Clinical trials: Functional Aging
Aging, Postural Balance
Postural Control During Concurrent Cognitive Tasks During Optic Flow Stimulation
The purpose of this study is to investigate brain activity during current visual and auditory tasks for balance control. The participants will perform cognitive, gait, and balance measures before the data collection to exclude…
- Trial name
- NCT05117463
- Testing
- Optic Flow Stimulation, Auditory Reaction Time
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Chia-Cheng Lin, PhD, PT, MSPT
Frailty, Age-Related Macular Degeneration
Visual Frailty in Ageing
The goal of this observational study is to define visual frailty and refine monitoring for an ageing population. It involves piloting a visual frailty assessment tool in a cohort of patients aged 60 and above with a known…
- Conditions
- Frailty, Age-Related Macular Degeneration, Functional Status, Mental Health
- Trial name
- VFiA (NCT06604104)
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Physical Activity
Comparing Effects and Neural Mechanisms of Tai Chi and Light-to-Moderate Intensity Aerobic Exercises
In this three-year project, investigators will target on sedentary middle-aged and older adults with cardiovascular risks, prescribe 24-week Tai Chi or aerobic exercises and examine: 1.
- Trial name
- NCT03275038
- Testing
- Tai-Chi exercise, Aerobic exercise
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Mild Cognitive Impairment (MCI)
Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI)
This research is being done to find out if daily use of the drug levetiracetam can improve memory function in individuals with memory problems like those associated with Mild Cognitive Impairment (MCI) and Alzheimer's disease…
- Trial name
- NCT01044758
- Testing
- Levetiracetam 62.5mg, Levetiracetam 125mg, Levetiracetam 250mg
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy
Diet and the Aging Brain
We investigate whether a change in diet could provide positive effects on general brain functions in healthy elderly people.
- Trial name
- NCT00463255
- Testing
- diet
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Alzheimer Disease, Dementia
Brain Safe: Consumer Intervention to Reduce Exposure to Drugs Linked to Alzheimer's Disease
This study is an RCT to evaluate the effectiveness of Brain Safe on reducing anticholinergic exposure. Over 42 months, the trial will enroll 700 community-dwelling older adults who were prescribed one or more strong…
- Trial name
- NCT04121858
- Testing
- Brain Safe App, Attention Control App
- Where
- 2 sites in United States
- Volunteers
- 706 people
- Sponsor
- Indiana University
Postmenopausal, Female
How Seasons Affect Kidney Health in Post-Menopausal Females
The investigators are assessing how seasonal changes affect kidney function biomarkers in post-menopausal women, an understudied group.
- Trial name
- NCT06866743
- Testing
- There will be no intervention.
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Florida State University
Fall Prevention, Functional Independence
A Strategy for Fall Prevention in Aging Women
This retrospective study examined the effects of a 12-month training program on physical performance and functional ability in healthy older women.
- Conditions
- Fall Prevention, Functional Independence, Balance Impairment
- Trial name
- STABLE-WOMEN (NCT07481409)
- Testing
- Multicomponent and Stability Exercise Program
- Where
- Serbia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Novi Sad
Aging, Cognitive Function 1, Social
Playfulness in Online and Face-to-face Interactions, From Adulthood to Aging
Playful interactions have an important role in human sociality. During playful interactions, two individuals continuously co-create an imaginary world together, such as playing roles in an imaginary scene or co-creating…
- Conditions
- Aging, Cognitive Function 1, Social, Social Behavior, Aging Well
- Trial name
- Play (NCT06081725)
- Testing
- Playful interactions in an online format, An active control condition in a face-to-face format, An active control condition in an online format
- Where
- 4 sites in Israel
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Cognitive Decline
A Home-based e-Health Intervention in the Elderly: MOVI-ageing
This protocol study aims to evaluate the efficacy of the MOVI-ageing intervention, a complex home-based eHealth intervention of cognitive-demanding exercise for the elderly, in improving: global cognitive function and basic…
- Trial name
- MOVI-ageing (NCT05928078)
- Testing
- intervention
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Hypertension
High-Intensity Interval Versus Moderate-Intensity Continuous Water Based Exercise in Hypertensive Older Individuals
This study will investigate the acute and chronic effects in hemodynamic and autonomic variables to high-intensity interval versus moderate-intensity continuous heated water-based exercise in older individuals with hypertension.
- Trial name
- HExOLD (NCT04126785)
- Testing
- High Intensity Interval Exercise in Heated Water-Based, Continuous Moderate Exercise in Heated Water-Based, Control Group
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Alzheimer's Disease
Cerebral Substrates of Prospective Memory in Young and Its Disruption in Normal Aging and in Alzheimer's Disease: A Study in Anatomical MRI, Diffusion Tensor MRI and Functional MRI
Investigators propose in this study to evaluate prospective memory (MP) in all its complexity as well as the processes, cognitive and brain, the underlying.
- Trial name
- IMPRO (NCT02522091)
- Testing
- functional brain MRI, Neuropsychology tests
- Where
- France
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Aging, Mortality
Human Observatory Study
The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level.
- Conditions
- Aging, Mortality, All-cause Mortality, Life Expectancy
- Trial name
- HOS (NCT07646782)
- Testing
- Multi-Domain Ecological and Clinical Data Linkage
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Endothelial Dysfunction, Aging
Passive Mobilization and Vascular Function
With aging, vascular function (VF) declines. Inactivity and sedentary life style have been shown to contribute to the worsening of VF.
- Conditions
- Endothelial Dysfunction, Aging, Bed Rest
- Trial name
- NCT03087643
- Testing
- Passive mobilization - PM
- Where
- 3 sites in Italy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Aging, Postmenopause
Oral Antioxidant Therapy Targeted to the Mitochondria for Improving Brain Artery Health in Postmenopausal Women
The goal of this clinical trial is to learn if 3 months of taking the dietary supplement MitoQ [a mitochondria-targeted antioxidant that targets to reduce mitochondrial reactive oxygen species (mitoROS)] works to treat age- and…
- Trial name
- NCT07406243
- Testing
- Mitoquinone (MitoQ)
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Colorado State University
Obesity, Frailty
Weight Loss and Exercise in Physically Limited Obese Elderly Subjects
The overall purpose of this research is to determine the effect of weight loss and physical training on quality of life, physical function, metabolism, bone strength, body fat and muscle mass.
- Conditions
- Obesity, Frailty, Elderly
- Trial name
- NCT00146133
- Testing
- diet, exercise
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Washington University School of Medicine
Aging, Frailty
A Randomized Controlled Trial Comparing Whole Body Vibration Therapy With Usual Care and Usual Care to Improve Muscle Health in Older Adults
This study is a randomized controlled trial where participants would be randomly assigned to one of 2 groups. One group would receive Whole body vibration therapy and usual care and the other group only usual care.
- Conditions
- Aging, Frailty, Sarcopenia, Muscle Strength
- Trial name
- NCT07205133
- Testing
- Whole Body Vibration Training, Otago Exercise
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Frailty, Sarcopenia
FrAilty Care and wEll-funcTion in Community Dwelling Older Adults
This study is looking at whether older people could benefit from an online monitoring platform to support their individual ambitions to maintain or improve functional ability.
- Conditions
- Frailty, Sarcopenia, Aging
- Trial name
- FACET (NCT03707145)
- Testing
- Consultation, Online Support, Empowered
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Aberystwyth University
Aging, Cognitive Function Abnormal
Executive Functioning Training Study
Cognitive aging in people with HIV (PWH) is of increasing concern for several reasons: 1) between 52%-59% of PWH experience cognitive impairment known as HIV-Associated Neurocognitive Disorder (HAND) which impacts everyday…
- Conditions
- Aging, Cognitive Function Abnormal, Cognitive Performance, Cognitive Training
- Trial name
- EFT (NCT05598047)
- Testing
- Executive Functioning Training
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Sarcopenia
A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults
The aim of the study is to compare the effects of Krill Oil and Fish Oil supplementation on muscle function in older adults. The secondary aim is to investigate the mechanisms underlying the beneficial effects previously observed.
- Trial name
- NCT05869526
- Testing
- Fish oil, Kril oil, Vegetable oil
- Where
- United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Glasgow