Clinical trials: Fuchs Dystrophy, active
Mild to Moderate Corneal Endothelial Decompensation, Bullous Keratopathy
Safety and Efficacy of Tissue Engineered Endothelial Keratoplasty
Assessment of safety and efficacy of tissue-engineered corneal endothelial graft material generated using cultured human corneal endothelial cells for tissue-engineered endothelial keratoplasty (TE-EK).
- Conditions
- Mild to Moderate Corneal Endothelial Decompensation, Bullous Keratopathy, Fuchs' Endothelial Dystrophy, Post-surgical Corneal Decompensation (Irreversible)
- Trial name
- TE-EK (NCT04319848)
- Testing
- TE-EK treatment group
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore Eye Research Institute
Fuchs Endothelial Corneal Dystrophy, Descemet Membrane Endothelial Keratoplasty (DMEK)
Influence of Supine Positioning on the Outcomes After Descemet Membrane Endothelial Keratoplasty (DMEK)
The goal of this clinical trial is to learn if a longer period of lying on the back after corneal transplant surgery (Descemet Membrane Endothelial Keratoplasty, DMEK) helps the transplant stick better in the eye.
- Trial name
- SUPINE (NCT07373821)
- Testing
- Duration of Supine Positioning
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- University Hospital Heidelberg
Fuchs Endothelial Corneal Dystrophy
Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy
This protocol will investigate whether topical application of N-acetyl cysteine (NAC) eye drops decreases oxidative stress and confers cytoprotection in patients with FECD.
- Trial name
- NCT04440280
- Testing
- N-acetyl cysteine (NAC) 10% solution, N-acetyl cysteine (NAC) 20% solution, Visine Dry Eye Relief eye drops
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Fuchs Endothelial Corneal Dystrophy
SUCCESS Score Validation in Fuchs Dystrophy
This prospective multicenter diagnostic study aims to externally validate and extend the SUCCESS Score for predicting the need for endothelial keratoplasty after cataract surgery in patients with Fuchs endothelial corneal…
- Trial name
- SUCCESS (NCT07265388)
- Testing
- Phacoemulsification Cataract Surgery
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Instituto Ramón y Cajal de Investigación Sanitaria
Fuchs, Fuchs Dystrophy
Descemet Endothelial Thickness Comparison Trial II
Descemet Endothelial Thickness Comparison Trial (DETECT) II is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 60 patients with Fuchs endothelial dystrophy to DMEK versus Descemet Stripping…
- Conditions
- Fuchs, Fuchs Dystrophy, Fuchs' Endothelial Dystrophy
- Trial name
- DETECT II (NCT05275972)
- Testing
- Ripasudil
- Where
- 8 sites in United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Corneal Edema, Corneal Endothelial Disorder
The Belgian Endothelial Surgical Transplant of the Cornea
This study is designed as a randomised multicentric parallel group pragmatic trial of Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK) in corneal endothelial…
- Conditions
- Corneal Edema, Corneal Endothelial Disorder, Fuchs' Endothelial Dystrophy, Bullous Keratopathy
- Trial name
- BESTCornea (NCT05436665)
- Testing
- UT-DSAEK, DMEK
- Where
- 11 sites in Belgium
- Volunteers
- 220 people
- Sponsor
- University Hospital, Antwerp
Fuchs Endothelial Corneal Dystrophy, Corneal Endothelial Decompensation
Effect of Donor Diabetes and Other Factors on Corneal Transplant Endothelial Cell Loss and Success at 5 Years
This multi-center clinical trial is designed to assess the association of diabetes in a cornea donor with transplant success and loss of endothelial cells 5 years following Descemet membrane endothelial keratoplasty (DMEK).
- Trial name
- DEKS (NCT07217249)
- Testing
- Descemet membrane endothelial keratoplasty
- Where
- 14 sites in United States
- Volunteers
- 570 people
- Sponsor
- Case Western Reserve University
Map Dot Fingerprint Dystrophy, Post-penetrating Keratoplasty
Brillouin Microscopy Used to Evaluate Corneal Mechanical Properties
This study aims to explore the mechanical properties of the cornea using a non-invasive imaging technique called Brillouin microscopy.
- Conditions
- Map Dot Fingerprint Dystrophy, Post-penetrating Keratoplasty, Post-Descemet Membrane Endothelial Keratoplasty, Healthy Corneas
- Trial name
- NCT06914817
- Testing
- Brillouin optical scanning system (Intelon Optics) (BOSS)
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Fuchs' Endothelial Dystrophy, Cataract
The Effects of Ripasudil in Patients With FED Undergoing Femtosecond Laser Assisted Cataract Surgery
The purpose of this research is to investigate the effects of ripasudil administered as an ophthalmic solution in patients with FED after femtosecond laser assisted cataract surgery.
- Trial name
- NCT06048380
- Testing
- Ripasudil
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Singapore Eye Research Institute
Corneal Edema, Corneal Endothelial Dystrophy
Study to Assess Safety and Tolerability of Multiple Doses of EO2002
The goal of this clinical study is to assess the safety of multiple intracameral injections of EO2002 with and without topical Ripasudil.
- Conditions
- Corneal Edema, Corneal Endothelial Dystrophy, Endothelial Dysfunction, Fuchs Dystrophy
- Trial name
- NCT05636579
- Testing
- EO2002, Ripasudil
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Fuchs Endothelial Corneal Dystrophy
Effect of Descemet Membrane Polishing in Fuchs Endothelial Corneal Dystrophy
Fuchs endothelial corneal dystrophy (FECD) is the leading indication for corneal transplantation worldwide. It is characterized by the accumulation of guttae and progressive loss of corneal endothelial cells, leading to corneal…
- Trial name
- Fuchs Polishin (NCT07539012)
- Testing
- Fuchs Polishing
- Where
- 5 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Keratoconus, Ectasia
A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to compare biomechanical properties…
- Conditions
- Keratoconus, Ectasia, Crosslinking, Fuchs' Endothelial Dystrophy
- Trial name
- NCT02118922
- Testing
- Brillouin imaging
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Fuchs' Endothelial Dystrophy
Glanatec(R) for Descemet Stripping in Fuch's Endothelial Dystrophy
In brief, the objective of this study is to investigate whether the drug Glanatec ® which is approved in Japan for glaucoma and ocular hypertension, can be used in patients with Fuchs endothelial dystrophy who have had a descemet…
- Trial name
- NCT03249337
- Testing
- Ripasudil hydrochloride hydrate 0.4% ophthalmic solution
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Marian Macsai, MD
Fuchs Endothelial Corneal Dystrophy, Cataract (Post-operative Cataract Surgery Follow-up)
Postoperative CCT in FECD vs. Non-FECD
This single-centre, prospective, controlled, non-interventional observational clinical study aims to characterize early postoperative corneal thickness behaviour after routine phacoemulsification cataract surgery in eyes with…
- Trial name
- NCT07731945
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Vienna Hospital Association
Corneal Dystrophies
Analysis of the Genotype/Phenotype Relationship in the Fuchs' Corneal Endothelial Dystrophy in France
The pathophysiology of the most common corneal endothelial dystrophies (Fuchs' Corneal Endothelial Dystrophy, FECD) is beginning to be dismembered.
- Trial name
- F3S2 (NCT05742321)
- Testing
- Genotyping, Histology, Collection of data
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cataract Surgery, Cataract and Fuchs Endothelial Corneal Dystrophy
Trial Comparing Cataract Surgery With Triple-DMEK in Patients With Cataract and Fuchs Endothelial Corneal Dystrophy
The purpose of the study is to investigate whether there is a difference in BCVA in patients who receive one of the following two surgeries: intervention group (arm 1) cataract surgery alone and control group (arm 2) cataract…
- Trial name
- ETCF (NCT06425666)
- Testing
- Intervention group /arm 1 (Cataract surgery alone), Control group /arm 2: Corneal transplantation as Descemet Membrane Endothelial Keratoplasty (DMEK) in combination with cataract surgery (triple-DMEK)
- Where
- 4 sites in Denmark, Germany and 2 more
- Volunteers
- 120 people
- Sponsor
- University of Cologne
Fuchs Endothelial Corneal Dystrophy, Fuchs
DT-168 in Keratoplasty Patients With Fuchs Endothelial Corneal Dystrophy
The purpose of this study is to evaluate the pharmacodynamics, safety, and tolerability of DT-168 Ophthalmic Solution in pre-keratoplasty patients with Fuchs endothelial corneal dystrophy.
- Trial name
- NCT07024693
- Testing
- DT-168
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Design Therapeutics, Inc.
Fuchs' Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy
Prognosis of Posterior Lamellar Keratoplasty
Over the past decade, the management of Fuchs' endothelial corneal dystrophy (FECD) and pseudophakic bullous keratopathy (PBK) has been revolutionized by the development of posterior lamellar keratoplasty techniques: DSAEK and…
- Trial name
- CORNEACOHORT (NCT06859411)
- Testing
- visual acuity comparaison
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Pseudophakic Bullous Keratopathy, Fuchs' Endothelial Dystrophy
The OPTIMISE Study
Rationale: The cornea is the most transplanted tissue in the Netherlands, with more than 1,500 procedures performed each year. A minimally invasive technique called Descemet Membrane Endothelial Keratoplasty (DMEK) has become the…
- Conditions
- Pseudophakic Bullous Keratopathy, Fuchs' Endothelial Dystrophy, Intraocular Pressure
- Trial name
- NCT05716945
- Testing
- Fluorometholone 0.1% Oph Susp, Dexamethasone 0.1% ophthalmic suspension, Stop steroids
- Where
- 8 sites in Netherlands
- Volunteers
- 342 people
- Sponsor
- Maastricht University Medical Center
Fuchs' Endothelial Dystrophy, Corneal Edema
Plasma Rich in Growth Factors in Corneal Endothelial Transplantation
The purpose of the study is to determine the safety and efficacy of brief intraoperative corneal endothelial graft incubation in plasma rich in growth factors (PRGF) for reducing postoperative endothelial cell loss.
- Trial name
- NCT06261346
- Testing
- Endothelial keratoplasty, PRGF
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Miami