Clinical trials: Functional Aging
Premature Ovarian Insufficiency, Ovarian Reserve Function
Therapeutic Effect of Vitamin C Supplementation in Patients With Ovarian Aging
The goal of this clinical trial is to learn if Vitamin C works to improve ovarian reserve in women with ovarian aging. It will also learn about the safety of Vitamin C.
- Trial name
- NCT06794060
- Testing
- Vitamin C (Ascorbic Acid)
- Volunteers
- 354 people
- Sponsor
- Peking University Third Hospital
Neuromuscular Function
Vitamin D Supplementation and Muscle Function in Older Adults
The purpose of this study is to see if vitamin D supplementation improves muscle function in older adults.
- Trial name
- EVIDENCE (NCT02015611)
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Cognitive Impairment, Cognitive Decline
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy…
- Trial name
- AIM (NCT05998031)
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Florida
Aging, Sarcopenia
Effect of L-arginine on Microcirculation, Myogenesis and Angiogenesis Associated With Aging, Sarcopenia and Diabetes
This study aims was evaluated the effect of L-arginine on microcirculation, vasoreactivity / endothelial function and vascular smooth muscle of young and old women with Sarcopenia or Type 2 Diabetes Mellitus measured by Nailfold…
- Conditions
- Aging, Sarcopenia, Type 2 Diabetes, Microcirculation
- Trial name
- NCT04112875
- Testing
- L-arginine, Maltodextrin
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Aging
Hiking Improves the Functional Autonomy
This is an experimental research study. The subjects were randomized into two groups: Experimental group (EG; n=58, age: 67 ± 6 old) and Control group (CG; n=40; age: 70 ± 6 old).
- Trial name
- NCT00981734
- Testing
- Hiking
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- Universidade Camilo Castelo Branco
Mild Cognitive Impairment, Alzheimer Dementia
Exercise, Brain, Cognition, OMICs, Molecular Markers and Functionality in People at Risk of Mild Cognitive Impairment
This project aims to examine the effect of a 5-month period supervised exercise intervention on brain, cognition, OMICs, Molecular Markers and functional status in older people at risk of mild cognitive impairment.
- Trial name
- NCT03923712
- Testing
- Supervised Exercise Programme
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- University of Cadiz
Functional Insufficiency, Aging
Therapeutic Exercise Training in the Elderly
In adulthood, limited mobility and pain are very common and often the first clear sign of functional decline. The loss of independent mobility is related to higher rates of functional disability and mortality; however, it is also…
- Trial name
- NCT02487667
- Testing
- Therapeutic exercise by fitness machines
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Obesity
Weight Loss and Exercise in Obese, Physically Limited, Older Women and Men
The purpose of this study is to determine the effect of weight loss and exercise on physical function, body fat and muscle mass, bone strength, and quality of life.
- Trial name
- NCT00146107
- Testing
- Diet, Exercise, Weight Loss and Exercise
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Washington University School of Medicine
Functional Limitation
Home-based Exercise Via a Telecommunications System
This study is investigating the effects of a home-based resistance exercise program, administered via an interactive telecommunications system, in functionally limited older veterans.
- Trial name
- NCT00248781
- Testing
- Telecommunications system, attention control
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Mobility Limitations, Aging
A Comparison of Weighted Vest Exercise and Strength Training
The purpose of this study is to evaluate two types of exercise therapy designed to improve muscle power and mobility: weighted vest exercise vs. progressive resistance training.
- Trial name
- NCT00158119
- Testing
- InVEST (Increased Velocity Exercise Specific to Task)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- National Institute on Aging (NIA)
Frail Elderly, Elderly
Fine-tuned Physical Training to Improve Quality of Life in Older Individuals
The overall aim of this project, which is based upon the interdisciplinary expertise of four research groups within the University of Rome Foro Italico, in the macro-areas of psychology, bioengineering, physiology, and internal…
- Conditions
- Frail Elderly, Elderly, Aging, Aging Frailty
- Trial name
- NCT07546734
- Testing
- Resistance Training (RT), Resistance training + CORE (RT+CORE), CMDT training
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- University of Rome Foro Italico
Frailty
High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans
Frailty is defined as a greater susceptibility to stressors resulting from age-related impairments in adaptive biological systems.
- Trial name
- HIIT@Home (NCT05625204)
- Testing
- Center based attention (stretching only) control, Center based HIIT, Home based HIIT
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cardiovascular Disease
Fitness and Daily Function in Adults
The purpose of this study is to examine the impact of aerobic fitness on the ability of able and disabled older adults to perform daily functional activities.
- Trial name
- NCT00018265
- Testing
- Task specific endurance training, Tai Chi
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Delayed Graft Function, Other Complications of Kidney Transplant
Biomarkers of Aging as Predictors of Kidney Transplant Function
The primary purpose of this study is to measure the correlation between baseline expression of aging biomarkers, SenesceTest in blood of organ donor and renal graft function.
- Trial name
- NCT02335333
- Testing
- No treatment
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Sapere Bio
Aging
Effects of Functional Incidental Training in VA NHCU Residents
This research on Functional Incidental Training ( FIT) primarily involves women residing in community nursing homes. It is an individualized rehabilitative protocol intended to improve mobility, endurance, strength and continence…
- Trial name
- NCT00013507
- Testing
- Falls
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- US Department of Veterans Affairs
Aging, Endothelial Dysfunction
Fisetin for Improving Vascular Function in Older Adults: A Phase II Clinical Trial
Aging is associated with the development of vascular dysfunction, which increases the risk for cardiovascular disease. This clinical trial will assess if supplementation with the natural compound fisetin can improve vascular…
- Conditions
- Aging, Endothelial Dysfunction, Cellular Senescence
- Trial name
- NCT07871162
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Type 2 Diabetes Mellitus (T2DM)
Effect of Tai Chi Versus Moderate-intensity Combined Exercise Training on Cardiovascular Health and Physical Functional Performance in Older Men and Women With T2DM: the Tai Chi Intervention for Diabetes Management During Aging (TIDA) Study
This randomized, single-blind, controlled clinical trial compares the effects of a 12-week Tai Chi program versus moderate-intensity combined exercise (MICE) training on cardiovascular health, glycemic control, and physical…
- Trial name
- TIDA (NCT07131761)
- Testing
- Tai chi, Moderate-Intensity Combined Exercise (MICE), Control ( No Exercise )
- Volunteers
- 66 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Healthy Young Adults, Healthy Elderly
Pectin, Aging and Intestinal Barrier Function
The population is aging worldwide, which requires more attention to health needs and leads to a dramatic increase in health care costs. Prevention or delay of onset of disorders associated with aging is needed.
- Trial name
- NCT02376270
- Testing
- Pectin, Maltodextrin
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sedentary Lifestyle, Blood Pressure
Blueberry Enhances Activity and Cognition Through Increased Vascular Efficiency
Recent evidence suggests that increased berry intake results in a variety of health benefits, across multiple health domains. This 3-month randomized, double-blind, placebo-controlled trial assess the effects of combining daily…
- Conditions
- Sedentary Lifestyle, Blood Pressure, Arterial Stiffness, Overweight and Obesity
- Trial name
- BEACTIVE (NCT04049162)
- Testing
- Blueberry Plus Exercise (BB-EX)
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Duke University
Type 2 Diabetes, Cognitive Decline in Older Adults
Exercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes
Type 2 diabetes and low levels of physical activity are associated with an increased risk of cognitive decline in older adults. Improving blood sugar control and engaging in regular exercise may help support brain health and…
- Trial name
- MOTIVATE (NCT07485062)
- Testing
- semaglutide, Moderate-Intensity Resistance Exercise, Balance and Tone (BAT) Exercise
- Where
- Canada
- Volunteers
- 164 people
- Sponsor
- Western University, Canada