Clinical trials: Functional Aging
Inflammation, Aging
Inflammation Control For Elders: ICE Study
This study will be the first to test whether a selected anti-inflammatory agent, methotrexate, reduces inflammation in a human body, improve cognitive and physical function, and reduce pain levels in older adults at risk for…
- Trial name
- ICE (NCT02079948)
- Testing
- Methotrexate + Folic Acid, Functional MRI Experimental Tasks, Muscle Biopsy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Diastolic Dysfunction
Effect of Exercise on Heart Function in Healthy Elderly People
The purpose of this study is to determine the effect of aerobic interval training on left- and right ventricular diastolic- and systolic function on healthy, sedate people over 70 years.
- Trial name
- NCT00804518
- Testing
- Aerobic interval training
- Where
- Norway
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Ageing, Frailty
Physiotherapy Interventions on Functional Capacity, Balance and Mental Domains in Community-Dwelling Older Adults: A Randomized Clinical Trial With Two Parallel Groups
This study will investigate whether two different physiotherapy exercise programs can improve physical function, balance and mental well-being in older adults living in the community in Angola.
- Conditions
- Ageing, Frailty, Sarcopenia, Decline, Cognitive
- Trial name
- NCT07424274
- Testing
- Multicomponent Physiotherapy Exercise Program, Reduced Functional Physiotherapy Exercise Program
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Aveiro University
Aging, Somatosensory Deficit
Noise-Enhanced Sensory Function in Elders at Risk for Falls
The long-term goal of this project is to develop a non-invasive, noise-based technique for enhancing somatosensation and thereby improving balance control in elderly fallers and older adults with somatosensory deficits.
- Trial name
- NCT00421759
- Testing
- Vibrating Insoles
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- National Institute on Aging (NIA)
Aging, Longevity
Psilocybin Effects on Healthy Aging Biomarkers and Purpose in Life
The LONG-LIFE study is a randomized Phase I, dose-ranging trial designed to evaluate whether psilocybin impacts aging-related biomarkers, cognitive function, and purpose/meaning in life in medically stable older adults.
- Conditions
- Aging, Longevity, Biomarkers of Aging
- Trial name
- LONG-LIFE (NCT07719088)
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Charles Raison
Aging, Health Promotion
Social Prescribing Intervention for Health Promotion in Community-Dwelling Older Adults
This study evaluates the effects of a social prescribing intervention on health promotion outcomes in community-dwelling older adults.
- Conditions
- Aging, Health Promotion, Mental Health
- Trial name
- NCT07540117
- Testing
- Mindfulness Meditation and Walking-Pole Exercise
- Where
- Taiwan
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Functional Decline, Aging
GRACE: Geriatric Resources for Assessment and Care of Elders
The purpose of this study is to test the effectiveness of a collaborative model of team care as compared to usual care in improving functional outcomes among community-dwelling low-income older adults.
- Trial name
- NCT00182962
- Testing
- Geriatric Resources for Assessment & Care of Elders (GRACE)
- Where
- United States
- Volunteers
- 1,270 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Plantar Fasciitis, Chronic
A Novel Approach to Plantar Fasciitis in the Aging Population
The goal of this study is to determine whether improving foot strength through foot exercises and minimal footwear can provide improved outcomes over the short and long term.
- Trial name
- NAPA (NCT05834491)
- Testing
- minimal shoes and foot strengthening and flexibility exercises, Supportive Footwear, foot orthotic device and foot flexibility exercises
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- University of South Florida
Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment
Pre-demential Motoric Cognitive Risk Syndrome in Ageing Subjects
The main aim of the study is to characterize and understand the pathological mechanisms underlying the motoric cognitive risk syndrome, which is a predictor of Alzheimer disease.
- Conditions
- Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- PRESAGE (NCT05640141)
- Testing
- MRI evaluation, Actimetry & IMU, Gait evaluation
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Anesthesia, Dexmedetomidine
The Neuroprotective Effect of Dexmedetomidine Preserving Brain Functional Connectivity in Elderly Patients
Older patients are more prone to adverse cognitive outcomes such as postoperative delirium (POD) and postoperative cognitive dysfunction (POCD).
- Conditions
- Anesthesia, Dexmedetomidine, Aging
- Trial name
- DEXPM (NCT04973124)
- Testing
- Dexmedetomidine
- Where
- Chile
- Volunteers
- 43 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Infectious Diseases, Immunosenescence
Research Project on the Interaction Between Immune Function and Infectious Diseases in Older Adults and the Development of Prevention and Control Strategies
As population aging accelerates, infectious diseases have become a major factor affecting the health, quality of life, and survival outcomes of older adults.
- Conditions
- Infectious Diseases, Immunosenescence, Aging
- Trial name
- NCT07644962
- Volunteers
- 23,000 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Premature Ovarian Insufficiency, Ovarian Reserve Function
Therapeutic Effect of Vitamin C Supplementation in Patients With Ovarian Aging
The goal of this clinical trial is to learn if Vitamin C works to improve ovarian reserve in women with ovarian aging. It will also learn about the safety of Vitamin C.
- Trial name
- NCT06794060
- Testing
- Vitamin C (Ascorbic Acid)
- Volunteers
- 354 people
- Sponsor
- Peking University Third Hospital
Healthy Aging
Dual-task Training in Older Adults
This study seeks to understand what factors influence the capacity to perform simultaneous motor and cognitive tasks in older adults to improve movement throughout their community with the least risk of injury.
- Trial name
- NCT05296551
- Testing
- Motor Task, Cognitive-motor dual-task
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- George Washington University
Fall Prevention in Healthy Aging, Fall
Effect of LiFE-SePBT on Postural Stability in Community-dwelling Older Adults: an Assessor-blinded Randomised Controlled Trial
This study is an assessor-blinded randomised controlled trial investigating the effects of combined Lifestyle-integrated Functional Exercise and Self-initiated Perturbation-based Balance Training (LiFE-SePBT) on postural…
- Conditions
- Fall Prevention in Healthy Aging, Fall, Fall Prevention Training, Postural Control
- Trial name
- LiFE-SePBT (NCT07842094)
- Testing
- Lifestyle-integrated Functional Exercise, Upper limb mobilisation and flexibility training
- Where
- Hong Kong
- Volunteers
- 44 people
- Sponsor
- The Hong Kong Polytechnic University
Atrial Fibrillation Recurrent, Aging
Investigating the Effects of a Museum Intervention on the Psychological and Cardiac Health of Older Adults
In a recent report, the World Organization for Health provided some evidence that artistic and cultural activities can support the health and well-being of the population.
- Trial name
- HeART-BRAIN (NCT06130358)
- Testing
- Experimental: Well-being intervention followed by classic intervention, Experimental: Classic intervention followed by well-being intervention
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louis Bherer
Depressive Symptom, Cognitive Functions
Cognicise Training for Seniors for Healthy Aging
The goal of this clinical trial is to assess the impact of two 8-week motor-cognitive exercise programs - Cognicise and yoga - on psychological, respiratory, cardiovascular, postural, and biochemical health in elderly women.
- Conditions
- Depressive Symptom, Cognitive Functions, Quality of Life, Physical Fitness
- Trial name
- NCT07098533
- Testing
- Cognicise Training, Yoga Training
- Where
- Poland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Aging, Healthy
Cognitive Aging and Training With Video-games
The ageing of the population will inevitably lead to a growing number of older people living alone and in need of care. Given the high cost of geriatric care, a critical research issue is exploring ways to improve or maintain…
- Trial name
- NCT02007616
- Testing
- Non-action video game training
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Educación a Distancia
Cardiovascular Disease, Aging
Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function
Healthy but sedentary aging leads to increased morbidity and mortality of cardiovascular disease. This is partly due to the accumulation of Advanced Glycation Endproducts (AGEs) and the stiffening of the myocardium and arteries.
- Conditions
- Cardiovascular Disease, Aging, Endothelial Dysfunction, Physical Activity
- Trial name
- NCT01417663
- Testing
- Alt-711, Physical exercise training
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Faecal Incontinence, Asymptomatic Condition
Anal Canal Functional Assessment Using EndoFLIP
Faecal incontinence (FI) is characterized by involuntary loss of rectal content through the anal canal. FI is psychologically and socially debilitating problem that can dramatically affect patient's quality of life, often in…
- Trial name
- NCT04741893
- Testing
- EndoFLIP
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Obesity, Weight Loss
Utilizing Protein During Weight Loss to Impact Physical Function and Bone
This study is an ancillary study to the Utilizing Protein During Weight Loss to Impact Physical Function (UPLIFT) trial (NCT03074643) to evaluate the effects of diet composition (i.e., amount of protein and carbohydrate) during a…
- Conditions
- Obesity, Weight Loss, Diet Modification, Aging
- Trial name
- UPLIFT-Bone (NCT03819478)
- Testing
- Weight loss intervention months 0-6, Exercise intervention months 0-6, NutraBio™ CarboMax Supplement
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- Wake Forest University Health Sciences