Clinical trials: Functional Aging
Retinal Ageing
Carotenoid Supplementation and Normal Ocular Health
Normal ageing affects vision as a result of preretinal and retinal changes. Photoreceptors, the light sensitive cells in the retina, degenerate and the rods (responsible for night vision) are most susceptible to damage with…
- Trial name
- NCT02147171
- Testing
- VisionAce
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Aging
Breaking Sitting with High-intensity Interval Training for Brain Health
This trial will examine whether interrupting 3.5 hours of sitting every 30 min with 6 min high intensity interval training (HIIT) breaks compared to light intensity interval training (LIIT) will improve brain health in…
- Trial name
- HIIT2SITLess (NCT06243016)
- Testing
- High-Intensity Interval Training (HIIT) Breaks to Sitting, Light-Intensity Interval Training (LIIT) Breaks to Sitting
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Arterial Stiffening, Aging
Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
The purpose of this study is to find out why women's arteries stiffen as they go through menopause, and how this is affected by estrogen loss.
- Conditions
- Arterial Stiffening, Aging, Menopause
- Trial name
- SHAPE (NCT00608062)
- Testing
- GnRHant - Ganirelix acetate, Transdermal estradiol patch
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Dementia, Cognitive Function
B-vitamins and Omega-3 Fatty Acids and Biomarkers of Brain Atrophy.
A poor nutrition status is a modifiable risk factor for cognitive decline and dementia. In particular, evidence links low status of certain B-vitamins and ω-3 fatty acids (ω-3 FA) with a greater risk of cognitive decline and…
- Trial name
- BOOMERANG (NCT07312435)
- Testing
- Intervention, Control
- Where
- Norway
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Spinal Cord Injuries
Low Oxygen Therapy to Enhance Walking Recovery After SCI.
The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury of different age…
- Trial name
- BO2ST-II (NCT06521723)
- Testing
- Daily acute intermittent hypoxia, Walking + tSTIM
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Spaulding Rehabilitation Hospital
Aging
L-Citrulline and Endothelial Function
The effect of L-Citrulline is well studied in relation to muscle strength, exhaustion, exercise performance, and endothelial function in health and disease.
- Trial name
- NCT05722860
- Testing
- L-Citrulline, capsule
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Aging, Cognitive Function 1, Social
Playfulness in Online and Face-to-face Interactions, From Adulthood to Aging
Playful interactions have an important role in human sociality. During playful interactions, two individuals continuously co-create an imaginary world together, such as playing roles in an imaginary scene or co-creating…
- Conditions
- Aging, Cognitive Function 1, Social, Social Behavior, Aging Well
- Trial name
- Play (NCT06081725)
- Testing
- Playful interactions in an online format, An active control condition in a face-to-face format, An active control condition in an online format
- Where
- 4 sites in Israel
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Osteosarcopenia
An Assessment of Risk Factors for Osteosarcopenia in Older Adults - the Role of Prevention, Lifestyle, Physical Activity and Education.
The aim of the study is to assess the risk factors for osteosarcopenia in older adults, taking into account physical activity, healthy eating habits and education.
- Trial name
- NCT07519720
- Testing
- As part of the study, participants will undergo body composition analysis, bone density testing, and tests of physical fitness and handgrip strength in both the older and younger age groups.
- Where
- Poland
- Volunteers
- 250 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Autism Spectrum Disorder
Strengthening Skills Behavioral Intervention for Adults With Autism Spectrum Disorder
The purpose of this study is to examine changes in adaptive functioning, quality of life, and prospective memory among adults with ASD (Autism Spectrum Disorder) who complete Strengthening Skills, a multi-faceted, behavioral…
- Trial name
- NCT04802434
- Testing
- Strengthening Skills Program, PEERS Social Skills Program
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Southwest Autism Research & Resource Center
Old and Very Old People, Independent Living
Development of an ICF Core Set for Geriatric Patients in Primary Care
The sum of medical interventions can do more harm than good. Supporting patients' resources instead of combating disease might effectively help reducing "too much medicine".
- Conditions
- Old and Very Old People, Independent Living, Functioning
- Trial name
- ICF (NCT03384732)
- Where
- Germany
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Aging, Dehydration
The Effect of Fluids Consumption on Balance and Gait Function in Old Adults
Experimental design overview The proposed project is a prospective experimental RCT study design. Independent old adults(age 65 years old and older) who do not suffer from balance problems willing to participate in the study will…
- Trial name
- NCT01181180
- Testing
- water consumption
- Where
- Israel
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Balance Disorders, Accidental Falls
Population Cohort Set-up for the Epidemiological Assessment of Balance Disorders in Elderly People
As people age, it becomes more common to experience balance problems. These issues can increase the risk of falling, which may lead to serious health consequences and loss of independence.
- Conditions
- Balance Disorders, Accidental Falls, Frailty, Aging
- Trial name
- EPIBAS (NCT06965660)
- Where
- Spain
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Sarcopenia, Osteopenia
Nutrient Support to Body Composition and Healthy Ageing
The focus is healthy ageing, i.e. delaying the deterioration in health status in older adults. Loss of lean tissue (skeletal muscle) mass, a process termed sarcopenia, or bone tissue mass, a process called osteopenia, is a…
- Trial name
- BCHA (NCT02529124)
- Testing
- CONTROL, PROTEIN, PHYSICAL ACTIVITY
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Phil Jakeman
Aging
Effect of Ageing on Airway Remodeling
The aim of the study is to investigate the relationship between aging and morphological changes in the lung. 120 consecutive healthy volunteers over 60 years will be enrolled for this trial.
- Trial name
- NCT01230879
- Testing
- EFR and TDM
- Where
- France
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Physical Activity
Investigations of the Effects and Associated Neural Mechanisms of Different Exercise in People With Metabolic Syndrome
Metabolic syndrome (MetS) is a risk for many chronic diseases of middle-aged and older adults. Hence, prevention and treatment of MetS is a crucial global health issue.
- Trial name
- NCT05672940
- Testing
- Aerobic plus resistance training, Stretching plus breathing training
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Functional Decline, Aging
GRACE: Geriatric Resources for Assessment and Care of Elders
The purpose of this study is to test the effectiveness of a collaborative model of team care as compared to usual care in improving functional outcomes among community-dwelling low-income older adults.
- Trial name
- NCT00182962
- Testing
- Geriatric Resources for Assessment & Care of Elders (GRACE)
- Where
- United States
- Volunteers
- 1,270 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Functional Ability, Cognitive Decline
Caregiver Training: Evidence of Its Effectiveness for Cognitive and Functional Improvement in Older Adults
Due to demographic changes that have resulted in an aging population, the role of caregiver of an older adult has become very important in recent years.
- Conditions
- Functional Ability, Cognitive Decline, Older Adults, Healthy Aging
- Trial name
- NCT04490070
- Testing
- Cognitive Stimulation
- Where
- 10 sites in Spain
- Volunteers
- 160 people
- Sponsor
- Universidad de Granada
Cognitive Change
Impact of Challenging Engagement on Cognition in Older Adults
The study will enroll 90 participants in the "Impact of Challenging Engagement" study and assign them to one of three groups: high-demand photography, moderate-demand photography, and active placebo.
- Trial name
- engAGE (NCT03962439)
- Testing
- High-Demand Photography, Moderate-Demand Photography, At-Home Engagement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Brain Aging, Cerebrovascular Function
AKG and Brain Health in Aging
This proposal will test the hypothesis that AKG supplementation will improve NGVC responses and cognitive performance in older adults.
- Trial name
- NCT07861867
- Testing
- Calcium AKG
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Aging, Heart Failure
The COmPLETE Study
The project is designed as a large scale, cross-sectional study. This research seeks to identify physical fitness and cardiovascular parameters that best resemble underlying cardiovascular risk with age.
- Trial name
- COmPLETE (NCT03986892)
- Testing
- Physical Activity
- Where
- Switzerland
- Volunteers
- 678 people, healthy volunteers welcome
- Sponsor
- Arno Schmidt-Trucksäss