Clinical trials: Frozen Embryo Transfer
Subfertility
Oral Dydrogesterone as Luteal Phase Support in Natural Cycle FET
This randomised double-blinded controlled trial aims to compare the live birth rate in natural FET cycles with and without oral dydrogesterone as luteal phase support.
- Trial name
- NCT03859921
- Testing
- Dydrogesterone
- Where
- China
- Volunteers
- 716 people
- Sponsor
- The University of Hong Kong
Adenomyosis, IVF
Artificial Cycle With or Without GnRH Agonist Pre-treatment for Frozen Embryo Transfer in Adenomyosis Patients
This randomized clinical trial aims to assess the comparative effectiveness of two distinct endometrial preparation protocols for frozen embryo transfer (FET) among women with adenomyosis undergoing IVF/ICSI.
- Conditions
- Adenomyosis, IVF, Frozen Embryo Transfer
- Trial name
- FET-ADE (NCT06239376)
- Testing
- GnRHa+AI - AC, Artificial cycle
- Where
- Vietnam
- Volunteers
- 222 people
- Sponsor
- Mỹ Đức Hospital
Infertility, Female, Polycystic Ovary Syndrome
Letrozole for Frozen Embryo Transfer (FET) in Patients With Polycystic Ovary Syndrome (PCOS)
To offer patients with oligomenorrhoea or amenorrhoea an alternative to frozen embryo transfer in an artificial cycle, endometrial preparation using letrozole may be a valuable option.
- Conditions
- Infertility, Female, Polycystic Ovary Syndrome, IVF, Ovulation Disorder
- Trial name
- LEFT (NCT04002635)
- Testing
- Letrozole, estradiol valerate
- Volunteers
- healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Ovarian Hyperstimulation Syndrome, Frozen-thawed Embryo Transfers
Association Between Live Birth Rate and Serum Progesterone During Hormonal Replacement Therapy
Nowadays, frozen-thawed embryo transfers (FET) are expending. This practice avoids risk of ovarian hyperstimulation syndrome (OHSS), as well as allowing better synchronization between endometrium and embryo, which is fundamental…
- Trial name
- PROGEVOL (NCT05588635)
- Testing
- Identification of predictive factors
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Infertility
SHorter Treatment of Replacement Therapy for Frozen Embryo Transfer (FET)
This is a Single-centre pilot study, randomized, controlled open-label trial with the aim to assess the clinical pregnancy rate and the early pregnancy loss rate between two different schemas for frozen embryo transfer cycles…
- Trial name
- ShoRT (NCT03930706)
- Testing
- Longer administration of estradiol (Progynova®)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitair Ziekenhuis Brussel
Primary Infertility, Secondary Infertility
LANDA Embryo Freezing Technique.
The aim of this study is to track the outcome from the patients who had embryo cryopreservation as part of their Advanced Reproductive Technology (ART) treatment at West Coast Fertility Centers.
- Conditions
- Primary Infertility, Secondary Infertility, Genital Diseases, Male, Genital Diseases, Female
- Trial name
- Freezing (NCT01271400)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- West Coast Fertility Centers
Infertility, Female, Endometriosis
Predicting Endometrial Receptivity for Optimal Reproductive Management
The purpose of this study is to understand why some women are infertile (unable to conceive a child). The investigators hope to learn if an endometrial biopsy after egg retrieval is feasible for detecting biomarkers for…
- Trial name
- PERFORM (NCT04107129)
- Testing
- Endometrial Biopsy, Euploid embryo transfer, Blood sample
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Stanford University
PCOS
Live Birth After Letrozole-stimulated Cycles Versus Hormone Replacement Treatment Cycles for the First Frozen Embryo Transfer in Women With PCOS
This is a multicenter randomized controlled trial comparing the efficacy and safety of two endometrial preparation protocols for the first frozen embryo transfer cycle in PCOS with whole embryo freezing.
- Trial name
- NCT05227391
- Testing
- Oral Letrozole, Oral estradiol valerate
- Where
- China
- Volunteers
- 1,078 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Thin Endometrium
Thin Endometrium Undergoing Frozen-thawed Embryo Transfer
The endometrium is essential for embryo implantation. The clinical pregnancy rate and live birth rate of patients with thin endometrium are significantly lower than those of normal endometrium.
- Trial name
- NCT04292886
- Testing
- Tamoxifen and femoston, Vitamin C and femoston
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Nanjing University
Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes
IVM - Fresh ET (THE SAIGON PROTOCOL) Versus IVF - FET in PCOS Women
Assisted Reproductive Technologies (ART) aim to increase success rates while minimizing patient risks. For women with high AFC or PCOS, conventional IVF carries a high risk of OHSS (Ho et al., 2019).
- Conditions
- Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes, Fresh Embryo Transfer
- Trial name
- SAIGON-PTC (NCT07171970)
- Testing
- IVM-Fresh (No gonadotropin + Fresh embryo transfer), IVF-FET (GnRH-Antagonist - Agonist Trigger - Frozen embryo transfer)
- Where
- Vietnam
- Volunteers
- 600 people
- Sponsor
- Mỹ Đức Hospital
Infertility Due to Nonimplantation, Infertility
Progesterone Supplementation in Frozen Embryo Transfer Cycles
Recurrent implantation failure (RIF) occurs after women undergo in vitro fertilization and have multiple embryos transferred but no resulting pregnancies.
- Trial name
- NCT03504345
- Testing
- Prometrium
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Infertility, Progesterone
Effect of Intervention on Progesterone Levels Before Euploid Embryo Transfer in Pregnancy Outcomes.
Transferring an euploid embryo avoids one of the main reasons of miscarriage and implantation failure (1), overcoming confounding factors such as embryo ploidy or maternal age.
- Conditions
- Infertility, Progesterone, Frozen Embryo Transfer, Euploid Embryo Transfer
- Trial name
- NCT03740568
- Testing
- Low Progesterone, Normal Progesterone
- Where
- Spain
- Volunteers
- 598 people
- Sponsor
- Fundacion Dexeus
Infertility
Uterine Contractions and Mode of Progesterone in Frozen Embryo Transfer (FET) Cycles: Randomized Clinical Trial
When patients undergo in vitro fertilization (IVF), they often make more embryos than it is safe to transfer back in the womb all at once. These excess embryos are frozen and stored for future use.
- Trial name
- NCT02078869
- Testing
- Progesterone in oil, vaginal progesterone suppositories
- Volunteers
- 34 people
- Sponsor
- Toronto Centre for Advanced Reproductive Technology
Endometrial Preparation, Frozen Embryo Transfer
Effect of Adding Sildenafil to Protocol of Endometrial Preparation in Outcome of Frozen-thawed Embryo Transfer Cycles
The target of this study was an estimate the result of sildenafil on ultrasonographic endometrial thickness, endometrial pattern investigation estrogen level on the day of progesterone administration, Implantation rate and…
- Trial name
- sildenafil (NCT01668446)
- Testing
- Sildenafil, estradiol valerat
- Where
- Iran
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- farzaneh hojjat
Frozen Embryo Transfer (FET)
Cryopreserved Pre-embryo Transfer in a Cytokine-rich Medium Versus Hyaluronic Acid
This multicenter, randomized, double-blind study compares a GM-CSF-enriched embryo transfer medium with a hyaluronic acid-enriched medium in women undergoing single frozen embryo transfer.
- Trial name
- CSF-EG (NCT07869576)
- Testing
- Cytokine-rich embryo transfer medium, Hyaluronic acid-enriched embryo transfer medium
- Volunteers
- 610 people
- Sponsor
- Vida Recoletas Sevilla
Infertility, Embryo Transfer
Progesterone as Luteal Support in Frozen IVF Natural Cycles
The ProFET study aims to investigate if luteal phase support by vaginal progesterone, is superior to no luteal phase support, in terms of live birth rate per woman after a frozen embryo transfer (FET), in a natural cycle (NC)…
- Trial name
- ProFET (NCT04725864)
- Testing
- Progesterone vaginal tablet
- Where
- Sweden
- Volunteers
- 1,800 people
- Sponsor
- Vastra Gotaland Region
Infertility
Administration of Vaginal and Rectal Progesterone During FET Cycles
Observational study of reproductive outcome after frozen embryo transfer in HRT with vaginal and rectal progesterone.
- Trial name
- NCT03470610
- Testing
- Progesterone
- Where
- Denmark
- Volunteers
- 277 people
- Sponsor
- Thor Haahr
Fertilization in Vitro, Embryo Transfer
Immediate Versus Delayed FET Following a Stimulated IVF Cycle
Information regarding the optimal timing for frozen-thawed embryo transfer (FET) following a stimulated in vitro fertilization (IVF) is lacking.
- Trial name
- NCT03201783
- Testing
- immediate frozen-thawed embryo transfer, delayed frozen-thawed embryo transfer
- Where
- China
- Volunteers
- 724 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Embryo Transfer
Natural Cycles With Spontaneous Versus Induced Ovulation in FET
In recent years, frozen-thawed embryo transfer procedure (FET) has been widely used to increase the cumulative pregnancy rate per IVF-cycle: which is the best preparation protocol remains a matter of debate.
- Trial name
- NCT03581422
- Testing
- hCG administration before embryo transfer
- Volunteers
- 2,866 people
- Sponsor
- Istituto Clinico Humanitas
Vaginal Dysbiosis
Effect of FB301 on Vaginal Bacterial Profile in Women With Asymptomatic Vaginal Dysbiosis Undergoing a Mock Frozen Embryo Transfer Cycle
The goal of this clinical trial is to evaluate FB301 during a mock frozen embryo transfer (FET) cycle in pre-menopausal women aged 18 to 45 years with a prior failed FET and a defined vaginal bacterial imbalance (dysbiosis).
- Trial name
- NCT07453069
- Testing
- FB-301, Chlorhexidine (0.5%) Vaginal Cleanse
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Freya Biosciences ApS