Clinical trials: Functional Cardiac Disorder
COVID-19, Endothelial Dysfunction
The Effect of Dietary Intervation on Endothelial Glycocalyx in COVID-19 Patients.
The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis.
- Trial name
- NCT05185934
- Testing
- Food supplement Endocalyx
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University of Athens
End Stage Renal Disease, Chronic Kidney Disease
Risk Stratification in End Stage Renal Disease (ESRD) - ISAR Study
The purpose of this study is to evaluate the use of non-invasive markers of the autonomic function and micro- and macrocirculation to predict mortality and cardiovascular end points in end-stage renal disease patients.
- Conditions
- End Stage Renal Disease, Chronic Kidney Disease, Cardiovascular Event, Sudden Cardiac Death
- Trial name
- ISAR (NCT01152892)
- Where
- 17 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Technical University of Munich
Hypertension
Does Ultraviolet Irradiation Reduce Platelet Reactivity and Improve Coronary Microvascular Function in Man?
Endothelium derived nitric oxide (NO) regulates vascular tone and blood pressure in man. NO also inhibits platelet aggregation and mediates a variety of beneficial anti-inflammatory and repair mechanisms.
- Trial name
- NCT01785511
- Testing
- UVA Radiation
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Heart Failure, Cognitive Impairment
Mind Your Heart-II
This projects studies the role of mindfulness training (MT) to improve self-care among patients with heart failure and cognitive impairment.
- Trial name
- MYH-II (NCT05431192)
- Testing
- Mindfulness Training + Enhanced Usual Care, Enhanced Usual Care
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- The Miriam Hospital
Dilated Cardiomyopathy
Intramuscular Injection of Mesenchymal Stem Cell for Treatment of Children With Idiopathic Dilated Cardiomyopathy
The main aim of the study is to determine whether intramuscular injection of umbilical cord mesenchymal stem cells can improve the ventricular function of children with idiopathic dilated cardiomyopathy(IDCM); Secondary…
- Trial name
- NCT01219452
- Testing
- umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Qingdao University
CHF
FAST PV and mGFR™ Technology in Congestive Heart Failure
This is an investigator-initiated, one-armed, phase 2 clinical trial using an injectable fluorescent tracer to assay and evaluate measured plasma volume (mPV) and measured glomerular filtration rate (mGFR) in hospitalized…
- Trial name
- NCT03808948
- Testing
- VFI
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Acute Kidney Injury
The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery
The purpose of study is to test whether perioperative sodium bicarbonate infusion can prevent acute kidney injury following open heart surgery in infective endocarditis patients.
- Trial name
- NCT01920126
- Testing
- sodium bicarbonate, Saline
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Yonsei University
Arrhythmia, Quality of Life
Psychosomatic Effects of Implantable Cardioverter Defibrillator With Home Monitoring Function (QUANTUM)
Quality of life (QOL) and psychological well-being of patients with implantable cardioverter-defibrillators (ICDs) are significantly influenced by the experience of shock therapies.
- Trial name
- NCT00325221
- Testing
- HM on, HM Off
- Where
- 7 sites in Austria, Germany and 1 more
- Volunteers
- 148 people
- Sponsor
- Biotronik SE & Co. KG
Quality of Life, Congenital Heart Disease
Exercise Training in Children With Corrective Cardiac Surgeries
To determine the effects of preoperative exercise therapy on postoperative cardiopulmonary outcomes and quality of life in children with corrective cardiac surgeries.Within literature there is limited evidence on preoperative…
- Conditions
- Quality of Life, Congenital Heart Disease, Heart; Surgery, Heart, Functional Disturbance as Result
- Trial name
- NCT05763238
- Testing
- INTERVENTION GROUP, CONTROL GROUP
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Riphah International University
Chronic Coronary Syndrome, Atherosclerosis
Comprehensive Assessment of Morphometric, Functional, Biomechanical and Biological Interactions Between Atherosclerotic Plaque and Platelets Within the Stenosed Coronary Artery
The main objective of the present study is to verify, in vivo, whether shear forces computed solely based on coronary angiography and computational fluid dynamics (CFD) techniques are associated with the biomarkers indicating the…
- Trial name
- INTERFORCE (NCT06275399)
- Testing
- OCT examination, Blood sampling, Assessment of vFFR and shear stress parameters
- Where
- Poland
- Volunteers
- 105 people
- Sponsor
- Medical University of Warsaw
Heart Failure
Investigation of the Effect of Inspiratory Muscle Training and Dual-Task Inspiratory Muscle Training on Cognitive Functions in Heart Failure
The goal of this clinical trial is to evaluate whether dual-task inspiratory muscle training (IMT) is effective in improving cognitive and functional outcomes in adults with heart failure.
- Trial name
- NCT07581587
- Testing
- Dual-Task IMT, IMT
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Istanbul University - Cerrahpasa
Cardiovascular Diseases, Postoperative Complications
Effects of Cerebral Oxygen Saturation on Neuropsychological Outcomes
The purpose of this study is to evaluate the effects of maintaining adequate cerebral oxygen saturation (over 40%) on patients undergoing cardiac surgery.
- Trial name
- NCT00151307
- Testing
- INVOS cerebral oximeter
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Cardiovascular Risk Factors
A Study of Different Types of Fatty Acid on Risk Factors for Heart Disease
Experimental elevation of non-esterified fatty acids (NEFA) impairs endothelial function and insulin sensitivity but the impact of NEFA composition is unknown.
- Trial name
- eFAIRE (NCT01351324)
- Testing
- Absence or presence of fish oil
- Where
- United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Reading
Fatigue
Effects of Oral Iron on Postoperative Fatigue Upon Coronary Artery Bypass Graft Patients
The purpose of this research study is to examine how an oral iron supplement (Feramax®) influences fatigue during early postoperative recovery (at three months) among CABG patients and, the effects on recovery outcomes (e.g.
- Trial name
- NCT01912261
- Testing
- Polysaccharide iron complex
- Where
- Canada
- Volunteers
- 121 people
- Sponsor
- Nova Scotia Health Authority
Modes of Exercise and Myocardial and Endothelial Function, Microcirculation
Investigation of Cardiac Function and Cardiovascular Risk Factors in Marathon Runners- The Munich Marathon Study
The purpose of this study is to determine the cardiovascular risk involved in the exertional exercise of marathon running. The researchers aim to investigate the beneficial effects of regular well-dosed exercise on health and…
- Conditions
- Modes of Exercise and Myocardial and Endothelial Function, Microcirculation, Subclinical Endorgan Damage, Obesity
- Trial name
- MMS (NCT00500773)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Tricuspid Valve Insufficiency
Transcatheter Tricuspid Valve Interventions and Right Ventricular Function: Evaluation with Magnetic Resonance Imaging
There is an urgent need for transcatheter tricuspid interventions, as pharmaceutical therapy becomes ineffective in advanced disease stages and surgery remains associated with high mortality rates.
- Trial name
- NCT04522154
- Testing
- Magnet resonance imaging
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Coronary Artery Disease
Effect of FFRCT-angio in Functional Diagnosis of Coronary Artery Stenosis
Coronary CT angiography (CTA) or invasive coronary angiography (CAG) is usually performed to evaluate the severity of coronary stenosis depending on the probability of CAD.
- Trial name
- NCT04493086
- Testing
- FFRCT-angio
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Heart Failure, Nursing Caries
Physical Activity Program on Clinical Output in Heart Failure
Background: This study was carried out to determine the effect of physical activity program applied to individuals with heart failure on quality of life, functional capacity and mortality risk level.
- Trial name
- Heartfailu (NCT05349786)
- Testing
- Physical activity program
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Pulmonary Hypertension
Investigation of H01 in Adults With Pulmonary Hypertension Including Interstitial Lung Disease (The SATURN Study).
This study is a prospective, randomized, double-blind, study of H01 (Hymecromone) in adults with pulmonary hypertension (PH). The primary objective of this study is to evaluate the safety and tolerability of oral H01 and the…
- Trial name
- SATURN (NCT05128929)
- Testing
- Hymecromone (H01)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Stanford University
Thrombocytopathy
Platelet Function in Minimal Extracorporeal Circulation in CABG
Rationale: Cardiac surgery with extracorporeal circulation (ECC) triggers platelets. Minimal extracorporeal circulation system (minimal-ECC) has several advantages compared with conventional ECC amongst less platelet activation.
- Trial name
- ECCTEG (NCT01935245)
- Testing
- Mini extracorporeal circulation, Conventional extracorporeal circulation
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
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