Clinical trials: Functional Aging
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Knee Osteoarthritis
High-speed Power Training in Older Adults With Knee Osteoarthritis (OA)
We are exploring a unique weight-training program for men and women 55 years or older with knee osteoarthritis (OA) that emphasizes high-speed movements.
- Trial name
- NCT01328340
- Testing
- High-speed power training, Slow-speed strength training
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Exercise Training, Neurocognitive Function
Exercise and Neurocognition in Adults Relative to ApoE Genotype
The current project is a single-blinded, double-arm, 6-month randomized controlled trial aiming to assess the effects of a integrated intervention program on neurocognitive function with respect to event-related potential in…
- Conditions
- Exercise Training, Neurocognitive Function, Aging
- Trial name
- NCT05101174
- Testing
- Integrated Intervention Group (IIG), Control Group
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Socioemotional Aging
Faces: Choices Study
The neuropeptide oxytocin (OXT), originally known for its role in inducing uterine contractions has been shown to be involved in many of the social capacities that seem to change with age, such as emotion detection and…
- Trial name
- NCT02409862
- Testing
- Oxytocin Spray
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Meditation, Health Education
Women's Healthy Aging and Menopause; (WHAM)
The present study will examine whether women at high risk for developing hypertension, i.e., post-menopausal status, at least mild psychological distress, and mildly elevated blood pressure, show improvements in these risk…
- Trial name
- NCT07314827
- Testing
- Transcendental Meditation (TM), Women's Health Education (WHE)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Miami
Aging
Aerobic Exercise to Improve Executive Language Function In Older Adults
The purpose of this study is to see if exercise can improve brain function in older adults
- Trial name
- NCT00979069
- Testing
- Aerobic group
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Sedentary Behavior / Physical Inactivity, Aging
Effects of Different Amounts of Plyometric Exercise Without Jumping in Physically Inactive Older Adults
The goal of this clinical trial is to investigate whether different amounts of plyometric exercise without jumping can improve lower-limb muscle strength, power, and muscle and tendon mechanical properties in sedentary and/or…
- Trial name
- NJPT-OLDER (NCT07891000)
- Testing
- High-Volume Non-Jumping Plyometric Training, Low-Volume Non-Jumping Plyometric Training
- Volunteers
- 54 people
- Sponsor
- University of Americas - Chili
Autophagy, Healthy Aging
Effects of Miricell Supplementation on Biomarkers of Healthy Aging and Autophagy
The goal of this clinical trial is to learn if a dietary supplement called Miricell works to improve cellular health and signs of healthy aging in adults. It will also learn about the safety of Miricell.
- Trial name
- NCT07675200
- Testing
- Spermidine
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Nutraland USA, Inc.
Aging, Healthy Aging
10-week Yoga Practice Effect on Cognitive and Motor Function in Older Adults
Thirty-three healthy elderly people, who were classified into two age groups, participated in this study. All participants had not practiced yoga before and were asked not to perform any sports activities while the research was…
- Trial name
- BDNF (NCT04314921)
- Testing
- Yoga trainings
- Where
- Lithuania
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Systemic Inflammation, Aging
Papaya Study ID:20140628
The purpose of this research study is to explore the effects of fermented papaya preparation (FPP) on whole body inflammation, physical function, fatigue, and health-related quality of life.
- Trial name
- NCT02051634
- Testing
- Fermented Papaya Preparation (FPP), Sugar Pill
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Kidney Scarring
Detection of Renal Fibrosis and Prediction of Kidney Function Decline
This study will investigate the ability of renal MRI to detect fibrosis, how this correlates to renal function and how well renal MRI biomarkers can predict decline in kidney function over time.
- Trial name
- MARS (NCT04625140)
- Where
- Norway
- Volunteers
- 72 people
- Sponsor
- University Hospital, Akershus
Dementia, Alzheimer Disease
Effects of Remote-based Resistance Training on Cardiometabolic Risk Factors, Cognitive Function, and Quality of Life in Adults Living With Alzheimer's Disease and/or Related Dementias
The investigators aim to study the effects of a 24-week remote-based resistance exercise training program on cardiovascular disease risk factors, cognitive function, and quality of life in older adults living with mild cognitive…
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular, Lewy Body Disease
- Trial name
- NCT05004558
- Testing
- Remote-based Resistance Exercise Training
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Drexel University
Frailty, Pre-Frailty
In-Person, Online, and Hybrid Healthy-Aging Education for Pre-Frailty and Frailty in Older Adults
The goal of this clinical trial is to determine whether a 6-month healthy-aging education program delivered in person, online, or in a hybrid format reduces frailty and is cost-effective compared with usual care in…
- Trial name
- FRAGSALUD-ON (NCT07738393)
- Testing
- In-person healthy aging education program, Hybrid healthy aging education program, Online healthy aging education program
- Where
- Spain
- Volunteers
- 276 people
- Sponsor
- University of Cadiz
Cerebrovascular Circulation
Blood Brain Flow and Exercise
Cerebral vasodilator responses to CO2 will be measured in young healthy adults, healthy sedentary older adults, and healthy exercise trained older adults.
- Trial name
- NCT02653638
- Testing
- Control, Indomethacin
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Persistent COVID-19, Quality of Life
Vascular Structure, Vascular Function and Vascular Aging in Adults Diagnosed With Persistent COVID
The ICOPER study aims to analyze the structure, vascular function, vascular aging and determining factors in 300 adults diagnosed with Persistent Covid in the field of Primary Health Care.
- Conditions
- Persistent COVID-19, Quality of Life, Lifestyles, Arterial Stiffness
- Trial name
- ICOPER (NCT05819840)
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Aging, Walking
Effects of a Powered Lower-Limb Exoskeleton on Walking Performance in Older Adults
The goal of this clinical trial is to learn whether a powered wearable lower-limb exoskeleton can improve walking performance in independently ambulatory older adults aged 65 to 75 years.
- Conditions
- Aging, Walking, Physical Function, Mobility Limitation
- Trial name
- E-WALK (NCT07633093)
- Testing
- Powered Lower-Limb Exoskeleton
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hunan Normal University
Overweight or Obesity
Precision Nutrition Strategies for Improving the Quality of Life of Pre-senior and Senior Populations
The number and proportion of people aged 60 years old and over is increasing worldwide. Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death.
- Trial name
- NCT04786925
- Testing
- Control diet, Nutriprecision diet
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Aging, Adults With Overweight and Obesity
Effects of Physical Exercise and a Nutritional Supplement on Body Composition, Metabolic Function, and Overall Health in Adults With a Metabolically Challenging Profile
Early-onset metabolic disturbances (such as mild hyperglycemia, subclinical dyslipidemia, excess body fat, and reduced functional capacity) represent one of the major public health challenges among middle-aged and older adults.
- Conditions
- Aging, Adults With Overweight and Obesity, Supplementation, Exercise
- Trial name
- NCT07504068
- Testing
- Group 1: Exercise + thermogenic supplement (EX-TS)
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- University of Valencia
Aging, Physical Functional Performance
Physical Function From the Perspective of Active Ageing
The aim of this study is to evaluate physical function from the perspective of active aging as well as to determine the relationship between physical activity and physical performance in the context of active aging.
- Conditions
- Aging, Physical Functional Performance, Physical Activity, Active Ageing
- Trial name
- NCT06733818
- Testing
- Functional assessment of physical performance
- Where
- Turkey (Türkiye)
- Volunteers
- 455 people
- Sponsor
- Suleyman Demirel University
Sarcopenia
Effect Study of Marine Protein Hydrolysates to Prevent Loss of Muscle Mass and Physical Function in Frail Elderly
The purpose of this study is to determine whether a marine protein hydrolysate given as a supplement can prevent age related loss of muscle mass and loss of physical function in frail elderly.
- Trial name
- NCT02890290
- Testing
- Marine Protein hydrolysate
- Volunteers
- 92 people
- Sponsor
- Molde University College