative pain management because it provides equivalent analgesia but with fewer adverse effects than either systemic or epidural analgesia.
- Trial name
- NCT03118076
- Testing
- 0.3% ropivacaine and 50 μg dexmedetomidine, Ropivacaine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xiaofeng Bai
Breast Reconstruction
Free Flap Breast Reconstruction Using Virtual Surgical Planning and 3-D Modeling
The purpose of this study is to determine if 3D modeling and Virtual Planning Surgery can improve the clinical outcome with patient who have a mastectomy requiring breast reconstruction.
- Trial name
- NCT03949491
- Testing
- 3D medical models
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Case Comprehensive Cancer Center
Tongue SCC
Virtual Planning of ALT Flap
This study evaluates the advantage of using preoperative virtual planning to design the volume and shape of antero-lateral thigh free flap tissue transfer to reconstruct tongue defects resulted from carcinoma resection and see…
- Trial name
- NCT05424328
- Testing
- ALTF (Anterolateral thigh flap) with preoperative virtual planning, ALTF (Anterolateral thigh flap) with conventional method
- Sponsor
- University of Florida
Hemodynamic Rebound, Volume Overload
Advanced Hemodynamic Monitoring in Free Flap Surgery
Background: Anesthesia in free flap surgery is challenging. Monitoring of hemodynamic changes and their influence on the cardiovascular system in permanent feedback loops allow control, which is what anesthesiologists aim for to…
- Conditions
- Hemodynamic Rebound, Volume Overload, Fluid Overload, Bloodpressure
- Trial name
- AHM (NCT03168126)
- Testing
- Pro-AQT
- Volunteers
- 31 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
General Anesthesia
Effect of Goal-directed Fluid Therapy Using Stroke Volume Variation in Patients Undergoing Free Flap Reconstruction After Head and Neck Cancer Resection
Investigators hypothesized that goal-directed fluid therapy using stroke volume variation will improve postoperative recovery in patients undergoing free flap reconstruction after head and neck cancer resection.
- Trial name
- NCT02003066
- Testing
- Standard fluid therapy, Conservative fluid therapy
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Yonsei University
Head and Neck Disorder, Free Flap
Platelet-Rich Fibrin in the Healing of Regional and Free Flaps
Determine if the use of platelet-rich fibrin (PRF) versus historical treatment methods improves the post-operative management of healing complications from flap donor sites.
- Trial name
- NCT04023474
- Testing
- Platelet Rich Fibrin (PRF) Application
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Florida
Breast Neoplasms, Ischemia-Reperfusion Injury
DIEP Flap Breast Reconstruction: Perioperative Biomarkers and Outcomes
Brief Summary This observational study will follow patients who undergo DIEP flap breast reconstruction to better understand a common surgical challenge called ischemia-reperfusion (I/R) injury.
- Conditions
- Breast Neoplasms, Ischemia-Reperfusion Injury, Postoperative Complications, Wound Healing
- Trial name
- NCT07263347
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hubei Cancer Hospital
Head and Neck Neoplasms
Multi-Modality Imaging for Head & Neck Cancer Free Flap Design Assessment
Surgical reconstruction of anatomical structures after head and neck cancer resection has made enormous strides in the past 20 years with advancing flap techniques and the usage of perforating vessels, but accurate and consistent…
- Trial name
- NCT02629029
- Testing
- Pre-op CTA with IV contrast, Computed tomography angiography (CTA)
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University Health Network, Toronto
Breast Reconstruction, Breast Cancer
Optimizing Postoperative Recovery After Breast Reconstruction With Autologous Tissue (BestDIEP)
Women who have their breast reconstructed with autologous tissue seem to be more satisfied with their breast. However, autologous breast reconstruction entails a bigger operation, and the usage of more health care resources, than…
- Trial name
- BestDIEP (NCT05363189)
- Testing
- Venous augmentation, Traditional ERAS (enhanced recovery after surgery) protocol, Sahlgrenska recovery protocol
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Vastra Gotaland Region
Agitation, Delirium
Dexmedetomidine to Prevent Agitation After Free Flap Surgery
Reconstruction using microvascular free tissue flap has been an important management in patients with maxillofacial tumor. It is often characterised as long operation time, more traumatic and require restriction of patient's head…
- Trial name
- NCT01904760
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University
Free Tissue Flaps
PVI Based Intraoperative Fluid Management in Head and Neck Free Flap Reconstructive Surgeries
Intraoperative fluid given according to BMI in group B and according to pulse oximeter- derived pleth variability index(MASIMO RAINBOW PULSE CO OXIMETRY) in group G.
- Trial name
- NCT03116178
- Testing
- Group G -PVI( Masimo co oximeter) guided fluid therapy, Group B- Body weight guided intravenous fluid @6-8ml/kg
- Volunteers
- 80 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Reconstructive Surgery Using Pedicled Perforating or Free Perforating Flaps, Pelvic Eschar
Study and Modeling of Perforator Flap Vascularization
The aim of reconstructive surgery is to restore physical integrity altered by trauma, congenital malformations or cancerous pathologies.
- Conditions
- Reconstructive Surgery Using Pedicled Perforating or Free Perforating Flaps, Pelvic Eschar, Traumatic Pathology of the Lower and/or Upper Limb
- Trial name
- EMoVaLP (NCT07084740)
- Testing
- PeriCam and PeriFlux measurements
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Reconstructive Surgery, Head and Neck Microvascular Free Flap
Postoperative Management of Patients Undergoing Head and Neck Microvascular Free Flap Reconstructive Surgery: is Admission to an Intensive Care Unit Necessary?
The aim of our study is to assess if patients undergoing head and neck free flap reconstructive surgery admitted to the ICU have equivalent postoperative outcomes to those admitted to an Otolaryngology specialty ward
- Trial name
- NCT07295548
- Testing
- free flap surgery
- Where
- Italy
- Volunteers
- 192 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Oncology
Pretreatment Quality of Life as a Predictor of Distant Metastasis-Free Survival and Overall Survival in Patients With Head and Neck Cancer
This study shed light on an under-researched area by examining the prognostic associations of pre-treatment QoL with overall survival and distant metastasis free survival among patients with head and neck cancer who underwent…
- Trial name
- NCT03290352
- Testing
- Questionnaire
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
Use of a Non-ICU Specialty Ward For Immediate Post-operative Management of Head and Neck Free Flaps
Patients undergoing free flap reconstructive surgery at University of California, Davis Medical Center (UCDMC) will be assigned randomly into no intervention group (immediate post operative care in an ICU) or intervention group…
- Conditions
- Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Head and Neck Carcinoma, Trauma
- Trial name
- ICU (NCT03340038)
- Testing
- Non-ICU Specialty ward
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of California, Davis
Reconstructive Surgery After Carcinological Excision
Evaluation of the Interest of the Neurorrhaphy in Resensitizing Free Flaps
The surgical procedure consists in removing a tumor of the oral cavity and then repairing the oral defect by the use of a free flap.
- Trial name
- NCT03677349
- Testing
- neurorrhaphy
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Maxillary Sinus Squamous Cell Carcinoma
Functional Evaluation After Maxillectomy and Scapular Free Flap Reconstruction
The goal of the study is to analyse the functional and aesthetic outcomes after removal of the maxillar bone and reconstruction with part of the scapular bone for people having maxillary tumor
- Trial name
- NCT06865313
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Hôpital de la Croix-Rousse
Reconstructive Surgical Procedures, Tissue Transplantation
Monitoring of Tissue Transfer Flaps by Modulated Imaging (MI) Spectroscopy
Tissue transfer flaps are a method of moving tissue from a donor location to a recipient location. In the case of a free tissue transfer flaps, the blood vessels to the transferred tissues are detached and then re-attached to…
- Trial name
- NCT00633503
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- University of California, Irvine
Oral Surgical Procedures, Surgery, Oral
Standardized Osteotomy Guides for Free Flap Reconstruction of Continuous Defects of the Jaws - a Simplified Method
The aim of the present project is to evaluate the outcome from reconstruction of the jaws, with a standardized simplified technique, after a continuous defect.
- Conditions
- Oral Surgical Procedures, Surgery, Oral, Mandibular Reconstruction
- Trial name
- NCT05715359
- Testing
- Reconstruction
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Lund University Hospital
Surgery
Difference Between Inhalation Anesthesia and Total Intravenous Anesthesia in Free Flap Surgery
The purpose of this study is to compare the difference between total intravenous anesthesia to inhaled anesthesia in free flap surgery.
- Trial name
- NCT03263078
- Testing
- Propofol, Sevoflurane
- Where
- Taiwan
- Volunteers
- 78 people
- Sponsor
- Taichung Veterans General Hospital