Clinical trials: Full Thickness Macular Hole
Macular Holes, High Myopia
Effects of Macular Buckle Versus Vitrectomy on Macular Hole and Macular Detachment in Highly Myopic Eyes
Full-thickness macular Hole associated with macular detachment is a one of the maculopathies of high myopia. There is controversy in the primary treatment for this situation.
- Conditions
- Macular Holes, High Myopia, Macular Detachment
- Trial name
- NCT03433547
- Testing
- Buckle, Vitrectomy, Limbal paracentesis
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Macular Holes
Clinical Characteristics and Surgical Outcomes of Full-thickness Macular Hole Without Focal Vitreomacular Traction.
This multicenter, retrospective, observational comparative study. We occasionally encounter FTMHs in which PVD has not been achieved and VMT is absent.
- Trial name
- NCT06560710
- Testing
- vitrectimy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St. Marianna University School of Medicine
Vitreomacular Traction (VMT), Full-thickness Macular Holes (MH)
Effects of Pneumatic Vitreolysis on Macular Hole
Eyes with vitreomacular traction (VMT) and full-thickness macular holes (MH) will be enrolled into a non-randomized cohort treated with pneumatic vitreolysis (PVL) to determine the proportion with VMT release and MH closure and…
- Trial name
- Protocol AH (NCT03677869)
- Testing
- Intraocular gas (C3F8)
- Where
- 45 sites in United States
- Volunteers
- 36 people
- Sponsor
- Jaeb Center for Health Research
Macular Hole
Outcomes of Macular Hole Surgery With Inverted Flap With vs Without Post op Posturing With SF6 in Macular Hole More Than 400 Micrometres
This study evaluated the outcomes of surgery for large full-thickness macular holes measuring more than 400 micrometres using the inverted internal limiting membrane flap technique with sulphur hexafluoride (SF6) gas tamponade.
- Trial name
- NCT07787390
- Testing
- Macular Hole Surgery With Inverted Internal Limiting Membrane Flap and SF6 Gas Tamponade, Face-Down Postoperative Positioning, No Face-Down Postoperative Positioning
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Lahore General Hospital
Full Thickness Macular Hole
Protocol for RCT of Posturing in Phacovitrectomy for Full Thickness Macular Hole (FTMH)
The purpose of this study is to determine the effect of postoperative posturing on the outcome of macular hole surgery. Current practice is divided; some individuals are advised to posture face-down for 10 days and others are…
- Trial name
- NCT01020760
- Testing
- Face down posture
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- NHS Greater Glasgow and Clyde
Macular Holes, Microperymetry
The Application of M-charts and Microperimetry for the Assessment of Visual Function in Patients After Vitrectomy Due to the Full Thickness Macular Hole.
To examine the relationship between morphological and functional results in eyes after vitrectomy due to the full thickness macular hole (FTMH).
- Conditions
- Macular Holes, Microperymetry, Vitrectomy, M-charts
- Trial name
- NCT03701542
- Testing
- Microperymetry, M-charts
- Volunteers
- 22 people
- Sponsor
- Medical University of Lublin
Full Thickness Macular Hole
Pilot Randomised Controlled Trial of Posturing Following Surgery for Full-thickness Macular Hole
This is a pilot randomised controlled trial (RCT) to investigate the effect of postoperative face-down positioning on the outcome of macular hole surgery.
- Trial name
- NCT01226160
- Testing
- Postoperative face-down posturing, Postoperative non-posturing group
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Macular Holes, Macular Hole Surgery
Autologous Tenon's Capsule Autograft for Large and Recurrent Full-Thickness Macular Holes
This prospective interventional clinical trial aims to evaluate the anatomical and functional outcomes of autologous Tenon's capsule autograft in the surgical management of large and recurrent full-thickness macular holes.
- Trial name
- ATCG-MH (NCT07760259)
- Testing
- Autologous Tenon's Capsule Autograft
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha University
Full Macular Hole
Changes InMPOD After Full-thickness Macular Hole Closure
The notable increase in MPOD following successful surgery suggests its potential role as a valuable adjunctive biomarker associated with a good visual prognosis following this type of macular hole surgical interventions.
- Trial name
- NCT06664515
- Testing
- Ciro Costagliola
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Federico II University
Ophthalmopathy
Single Superior ILM/ERM Flap for the FTMH.
In this study, the investigators will make the only upper flap either from the internal limiting membrane or from the epiretinal membrane to cover the full thickness macular hole.
- Trial name
- NCT05494242
- Testing
- Surgical intervention
- Where
- Iraq
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Omer Othman Abdullah
Retinal Detachment, Full Thickness Macular Hole
Inflammasomes in Cell Death in FTMH, ERM, and RRD
Prospective study evaluating the role of inflammasomes in cell death in retinal detachment, full thickness macular hole, and epiretinal membrane.
- Conditions
- Retinal Detachment, Full Thickness Macular Hole, Epiretinal Membrane
- Trial name
- NCT03332758
- Testing
- Pars plana vitrectomy, External drainage
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Allen C. Ho, MD
Macular Holes
Full-Thickness Macular Hole Surgery: A Comparison of Ten Techniques
This study compares ten modern vitreoretinal surgical techniques for full-thickness macular hole repair. Participants will be randomly assigned to one of the surgical approaches during pars plana vitrectomy, using stratified…
- Trial name
- FTMH-10 (NCT07606404)
- Testing
- Pars Plana Vitrectomy (PPV)-Based Macular Hole Surgery, Autologous Platelet-Rich Plasma (PRP), Human Amniotic Membrane (hAM) Graft
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- Kazakh Eye Research Institute
Macular Holes
The Correlation of Preoperative Measurement Parameter on the Predicting of Visual Outcomes Among Patients With Idiopathic Macular Holes
This study retrospectively analyzed the relationship between the preoperative optical coherence tomography(OCT) and optical coherence tomography angiography(OCTA) software related parameters of patients with idiopathic macular…
- Trial name
- NCT04957459
- Testing
- No intervention
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Full Thickness Macular Hole
Foveal Sparing ILM Peeling With ILM Flap Transposition
Foveal sparing internal limiting membrane (ILM) peeling with ILM flap transposition over the macular hole combines the benefits of foveal sparing ILM peeling with ILM flap techniques.
- Trial name
- NCT05897671
- Testing
- retrospective data analysis
- Where
- Austria
- Volunteers
- 42 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Full Thickness Macular Hole
Inverted Flap Versus Internal Limiting Membrane Peeling in Small Full Thickness Macular Holes
Primary outcome: difference of microperimetry retinal sensitivity after primary vitrectomy for idiopathic full thickness macular holes with inverted flap technique versus internal limiting membrane (ILM) peeling technique…
- Trial name
- NCT04498624
- Testing
- inverted flap, peeling internal limiting membrane (ILM)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Turin, Italy
Macular Holes
ILM Peeling Versus Inverted Flap Technique for Treatment of Macular Hole: Near Visual Acuity Outcomes
A prospective randomised study comparing the near visual acuity outcomes using Salzburg Reading Desk in pseudophakic patients with idiopathic full-thickness macular hole treated with pars plana vitrectomy with internal limiting…
- Trial name
- NCT04698226
- Testing
- 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling and SF6 tamponade, 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Stage 2 or 3 Full Thickness Macular Hole
Full Thickness Macular Hole and Internal Limiting Membrane Peeling Study
A macular hole is a fairly common problem in the retina and is an important cause of loss of central vision. The aim of this study is to determine whether, in patients with a stage 2 or 3 full thickness macular hole (FTMH)…
- Trial name
- FILMS (NCT00286507)
- Testing
- Vitrectomy, post hyaloid detachment and gas injection with or without ILM peel.
- Where
- 9 sites in Ireland, United Kingdom
- Volunteers
- 141 people
- Sponsor
- University of Aberdeen
Epiretinal Membranes, Retinal Detachment
Subjective Pain Scoring for Subtenonal Anesthesia During Vitrectomy
Subtenonal anesthesia is a well-known technique of local anesthesia for patients undergoing pars plana vitrectomies. It was described to be efficient with respect to anesthesia of the eye and it showed less risks compared to…
- Conditions
- Epiretinal Membranes, Retinal Detachment, Full Thickness Macular Hole
- Trial name
- NCT06830070
- Testing
- subjective pain score assessment
- Where
- Austria
- Volunteers
- 70 people
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Macular Holes
Inverted ILM Repositioning as Treatment for Full Thickness Macular Holes
The purpose of this study is to evaluate the efficacy and safety of surgical treatment of FTMH using an inverted ILM repositioning to improve anatomical and functional outcomes in patients with a macular hole.
- Trial name
- NCT01228188
- Testing
- Inverted ILM Repositioning
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Military Institute od Medicine National Research Institute
Idiopathic Macular Hole, Macular Hole
Intraocular Gas Tamponade for Treatment of Large Idiopathic Macular Holes
The goal of this clinical trial is to evaluate the visual and anatomical outcomes of large (410-1000 μm) full-thickness macular holes repair surgery using perfluoropropane (15% C3F8), sulfur hexafluoride (20% SF6) gas tamponade.
- Conditions
- Idiopathic Macular Hole, Macular Hole, Macular Holes, Full Thickness Macular Hole
- Trial name
- NCT06927544
- Testing
- Pars plana vitrectomy
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- The Filatov Institute of Eye Diseases and Tissue Therapy