Clinical trials: Functional Aging
Healthy Aging, Healthy
Investigating the Effects of Daily Consumption of Blueberry (Poly)Phenols on Vascular Function and Cognitive Performance
Foods rich in certain (poly)phenols, particularly flavonoids, such as berries and cocoa, have been shown to improve measures of vascular function as well as cognitive performance in human intervention studies.
- Trial name
- BluFlow (NCT04084457)
- Testing
- Wild Blueberry powder
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- King's College London
Uveitis, Iritis
Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications
Retinal optical coherence tomography (OCT) is an established technology which enables a detailed cross-sectional visualization of the retinal micro-anatomy, and an objective measurement of its thickness in-vivo.
- Conditions
- Uveitis, Iritis, Iridocyclitis, Anterior Uveitis
- Trial name
- NCT00476593
- Testing
- Diclofenac, Dexamethasone
- Where
- 2 sites in Norway
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Prediabetes, Healthy (Controls)
Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?
Brief Summary The goal of this clinical trial is to learn whether older adults with prediabetes, but no diagnosed cognitive impairment, show early changes in brain energy use and thinking speed compared to older adults with…
- Trial name
- NCT07546409
- Testing
- Ketone Monoester (KE)
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Aging, Postoperative Cognitive Dysfunction
Postoperative Cognitive Function and EEG
In the elderly patients undergoing elective non-cardiac major surgery, the differences of EEG parameters between those with and without postoperative cognitive dysfunction were observed to determine the characteristic changes of…
- Conditions
- Aging, Postoperative Cognitive Dysfunction, EEG With Periodic Abnormalities
- Trial name
- POEM (NCT04219033)
- Testing
- EEG(Electroencephalogram) change
- Where
- 18 sites in China
- Volunteers
- 1,250 people
- Sponsor
- Air Force Military Medical University, China
Aging, Cognitive Decline
Impact of a Novel Brain Longevity Supplement Containing the Postbiotic Urolithin A (Mitopure) on Cognitive Function and Related Health Outcomes
This is a parallel group, randomized, double-blind, placebo-controlled clinical study assessing the safety and effects of a novel nutritional product on self-reported cognitive function and health in adults that reside in the…
- Conditions
- Aging, Cognitive Decline, Brain Fog, Cognitive Function
- Trial name
- CLARITY (NCT07060898)
- Testing
- Active Product
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Fall Risk, Exercise
Effects of Regular Exercise on Sensory-motor Functions and Fall Risk in the Elderly
Falls in elderly population are an important public health problem. The aim of this study is to examine the vibration, proprioception, muscle strength, static balance, reaction time and postural stability parameters of female…
- Conditions
- Fall Risk, Exercise, Functional Outcomes, Aging
- Trial name
- FallRisk (NCT06891014)
- Testing
- Combine Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Cyprus International University
Kidney Scarring
Detection of Renal Fibrosis and Prediction of Kidney Function Decline
This study will investigate the ability of renal MRI to detect fibrosis, how this correlates to renal function and how well renal MRI biomarkers can predict decline in kidney function over time.
- Trial name
- MARS (NCT04625140)
- Where
- Norway
- Volunteers
- 72 people
- Sponsor
- University Hospital, Akershus
Healthy Volunteers
Neural Bases of Social Cognitive Processing in Healthy Individuals
The goal of this single center non-interventional fMRI and EEG study is to assess the neural bases of social cognitive processing in healthy individuals, and whether/how their responsiveness is modulated by ageing.
- Trial name
- NCT05774860
- Testing
- No intervention
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Cognition, Aged
WhatsApp Intervention for Seniors' Digital and Cognitive Management (WISDOM)
The goal of this clinical trial is to learn if a digital health literacy program using mobile phone chat-based application called WISDOM (WhatsApp Intervention for Seniors' Digital and cOgnitive Management) can help older adults…
- Conditions
- Cognition, Aged, Digital Health Literacy
- Trial name
- NCT07161674
- Testing
- Digital health literacy program
- Where
- Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Overweight or Obesity
Precision Nutrition Strategies for Improving the Quality of Life of Pre-senior and Senior Populations
The number and proportion of people aged 60 years old and over is increasing worldwide. Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death.
- Trial name
- NCT04786925
- Testing
- Control diet, Nutriprecision diet
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Mild Cognitive Impairment (MCI), Healthy Aging
Computerized Cognitive Training in Healthy Older Adults and Mild Cognitive Impairment
The overall objective of this study is to assess the effect of an adaptive computerized cognitive training program for executive functions (CogniFit platform) on improving these functions in older adults, both healthy and with…
- Trial name
- COGNI-AGE (NCT07598409)
- Testing
- Computerized Cognitive Training, Active Control Computerized Activities
- Where
- 2 sites in Spain
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Universidad Antonio de Nebrija
Autophagy, Healthy Aging
Effects of Miricell Supplementation on Biomarkers of Healthy Aging and Autophagy
The goal of this clinical trial is to learn if a dietary supplement called Miricell works to improve cellular health and signs of healthy aging in adults. It will also learn about the safety of Miricell.
- Trial name
- NCT07675200
- Testing
- Spermidine
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Nutraland USA, Inc.
Aging, Healthy
Healthy Aging Through Dietary Intervention
To test the impact of flavanol supplementation of cardiac and vascular function and subsequently on exercise capacity in elderly individuals
- Trial name
- NCT05782309
- Testing
- Flavanol
- Where
- Germany
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Hypertension, Elevated Blood Pressure
Feasibility of a Community-Integrated Isometric Handgrip Exercise Program and Its Preliminary Effects on Blood Pressure and Cognitive Function in Older Adults
The goal of this clinical trial is to evaluate whether a short, supervised isometric handgrip exercise program is feasible and acceptable for older adults with elevated blood pressure or hypertension.
- Trial name
- NCT07648498
- Testing
- Zona Plus 4-Week Isometric Handgrip Exercise Intervention, Squegg 4-Week Isometric Handgrip Exercise Intervention
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Accidental Falls, Aging
Evaluation of the Effects of a Cognitive-Motor Fall Prevention Program on Fall Risk Factors
The goal of this interventional study is to compare in community dwelling elderly people the effects of two physical activity programs to prevent accident falls : "SILVER XIII EQUILIBRE" program and "VIVIFRAIL" program, on…
- Conditions
- Accidental Falls, Aging, Mild Cognitive Impairment
- Trial name
- 13EVAL (NCT05625828)
- Testing
- Cognitive-motor Physical Activity, Multifactorial Physical Activity
- Where
- France
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- EZUS-LYON 1
Sarcopenic Obesity
Nutritional Strategies for Metabolic Health in Aging
Sarcopenic obesity in older individuals presents a clinical conundrum without an effective therapeutic strategy. This study will determine the impact of precision amino acid delivery as part of a meal replacement (EMR) during…
- Trial name
- NSMH (NCT04282603)
- Testing
- Weight Loss and Weight Maintenance
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Alaska Fairbanks
Aging
Nitrate and Exercise Performance in Middle to Older Aged Adults
Research with young healthy individuals has shown that beetroot juice beverages that contain large amounts of nitrate can improve exercise performance.
- Trial name
- NCT03371966
- Testing
- High Nitrate Beetroot Juice, Low Nitrate Beetroot Juice
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Age-related Cognitive Decline
Cognitive Multi-Tasking Training in Healthy Older Adults
This study evaluated the feasibility of a remote web-based ecological cognitive training protocol to healthy older adults. The training protocol involves 5 training sessions.
- Trial name
- NCT04195230
- Testing
- Multi-tasking Training
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Columbia University
Aging, Cognitive Decline
Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and Muscle
BRAIN-M is a randomized controlled trial designed to examine the effects of a single bout or 12 weeks of blood-flow restriction training or high-intensity resistance training on cognitive function, brain health, muscular…
- Conditions
- Aging, Cognitive Decline, Sarcopenia, Frailty
- Trial name
- BRAIN-M (NCT05744167)
- Testing
- BFRT, MDRT
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Aging, Hypertension
Aging, Nitrate, Endothelial Function and Muscle Oxygenation
Aging has been associated with reduced bioavailability of nitric oxide (NO) and endothelial dysfunction. Beetroot consumption, a nitrate-rich food, has been associated with increased NO bioconversion, which may promote beneficial…
- Conditions
- Aging, Hypertension, Dyslipidemia, Abdominal Obesity
- Trial name
- NCT02772900
- Testing
- Beetroot-based nutritional gel
- Volunteers
- 25 people
- Sponsor
- Universidade Federal do Rio de Janeiro