Clinical trials: Functional Aging
Mild Cognitive Impairment
Making Memory Better for Seniors With Mild Cognitive Impairment
The purpose of this study is to investigate the feasibility and effectiveness of a cognitive training group in individuals with Mild Cognitive Impairment, using a new paradigm that will optimize ecological validity by (1)…
- Trial name
- NCT01532739
- Testing
- Cognitive training
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Nova Scotia Health Authority
Aging
The Effect of Long Duration Exercise on the Diastolic Function of the Heart
The purpose of this study is to determine whether vigorous exercise training 4-5 days/week for 2 years in sedentary middle aged men and women (ages 45-64) will improve cardiac and vascular compliance to a degree equivalent to…
- Trial name
- PEP (NCT02039154)
- Testing
- Aerobic and strength training group, Balance and flexibility group
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Frailty, Aging
Community-Based Multicomponent Exercise and Recreational Programme for Older Adults
This quasi-experimental, non-randomized controlled evaluation examined whether participation in ELDERPLAY, a community-based programme combining Vivifrail-based multicomponent exercise with adapted traditional games, was…
- Conditions
- Frailty, Aging, Physical Functional Performance, Postural Balance
- Trial name
- ELDERPLAY (NCT07864831)
- Testing
- ELDERPLAY multicomponent exercise and recreational programme
- Where
- Spain
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Cardiovascular Disease, Diabetes
Taste Perception and Chronic Disease Risk
The purpose of the Taste Perception Study is to assess variations in the ability to taste and perceive sensations from various stimuli in younger (18-49 years) and older (50-85 years) volunteers.
- Conditions
- Cardiovascular Disease, Diabetes, Obesity, Metabolic Syndrome
- Trial name
- NCT01023906
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Tufts University
Aging
Preliminary Testing of Cafe Move for Primary Prevention of Physical Frailty
This project explores a novel means of health promotion and prevention of age-related physical frailty, which is designed to overcome barriers to access and promote autonomy in managing physical health.
- Trial name
- NCT05720507
- Testing
- Cafe Move
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Montana
Aging, Mitochondrial Dysfunction
A Single and Multiple Dose Study of AMAZ-02 to Evaluate Safety and Pharmacokinetics in Elderly Subjects
Part A: The study is a double-blind, randomized, single ascending doses, study in 24 healthy elderly male and female volunteers. Each subject will be randomized for two subsequent doses in three cohorts.
- Conditions
- Aging, Mitochondrial Dysfunction, Muscle Function
- Trial name
- NCT02655393
- Testing
- Mitopure
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Aging
Fit & Active Seniors Trial
The investigators propose to test the hypothesis that a six-month intervention of combined fitness and cognitive training in the form of dancing will have a significant positive effect on a variety of executive control and memory…
- Trial name
- FAST (NCT01472744)
- Testing
- Dance Group, Strength, Stretching, Stability, Walking
- Where
- United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Cognitive Aging
Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects
This proposal aims to determine whether low does of the alpha-2A-adrenoceptor agonist guanfacine can improve deficits in prefrontally-mediated cognitive functions in healthy elderly subjects.
- Trial name
- NCT00935493
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Yale University
Fragility
Biological Markers of Functional Effects of Physical Activity in an Elderly Population
Circulating biomarkers are promising tools for the early diagnosis of aging-associated pathologies. Inflammation and immunity are associated with the risk of sarcopenia and frailty in elderly patients.
- Trial name
- BIO-APAS (NCT04080063)
- Testing
- adapted physical activity
- Where
- France
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Peripheral Artery Disease, Peripheral Vascular Disease
Far Red Light to Improve Functioning in PAD
The LIGHT PAD Trial is a Phase II multi-centered randomized clinical trial to collect preliminary data to test whether daily far red light treatment of the lower extremities in people with PAD improves six-minute walk distance…
- Conditions
- Peripheral Artery Disease, Peripheral Vascular Disease, Aging, Walking, Difficulty
- Trial name
- LIGHT PAD (NCT06165016)
- Testing
- Far red light therapy
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Northwestern University
Systemic Inflammation, Aging
Papaya Study ID:20140628
The purpose of this research study is to explore the effects of fermented papaya preparation (FPP) on whole body inflammation, physical function, fatigue, and health-related quality of life.
- Trial name
- NCT02051634
- Testing
- Fermented Papaya Preparation (FPP), Sugar Pill
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Fall Prevention in Healthy Aging
The Effects of an Exergame Training on Body and Brain of Older Adults
This study investigates the effects of an exergame training including strength, balance, and cognitive training components on motor functions, cognition and brain structure of older adults.
- Trial name
- Active@Home (NCT03676452)
- Testing
- Active@Home exergame training
- Where
- Switzerland
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Eling DeBruin
Aging
Aquatic Exercises Combined With Cognitive Tasks for Older Adults
The aquatic environment has characteristics that favor the adherence of older adults to exercise programs, and studies have shown that programs in this setting are effective in enhancing various aspects of physical fitness as…
- Trial name
- WaterCog (NCT07156708)
- Testing
- Aquatic aerobic exercise program, Cognitive tasks
- Where
- Brazil
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Sarcopenic Obesity, Obesity and Obesity-related Medical Conditions
Plant vs Animal-based Protein Sources as an Anabolic and Metabolic-protective Options for SO in Older Adults
This study is testing how different types of protein - from red meat, legumes (like lentils and beans), or a mix of both - affect muscle strength, body composition, and metabolic health in older adults with obesity who are also…
- Conditions
- Sarcopenic Obesity, Obesity and Obesity-related Medical Conditions, Obesity (Body Mass Index >30 kg/m2), Sarcopenia
- Trial name
- NCT07030738
- Testing
- Legume-Based High-Protein Diet + Resistance Training, Meat-Based High-Protein Diet + Resistance Training, Mixed Legume and Meat High-Protein Diet + Resistance Training
- Where
- Israel
- Volunteers
- 180 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Physiological Processes, Aging
Age-Related Changes in Stress Hormone Regulation
Studies investigating physiological processes involved in aging-related deficits in regulation of stress hormone systems.
- Trial name
- NCT00018369
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Cognitive Decline, Executive Dysfunction
Fitness on White Matter and Cognition in Aging
Cardiorespiratory fitness (CRF) is associated with decreased risk for mild cognitive impairment (MCI) and dementia. CRF is linked with more conserved gray and white matter (WM) volume, improved WM microstructural integrity, and…
- Conditions
- Cognitive Decline, Executive Dysfunction, Cardiovascular Risk Factor
- Trial name
- NCT03775941
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- Suffolk University
Transgender, Gender Identity
Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Women
This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in younger versus older transgender women (people who were assigned male at birth but whose gender identity is female).
- Conditions
- Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation
- Trial name
- NCT04066283
- Testing
- No intervention
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Citrulline, Blood Flow
Effect of L-Citrulline on Vascular Function
The objective of this project is to determine the importance of peripheral vascular function on gait performance in older adults.
- Conditions
- Citrulline, Blood Flow, Aging
- Trial name
- NCT03127917
- Testing
- L-citrulline
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Aging, Inflammation
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence
The MIRACLE study aims to investigate age-related mitochondrial dysfunction, mitochondrial RNA (mtRNA) release, inflammation, and cellular senescence in adult participants across three age groups.
- Conditions
- Aging, Inflammation, Healthy Ageing
- Trial name
- MIRACLE (NCT07596615)
- Testing
- Skin biopsy and venous blood sampling
- Where
- 2 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Aging
The Effect of Velocity Training in Functionally Limited Elderly
We are exploring a unique weight-training program for men and women 65 years or older that emphasizes high speed training. We believe that the speed at which muscles move may be more important to the performance of functional…
- Trial name
- NCT01211496
- Testing
- High-speed power training, Slow-speed strength training
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia