Clinical trials: Functional Cognitive Disorder
Obsessive-Compulsive Disorder (OCD)
Neural Predictors and Neural Changes Associated With Cognitive Behavior Therapy for Obssesive Compulsive Disorder
The goals of the project are 1) to understand what are the neural mechanisms involved in the psychological treatment of obsessive-compulsive disorder (OCD) in children/adolescents and adults, 2) to assess potential differences in…
- Trial name
- NCT04042038
- Testing
- Cognitive-behavior therapy (psychological treatment)
- Where
- 3 sites in Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Huntington Disease
Evaluation of Three Tests to Assess Social Cognition in Huntington Disease
The goal of this observational study is to learn about the usefulness of a test of social functioning in persons with Huntington disease.
- Trial name
- NCT07253038
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Region Skane
Healthy Aging, Alzheimer's Disease (AD)
Improving Executive Control in Cognitively Healthy Older Adults: the MUltitasking STrategy (MUST) Study
Developing efficient cognitive intervention for cognitively health older adults is a major public health goal, due to its potential for reducing age-related cognitive decline and Alzheimer's disease/dementia risk.
- Trial name
- MUST (NCT06995638)
- Testing
- Web-based Cognitive Training (with strategy), Web-based Cognitive Training (without strategy)
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Stroke
Cognitive Control Functions of the Human Thalamus
The goal of this research project is to investigate how brain lesions affect our ability to generate goal-directed behaviors - a cognitive function commonly referred to as cognitive control.
- Trial name
- NCT06920992
- Testing
- measuring cognitive flexibility including working memory and set-switching
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Kai Hwang
Aging, Age Related Hearing Loss
Cognitive Training to Improve Mobility in Middle-aged and Older Adults
The proposed study is designed to evaluate the effect of at-home executive function training on cognition and mobility in older adults with age-related hearing loss (ARHL), older adults with normal hearing, and middle-aged adults.
- Trial name
- HnW (NCT05418998)
- Testing
- Executive function (EF) training
- Where
- Canada
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Concordia University, Montreal
Carotid Artery Stenosis, Image
Evaluation of Brain Health and Surgical Efficacy in Patients With Carotid Artery Stenosis
The purpose of this study is to explore the relationship between the recovery of cerebrovascular morphology and cognitive function before and after surgical treatment in patients with carotid artery stenosis and their…
- Trial name
- NCT05848921
- Testing
- magnetic resonance image, Neuropsychological scale
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing University of Traditional Chinese Medicine
Physical Function, Cognitive Decline
Face-to-face vs Online Physical Exercise in Seniors Living in Nursing Homes (ExerMOT-NH)
The benefits of multicomponent physical exercise (MPE) in the mental and physical health of older adults are widely accepted. However, during Covid19 pandemic, some face-to-face programs for physical exercise were canceled.
- Conditions
- Physical Function, Cognitive Decline, Psychological Well-Being
- Trial name
- ExerMOT-NH (NCT06352749)
- Testing
- Advice to increase physical activity and reduce sedentary behavior, Online Physical Exercise, Face-to-Face Exercise
- Where
- 4 sites in Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of the Basque Country (UPV/EHU)
Primary Brain Tumour, Radiation Toxicity
Cognitive Function After Radiation Therapy for Primary Brain Tumours
This study will assess cognitive function in patients with a primary brain tumour treated with radiation therapy (RT) to generate radio-sensitivity and volume effect parameters for the development of cognitive dysfunction.
- Conditions
- Primary Brain Tumour, Radiation Toxicity, Cognitive Impairment
- Trial name
- NCT04306432
- Testing
- Cognitive tests and Patient Reported Outcomes
- Where
- 5 sites in Denmark
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Epilepsy, Cognitive Function 1, Social
The Effect of Dual Task on Postural Control in Children Diagnosed with Epilepsy
An individual's postural control is often accompanied by other tasks in daily life, such as cognitive tasks. Cognitive dual task (cognitive dual task) is the ability to perform two or more cognitive and motor activities…
- Conditions
- Epilepsy, Cognitive Function 1, Social, Balance; Distorted, Children
- Trial name
- NCT06529133
- Testing
- Evaluation of postural control
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Acquired Brain Injury, Development, Child
COgnitive REhabilitation in Pediatric Patients with ABI, from Vegetative State to Functional Recovery
Acquired brain injuries (ABI) represent one of the most important cause of disability and mortality during the pediatric age, also in the western Countries.
- Trial name
- COREABI (NCT04499092)
- Testing
- Personalized Neuropsychological treatment (CORE-ABI), Sequential Neuropsychological treatment (SET-ABI)
- Where
- Italy
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Type 1 Diabetes Mellitus, Hypoglycemia Unawareness
The Role of Endogenous Lactate in Brain Preservation and Counterregulatory Defenses Against Hypoglycemia
Iatrogenic hypoglycemia is the most frequent acute complication of insulin therapy in people with type 1 diabetes (T1DM). Recurrent hypoglycemic events initiate a process of habituation, characterized by suppression of…
- Trial name
- NCT02308293
- Testing
- High intensity exercise, Lay down comfortably
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Attention Deficit Hyperactivity Disorder
Standardized Lycium Chinense Fruit Extract Enhances Attention and Cognitive Function in Healthy Young People
Lycium chinense fruit (LCF) is widely distributed in East Asia that has been used traditionally for anti-aging purposes. This study was performed to examine the effects of LCF on attention and cognitive function in healthy young…
- Trial name
- NCT03439111
- Testing
- Standardized Lycium chinense Fruit Extract (LCF) capsules
- Where
- South Korea
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Biomix
Cognitive Impairment, Mild, Executive Dysfunction
Does Computerized Cognitive Training Improve Executive Functioning in the Older Adult?
Explanation of the study: As the older adult population continues to rise, so will normal cognitive aging. This increase raises concern for maintaining cognitive function and possibly delaying the onset of disorders such as…
- Trial name
- CCT (NCT03170492)
- Testing
- RehaCom Computerized Cognitive Training for 480 minutes, Pencil-and-Paper Cognitive Training for 480 minutes
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of the Sciences in Philadelphia
Metabolic Syndrome, Coronary Heart Disease
Cognition and Exercise Training
The aim of study is to investigate the impact of two different training modalities (high intensity interval training (HIIT) versus moderate intensity continuous exercise training (MICET) on cognitive performance, cerebral…
- Conditions
- Metabolic Syndrome, Coronary Heart Disease, Chronic Heart Failure
- Trial name
- COGNEX-2 (NCT01906957)
- Testing
- high intensity interval training (HIIT), moderate intensity continuous exercise training
- Where
- 2 sites in Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Mild Cognitive Impairment
EXCEL: Exercise for Cognition and Everyday Living for Seniors With Memory Complaints
Alzheimer's disease (AD) is a major health issue in Canada; it affects over 8% of the population aged over 65 years. Persons with AD have a reduced quality of life as they become dependent on others for activities of daily living…
- Trial name
- NCT00958867
- Testing
- Exercise program (AT), Exercise training (RT), Exercise training (S & R; control)
- Where
- Canada
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy
Efficacy, Transfer, and Neuro-functional Basis of a Memory Training Targeting Episodic Retrieval in Older Adults.
Aging leads to cognitive changes that affect memory, particularly episodic retrieval. These impairments are detrimental to seniors' quality of life.
- Trial name
- SPECTRA (NCT06110234)
- Testing
- Episodic Specificity Induction, Associative Memory
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Alzheimer's Disease, Huntington's Disease
A Phase 1, Non-Randomized, Open-Label, Single-Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF 01913539] In Subjects With Severely-Impaired And Normal Renal Function
This study is to compare the pharmacokinetics of Dimebon in subjects with severe renal impairment to subjects with normal renal function after oral administration of a single oral 20-mg dose of Dimebon.
- Trial name
- NCT00824590
- Testing
- Dimebon
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer
Energy Restriction, Sleep Deprivation
Brain Energy and Cognition
This proposed laboratory study will extend previous findings on relationships between cognitive function and nutritional status to conditions that more closely resemble military operations where aerobic exercise, inadequate…
- Trial name
- NCT01603550
- Testing
- Sleep Deprivation, Energy Restriction
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Mild Cognitive Impairment
Study of Motor Representations in Healthy Subjects and Amnestic MCI
Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.
- Trial name
- IRMARCHE (NCT02574182)
- Testing
- Brain MRI
- Where
- France
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Schizophrenia
Neuroendocrine and Metabolite Substrates in Schizophrenia
Background: Schizophrenia is a serious mental illness. The diagnosis and severity evaluations of schizophrenia are generally based on patient behaviors.
- Trial name
- NCT02423096
- Testing
- Risperidone
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital