Clinical trials: Fuchs Dystrophy
Corneal Endothelial Dystrophy, Fuchs Endothelial Corneal Dystrophy
A Phase 1/ Phase 2 Study of TTHX1114(NM141)
Prospective, multicenter, randomized, masked, vehicle-controlled, dose-escalation study
- Conditions
- Corneal Endothelial Dystrophy, Fuchs Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy, Endothelial Dysfunction
- Trial name
- INTREPID (NCT04520321)
- Testing
- TTHX1114(NM141)
- Where
- 8 sites in United States
- Volunteers
- 22 people
- Sponsor
- Trefoil Therapeutics, Inc.
Fuchs Dystrophy
Association Between Fuchs' Endothelial Corneal Dystrophy Severity and Estrogen Exposure
This study is being done to discover if there is a link between estrogen exposure and the severity of Fuchs Endothelial Corneal Disease.
- Trial name
- NCT04564378
- Testing
- This is an observational study. There is no therapeutic intervention.
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- State University of New York at Buffalo
Fuchs' Endothelial Dystrophy
Evaluation of the Efficacy of Descemet Membrane Transplantation for the Treatment of Fuchs' Endothelial Dystrophy
Fuchs Endothelial Dystrophy (FED) is a degenerative disease affecting the corneal endothelium. The current gold-standard for treatment of severe FED is endothelial keratoplasty, wherein a cadaveric Descemet's membrane /…
- Trial name
- NCT03275896
- Testing
- Descemet Membrane Transplantation
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- Singapore National Eye Centre
Cystoid Macular Edema, Fuchs Dystrophy
Descemet Membrane Endothelial Keratoplasty vs. Descemet's Stripping With Endothelial Keratoplasty vs. Descemet Stripping Only
This study aims to evaluate and compare incidence of post-operative cystoid macular edema (CME) after Descemet Membrane Endothelial Keratoplasty (DMEK), Descemet's Stripping Automated endothelial Keratoplasty (DSEK) and Descemet…
- Trial name
- NCT04527523
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Wake Forest University Health Sciences
Fuchs' Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy
Prognosis of Posterior Lamellar Keratoplasty
Over the past decade, the management of Fuchs' endothelial corneal dystrophy (FECD) and pseudophakic bullous keratopathy (PBK) has been revolutionized by the development of posterior lamellar keratoplasty techniques: DSAEK and…
- Trial name
- CORNEACOHORT (NCT06859411)
- Testing
- visual acuity comparaison
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Fuchs' Endothelial Dystrophy, Pseudophakic Bullous Keratopathy
The Effect Of Preoperative Parameters On Success After DMEK Surgery
The aim of this study is to evaluate the effect of preoperative parameters on surgical results in Descemet Membrane Endothelial Keratoplasty (DMEK) surgery.
- Conditions
- Fuchs' Endothelial Dystrophy, Pseudophakic Bullous Keratopathy, Descemet's Membrane; Defect, Herpetic Keratitis
- Trial name
- NCT04420429
- Testing
- Descemet membrane endothelial keratoplasty (DMEK)
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Beyoglu Eye Research and Education Hospital
Corneal Edema
A Phase 2 Study Evaluating the Safety and Efficacy of Netarsudil Ophthalmic Solution in Patients With Corneal Edema Due to Fuchs Corneal Dystrophy
Two different dosing regimens (QD and BID) of netarsudil will be studied to evaluate their efficacy in reducing or resolving corneal edema in subjects with FCD.
- Trial name
- Fuchs (NCT04498169)
- Testing
- Netarsudil Ophthalmic
- Where
- 12 sites in United States
- Volunteers
- 40 people
- Sponsor
- Aerie Pharmaceuticals
Fuchs, Fuchs Dystrophy
Descemet Endothelial Thickness Comparison Trial II
Descemet Endothelial Thickness Comparison Trial (DETECT) II is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 60 patients with Fuchs endothelial dystrophy to DMEK versus Descemet Stripping…
- Conditions
- Fuchs, Fuchs Dystrophy, Fuchs' Endothelial Dystrophy
- Trial name
- DETECT II (NCT05275972)
- Testing
- Ripasudil
- Where
- 8 sites in United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Fuchs' Endothelial Dystrophy, Cataract
The Effects of Ripasudil in Patients With FED Undergoing Femtosecond Laser Assisted Cataract Surgery
The purpose of this research is to investigate the effects of ripasudil administered as an ophthalmic solution in patients with FED after femtosecond laser assisted cataract surgery.
- Trial name
- NCT06048380
- Testing
- Ripasudil
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Singapore Eye Research Institute
Fuchs Endothelial Corneal Dystrophy
SUCCESS Score Validation in Fuchs Dystrophy
This prospective multicenter diagnostic study aims to externally validate and extend the SUCCESS Score for predicting the need for endothelial keratoplasty after cataract surgery in patients with Fuchs endothelial corneal…
- Trial name
- SUCCESS (NCT07265388)
- Testing
- Phacoemulsification Cataract Surgery
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Instituto Ramón y Cajal de Investigación Sanitaria
Corneal Dystrophies
Analysis of the Genotype/Phenotype Relationship in the Fuchs' Corneal Endothelial Dystrophy in France
The pathophysiology of the most common corneal endothelial dystrophies (Fuchs' Corneal Endothelial Dystrophy, FECD) is beginning to be dismembered.
- Trial name
- F3S2 (NCT05742321)
- Testing
- Genotyping, Histology, Collection of data
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Fuchs Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy
The Postoperative Head Position as a Predictor of the Surgical Outcome After DMEK
This study aims to investigate the influence of postoperative head position on clinical outcomes after DMEK via a wearable sensor.
- Conditions
- Fuchs Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy, Chemical Burn of Cornea, Posterior Polymorphous Corneal Dystrophy
- Trial name
- NCT04387331
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Peter Wiedemann
Fuchs' Endothelial Dystrophy
OCT-guided DSAEK Graft Shaping and Smoothing
The primary goal of this study is to determine if excimer laser smoothing of the cornea before Descemet's stripping automated endothelial keratoplasty (DSAEK)improves postoperative Best Spectacle Corrected Visual Acuity (BSCVA).
- Trial name
- DSAEK (NCT01586234)
- Testing
- DSAEK with graft shaping and smoothing, Standard DSAEK
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Oregon Health and Science University
Keratoconus, Fuchs' Endothelial Dystrophy
Long Term Cornea Graft Survival Study
Corneal transplantation have been performed for several decades, follow-up time in some centers now exceeds 30 years. Published long term (10 years and up) graft survivals vary considerably from center to center.
- Trial name
- BELIEvE (NCT02849808)
- Where
- France
- Volunteers
- 564 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Corneal Endothelial Decompensation, Fuchs' Endothelial Dystrophy
Impact of Donor Diabetes on DMEK Success and Endothelial Cell Loss
This double-masked multi-center trial will evaluate the association of diabetes in the cornea donor with transplant success and loss of endothelial cells through 1 year following Descemet membrane endothelial keratoplasty (DMEK).
- Trial name
- DEKS (NCT05134480)
- Testing
- Descemet membrane endothelial keratoplasty
- Where
- 2 sites in United States
- Volunteers
- 1,097 people
- Sponsor
- Case Western Reserve University
Fuchs Dystrophy, Corneal Edema
A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal Edema
The objectives of this study are to compare the visual and refractive outcomes of deep lamellar endothelial keratoplasty (DLEK) with penetrating keratoplasty as treatment for certain cases of corneal edema due to endothelial…
- Trial name
- NCT00346138
- Testing
- Corneal transplantation
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mayo Clinic
Fuchs' Endothelial Dystrophy
DMEK Versus DSAEK Study
The purpose of this study is to determine whether corneal transplantation by Descemet Membrane Endothelial Keratoplasty more favourable and cost-effective is compared to Descemet Stripping Automated Endothelial Keratoplasty for…
- Trial name
- DMEK (NCT02793310)
- Testing
- DMEK, DSAEK
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- Maastricht University Medical Center
Fuchs' Endothelial Dystrophy, Fuchs Dystrophy
TTHX1114(NM141) in Combination With DWEK/DSO
Open label, single-treatment, with a concurrent non-treatment control
- Conditions
- Fuchs' Endothelial Dystrophy, Fuchs Dystrophy, Fuchs
- Trial name
- NCT04676737
- Testing
- TTHX1114(NM141)
- Where
- 11 sites in United States
- Volunteers
- 49 people
- Sponsor
- Trefoil Therapeutics, Inc.
Fuchs' Dystrophy, Bullous Keratopathy
Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)
The purpose of this study is to compare two different commonly used steroid dosing regimens after Descemet's membrane endothelial keratoplasty (DMEK) transplant surgery.
- Trial name
- NCT01448213
- Testing
- Prednisolone acetate, Fluorometholone
- Where
- 2 sites in United States, Germany
- Volunteers
- 264 people
- Sponsor
- Price Vision Group
Fuchs Endothelial Corneal Dystrophy
A Study to Evaluate the Safety and Efficacy of K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)
A study to assess the safety and efficacy of K-321 in participants with FECD after descemetorhexis.
- Trial name
- NCT05795699
- Testing
- Ripasudil
- Where
- 50 sites in United States, Canada and 4 more
- Volunteers
- 107 people
- Sponsor
- Kowa Research Institute, Inc.