Clinical trials: Functional Immune Response
Gut Microbiome, Immune Responses
Effects of Probiotic Supplementation on Gut Health, Immune Response, and Well-Being
This randomized, double-blind, placebo-controlled exploratory study will evaluate the effects of daily probiotic supplementation on gut barrier function, immune-related markers, and well-being in healthy adults with mild to…
- Conditions
- Gut Microbiome, Immune Responses, Well-being
- Trial name
- NCT07779265
- Testing
- Probiotic capsules
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Orthomol Pharmazeutische Vertiebs GmbH
Inflammatory Response, Metabolic Disturbance
Astaxanthin, Exercise Inflammation, Skin Health
Vigorous exercise can stress the body. Consuming special types of diet supplements may help the body recover better from exercise.
- Conditions
- Inflammatory Response, Metabolic Disturbance, Immune Suppression
- Trial name
- NCT05409092
- Testing
- Astaxanthin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Infection
Cholera Toxin B Subunit (CTB) Administered by Mucosal Way in Healthy Adult Volunteer
It is a biomedical research without direct individual benefit, exploring and comparing the mucosal immune response after oral, nasal and sublingual administration of B-subunit of non-toxic cholera toxin (CTB) in healthy adult…
- Trial name
- NCT00820144
- Testing
- CTB by nasal way, absorption of CTB by oral way, absorption of dukoral by oral way
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Colorectal Cancer, Surgery
Human Blood Specimen Collection to Evaluate Immune Cell Function
Natural killer (NK) cells are leukocytes of the innate immune system and play a central role in the control of cancer metastases.
- Conditions
- Colorectal Cancer, Surgery, Perioperative Care
- Trial name
- NCT03422120
- Testing
- Natural Killer Cell Activity Assay
- Where
- Canada
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Diabetes Mellitus, Type 2, Obesity
The Alberta NutrIMM Study - Nutrition and Immunity
This study will investigate the effect of body weight, diet, and high blood sugar levels, under controlled feeding conditions, on immune function in individuals with and without obesity.
- Trial name
- NutrIMM (NCT04291391)
- Testing
- North American-type diet
- Where
- Canada
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Respiratory Tract Infections (RTI), Mucosal Immunity
Fermented Milk Drink With Lacticaseibacillus Paracasei Strain Shirota Helps Triathletes With Cold-Like Symptoms Before and After a Race
This study aims to evaluate whether a fermented milk drink containing the probiotic strain Lacticaseibacillus paracasei strain Shirota (LCS), commonly found in Yakult®, can help reduce upper respiratory symptoms in triathletes…
- Conditions
- Respiratory Tract Infections (RTI), Mucosal Immunity, Systemic Inflammation, Depressive Disorder
- Trial name
- NCT06970964
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Type 1 Diabetes Mellitus, Hypoglycemia Unawareness
The Role of Endogenous Lactate in Brain Preservation and Counterregulatory Defenses Against Hypoglycemia
Iatrogenic hypoglycemia is the most frequent acute complication of insulin therapy in people with type 1 diabetes (T1DM). Recurrent hypoglycemic events initiate a process of habituation, characterized by suppression of…
- Trial name
- NCT02308293
- Testing
- High intensity exercise, Lay down comfortably
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Rheumatoid Arthritis
Cortisol Circadian Rhythm in Patients With RA
The European League Against Rheumatism (EULAR), acknowledging the critical issue of the complications, of long term treatment with glucocorticoids in the most recent update of the management guidelines for Rheumatoid arthritis…
- Trial name
- CortRyRA (NCT05671627)
- Testing
- DMARDs
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Sleep Deprivation, Sleep
Sleep Deprivation's Regulation of Immune System Function and Behavior
The study proposes to investigate whether sleep deprivation will affect a variety of measures, including hormones, immune system functioning, and behaviors related to food intake and hunger.
- Trial name
- SS (NCT01730742)
- Testing
- Neuroeconomics task, Portion Size Task, Blood sample
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Uppsala University
HIV Infections
Quality of Life, Depression and Sexual Function in Men Living With HIV
This observational case-control study evaluates quality of life, depressive symptoms, and sexual function in heterosexual men living with HIV who are receiving effective combination antiretroviral therapy and have achieved…
- Trial name
- NCT07376239
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
T Cell Response to Dried Plum, Vitamin D Influence on Immune Response
Prebiotics (Dried Plum) and Immune Function in Postmenopausal Women
Prior studies have shown that dietary supplementation with dried plums (also known as prunes) reduces bone loss in postmenopausal women.
- Conditions
- T Cell Response to Dried Plum, Vitamin D Influence on Immune Response, Dried Plum and Immune Function
- Trial name
- NCT07222111
- Testing
- Dried plums
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation
NAC Supplementation and Soccer Specific Performance
In this investigation the investigators utilized NAC supplementation to boost GSH availability during an one-week-microcycle consisting of three soccer games, in order to test the hypotheses that: i) antioxidant supplementation…
- Conditions
- Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation, Skeletal Muscle Performance, Antioxidant Status
- Trial name
- NCT04523675
- Testing
- N-acetylcysteine
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
Comparison of Alveolar Macrophages in Individuals With COPD Versus Smokers With Normal Pulmonary Function
The purpose of this study is to determine whether the alveolar macrophages (AMø) of patients with chronic obstructive pulmonary disease (COPD ) show abnormal responsiveness to bacterial and viral products, relative to smokers…
- Trial name
- NCT00281190
- Testing
- Blood drawing, Bronchoalveolar lavage during indicated bronchoscopy
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Immune Response
LIFEHOUSE: Description of the Tent Bucket -Immune Support
This immune support program will be an extension to the existing LIFEHOUSE program. Essential employees in Gig Harbor, WA; Colonial Heights, VA; Lenexa, KS, and Santa Fe Springs, CA, will be offered complimentary supplementation…
- Trial name
- LIFEHOUSE (NCT04734288)
- Testing
- Vit.D3 5000 IU, Immune Active
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Allergic Rhinitis, Allergy
Pollutant Altered Allergic Responses
This study is designed to investigate whether exposure to particulate air pollution increases the allergic response to allergens.
- Trial name
- NCT00011440
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Vitamin D Deficiency
The Effect of Combinatorial Nutritional Supplementation on Immune Function in Healthy Older Adults
Many older adults do not get enough zinc, vitamin C and vitamin D, and this can be related to decreased ability to fight infection.
- Trial name
- NCT02876315
- Testing
- Redoxon VI
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Oregon State University
Healthy
Resistant Maltodextrin Supplementation: Gastrointestinal Health
Resistant maltodextrin (RMD) is an indigestible water soluble fiber that increases fecal bulk by enhancing growth of specific microbial populations; however the effect of RMD on bifidobacteria and total fecal weight is not clear.
- Trial name
- DEX (NCT02733263)
- Testing
- 15 g RMD, 25 g RMD, 0 g RMD
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Florida
Yogurt Intake, Gastrointestinal Immune Function
Yogurt and GI Health
The purpose of this research is to assess mucosal immune function responses in the gastrointestinal (GI) tract to twice-daily yogurt consumption.
- Conditions
- Yogurt Intake, Gastrointestinal Immune Function, Gut Microbiome, Gut Health
- Trial name
- NCT05931471
- Testing
- Yogurt Intervention
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Shock, Septic
Mitochondrial Function of Immune Cells in Sepsis
Introduction: Evidence suggests that sepsis and septic shock severely impair mitochondria and that the resulting mitochondrial dysfunction is related to the severity and outcome of the resulting organ dysfunction.
- Trial name
- MitoSepsis (NCT01600989)
- Testing
- blood sampling
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Familial Mediterranean Fever, MEFV Gene Mutation
Characterization of a Functional Test for Mediterranean Family Fever Screening - 2
Familial Mediterranean fever (FMF) is the most common auto-inflammatory disease (prevalence: 1-5 / 10,000 inhabitants). It is caused by mutations in the MEFV gene, which encodes variants of the Pyrine inflammasome.
- Trial name
- DEPIST-FMF 2 (NCT04478409)
- Testing
- one additional blood sample during a planned blood test
- Where
- 8 sites in France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon