Clinical trials: Functional Aging
Aging, Heart Failure With Preserved Ejection Fraction
Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure
In a randomized controlled trial, to study the utility of inspiratory muscle training (IMT) to improve functional outcomes in adults aged ≥70 years with heart failure (HF) who have been referred to palliative care for end-stage…
- Conditions
- Aging, Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Frailty
- Trial name
- RETRO (NCT06576297)
- Testing
- Inspiratory Muscle Training (IMT), Standard of Care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Lower Urinary Tract Symptom, Voiding Dysfunction
Association Between Qmax/eGFR Ratio and LUTS Severity in Men Over 40
This study will look at how well a measure called the Qmax/eGFR ratio is related to the severity of urination problems in men over the age of 40.
- Conditions
- Lower Urinary Tract Symptom, Voiding Dysfunction, Male Urological Health, Renal Function
- Trial name
- NCT07055425
- Volunteers
- 100 people
- Sponsor
- Marmara University
Aging, Hospitalization
Personalized Exercises Program Prescription to Prevent Functional Decline Throughout Older Adults Hospitalization
Bed rest related to hospitalization contributes to the physical decline in capacities of the elderly, the loss of autonomy accelerated in post-hospitalization and the prevalence of the iatrogenic functional decline is about 20 to…
- Trial name
- NCT04078334
- Testing
- MATCH, PATH, PATH 2.0
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Université du Québec a Montréal
Healthy Aging, Cognitive Impairment
MusiCare: Music Therapy & Innovative Technology
The number of older people living with cognitive impairment or dementia has increased the need for simple, inexpensive interventions to improve the quality of life for such individuals and their families.
- Trial name
- MusiCare (NCT04851028)
- Testing
- Music Therapy
- Where
- United Kingdom
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Middlesex University
COPD, Aging
D Vitamine and Whole Body Vibration in Functional Outcomes
Older with Chronic obstructive Pulmonary Disease (COPD) were submitted to chronic whole body vibration training during 03 months, receiving a vitamine D dose for each week or placebo vitamine.
- Trial name
- NCT03684837
- Testing
- Vitamine D supplementation, chronic exercise in whole body vibration (WBV)
- Where
- Brazil
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Maíra F Pessoa
Sleep, Anxiety
Xbox Kinect, Sleep Quality, Anxiety and Functional Capacity in Older Adults
The present study aims to examine the effects of Xbox Kinect exercise training program on the sleep quality, anxiety and functional capacity in older adults. Older adults were randomized into two groups.
- Conditions
- Sleep, Anxiety, Aging, Exercise
- Trial name
- NCT04692272
- Testing
- Exercise in the XBOX kinect
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Memory Decline, Cognitive Decline
Anti-inflammatory Probiotics in Cognitive Functioning
The goal of this study is to explore the potential impact of an anti-inflammatory probiotic mixture of psychobiotics including Bifidobacterium longum Rosell®-175 and Lactobacillus helveticus Rosell®-52 on cognitive functions in…
- Conditions
- Memory Decline, Cognitive Decline, Cognitive Aging
- Trial name
- CoProM (NCT07165977)
- Where
- Poland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Social Sciences and Humanities, Warsaw
Frailty Syndrome
TrackFrailty Project
The TRACKFRAILTY project aims to answer the following main research questions: i) What is the prevalence of physical frailty in individuals living in residential care facilities (RCF) from Portugal's Cova da Beira subregion…
- Trial name
- TrackFrailty (NCT06812286)
- Testing
- Less-volume, More-volume, Control
- Where
- 6 sites in Portugal
- Volunteers
- 45 people
- Sponsor
- University of Beira Interior
Frailty
Safety, Efficacy of FFP From Healthy Donors to Ameliorate Frailty and Enhance Immune Function in Older Individuals
1. Primary Objective To determine the safety and tolerability of 12 once monthly transfusions of GMFFP (Granulocyte - Colony Stimulating Factor (G-CSF) Mobilized Fresh Frozen Plasma harvested from young, healthy donors), given to…
- Trial name
- NCT03458429
- Testing
- GMFFP
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dipnarine Maharaj
Aging, Cognitive Decline
Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and Muscle
BRAIN-M is a randomized controlled trial designed to examine the effects of a single bout or 12 weeks of blood-flow restriction training or high-intensity resistance training on cognitive function, brain health, muscular…
- Conditions
- Aging, Cognitive Decline, Sarcopenia, Frailty
- Trial name
- BRAIN-M (NCT05744167)
- Testing
- BFRT, MDRT
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Aging, Cognitive Function 1, Social
Effects of Physical and Cognitive Training in Neuroplasticity, Health and Cognition. Movement Project
The MoveMent project applies non-pharmacological strategies - physical exercise and cognitive training - that have been shown to be effective in promoting active and healthy aging.
- Trial name
- NCT03123900
- Testing
- Physical exercise, Cognitive training, Combined training
- Where
- Spain
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Pharmacokinetics of New Curcumin Formulations, Safety of New Curcumin Formulations
Improved Oral Bioavailability of Curcumin Incorporated Into Micelles
Curcumin, a lipophilic polyphenol derived from the plant curcuma longa possesses numerous health-promoting activities. The oral bioavailability of curcumin is low due to its poor aqueous solubility, limited gastrointestinal…
- Trial name
- NCT01982734
- Testing
- curcumin
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Aging, Mortality
Longevity Metrics AI/ML Development Study
This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy.
- Conditions
- Aging, Mortality, Cardiovascular Disease Prevention, Metabolic Syndrome
- Trial name
- NCT07808619
- Testing
- AIML scored health screening battery
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Aging
Stretching and Yoga Exercise Study
The investigators propose to test the effects of an 8-week supervised, site-based, group yoga intervention on cognition and functional fitness in older adults.
- Trial name
- SAYExercise (NCT01650532)
- Testing
- Yoga Condition, Stretching Condition
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Aging, Physical Fitness
Myogenic and Osteogenic Responses to eXercise and Ibuprofen
The purpose of this study is to determine if the use of ibuprofen blocks the benefits of exercise to build bone and muscle mass.
- Trial name
- MOXI (NCT00462722)
- Testing
- Ibuprofen, musculoskeletal-loading exercise
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sarcopenia, Aging
Dual-benefits of Aerobic and Resistance Training
This study evaluates the effect of three different exercise strategies on physical function in older adults. Participants will be randomly assigned to one of three exercise groups: resistance training, moderate-intensity…
- Conditions
- Sarcopenia, Aging, Disability Physical
- Trial name
- DART (NCT03978572)
- Testing
- Resistance Training, Moderate-Intensity Continuous Cycling, High-Intensity Interval Cycling
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ohio University
Fall Prevention, Falls (Accidents) in Old Age
Validation of the Self-Assessment for Falls in the Elderly (SAFE) Questionnaire to Assess the Risk of Falls in People Aged 60 or Over.
This single-centre, cross-sectional diagnostic study will determine whether the new self-completed Self-Assessment for Falls in the Elderly (SAFE) questionnaire can classify fall-risk level (low, moderate, high) in adults ≥ 60…
- Trial name
- SAFE (NCT06961812)
- Testing
- Questionnaire and Physical Exam, Safe Self-Administered Questionnaire
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Inflammation
Oxytocin Aging Study
The life expectancy of older Americans continues to increase, with persons aged > 65 years representing the fastest growing segment of the US population (Manton et al., 1995).
- Trial name
- NCT02069431
- Testing
- Intranasal Oxytocin spray
- Where
- 2 sites in United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Florida
Mobility Disability, Older Adults
Community-based Functional Fitness for Adults Aging With Mobility Disability
Evaluate the feasibility and potential effectiveness of a 12-week, high-intensity functional training (HIFT) intervention on frailty in older adults (60+) with mobility disabilities (MD) who are ambulatory
- Trial name
- AAIMLCOA (NCT07283510)
- Testing
- Functional Fitness
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Kansas
Aging, Alzheimer's Disease
Effects of Exercise and Cognitive Training on Cognitive Function in Older Adults
The purpose of this study is to gain a better understanding of the effects of exercise and cognitive training on improving brain function in healthy older adults who may be at risk for developing Alzheimer's Disease.
- Trial name
- NCT01038726
- Testing
- Exercise Training, Cognitive Training, Flexibility Training
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic