Clinical trials: Functional Cognitive Disorder
Mild Cognitive Impairment
Probiotic Intervention on Gut Microbiota and Cognitive Functioning in Older Adults With a Mild Cognitive Impairment
Recent studies suggest that gut microbiota is linked to cognitive performance and modulating gut microbiota is a safe and promising approach to enhance cognition.
- Trial name
- NCT05859230
- Testing
- Experimental: The probiotic drink study group
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- National University of Singapore
Anxiety
40-Hz Audiovisual Stimulation in Schizophrenia Spectrum Disorders
This randomized, sham-controlled trial evaluated the effects of 40-Hz binaural beat music (BBM) combined with 40-Hz rhythmic photic stimulation (RPS) in adults with schizophrenia spectrum disorders.
- Trial name
- NCT07782034
- Testing
- 40-Hz Binaural Beat Music Combined With 40-Hz Rhythmic Photic Stimulation
- Where
- Taiwan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Cheng Kung University
Focal Epilepsy, Electrodes, Implanted
Multi-level Approach of Brain Activity Using Intracranial Electrodes in Epileptic Patients
The main goal of this project is to study the mechanisms of epileptic activities using intracranial macro and micro electrodes in epileptic patients undergoing pre-surgical investigation.
- Conditions
- Focal Epilepsy, Electrodes, Implanted, Cognitive Function, Neurophysiology
- Trial name
- EpiMicro (NCT04653012)
- Testing
- Intracranial macro-microelectrode recording
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Aging, Cognitive Decline
The Effect of a Single Bout of Balance and Coordination Exercise on Cognitive Function in Elderly People
Individuals of advanced age are at higher risk of cognitive deterioration.A single bout of aerobic exercise was found to improve cognitive functions.
- Trial name
- NCT03420365
- Testing
- Aerobic exercise
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Dementia, Mild Cognitive Impairment
HOme-based Brain Monitoring With a GARment-EEG to Study Cognitive Decline in the Aging Population
This study will investigate the validity of the HOGAR EEG/PSG monitoring kit designed by Bitbrain as a tool for characterizing and assessing cognitive function in older adults, as well as for detecting and predicting cognitive…
- Conditions
- Dementia, Mild Cognitive Impairment, Dementia Alzheimers, Dementia, Mixed
- Trial name
- Hogar (NCT06993207)
- Testing
- Home Lab
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Bitbrain
Autism Spectrum Disorder, Anxiety
Specifying and Treating Anxiety in Autism Research
In the Specifying and Treating the Anxiety Phenotype in Autism Spectrum Disorder (STAAR) study, we conducted a16-week randomized comparative treatment trial of the Behavioral Intervention for Anxiety in Children with Autism…
- Trial name
- STAAR (NCT03279471)
- Testing
- Sertraline, CBT/BIACA
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of California, Davis
Multiple Sclerosis, Relapsing-Remitting
Cognitive Disability and Quality of Life of Patients Suffering From Multiple Sclerosis and Treatment With Immunosuppressant
Multiple Sclerosis is the first cause of neurological handicap in France. The importance of cognitive disabilities, their evaluation and their impact on patients' life have only been comprehended recently.
- Trial name
- CoQualSEP (NCT01392872)
- Testing
- Neuropsychological assessment
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cognitive Impairment, Mild
Walking on Cognitive Function in Individuals With Mild Cognitive Impairment: A Pilot Project
Background: Many studies suggest physical activity reduces risk of dementia and improves global cognitive function in individuals with mild cognitive impairment (MCI).
- Trial name
- NCT04498195
- Testing
- increased exercise and physical activity
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Samuel Merritt University
Cognitive Impairment
AI-Driven Cognitive Digital Therapeutics for Dementia Management
The study would investigate the effect of a cognitive digital therapeutics system. The intervention group would receive three digital therapeutics sessions per week for 8 weeks, while the control group would receive usual care.
- Trial name
- NCT06783465
- Testing
- Digital therapeutics session
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University WanFang Hospital
Alzheimer's Disease, Dementia
A Study to Evaluate the Effects of MK-0249 and an Alzheimer's Disease Medication on Cognitive Function in Adults With Alzheimer's Disease (MK-0249-023)
This study will evaluate acute symptomatic improvements in cognitive performance in healthy elderly participants with mild-to-moderate Alzheimer's disease.
- Trial name
- NCT00874939
- Testing
- MK-0249 7.5 mg, MK-0249 25 mg, Donepezil 5mg
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Haemodialysis, Kidney Failure
Dialysate Cooling for the Preservation of Cognitive Function in People Receiving Haemodialysis
When a person's kidneys are not working properly, they need a life-saving treatment called haemodialysis three times a week to filter the waste and extra fluids from the blood.
- Trial name
- COOL HD (NCT07377500)
- Testing
- Dialysis cooling
- Where
- United Kingdom
- Volunteers
- 356 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Cognitive Impairment, Mild, Executive Dysfunction
Does Computerized Cognitive Training Improve Executive Functioning in the Older Adult?
Explanation of the study: As the older adult population continues to rise, so will normal cognitive aging. This increase raises concern for maintaining cognitive function and possibly delaying the onset of disorders such as…
- Trial name
- CCT (NCT03170492)
- Testing
- RehaCom Computerized Cognitive Training for 480 minutes, Pencil-and-Paper Cognitive Training for 480 minutes
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of the Sciences in Philadelphia
Psychotic Disorder
Yoga and Aerobic Exercise in Psychosis
The current study aims to evaluate the impacts of yoga and aerobic exercise on neuro-cognitive function, symptoms and brain changes in early psychosis.
- Trial name
- YEP (NCT01207219)
- Testing
- Yoga therapy, Aerobic exercise
- Where
- Hong Kong
- Volunteers
- 140 people
- Sponsor
- The University of Hong Kong
Schizophrenia
The Effectiveness of the Meta-cognitive Training Among Patients With Chronic Schizophrenia
The aim of the study is to compare the effectiveness of the meta-cognitive training (MCT) for schizophrenia against treatment as usual (TAU) among patients who attends community support groups.
- Trial name
- NCT02187692
- Testing
- MCT
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Cognitive Decline
Effects of the Physical Activity and Cognitive Training Program
Investigators assume that there are some positive effects of cognitive training and physical activities on cognitive function, depression and quality of life in a sample of older residents in long-term care facilities.
- Trial name
- NCT02114125
- Testing
- Physical Activity, Cognitive Training
- Where
- Taiwan
- Volunteers
- 270 people
- Sponsor
- National Taiwan University Hospital
Neurodegenerative Diseases, Cognition Disorders in Old Age
Probiotics in Mild Alzheimer's Disease
The main objective is to investigate whether administration of probiotics to patients with mild Alzheimer's Disease (AD) reduces neuroinflammation, improves cognitive function and modifies neurophysiological measures, compared to…
- Trial name
- NCT06181513
- Testing
- Probiotic Blend Capsule
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- University of Nicosia
Sleep Disturbances, Aging
Low-intensity Hippocampal Transcranial Ultrasound Stimulation for Managing Cognitive and Sleep Dysfunction in Preclinical Alzheimer's Disease
Background: Sleep disturbances, as a common symptom, can jeopardize the brain health and cognitive function and even lead to cognitive impairments in older adults.
- Conditions
- Sleep Disturbances, Aging, Cognitive Impairment, Mild
- Trial name
- NCT07298876
- Testing
- Low-intensity transcranial ultrasound stimulation
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Geriatric Patient Care Improvement, Postoperative Delirium (POD)
The Effects of Anesthesia Depth Monitoring on Postoperative Recovery and Cognitive Functions in the Geriatric Patient Population
This study will be conducted on patients aged 65 and older scheduled for surgery due to lumbar or cervical disc herniation. General anesthesia is routinely used for these types of surgeries in the hospital.
- Conditions
- Geriatric Patient Care Improvement, Postoperative Delirium (POD), Burst Suppression
- Trial name
- NCT06844279
- Testing
- Control Group: Standard Hemodynamic Monitoring, Processed Electroencephalogram (BIS Index), Processed Electroencephalogram (DSA Mode)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Aslıhan Güleç
Healthy
Phase I Single and Multiple Escalating Dose Study of RGN1016 in Healthy Male Subjects
This is a double-blind, randomized, placebo-controlled, dose-escalating, single dose and multiple dose study.
- Trial name
- NCT02820155
- Testing
- RGN1016
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Schizophrenia, Cognitive Impairment
Functional Magnetic Resonance Imaging Study in Schizophrenia Patients and Correlation With Cognitive Impairments
1. Comparison of functional activity at different brain areas related to different cognitive domains e.g. Memory, visuospatial abilities, executive functions, attention, concentration, language, orientation in schizophrenia to…
- Trial name
- NCT06471179
- Testing
- Functional MRI
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
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