Clinical trials: Fuch's Dystrophy
Fuchs Endothelial Corneal Dystrophy
Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy
This protocol will investigate whether topical application of N-acetyl cysteine (NAC) eye drops decreases oxidative stress and confers cytoprotection in patients with FECD.
- Trial name
- NCT04440280
- Testing
- N-acetyl cysteine (NAC) 10% solution, N-acetyl cysteine (NAC) 20% solution, Visine Dry Eye Relief eye drops
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Fuch's Endothelial Dystrophy, Cataracts
Study of the Effect of Aspheric Lenses in Patients With Fuch's Dystrophy
The proposed study will recruit patients with mild to moderate Fuch's dystrophy who need cataract surgery alone. They will be randomly assigned to receive either spheric or aspheric lenses.
- Trial name
- NCT02109276
- Testing
- Spheric Sensar(R) 3-piece IOL, Aspheric Tecnis(R) 3-piece IOL
- Where
- Canada
- Sponsor
- Queen's University
Corneal Disease, Fuch's Dystrophy
Cornea Donor Study
The Cornea Donor Study (CDS) was designed as a prospective cohort study with the following objectives: To determine whether the graft-failure rate over a 5-year follow-up period following corneal transplantation is the same when…
- Conditions
- Corneal Disease, Fuch's Dystrophy, Pseudophakic Corneal Edema
- Trial name
- CDS (NCT00006411)
- Testing
- corneas assigned by donor age group
- Where
- United States
- Volunteers
- 1,090 people
- Sponsor
- National Eye Institute (NEI)
Fuchs' Endothelial Corneal Dystrophy
Assessment of Corneal Endothelial Function Following Hypoxic Stress
The purpose of this study is to determine the difference in the cornea's response to contact lens placement between healthy and unhealthy eyes.
- Trial name
- NCT04175938
- Testing
- Wearing of contact lens
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Fuch's Endothelial Dystrophy, Bullous Keratopathy, Unspecified Eye
Comparing Endoglide to Endoserter for DSAEK Graft Insertion
The purpose of this study is to compare the Tan EndoGlide with the new Endoserter injector in terms of damage to the donor corneal endothelium by comparing the endothelial cell loss at 1 month, 3 months, 6 months, and 1 year post…
- Trial name
- NCT01791075
- Testing
- Tan Endoglide, Endosaver
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University Health Network, Toronto
Fuchs' Endothelial Dystrophy
Glanatec(R) for Descemet Stripping in Fuch's Endothelial Dystrophy
In brief, the objective of this study is to investigate whether the drug Glanatec ® which is approved in Japan for glaucoma and ocular hypertension, can be used in patients with Fuchs endothelial dystrophy who have had a descemet…
- Trial name
- NCT03249337
- Testing
- Ripasudil hydrochloride hydrate 0.4% ophthalmic solution
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Marian Macsai, MD
Fuch's Endothelial Dystrophy, Pseudophakic Bullous Keratopathy
Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media
The goal of this clinical trial is to compare the quality of corneal grafts cultured in a serum-free culture medium with a defined composition versus corneal grafts cultured in a standard serum supplemented culture medium…
- Trial name
- SFM (NCT00623584)
- Testing
- Corneal transplantation
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Klinikum Chemnitz gGmbH
Fuch's Endothelial Dystrophy
Comparison of Two Techniques in Achieving Corneal Graft
The cornea is a transparent membrane, half a millimeter thick, embedded as a window in front of the eye. When the eye becomes opaque, the eye is not seeing and the only way to restore the visual acuity is to replace the cornea by…
- Trial name
- NCT01610973
- Testing
- Endothelial descemet membrane graft
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Rouen
Fuch's Dystrophy, Corneal Disorders
Novel Diagnostics With Optical Coherence Tomography: Imaging the Anterior Eye
The purpose of this research is to evaluate the optical coherence tomography (OCT), to image diseases of the eye. OCT may be useful for the early diagnosis and monitoring of a variety of diseases involving the eye, such as Fuch's…
- Conditions
- Fuch's Dystrophy, Corneal Disorders, Prior Surgery
- Trial name
- NCT00343473
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health