Clinical trials: Frozen Embryos
Infertility, Progesterone
Effect of Intervention on Progesterone Levels Before Euploid Embryo Transfer in Pregnancy Outcomes.
Transferring an euploid embryo avoids one of the main reasons of miscarriage and implantation failure (1), overcoming confounding factors such as embryo ploidy or maternal age.
- Conditions
- Infertility, Progesterone, Frozen Embryo Transfer, Euploid Embryo Transfer
- Trial name
- NCT03740568
- Testing
- Low Progesterone, Normal Progesterone
- Where
- Spain
- Volunteers
- 598 people
- Sponsor
- Fundacion Dexeus
In Vitro Fertilization
Follow-up Protocol on the Outcome of Frozen-thawed Embryo Transfer Cycles From Clinical Trial P05690 (P05711)
Clinical trial objective is to collect the outcome of Frozen-Thawed Embryo Transfer (FTET) cycles performed after the embryos are cryopreserved in the base study P05690 in order to estimate the cumulative pregnancy rate for each…
- Trial name
- NCT00702546
- Testing
- corifollitropin alfa, recFSH (follitropin alfa), gonadatropin releasing hormone (GnRH) antagonist ganirelix
- Volunteers
- 102 people
- Sponsor
- Organon and Co
Infertility, Female, Infertility of Uterine Origin
Progesterone Levels and Endometrial Compaction in Frozen-Thawed Embryo Transfer Cycles
This study is intended to determine whether there is a correlation between endometrial compaction and serum progesterone levels on the day of frozen embryo transfers by using transvaginal sonography for the endometrial assessment.
- Conditions
- Infertility, Female, Infertility of Uterine Origin, Implantation; Placenta
- Trial name
- NCT04554654
- Testing
- transvaginal ultrasound,
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cem Demirel
Infertility, Frozen Embryo Transfer
Natural Cycle vs Programmed Cycle Frozen Embryo Transfer
The goal of this[ type of study: randomized controlled trial]is to compare Preeclampsia following Natural vs. Artificial Cycle in patients undergoing frozen embryo transfer.
- Conditions
- Infertility, Frozen Embryo Transfer, Preeclampsia and Eclampsia
- Trial name
- NCT05716139
- Testing
- Natural Cycle, Artificial Cycle
- Where
- India
- Volunteers
- 172 people
- Sponsor
- Indira IVF Hospital Pvt Ltd
Infertility
Cumulative Live Birth Rate With eSET After Preimplantation Genetic Screening Versus Conventional In-vitro Fertilization
The purpose of this randomized clinical trial is to compare the efficacy and safety with transfer of embryos selected by next generation sequencing (NGS) versus conventional morphological criteria.
- Trial name
- CESE-PGS (NCT03118141)
- Testing
- blastocyst morphologic score, blastocyst biopsy and sequencing, freeze-all and single thawed blastocyst transfer
- Where
- China
- Volunteers
- 1,215 people
- Sponsor
- Chen Zi-Jiang
Fertility Disorders
The Circadian Variability of Serum Progesterone During the Day of a Frozen Embryo Transfer
Serum progesterone levels will be evaluated at four different time points during the day of an artificially prepared frozen embryo transfer cycle (HRT FET cycle) and a modified natural cycle frozen embryo transfer cycle (mNC FET…
- Trial name
- CIRCAPRO (NCT05511272)
- Testing
- blood test
- Where
- Belgium
- Volunteers
- 44 people
- Sponsor
- Universitair Ziekenhuis Brussel
Ivf, Frozen Embryo Transfer (FET)
Comparison of Pregnancy Rates in Modified Natural Frozen Embryo Transfer (FET) Cycle After Luteal Support with GnRH Agonist Versus Progesterone
Background: The capability to transfer frozen embryos reduces embryo loss following in vitro fertilization (IVF) and results in higher pregnancy rates compared to a single IVF cycle.
- Trial name
- NCT06870266
- Testing
- Nafarelin nasal spray, Utrogestan®
- Volunteers
- 150 people
- Sponsor
- Shaare Zedek Medical Center
Fertility Disorders
ASA 81 mg vs 162 mg During Frozen Embryo Transfer (FET)
The use of low dose aspirin is recommended for high risk patients to reduce the risk of pre-eclampsia, placental abruption and antepartum hemorrhage.
- Trial name
- NCT06128395
- Testing
- Frozen embryo transfer
- Where
- Canada
- Volunteers
- 1,207 people
- Sponsor
- Clinique Ovo
Thin Endometrium, Infertility Female
Effectiveness of Intrauterine Growth Hormone Administration as an add-on Therapy to Conventional Hormone Therapy Compared to Placebo in Patients With Thin Endometrium Undergoing Frozen Thawed Embryo Transfer
The purpose of this clinical trial is to see if intrauterine growth hormone infusions can help subjects reach a suitable endometrial thickness in patients who are resistant to routine hormonal therapy for embryo transfer in the…
- Conditions
- Thin Endometrium, Infertility Female, Infertility
- Trial name
- NCT06379659
- Testing
- Growh hormone
- Where
- Iran
- Volunteers
- 54 people
- Sponsor
- Isfahan University of Medical Sciences
Assisted Hatching, Advanced Age
The Impact of Assisted Hatching on Pregnancy Outcomes After Vitrified-Warmed Embryo Transfer in Advanced-age Patients
The goal of this clinical trial is to evaluate the effect of laser assisted hatching (LAH) on pregnancy outcomes, with live birth rate as the primary outcome, in advanced age infertile women aged ≥35 years who are undergoing…
- Trial name
- NCT07490561
- Testing
- Laser assisted hatching
- Volunteers
- 916 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
IVF
Progesterone Levels and Frozen Embryo Transfer Outcomes
Frozen embryo transfers (FET) now represent the majority of all embryo transfer cycles, and upwards of 60% live births in United States are now attributable to frozen embryo transfers (1).
- Trial name
- PLATO (NCT07252622)
- Testing
- Blood draw
- Volunteers
- 659 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Female Infertility
Extended Culture of Day 3 to Day 5 Frozen Thawed Day 3 Embryos Versus Day 5 Frozen-Thawed Embryos
Cryopreservation of embryos and oocytes has become routine in assisted reproduction technology (ART). Live birth rates following frozen embryo transfers have increased significantly.
- Trial name
- NCT05858333
- Testing
- Extended culture for Group 2: (day 3-5 group)
- Where
- Egypt
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Reproductive Behavior
Endometrial Preparation in Frozen Embryo Transfer Cycles
Comparison of protocols for frozen embryo transfer (ET): One protocol using Estrogen supplements and the second protocol using Letrozole
- Trial name
- NCT03540979
- Testing
- endometrial preparation for frozen blastocyst transfer, Letrozole, Ovidrel
- Volunteers
- 100 people
- Sponsor
- Meir Medical Center
ART, IVF
Health in Childhood Following Assisted Reproductive Technology
The purpose of this trial is to investigate the metabolic and cardiovascular health in children aged 6-8 years born after in-vitro fertilization with frozen embryo transfer
- Conditions
- ART, IVF, Cardiovascular Risk Factor, Hypertension
- Trial name
- HiCART (NCT03719703)
- Where
- Denmark
- Volunteers
- 606 people, healthy volunteers welcome
- Sponsor
- Anja Bisgaard Pinborg
Infertility
CuMulativE Live bIrth Rate of Patients at High Risk of OHSS After Freeze-all Embryos at Cleavage or blAstocyst Stage
Ovarian stimulation for the induction of multifollicular growth by gonadotrophins represents an important part of In Vitro Fertilization (IVF).
- Trial name
- MELISSA (NCT03817060)
- Testing
- cryopreservation of embryos at cleavage stage, cryopreservation of embryos at blastocyst stage
- Volunteers
- 128 people
- Sponsor
- Université Libre de Bruxelles
Infertility, Endometriosis
Comparison Elagolix vs Depot Leuprolide Prior to Frozen Embryo Transfers in Patients With Endometriosis
Patients who have been previously surgically diagnosed with endometriosis and have embryos predicted to be euploid after in vitro fertilization will be divided into 2 groups via randomization.
- Trial name
- NCT04445025
- Testing
- Elagolix 200 MG, Leuprolide Acetate 3.75 MG/ML, Lab work
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Colorado Center for Reproductive Medicine
Adenomyosis of Uterus, Frozen Embryo Transfer (FET)
GnRH Agonist Pretreatment Duration and Letrozole Supplementation in Frozen Embryo Transfer for Adenomyosis Patients
This randomized clinical trial aims to assess the comparative effectiveness of different pre-treatment protocols prior to frozen embryo transfer (FET) among women with adenomyosis, providing evidence-based guidance for clinical…
- Trial name
- GOLD-FET (NCT07065539)
- Testing
- GnRH-a-1M, GnRH-a-2M, GnRH-a+LE-1M
- Where
- China
- Volunteers
- 432 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Frozen Embryo Transfer (FET), Assisted Reproductive Techniques
Direct Warming Frozen Embryo Transfer Outcomes in Assisted Reproductive Technology
The goal of this clinical trial is to evaluate whether the direct warming method for frozen embryo transfers (FET) can improve live birth and pregnancy outcomes in women aged 18-45 undergoing IVF treatments.
- Conditions
- Frozen Embryo Transfer (FET), Assisted Reproductive Techniques, In Vitro Fertilization (IVF), Cryopreservation of Embryos
- Trial name
- DW-FET-RCT (NCT06741748)
- Testing
- Direct Warming Method, Conventional Multi-step Thawing Method
- Where
- 3 sites in Hong Kong, United Kingdom
- Volunteers
- 578 people
- Sponsor
- Chinese University of Hong Kong
Stress, Physiological, Infertility
Evaluation of the Impact of Stress on IVF Outcome
The purpose of this study is to determine if physiological measures of stress, measured by the non-invasive OTO device, are significantly correlated with IVF outcome.
- Conditions
- Stress, Physiological, Infertility, Stress, Psychological
- Trial name
- NCT05589571
- Where
- 43 sites in United States
- Volunteers
- 240 people
- Sponsor
- Inception Fertility Research Institute, LLC
Invitro Fertilization
Long Protocol and Freeze All Embryos vs Antagonist Protocol With Fresh Embryo Transfer in PCOS Patients Undergoing ICSI
Patients will be divided into two groups Group A; patients using long protocol and freeze all embryos Group B; patients using antagonist protocol with fresh embryo transfer Patients will be carefully chosen according to a strict…
- Trial name
- NCT03118830
- Testing
- Triptorelin, cetrorelix, Recombinant Follicle Stimulating Hormone
- Where
- Egypt
- Volunteers
- 204 people
- Sponsor
- Cairo University