Clinical trials: Fructose Metabolism Disorder
Metabolic Syndrome, Insulin Resistance
The Metabolic Effects of Consuming Sugar-Sweetened Beverages for Two Weeks
The purpose of this study is to examine the effects of consumption of sugar-sweetened beverages on blood triglycerides and cholesterol, cholesterol concentrations, and the body's sensitivity to insulin.
- Conditions
- Metabolic Syndrome, Insulin Resistance, Dyslipidemia
- Trial name
- DRS (NCT01103921)
- Testing
- Glucose, Fructose, High-Fructose Corn Syrup
- Where
- United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Hereditary Fructose Intolerance
Fructose Supplementation in Carriers for Hereditary Fructose Intolerance
This study aimed to examine metabolic response to a short-term fructose enriched diet in carriers for hereditary fructose intolerance compared to controls.
- Trial name
- NCT03545581
- Testing
- Experimental diet Fru rich diet, Experimental low Fru diet
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Fructose Metabolism Disorder, Fructose Rich Diet
Fructose Rich Diet and Endothelial Function
Cardiometabolic diseases have been associated with high consumption of sweetened beverages. These products are responsible for the largest portion of the total consumption of fructose in the diet and it is suggested that…
- Conditions
- Fructose Metabolism Disorder, Fructose Rich Diet, Metabolic Disease, Aerobic Exercise
- Trial name
- NCT03939130
- Testing
- Fructose, Glucose, Fructose and exercise
- Where
- Brazil
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Non-Alcoholic Fatty Liver Disease, Obesity
Effects of Dietary Fructose on Gut Microbiota and Fecal Metabolites in Obese Men and Postmenopausal Women: A Pilot Study
Non alcoholic fatty liver disease (NAFLD) is the most common cause of abnormal liver function tests in the U.S. (Browning, et al., 2004), ranging from steatosis to end-stage liver disease.
- Trial name
- NCT03339245
- Testing
- Fructose Solution (75 Grams), Glucose Solution (75 grams)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Chronic Disease of Cardiovascular System, Type 2 Diabetes
Adverse Metabolic Effects of Dietary Sugar
It is not known whether consumption of excessive amounts of sugar can increase risk factors for cardiovascular disease or diabetes in the absence of increased food (caloric) intake and weight gain, nor whether the negative…
- Conditions
- Chronic Disease of Cardiovascular System, Type 2 Diabetes, Obesity
- Trial name
- NCT02548767
- Testing
- high fructose corn syrup, aspartame, Energy-balanced diet
- Where
- 3 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Fructose Metabolism Disorder
Low Fructose Diet in Diabetes Type 2
Diabetes is one of the most common and chronic diseases in the world, with the prevalence and incidence of this disease rising in most societies, especially in Iran.
- Trial name
- NCT03352596
- Testing
- low frutose diet
- Volunteers
- 48 people
- Sponsor
- National Nutrition and Food Technology Institute
Type 1 Diabetes
Fructose and Glucose and TAS1R2 in Type 1 Diabetes
BACKGROUND: Individuals with diabetes report innate preference for sweet foods, possibly due to genetic variants. In addition, studies have shown that ingestion of fructose promotes lower postprandial blood glucose, compared to…
- Trial name
- TAS1R2 (NCT01713023)
- Testing
- Glucose, Fructose
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Obesity, Metabolic Syndrome
Metabolic Impact of Fructose Restriction in Obese Children
The sugar fructose has been implicated not just as a cause of obesity, but as a cause of the metabolic diseases that go along with obesity, termed "metabolic syndrome".
- Trial name
- SUCRE (NCT01200043)
- Testing
- fructose restriction diet
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of California, San Francisco
Type 1 Diabetes Mellitus, Diabetes Complications
Fructose in Exercising Individuals With Type 1 Diabetes Using Insulin Degludec
To determine and compare the time-to-hypoglycaemia (defined as plasma glucose <3.9mmol/L) in individuals with type 1 diabetes treated with ultra-Long acting insulin degludec during aerobic exercise with or without prior ingestion…
- Trial name
- FruDeg (NCT03497260)
- Testing
- Fructose, Plain water
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Fructose Metabolism, Inborn Errors, Glycogen Storage Disease
Biomarker for Glycogen Storage Diseases (BioGlycogen)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Glycogen Storage Diseases from plasma. Testing for clinical robustness, specificity and long-term stability of the biomarker.
- Conditions
- Fructose Metabolism, Inborn Errors, Glycogen Storage Disease, Glycogen Storage Disease Type I, Glycogen Storage Disease Type II
- Trial name
- BioGlycogen (NCT02385162)
- Where
- 4 sites in Germany, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
Fructose Metabolism Disorder
Effect of Matrices on Serum Fructose.
Epidemiological evidence is accumulating that a high consumption of added sugars is associated with metabolic diseases such as non-alcoholic fatty liver disease and type 2 diabetes.
- Trial name
- NCT05826717
- Testing
- Apple, Mashed apple, Apple juice
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sedentary Lifestyle, Dyslipidemias
Effects of Exercise on Fructose-induced Postprandial Lipemia
Cardiovascular Diseases (CVDs) are the leading causes of death in the world and in Brazil. In 2001, 12.45 million deaths on the globe (21% of the total) were caused by some CVD.
- Conditions
- Sedentary Lifestyle, Dyslipidemias, Lipid Metabolism Disorders, Carbohydrate Inducible Hyperlipemia
- Trial name
- NCT03173495
- Testing
- FRUCTOSE, DEXTROSE, EXERCISE
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Overweight, Obesity
Sweetened Beverages and Food Intake
The purpose of this study is to investigate whether beverages sweetened with fructose promote overconsumption of calories as compared to beverages sweetened with glucose or a non-caloric sweetener.
- Trial name
- NCT00475475
- Testing
- Fructose, glucose, non-caloric sweetener
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Washington
Chronic Kidney Diseases, Diabetes Mellitus, Type 2
Effect of Acute Fructose Load in Human
The metabolism of the monosaccharide fructose is less controlled than the metabolism of glucose, which will result in the metabolic product uric acid.
- Trial name
- NCT03157960
- Testing
- Blueberry drink, Blueberry and pizza, Soft beverage
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Irritable Bowel Syndrome, Fructose Intolerance
Is the Expression of the GLUT5 Specific Fructose Transport Protein Abnormal in Patients With Fructose Intolerance?
In this study we will investigate the expression of the fructose transport protein GLUT5 in the small intestine in patients with functional GI disoders and fructose intolerance compared to matched healthy controls.
- Trial name
- NCT01705171
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brain-Gut Research Group
Type 2 Diabetes
The Fructose and Allulose Catalytic Effects (FACE) Trial
Diabetes remains one of the most important unmet prevention and treatment challenges, and the prevalence of diabetes continues to grow. Some functional food ingredients may hold promise as potential therapies for diabetes.
- Trial name
- NCT02459834
- Testing
- Allulose, Fructose, Control
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Irritable Bowel Syndrome, Fructose Malabsorption
Fructose Malabsorption in Northern Norway
Different published studies has shown a possible co-variation between leakage of fructose to the great bowel and exacerbation of irritable bowel syndrome (IBS) symptoms.
- Trial name
- FINN (NCT00555191)
- Testing
- diet restriction
- Where
- Norway
- Volunteers
- 182 people
- Sponsor
- University Hospital of North Norway
Metabolic Syndrome
The Effect of Allopurinol on Insulin Resistance and Blood Pressure
Studies in animals have found that allopurinol can markedly improve fructose induced metabolic syndrome. In this study we test the hypothesis that allopurinol may lower BP, reduce triglycerides, and improve metabolic parameters…
- Trial name
- NCT00639756
- Testing
- Allopurinol
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Mateo Orfila
Obesity, Childhood, Neural Development
Effect of Liraglutide on Neural Responses to High Fructose Corn Syrup in Individuals With Obesity.
To study the effects of liraglutide on neural responses to high fructose corn syrup (HFCS) in individuals with obesity.
- Trial name
- NCT03500484
- Testing
- Liraglutide
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Yale University
Insulin Resistance
Effect of Dietary SFA and Fructose on Hepatic Insulin Sensitivity
High rates of de novo lipogenesis (DNL) and high saturated fatty acid (SFA) fraction in the liver both have been associated with poor metabolic health and hepatic insulin resistance.
- Trial name
- NCT05017675
- Testing
- High fructose diet, High saturated fat diet
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center