Clinical trials: Freezing of Gait
Parkinson Disease, Freezing of Gait
Neurorehabilitation of Sequence Effect in Parkinson's Disease
The sequence effect (SE), defined as a reduction in amplitude of repetitive movements, is a common clinical feature of Parkinson's disease (PD), being a major contributor to freezing of gait (FOG).
- Trial name
- NCT04921748
- Testing
- Neurorehabilitation
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Parkinson Disease
Deep Brain Stimulation of the Cuneiform Nucleus for Levodopa-resistant Freezing of Gait in Parkinson's Disease
The purpose of this research study is to determine if DBS is a safe and effective therapy for severe freezing of gait in patients with Parkinson's Disease.
- Trial name
- DBS + FOG (NCT04218526)
- Testing
- Vercise DBS System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Jonathan Jagid
Parkinson Disease, Gait Disorders, Neurologic
Automated Mechanical Peripheral Stimulation to Treat Freezing of Gait in Patients With Parkinson's Disease and STN-DBS
The objective is to investigate whether AMPS (Automated Mechanical Peripheral Stimulation) is effective in reduction of FOG measured via the FOG-AC (Freezing Of Gait Assessment Course) in people with Parkinson Disease and STN-DBS…
- Trial name
- AMBITION (NCT04831879)
- Testing
- GONDOLA AMPS
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Gondola Medical Technologies SA
Parkinson's Disease
The Effects of Multi-focal tDCS on Motor-cognitive Dysfunctions in Parkinson's Disease
The current RCT aims to establish the therapeutic potential of tDCS for freezing of gait (FOG) and motor-cognitive dysfunctions in PD.
- Trial name
- NCT02656316
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Parkinson's Disease, Freezing of Gait
Atomoxetine for Freezing of Gait in Parkinson's Disease
Subjects are being asked to participate in this study to determine the safety and effectiveness of a drug called atomoxetine in the treatment of freezing of gait for Parkinson's Disease patients.
- Trial name
- ATMFOG (NCT03651856)
- Testing
- ATM FOG in PD
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical University of South Carolina
Parkinson Disease, Freezing of Gait
Application of Thoracic Epidural SCS for Managing FOG in Patients With Advanced Parkinson's Disease
Spinal cord stimulation (SCS) has proven to be effective for pain that is unresponsive to medication. This technique involves an anesthesiologist or a neurosurgeon placing stimulation electrodes at the thoracic vertebrae to…
- Conditions
- Parkinson Disease, Freezing of Gait, Spinal Cord Stimulation
- Trial name
- NCT06630702
- Testing
- SCS electrode stimulation 1, SCS electrode stimulation 2, SCS electrode stimulation 3
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Parkinson Disease
Function-based Accelerated Stimulation Therapy (FAST-therapy) for Freezing of Gait (FOG) After Parkinson's Disease (PD)
Parkinson disease (PD) is a common disorder in which reduced speed of movement results from inadequate brain production of the chemical dopamine.
- Trial name
- NCT05509842
- Testing
- rTMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Parkinson Disease
Subthalamic Nucleus Stimulation Effect on Gait Symmetry and Freezing of Gait
Impact of unilateral modulation of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's disease
- Trial name
- STIMSYM (NCT02704195)
- Testing
- Unilateral reduction of stimulation, Chronic Subthalamic nucleus stimulation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Grenoble
Parkinson's Disease
Amyloidopathy, Cholinopathy, Dopamine Responsiveness and Freezing of Gait in PD
Early stage Parkinson disease (PD) is characterized by a 'honeymoon' phase in terms of responsiveness of motor symptoms, including gait, to dopaminergic pharmacotherapy.
- Trial name
- FOG (NCT03647137)
- Testing
- Detailed motor testing, including FoG, in PD subjects
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease
Combined Deep Brain Stimulation in Parkinson's Disease
The study is a pilot study on Parkinson's disease patients to evaluate Combined deep brain stimulation of the substantia nigra pars reticulata and of the subthalamic nucleus for unresponsive freezing of gait.
- Trial name
- SCP-FOG (NCT05415774)
- Testing
- 1 : S-C1-C2, 2 : S-C2-C1, 3 : C1 - S - C2
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Toulouse
Patients With Parkinson's Disease
Effect of Freezing Phenomenon in Patients With Parkinson's Disease
Although the literature review indicates that plantar pressure may be related to freezing, there are not enough studies examining the effect of freezing phenomenon on pedobarographic pressure distribution and gait parameters.
- Trial name
- NCT06505343
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Parkinson Disease, Freezing of Gait
Use of CereGate Therapy for Freezing of Gait in PD
A Multi-Center, Controlled Study to Evaluate Use of CereGate Therapy to Reduce Freezing of Gait in Participants Diagnosed with Parkinson's Disease.
- Conditions
- Parkinson Disease, Freezing of Gait, Deep Brain Stimulation
- Trial name
- NCT05292794
- Testing
- CereGate Software; BSN cDBS Programmer; BSN Burst Programmer
- Where
- 7 sites in United States
- Volunteers
- 41 people
- Sponsor
- CereGate Inc.
Parkinsons Disease
A Responsive Closed-Loop Approach to Treat Freezing of Gait in Parkinson's Disease
The study objective is to explore Deep Brain Stimulation (DBS) in two specific brain regions (Globus Pallidum, or GPI, plus the pedunculopontine nucleus, or PPN) for on medication freezing of gait (FoG) in Parkinsons Disease…
- Trial name
- NCT02318927
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Parkinson Disease, Freezing of Gait
Moving Mindfully for Freezing in Parkinsons
The investigators will modify and evaluate the feasibility of a mindfulness intervention among people living with Parkinson disease (PD) and freezing of gait (FOG).
- Trial name
- MMR34 (NCT05309083)
- Testing
- Mindfulness Based Walking Therapy (MBWT)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Washington University School of Medicine
Parkinson Disease
SCH: Context-aware Freezing of Gait Mitigation in Real-world Setting
People with Parkinson's disease (PD) may experience a walking problem called freezing of gait (FoG) that can interfere with the person's ability to conduct daily activities.
- Trial name
- NCT04746846
- Testing
- UG motion sensor with PDVibe3
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Freezing of Gait, Parkinson Disease
DBS and Levodopa for Treating Freezing of Gait in Parkinson's Disease
Freezing of gait (FoG) is a complex symptom of Parkinson's disease (PD) that cause falls and disability in PD patients, heavily affect patients' autonomy and quality of life.
- Trial name
- NCT06316232
- Testing
- STIM ON plus, MED ON plus
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Istituto delle Scienze Neurologiche di Bologna
Parkinson Disease
Cue2Walk, Cost-effectiveness of Automated Freezing Detection and Provision of External Cues in Comparison to Usual Care in People With Parkinson's Disease
The majority of people with Parkinson's disease incur Freezing of Gait (FoG), which is not addressed adequately by medication. Cueing is a proven strategy to overcome FoG.
- Trial name
- NCT06416345
- Testing
- Cue2Walk, Usual Care
- Where
- 2 sites in Netherlands
- Volunteers
- 84 people
- Sponsor
- Amsterdam UMC, location VUmc
Freezing of Gait, Parkinson's Disease
Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)
This study is a prospective, multicenter, observational cohort (patient registry) designed to better understand freezing of gait (FOG), a disabling walking problem that can occur in Parkinson's disease and other related…
- Conditions
- Freezing of Gait, Parkinson's Disease, Parkinsonism, Vascular Parkinsonism
- Trial name
- NCT07386015
- Testing
- Observational Data Collection
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Tianjin Huanhu Hospital
Parkinson's Disease, Somatosensory Disorders
Somatosensory Dysfunction as the Underlying Mechanism of Upper Limbs Motor Blocks in People With Parkinson's Disease
Motor blocks during gait and upper limb movements (FOULs) are a disabling and common motor impairment in mild to severe stages of Parkinson's disease (PD).
- Trial name
- NCT02610257
- Testing
- Mechanical stimulus (vibration) applied on the forearm
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Gait Disorders, Neurologic
Transcutaneous Magnetic Spinal Cord Stimulation for Freezing of Gait in Parkinson's Disease
Dopaminergic drugs partially alleviate gait problems in Parkinson's disease, but the effects are not sustained in the long-term.
- Trial name
- TMS (NCT04783493)
- Testing
- Non-invasive magnetic stimulation of the spinal cord, Coil will not be connected to the stimulation device
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- University of Sao Paulo General Hospital