Clinical trials: Frozen Embryos
Luteal Phase Defect
Progesterone Levels and Clinical Outcomes Using a Single Pessary of 400 mg of Vaginal Progesterone in Substitutive Cycles for Embryo Transfer.
This study aims to compare the efficacy, in terms of progesterone levels and clinical outcomes, of two different presentations of micronized vaginal progesterone (400 mg vs.
- Trial name
- CycloCT (NCT04722471)
- Testing
- Vaginally administered progesterone
- Where
- Spain
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Adenomyosis
FET in Adenomyosis
Purpose of the Study: To compare the effectiveness of GnRH agonist downregulation alone versus GnRH agonist combined with letrozole in improving pregnancy outcomes in women with adenomyosis undergoing frozen embryo transfer…
- Trial name
- ADY (NCT06913075)
- Testing
- GnRH agonist downregulation, GnRH agonist and Letrozole
- Where
- India
- Volunteers
- 700 people
- Sponsor
- Indira IVF Hospital Pvt Ltd
Obesity, Maternal
The Application of HCG in Luteal Support for Frozen Embryo Transfer in Ovulation Cycle of Obese Women
This study aims to explore whether the application of low-dose HCG in luteal support can improve the pregnancy outcomes of natural cycle frozen embryo transfer in obese patients
- Trial name
- NCT07633002
- Testing
- Human Chorionic Gonadotropin
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Shandong University
ART, IVF
Cardiometabolic Function in Offspring, Mother and Placenta After Assisted Reproductive Technology
The overall objective is to establish the first-of-its-kind longitudinal cohort of pregnant women, biological fathers/partners and offspring from pregnancies achieved by frozen embryo transfer (FET), fresh-embryo transfer (fresh…
- Conditions
- ART, IVF, Children, Only, Cardiovascular Disease Other
- Trial name
- COMPART (NCT06334003)
- Where
- 3 sites in Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
ART
Oral Dydrogesterone vs. Vaginal Micronized Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer
The current trial is intended to assess the efficacy of oral versus vaginal progesterone for luteal support in frozen IVF cycles.
- Trial name
- NCT03832699
- Testing
- Dydrogesterone 10 MG, Endometrin 100Mg Vaginal Insert
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Endometrial Disorder, Infertility, Female
Endometrial Compaction and Its Influence on Pregnancy Rate in Frozen Embryo Cycle Regimes
For a pregnancy to occur, an euploid embryo at blastocyst developmental stage, a receptive endometrium and the synchrony of both is crucial.
- Conditions
- Endometrial Disorder, Infertility, Female, IVF, Pregnancy Early
- Trial name
- NCT04454749
- Testing
- Blood test, Ultrasound
- Where
- United Arab Emirates
- Volunteers
- 3 people
- Sponsor
- ART Fertility Clinics LLC
Subfertility
GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FET
The objectives of this study are to compare the efficacy of the dual trigger group vs the hCG trigger group on the live birth rate in women undergoing IVF and the efficacy of the agonist in LP group vs the placebo group on the…
- Trial name
- NCT04064840
- Testing
- IVF: Decapeptyl and hCG, FET: Decapeptyl, IVF: hCG and normal saline
- Where
- China
- Volunteers
- 784 people
- Sponsor
- The University of Hong Kong
Thin Endometrium
The Effect of the GM-CSF Gel on the Endometrial Thickness in Infertile Women With Thin Endometrium
The purpose of this study is to investigate the efficacy of the granulocyte-macrophage colony stimulating factor(GM-CSF) gel on the endometrial thickness in infertile women with thin endometrium.
- Trial name
- NCT04100655
- Testing
- GM-CSF, 17-ß estradiol
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Sir Run Run Shaw Hospital
Duration of Estrogen Administration
The Impact of Estrogen Administration Duration in Hormonally Prepared Frozen Embryo Transfer Cycles
This prospective controlled study aimed to investigate the effect of the duration of estrogen (E2) administration prior to progesterone (P) initiation on live birth rates (LBR) in frozen embryo transfer (FET) cycles.
- Trial name
- NCT05825885
- Testing
- E2
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people
- Sponsor
- Akdeniz University
Infertility
Administration of Vaginal and Rectal Progesterone During FET Cycles
Observational study of reproductive outcome after frozen embryo transfer in HRT with vaginal and rectal progesterone.
- Trial name
- NCT03470610
- Testing
- Progesterone
- Where
- Denmark
- Volunteers
- 277 people
- Sponsor
- Thor Haahr
PCOS
Live Birth After Letrozole-stimulated Cycles Versus Hormone Replacement Treatment Cycles for the First Frozen Embryo Transfer in Women With PCOS
This is a multicenter randomized controlled trial comparing the efficacy and safety of two endometrial preparation protocols for the first frozen embryo transfer cycle in PCOS with whole embryo freezing.
- Trial name
- NCT05227391
- Testing
- Oral Letrozole, Oral estradiol valerate
- Where
- China
- Volunteers
- 1,078 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Recurrent Implantation Failure in Setting of Artifically Prepared Endometrium
Trial of Endometrial Scratch Prior to Frozen Embryo Transfer in Patients With Recurrent Implantation Failure
Patients with a history of recurrent implantation failure who are planning a frozen embryo transfer (FET) are enrolled into the program.
- Trial name
- NCT03157765
- Testing
- endometrial biopsy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brown Fertility
Pre-Eclampsia, Frozen Embryo Transfer
Impact of Corpus Luteum Presence or Absence in the Incidence of Preeclampsia After Frozen Embryo Transfer
Identifying modifiable factors that contribute to preeclampsia risk associated with assisted reproduction can improve maternal health.
- Trial name
- PREECLAM-2019 (NCT04092829)
- Testing
- FROZEN EMBRYO TRANSFER IN SUBSTITUTED CYCLE
- Where
- Spain
- Volunteers
- 591 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility, Female, Polycystic Ovary Syndrome
Letrozole for Frozen Embryo Transfer (FET) in Patients With Polycystic Ovary Syndrome (PCOS)
To offer patients with oligomenorrhoea or amenorrhoea an alternative to frozen embryo transfer in an artificial cycle, endometrial preparation using letrozole may be a valuable option.
- Conditions
- Infertility, Female, Polycystic Ovary Syndrome, IVF, Ovulation Disorder
- Trial name
- LEFT (NCT04002635)
- Testing
- Letrozole, estradiol valerate
- Volunteers
- healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Cleavage Stage, Ovum
Vitrification Versus Slow Freezing of Human Day 3 Embryos
In assisted reproduction technology (ART), cryopreservation of embryos maximizes the potential of IVF cycles. Currently different cryopreservation methods are used, the conventional slow freezing method and vitrification.
- Trial name
- NCT00710723
- Testing
- vitrification
- Where
- Belgium
- Volunteers
- 901 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Infertility, Preimplantation Genetic Diagnosis/Screening
Estradiol, Progesterone and Endometrial Thickness in Frozen Euploid Embryo Transfer
The development and improvement in Preimplantation genetic diagnosis/screening (PGS) in association with the efficacy and security of vitrification and trophectoderm biopsy, more efficient stimulation schemes and laboratory…
- Conditions
- Infertility, Preimplantation Genetic Diagnosis/Screening, Miscarriage
- Trial name
- NCT03395665
- Testing
- Estradiol level, Progesterone level, Endometrial thickness
- Where
- Spain
- Volunteers
- 299 people
- Sponsor
- Fundacion Dexeus
Frozen Embryo Transfer, Hormone Replacement Therapy
Oral Versus Vaginal Progesterone for Luteal Phase Supplementation in Frozen Embryo Transfer Cycles
To investigate the efficacy of dydrogesterone 30 mg compared to micronized vaginal progesterone 800 mg daily for luteal phase support in hormone replacement therapy frozen embryo transfer cycles, as confirmed by visualization of…
- Conditions
- Frozen Embryo Transfer, Hormone Replacement Therapy, Dydrogesterone, Infertility, Female
- Trial name
- REMODEL (NCT04758871)
- Testing
- Dydrogesterone 10 MG Oral Tablet, Micronized progesterone
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- CRG UZ Brussel
Infertility, IVF
Immediate Versus Postponed Single Blastocyst Transfer in Programmed or Stimulated Cycle Frozen Embryo Transfer
The aim of this randomized controlled trial is to examine whether single blastocyst transfer in the first cycle after oocyte retrieval (immediate) is non-inferior to single blastocyst transfer in a subsequent cycle (postponed) in…
- Trial name
- NCT06304792
- Testing
- Immediate FET in a stimulated or programmed cycle
- Where
- Denmark
- Volunteers
- 484 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infertility
Subcutaneous Progesterone in Frozen- Thawed Single Euploid Blastocyst Transfer.
This is a multicenter, randomized, double-blind, double-dummy, active-controlled, non-inferiority clinical study in women aged 35 to 42 years.
- Trial name
- PROGRESS (NCT04549116)
- Testing
- Progesterone-IBSA Injectable Solution, Progesterone Vaginal Gel with Applicator
- Where
- 24 sites in United States
- Volunteers
- 688 people
- Sponsor
- IBSA Institut Biochimique SA
IVF, Frozen Embryo Transfer (FET)
Maternal Cardiovascular Adaption to Pregnancy in IVF Patients Following Frozen Embryo Transfer (FET)
Aim of the study is to explore the effect of a lacking corpus luteum on maternal cardiovascular and metabolic adaption to pregnancy by the use of magnetic resonance imaging (MRI).
- Conditions
- IVF, Frozen Embryo Transfer (FET), Cardiovascular Adaption, Magnetic Resonance Imaging (MRI)
- Trial name
- NCT06471140
- Testing
- magnetic resonance imaging (MRI)
- Where
- Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital