Clinical trials: Functional Cardiac Disorder
Obesity, High Blood Pressure
Effects of Curcumin Supplementation on Gut Barrier Function in Patients With Metabolic Syndrome
This study will investigate the effects of curcumin on the structure/function of the body by investigating whether targeted improvement of intestinal barrier function by supplementation with oral curcumin will result in…
- Conditions
- Obesity, High Blood Pressure, High Cholesterol, Type2 Diabetes
- Trial name
- NCT03542240
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Virginia Commonwealth University
Hypertension, Cardiovascular Diseases
Effect of Empagliflozin on Left Atrial Function in Adults at Risk for Heart Failure
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce CVD events, including incident HF. SGLT2 is a glucose transport protein in the kidneys. Inhibition of this protein results in glucosuria and lower serum blood sugar.
- Trial name
- NCT06507657
- Testing
- empagliflozin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Minnesota
Heart Failure, Chronic Systolic Heart Failure
SCD for CRS in Congestive Heart Failure (CHF) (No Left Ventricular Assist Device)
The purpose of this clinical trial is to see if a new device (SCD) is safe and if it can reduce damage to the kidney enough to allow medications to work to improve heart and kidney function for use in patients that have moderate…
- Conditions
- Heart Failure, Chronic Systolic Heart Failure, Renal Failure, Cardiorenal Syndrome
- Trial name
- NCT04589065
- Testing
- Selective Cytopheretic Device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Lenar Yessayan
Hemodialysis
Intradialytic Exercise and Remote Ischaemic Preconditioning: a Cardioprotective Role ?
The aim of this clinical trial is to evaluate whether intermittent exercise and remote ischaemic preconditioning (rIPC) during haemodialysis (HD) can provide cardioprotection in adult patients (aged 20-79 years) undergoing HD for…
- Trial name
- EXPI-DIAL (NCT06856512)
- Testing
- Remote ischaemic preconditioning, Exercise, standard dialysis
- Where
- 3 sites in France
- Volunteers
- 33 people
- Sponsor
- University of Avignon
Heart Failure
Erythropoietin Treatment in Patients With Systolic Left Ventricular Dysfunction, Mild Anemia and Normal Renal Function
Erythropoietin Treatment in Patients with systolic left ventricular dysfunction, mild anemia and normal renal function
- Trial name
- NCT00418119
- Testing
- erythropoietin
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Myocardial Ischemia, Cardiovascular Morbidity
The Effect of Peri-percutaneous Coronary Intervention Oxygenation on Myocardial Protection & Cardiovascular Fitness
Elective percutaneous coronary intervention (PCI) is often associated with myocardial necrosis evidenced by peri-procedural troponin release. This is a surrogate for subsequent cardiovascular events.
- Trial name
- NCT03256175
- Testing
- Percutaneous Coronary Intervention
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Atrial Fibrillation, Mitral Regurgitation Functional
Treatment of Functional Mitral Regurgitation in Patients With Atrial Fibrillation
The objective of the CAMERA-Pilot trial is to generate a hypothesis for a proper randomized controlled clinical endpoint trial to show the noninferiority of restoration and maintenance of sinus rhythm (via catheter ablation [CA]…
- Trial name
- CAMERA-Pilot (NCT05846412)
- Testing
- Catheter Ablation and M-TEER
- Volunteers
- 66 people
- Sponsor
- University of Luebeck
Diabetes Mellitus, Type 2
The Effect of Empagliflozin on Glucose Metabolism, Weight, Blood Pressure and Cardiac Function (NT-proBNP) Should be Investigated
In summary, the registry should provide novel insight into potential mechanisms of cardiovascular risk reduction in patients treated with Empagliflozin with an indication of intensified glucose lowering therapy based on their…
- Trial name
- Empa (NCT03131232)
- Volunteers
- 46 people
- Sponsor
- RWTH Aachen University
Congestive Heart Failure
Autonomic Neural Regulation Therapy to Enhance Myocardial Function in Heart Failure (ANTHEM-HF) Study
The ANTHEM-HF Study is designed to demonstrate the safety and efficacy of vagus nerve stimulation (VNS) with the Cyberonics VNS Therapy System for the treatment of subjects with symptomatic heart failure.
- Trial name
- ANTHEM-HF (NCT01823887)
- Testing
- Vagus Nerve Stimulation (VNS)
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Cyberonics, Inc.
Heart Failure, Systolic
The Correlation Between Serum PRMT5 Level and Cardiac Ultrasound Indicators in Patients With Heart Failure
Pathological cardiac hypertrophy is characterized by abnormal cardiomyocyte metabolism, reduced myocardial contractility, and dysregulated synthesis of myocardial contractile proteins.
- Trial name
- NCT07050706
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
Atrial Fibrillation
Renal Function and Hemolysis After Pulsed-field Ablation for Atrial Fibrillation
The aim of the project is to assess hemolysis and renal function after catheter ablation for atrial fibrillation using pulsed-field energy.
- Trial name
- NCT06198933
- Testing
- Pulsed-field ablation
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Charles University, Czech Republic
Coronary Artery Disease, Decreased Left Ventricular Function
Glucagon-like Peptide 1 Agonist Exenatide for Improved Glucose Control and Cardiac Function in Patients With Aortocoronary Bypass
GLP-1 has not only beneficial effects on glucose metabolism but also direct positive effects on cardiac function and metabolism in both experimental models and in patients with type 2 diabetes mellitus.
- Trial name
- Executive (NCT01373216)
- Testing
- Exenatide
- Where
- Czechia
- Volunteers
- 38 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation
Assessment of Left Ventricular Diastolic Function in Patients With Atrial Fibrillation
This study is a single-center, prospective cohort study to investigate non-invasive method to assess left ventricular diastolic function using echocardiography.
- Trial name
- DIAAF (NCT04654806)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Cardiac Failure
Renal Denervation in Heart Failure With Preserved Ejection Fraction
The purpose of this study is to determine whether renal sympathetic denervation (RSD)(a treatment that lowers the activity of the sympathetic nervous system) is useful in the management of patients with heart failure with…
- Trial name
- RDT-PEF (NCT01840059)
- Testing
- Renal sympathetic denervation
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Heart Transplantation, Renal Failure
Rapamycin Use in Calcineurin Inhibitor (CNI)-Free Immunosuppression for Stabilization/Improvement of Renal Function After Heart Transplantation
Clinical Problem: Renal insufficiency after heart transplantation caused by cyclosporine medication was addressed. Current therapeutic approaches include cyclosporine reduction or discontinuation.
- Trial name
- NCT00123331
- Testing
- Cyclosporine discontinuation, Rapamycin medication
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Heidelberg University
Kidney Diseases, Heart Transplantation
Safe Renal Function In Long Term Heart Transplanted Patients
The purpose of this study is to verify whether the reduction of cyclosporine dosages associated with Everolimus administration may improve renal function as compared to patients maintained on standard immunosuppressive therapy
- Trial name
- SAREFU (NCT00505102)
- Testing
- Everolimus
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Cardiovascular Diseases, Heart Diseases
Vascular Function in the Framingham Third Generation
To investigate the role of endothelial dysfunction and increased vascular stiffness as contributors to the pathogenesis of cardiovascular disease.
- Trial name
- NCT00035737
- Sponsor
- Boston University
Acute Myocardial Infarction
Impact of EMpagliflozin on Cardiac Function and Biomarkers of Heart Failure in Patients With Acute MYocardial Infarction
This study is planned to investigate the impact of Empagliflozin on biomarkers of heart failure in patients with myocardial infarction with and without type 2 diabetes mellitus within 6 months after the event.
- Trial name
- EMMY (NCT03087773)
- Testing
- Empagliflozin 10 mg
- Where
- 11 sites in Austria
- Volunteers
- 476 people
- Sponsor
- Medical University of Graz
Hypertension
Clinical Study of Blood Pressure Monitor in Conformance With the ANSI/AAMI SP10
The clinical protocol of the clinical testing of this device: 1. Objective of the test: To verify the function of device. 2. Test methods and procedures: Performance test in two positions: Seated and Supine. 3.
- Trial name
- BPM_S (NCT01502553)
- Testing
- Comparison Test to Yuyue Medical BP Meter, YYBP-212
- Where
- China
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Leo Wang
Breast Cancer
An Integrated Consent Model Study to Compare Two Standard of Care Schedules for Monitoring Cardiac Function in Patients Receiving Trastuzumab for Early Stage Breast Cancer
Several large adjuvant trastuzumab trials have demonstrated improved overall survival in participants with early stage breast cancer, with a 33% decrease in risk of death.
- Trial name
- OTT 15-05 (NCT02696707)
- Testing
- LVEF 3 month, LVEF 4 month
- Where
- 4 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Hospital Research Institute
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