Clinical trials: Functional; Bleeding
Thrombocytopenia, Postpartum Haemorrhage (PPH)
Prediction of Platelet Function Using Viscoelastic Test (ROTEM® Sigma) in Obstetric Anesthesia.
This prospective observational, non-interventional, single-center study aims to evaluate whether the viscoelastic parameter PLTEM, derived from ROTEM® sigma testing (EXTEM-A5 minus FIBTEM-A5), can accurately estimate platelet…
- Trial name
- NCT07616349
- Testing
- No Intervention: Observational Cohort
- Where
- Spain
- Volunteers
- 85 people
- Sponsor
- Nicolas Brogly
Blood Platelet Disorder, Hemorrhage
Correlation Between Platelet Function Analyzer-100 Testing and Bleeding Events After Percutaneous Kidney Biopsy
Kidney biopsy represents the criterion standard to obtain information on diagnosis and prognosis of renal dysfunctions . Many patients with kidney disease have a predisposition to bleed, especially when they undergo an invasive…
- Conditions
- Blood Platelet Disorder, Hemorrhage, Kidney Diseases
- Trial name
- NCT03762707
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Abdominal Aortic Aneurism, Abdominal Aortic Rupture
Haemostasis Management of Abdominal Aortic Procedures
Comparative study on efficacy of haemostatic therapy guided either by standard laboratory coagulation parameters or point-of-care testing in patients undergoing vascular surgical procedures.
- Conditions
- Abdominal Aortic Aneurism, Abdominal Aortic Rupture, Perioperative/Postoperative Complications, Surgical Blood Loss
- Trial name
- NCT03426839
- Testing
- Coagulation tests
- Volunteers
- 40 people
- Sponsor
- University of Pecs
Blood Loss Anemia, Extracorporeal Membrane Oxygenation Complication
Red Blood Cell Transfusion in ECMO - A Feasibility Trial
Extracorporeal Membrane Oxygenation (ECMO) is an invasive and resource intense treatment used to support critically ill patients who have suffered severe cardiac arrest, cardiac failure or respiratory failure (including severe…
- Conditions
- Blood Loss Anemia, Extracorporeal Membrane Oxygenation Complication, Disability Physical, Cognitive Ability, General
- Trial name
- ROSETTA (NCT05814094)
- Testing
- Red Blood Cell Transfusion
- Where
- 2 sites in Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Intracerebral Hemorrhage
Chinese Multicenter Cohort Study of Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage is a severe form of stroke associated with high mortality and long-term disability. The Chinese Multicenter Cohort Study of Intracerebral Hemorrhage (CASA) is a prospective observational…
- Trial name
- CMCS-ICH (NCT07833410)
- Where
- China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Subarachnoid Hemorrhage, Aneurysmal, Intracranial Aneurysm
Predictors of Rupture Risk of Intracranial Aneurysms
Patients admitted to Haukeland University Hospital with either UIA or aSAH underwent a measurement of bioelectrical impedance and body mass composition using InBody 10. Lipids and lipoproteins were collected from plasma.
- Trial name
- RAPID (NCT04613427)
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- University of Bergen
Stroke, Stiffness of Right Hand, Not Elsewhere Classified
Relationship Between Upper Extremity' Viscoelastic Properties and Functionality in Subacute Stroke
In stroke patients, the shoulder-upper extremity complex is affected and reduces independence and quality in activities of daily living.
- Conditions
- Stroke, Stiffness of Right Hand, Not Elsewhere Classified, Muscle Tone Abnormalities, Functional; Bleeding
- Trial name
- NCT05920837
- Testing
- MyotonPRO, Box and Block Test
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- University of Gaziantep
Endoscopic Sinus Surgery
SPI-guided vs PRD-guided Analgesia During FESS for Intraoperative Blood Loss
The aim of this randomized trial is to assess the efficacy of analgesia , compare the utility of Pupillary Dilatation Reflex (PRD), Surgical Pleth Index (SPI) for monitoring pain perception intraoperatively and their influence on…
- Trial name
- NCT03389763
- Testing
- Remifentanil
- Where
- Poland
- Volunteers
- 105 people
- Sponsor
- Medical University of Silesia
Bleeding
Nasal Desmopressin Versus Oral Bisoprolol for Controlling Bleeding During Endoscopic Sinus Surgery
Functional endoscopic sinus surgery (FESS) is well established for treatment of chronic rhinosinusitis and nasal polyps. Masking of the surgical field can lead to severe complication as tissue injury, increase post-operative…
- Trial name
- NCT05430048
- Testing
- nasal Desmopressin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Zagazig University
Leiomyoma (Uterine Fibroids), Adenomyoma of Uterus
The Effect of Uterine Manipulator Use During Abdominal Hysterectomy on Postoperative Sexual Function
This prospective, single-center, randomized controlled trial aims to evaluate the effect of uterine manipulator use during total abdominal hysterectomy on postoperative female sexual function at 3 months, assessed by the Female…
- Conditions
- Leiomyoma (Uterine Fibroids), Adenomyoma of Uterus, Uterine Bleeding
- Trial name
- UMAH (NCT07431788)
- Testing
- Uterine Manipulator, Conventional Abdominal Hysterectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Erkan Gol
Functional Disability, Dementia
Aspirin in Reducing Events in the Elderly-Extension (ASPREE-XT)
ASPREE-XT is a post-treatment, longitudinal observational follow-up study of ASPREE participants. Although the ASPREE trial medication was ceased, the study activity was not stopped and ASPREE participants are continuing with…
- Conditions
- Functional Disability, Dementia, Heart Disease, Stroke
- Trial name
- NCT07224347
- Where
- 36 sites in United States, Australia
- Volunteers
- 19,114 people, healthy volunteers welcome
- Sponsor
- Anne Murray
Rhinoplasty
The Effect of Different Bed Head Heights on Patients After Rhinoplasty
This study will be conducted to evaluate the effect of different bed head heights (thirty degrees and forty-five degrees) given to patients after rhinoplasty surgery on periorbital edema, periorbital ecchymosis, respiratory…
- Trial name
- NCT05695794
- Testing
- the group with a bed head height of 45 degrees, the group with a bed head height of 30 degrees
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bartın Unıversity
Acute Coronary Syndrome
Timing of Coronary Artery Bypass Surgery Among Patients With Acute Coronary Syndromes Initially on Ticagrelor
Ticagrelor, a more potent P2Y12 inhibitor, has been shown to reduce major adverse cardiac events (MACE) in acute coronary syndromes (ACS). It is increasingly used as a first line therapy in ACS.
- Trial name
- RAPID CABG (NCT02668562)
- Testing
- Early CABG (Day 2-3 after ticagrelor discontinuation), Delayed CABG (Day 5-7 after ticagrelor discontinuation)
- Where
- 2 sites in Canada
- Volunteers
- 143 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Stroke
Akershus Early Mobilisation in Stroke Study
Treatment in stroke units compared with treatment in general medical wards reduces the odds of being dead or disabled. Little is known about which components of acute stroke care that is responsible for this benefit.
- Trial name
- AKEMIS (NCT00832351)
- Testing
- Mobilisation
- Where
- Norway
- Volunteers
- 65 people
- Sponsor
- University Hospital, Akershus
Hemorrhage, Cerebral Amyloid Angiopathy
Brain Hemorrhage and Functional Outcome in Stroke Patients With CAA Features on Pre-thrombolysis MRI Treated With Intravenous Thrombolysis (Thrombolysis in CAA) ( Thromb in CAA )
Background: In stroke patients treated with intravenous thrombolysis (IVT), presence and high number of strictly lobar cerebral microbleeds (compatible with cerebral amyloid angiopathy, CAA) seems to be associated with increased…
- Conditions
- Hemorrhage, Cerebral Amyloid Angiopathy, Stroke
- Trial name
- Thromb in CAA (NCT05565144)
- Testing
- None, pure observational study
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Genital Diseases, Female, Hysterotomy; Affecting Fetus
Effect of Salpingectomy During Conservative Hysterectomy
The study compares the effect of bilateral salpingectomy associated with conservative hysterectomy on ovarian function to the standard hysterectomy with conservation of both ovaries and tubes in terms of hormone assays, ovarian…
- Conditions
- Genital Diseases, Female, Hysterotomy; Affecting Fetus, Leiomyomata Uteri, Adenomyosis, Endometriosis
- Trial name
- SALPINGOVA (NCT01628432)
- Testing
- conservative hysterectomy I, Conservative hysterectomy II
- Where
- 7 sites in France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Tours
Kidney Failure, Acute, Kidney Failure, Chronic
Does An Abnormal PFA 100 Predict Bleeding After Renal Biopsy?
The kidneys are highly vascular organs and any trauma or surgery poses risk of severe bleeding. Platelet function is an integral part of the blood clotting during the initial, so-called vascular phase.
- Conditions
- Kidney Failure, Acute, Kidney Failure, Chronic, Blood Platelet Disorders, Hemorrhage
- Trial name
- NCT00334204
- Testing
- measuring Platelet Function Analyser-100 (PFA-100) platelet function before kidney biopsy
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Mississippi Medical Center
Subarachnoid Hemorrhage
Changes in Physical, Cognitive and Emotional Function 5 and 10 Years After Aneurysmal Subarachnoid Hemorrhage (aSAH)
The current study is a continuation of the study "Effect of early rehabilitation in patients with acute aSAH" which was approved by the Regional Committee for Medical Research Ethics, South-East Norway, archive number 2011/2189…
- Trial name
- NCT02795533
- Testing
- Clinical follow-up
- Where
- Norway
- Volunteers
- 112 people
- Sponsor
- Oslo University Hospital
Seizures, Subdural Hematoma
Diagnostic Subdural EEG-electrode And Subdural hEmatoma (DISEASE)
Epileptic seizures are one of the frequent complications in patients with traumatic brain injury; the incidence lies approximately at 20%.
- Trial name
- NCT04211233
- Testing
- invasive subdural grid electrode, Control arm
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University Clinic Frankfurt
Intracerebral Hemorrhage
Statins in Patients With Spontaneous Intracerebral Hemorrhage
The relation between improvement in results of treating spontaneous intracerebral hemorrhage (SICH) and the application of statins has been subject to numerous analyses, and yet still remains debatable.
- Trial name
- NCT06094244
- Testing
- Atorvastatin, Rosuvastatin, No drugs
- Where
- Poland
- Volunteers
- 153 people
- Sponsor
- Pomeranian Medical University Szczecin