Clinical trials: Functional Cardiac Disorder
Acute Coronary Syndrome
The ACS Ethnicity Platelet Function Study
This study is being done to assess the effects of the CTP inhibitor on the function of your platelets (cells within your blood that are involved in the formation of blood clots) and to assess whether you have responded to the…
- Trial name
- NCT01829659
- Testing
- Ticagrelor
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medstar Health Research Institute
Infarction, Myocardial Infarction
Which Platelet Function Test Best Reflects the In Vivo Plasma Concentrations of Ticagrelor and Its Active Metabolite?
Ticagrelor is a direct-acting, reversible platelet P2Y12 receptor inhibitor recommended by the recent European Society of Cardiology guidelines in patients with acute coronary syndromes (ACS) (class of recommendation I, level of…
- Conditions
- Infarction, Myocardial Infarction, Cardiovascular Diseases, Heart Diseases
- Trial name
- HARMONIC (NCT02690454)
- Where
- Poland
- Volunteers
- 45 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Mitral Regurgitation Functional, Heart Failure
Optimizing Clinical Outcomes in Patients Undergoing Mitral Transcatheter Edge-to-edge Repair (M-TEER) for Severe Functional Mitral Regurgitation Towards Improved Guideline-directed Medical Therapy
A multi-centre, prospective, observational pilot registry in patients undergoing mitral valve repair for severe functional mitral regurgitation to report the heart failure drug therapy and dosing before the mitral valve procedure…
- Conditions
- Mitral Regurgitation Functional, Heart Failure, M-TEER
- Trial name
- MOTOR (NCT06702527)
- Testing
- Mitral transcatheter edge-to-edge repair
- Where
- 2 sites in Germany
- Volunteers
- 9 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Type 2 Diabetes, Coronary Heart Disease
Myocardial Dysfunction in Type 2 Diabetes Mellitus (T2DM)
The purpose of this study is to examine the existence of heart abnormalities in patients with diabetes and the effect of pioglitazone in correcting these abnormalities.
- Trial name
- NCT01588470
- Testing
- pioglitazone
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Coronary Artery Bypass Graft (CABG), Cardiac Surgery Subjects
Multisensory and Cognitive Interventions in the ICU: Effects on Health and Recovery
The goal of this clinical trial is to examine the effects of sensory and cognitive stimulation on physiological, psychological, and functional recovery in adult patients after cardiac surgery who are treated in the intensive care…
- Conditions
- Coronary Artery Bypass Graft (CABG), Cardiac Surgery Subjects, Postoperative Care
- Trial name
- MICU-CARE (NCT07116941)
- Testing
- Cognitive Exercises, Auditory Stimulation, Multisensory Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people
- Sponsor
- Abant Izzet Baysal University
Becker Muscular Dystrophy
Effect of Modulating the nNOS System on Cardiac, Muscular and Cognitive Function in Becker Muscular Dystrophy Patients
This study is done to evaluate whether treatment with the drug sildenafil (Revatio®) can improve muscular, cardiac, cerebrovascular or cognitive function in patients with Beckers muscular dystrophy when compared to placebo…
- Trial name
- NCT01350154
- Testing
- Sildenafil
- Where
- Denmark
- Volunteers
- 17 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Myocardial Infarction, Cardiac Arrest
Platelet Function in Resuscitated Patients-2
Approx. 65% of resuscitated patients at the intensive care unit for internal medicine are due to myocardial infarction. Almost all patients are initially diagnosed and treated in the cath lab.
- Trial name
- NCT03445546
- Testing
- diagnostic test of platelet function
- Where
- Austria
- Volunteers
- 25 people
- Sponsor
- Medical University of Graz
Esophageal Diseases
Investigation of Cannabinoid Receptor Agonist Dronabinol in Patients With Functional Chest Pain
In a recent study, Dronabinol was shown to reduce symptoms in patients with Functional Chest Pain (non-cardiac chest pain). Additionally, metabolic measures and patients' weights were not adversely affected by this regiment.
- Trial name
- ICAMP (NCT02569073)
- Testing
- Dronabinol
- Where
- United States
- Sponsor
- Temple University
Irritable Bowel Syndrome
Brain Imaging, Heart Rate Variability and Serum Fatty Acid in Subjects With Irritable Bowel Syndrome
This study is to analyze the relationship between brain structure, the heart rate variability and the serum fatty acid component of the irritable bowel syndrome patients.
- Trial name
- NCT02179905
- Where
- Taiwan
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Coronary Artery Disease
Uric Acid Levels and Endothelial Functions
Uric acid is a risk factor for coronary artery disease (CED) in postmenopausal women but the association with inflammation and coronary microvascular endothelial dysfunction is not well-defined.
- Trial name
- NCT02862522
- Testing
- Questionnaire of overall health
- Where
- United States
- Volunteers
- 229 people
- Sponsor
- Mayo Clinic
Coronary Heart Disease
Testosterone and Myocardial Perfusion in Coronary Heart Disease (CHD)
Testosterone has traditionally been regarded as a risk factor for heart disease due to the fact that males have a higher incidence of this disease than women, at least until the menopause.
- Trial name
- NCT00239590
- Testing
- Testosterone undecanoate
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Imperial College London
Diabetes, Prognosis
A Multicenter Clinical Study of Echocardiographic Assessment of Right Heart Function and Implications of Prognosis in Diabetes
The aims of this study are to 1. Evaluate the right heart structure and function in T2DM and Prediabetes patients by speckle tracking echocardiography, and to further investigate the influence of left heart on right heart…
- Trial name
- NCT04964713
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Xie Mingxing
Aortic Valve Stenosis
Impact of SAVR and TAVR on Patient's Activity and Mobility
This is an independent, investigator-initiated, prospective multicenter observational study with restricted grant provided by Edwards Lifesciences that aims to describe baseline (preoperative) physical function and to assess and…
- Trial name
- CAPABILITY (NCT03843320)
- Testing
- SAPIEN 3, SAPIEN XT, INSPIRIS RESILIA
- Where
- 2 sites in Italy
- Volunteers
- 340 people
- Sponsor
- University of Padova
Coronary Artery Disease
Evaluation of a Fasting Mimicking Diet
Randomized, open-label, 7-month trial in eighty (80) adult subjects. Forty (40) subjects will be randomized to the intervention FMD arm with a 5 day meal program every month for four (4) months.
- Trial name
- NCT04150159
- Testing
- FMD Arm
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hypertension Institute, Nashville
Drug Reaction, Anesthetic
Pharmacogenetics Study on the Effects of Anesthetic Drugs on Circulatory Function
This study intends to study the effects of anesthetics on Circulatory Function Genomics and find the anesthetic effects in pharmacodynamics, pharmacokinetics, drug receptor or target DNA level differences, further guiding…
- Conditions
- Drug Reaction, Anesthetic, Hemodynamic Rebound, Gene
- Trial name
- NCT03839186
- Where
- China
- Volunteers
- 223 people
- Sponsor
- Xiangya Hospital of Central South University
Aortic Valve Stenosis
Outcome, Recuperation and Hemodynamics in Aortic Stenosis
Indication for aortic valve replacement (AVR) in aortic stenosis (AS) is currently based on the classical triad of clinical AS symptoms, estimation of AS severity, and cardiac repercussion at rest.
- Trial name
- PROCARE-AS (NCT05272020)
- Testing
- CPET, 6MWT, QOL assessment
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Jessa Hospital
Chagas Cardiomyopathy, Heart Failure
Cardiac Contractility Modulation in Chagas Heart Disease
Chagas disease is an endemic problem in Latin America, where millions of people are chronically infected with T. cruzi. Recently, it was assumed to have clinical and epidemiological relevance in several other countries due to…
- Conditions
- Chagas Cardiomyopathy, Heart Failure, Systolic Dysfunction, Right Bundle Branch Block and Left Anterior Fascicular Block
- Trial name
- FIX-Chagas (NCT05519046)
- Testing
- Cardiac Contractility Modulation (CCM), CRT
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- InCor Heart Institute
Heart Failure, Central Sleep Apnea
Central Sleep Apnea Prevalence and Impact on Cognitive Function in Patients With Heart Failure With Reduced or Mildly Reduced Left Ventricular Ejection Fraction
Study to assess the prevalence of central sleep apnea in patients with heart failure with reduced or mildly reduced left ventricular ejection fraction (LVEF <50%) followed by case-control study to assess the link between central…
- Trial name
- COG01 (NCT06313840)
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Zoll Medical Corporation
Cardiovascular Diseases, Sedentary Behavior
SB and Cardiac Function and Structure in IHD
Cardiovascular Disease (CVD) is the leading cause of mortality and morbidity globally. Following a myocardial infarction (MI), an individual is at an increased risk of a secondary event (20-50% higher risk post MI), compared to…
- Trial name
- NCT05771610
- Testing
- Activity pattern in CVD
- Volunteers
- 67 people
- Sponsor
- University of Bedfordshire
Heart Failure, Systemic Inflammation
A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation
The study is being done to see if ziltivekimab can be used to treat participants living with heart failure and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (inactive substance that looks…
- Trial name
- ATHENA (NCT06200207)
- Testing
- Ziltivekimab
- Where
- 217 sites in United States, Argentina and 14 more
- Volunteers
- 673 people
- Sponsor
- Novo Nordisk A/S
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