Clinical trials: Functional Immune Response
Healthy
Maca in Healthy Subjects After Strenuous Endurance Exercise
The aim of this study is to investigate Lepidium meyenii (Maca) extract supplementation on exercise-induced responses of the biochemical, and physiological parameters.
- Trial name
- NCT05779488
- Testing
- maca
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Asthma, Obesity
Meal-Exercise Challenge and Physical Activity Reduction Impact on Immunity and Inflammation
In a society where exercise is prescribed by physicians to increase physical condition, improve dietary habits and reduce cardiovascular risk, the impact of exercise, acute or chronic, and diet in inflammation and immunity is…
- Trial name
- MERIIT (NCT02027675)
- Testing
- High fat poor micronutrient meal, Mediterranean meal
- Where
- 3 sites in Portugal
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Critical Illness, Fasting State
Ketosis, Immune Function and Metabolic Adaptation in Response to Short-term Fasting in Critical Illness
KETO-FAST is a pre-planned translational substudy of the FAST-ICU cluster-randomized cross-over trial. The substudy will characterize ketone body production and associated metabolic, autophagy-related, and immune cellular…
- Conditions
- Critical Illness, Fasting State, Ketosis, Nutrition
- Trial name
- KETO-FAST (NCT07738536)
- Testing
- Delayed nutrition, Standard nutrition, Fasting
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Immune Response
The Immune Function Intervention Trial
The purpose of the study is to examine whether cardiovascular exercise training improves immune responses to vaccination in previously sedentary older adults.
- Trial name
- ImFIT (NCT00548990)
- Testing
- cardiovascular exercise training, flexibility/balance control
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Vascular Function, Healthy
Effects of Sodium Chloride or Its Substitute Salt Potassium Chloride on Vascular Function
This is a prospective, monocentric, randomized trial to investigate how sodium chloride or its substitute potassium chloride acutely affects vascular function by ingestion via a salted soup.
- Conditions
- Vascular Function, Healthy, Diabetes
- Trial name
- ESCAPE-SALT (NCT05970601)
- Testing
- Soup
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. med. Johannes Stegbauer
Somatoform Disorders, Fibromyalgia
Immune Patterns in Pain Patients DSM-IV
The purpose of this study is to define subgroups of patients with somatoform disorders due to DSM-IV by immunological, psychological and genetic characterization.
- Conditions
- Somatoform Disorders, Fibromyalgia, Myofascial Pain Syndrome, Diffuse, Depression
- Trial name
- IPPPDIV (NCT01106339)
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Inflammation, Immune System
Design and Development of a Functional Plant-based Beverage to Improve Nutritional Status and Immunity for the Early Elderly People to Get Well-healthy Ageing
In 2018, for the first time, the number of people aged 65 and over exceeded the number of children under the age of 5. A rise in ageing societies is coming, and new efforts are needed to ensure that this increase in life…
- Trial name
- Immugold (NCT07409480)
- Testing
- Functional plant-based beverage, Control Beverage
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Type 1 Diabetes Mellitus
The Effect of Cocoa Flavanol on the BOLD Response and Cognitive Function in Type 1 Diabetes
Type 1 Diabetes (T1D) is associated with microvascular changes in the brain, which can cause cognitive dysfunction. Cocoa flavanols (CF) can stimulate vasodilation, resulting in enhanced cerebral blood flow and better cognitive…
- Trial name
- NCT03452605
- Testing
- cocoa flavanol supplementation
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Glycemic and Insulinemic Response, Type 1 Diabetes (T1D)
Glycemic Response to Carbob-Enriched Pasta in Healthy and With Type 1 Diabetes People
Carob (Ceratonia siliqua) is a fruit traditionally used in various Mediterranean countries for the preparation of sweets and beverages.
- Trial name
- GR-CEP (NCT06994403)
- Testing
- Durum wheat pasta enriched with carob flour, Standard durum wheat pasta, White bread reference meal
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Federico II University
Stress (Psychology)
Effects of Mechanical Massage on Sleep Quality, Immunity, and Stress
This bicentric, randomized, single-blind clinical investigation aims to evaluate the effects of a multisession mechanical massage (endermologie) program on sleep quality, immune function, and stress levels in individuals…
- Trial name
- NCT07811284
- Testing
- Mechanized Massage (LPG Cellu M6 Alliance)
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bescored
Familial Mediterranean Fever, MEFV Gene Mutation
Characterization of a Functional Test for Mediterranean Family Fever Screening - 2
Familial Mediterranean fever (FMF) is the most common auto-inflammatory disease (prevalence: 1-5 / 10,000 inhabitants). It is caused by mutations in the MEFV gene, which encodes variants of the Pyrine inflammasome.
- Trial name
- DEPIST-FMF 2 (NCT04478409)
- Testing
- one additional blood sample during a planned blood test
- Where
- 8 sites in France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Major Depressive Disorder
Depression, Epinephrine, and Platelet Function
Men and women who have suffered sexual and/or physical abuse before the age of 12 are at increased risk for anxiety and mood disorders, other serious psychiatric disorders, and likely medical illnesses.
- Trial name
- NCT00166114
- Testing
- Escitalopram, Desipramine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Inflammatory Response, Metabolic Disturbance
Blueberries, Bananas, Exercise Recovery
The PURPOSE of this study is to investigate the combined influence of 2-weeks blueberry ingestion and banana ingestion (during exercise) on performance and in mitigating metabolic perturbation, immune dysfunction, and increase in…
- Conditions
- Inflammatory Response, Metabolic Disturbance, Immune Suppression
- Trial name
- NCT03445234
- Testing
- Blueberry, banana, No banana
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Crohn's Disease
Acupuncture Treatment for Active Crohn's Disease
The purpose of this study is to observe the efficacy and safety of acupuncture and moxibustion for Crohn's disease and the regulation mechanism of intestinal microbiota and peripheral immunity.
- Trial name
- NCT02559037
- Testing
- Acupuncture and moxibustion
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Healthy Volunteers, Abnormal Phagocyte Function
Inflammatory Responses in Normal Volunteers and Patients With Abnormal Immune Responses
This study will investigate the inflammatory response. People with abnormal regulation of inflammation and immune defects often have an exaggerated or depressed inflammatory response that results in poor healing of recurrent…
- Trial name
- NCT00001257
- Where
- United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Fasting
Fasting Effects on Metabolism and Immunity Study in Human
This study aims to investigate the effects of 1-week fasting but not prohibiting water drink on human immune function, metabolic indicators, and brain function in human, and to explore the underlying mechanisms of these changes…
- Trial name
- NCT06779201
- Testing
- Fasting
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Healthy, Helminthiasis
Comparison of Immune Response in Normal Volunteers and Patients With Helminth Infections
This study will compare the structure, chemical composition and other characteristics of skin and blood in people with and without parasitic infections. Cell samples will be taken from blisters produced by suction blistering.
- Trial name
- NCT00004996
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy
T Cell Responses to Various Levels of Exercise Stress
The objective of this project is to quantify the immunoendocrine response to acute stress events combining both physical and psychological challenges.
- Trial name
- NCT06638684
- Testing
- Exercise
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Kansas
Healthy
Selenium and Immune Function
The aim of the study is to investigate the relationship between dose and form of selenium on immune function, and to identify functional markers of selenium status.
- Trial name
- NCT00279812
- Testing
- 50ug selenium enriched yeast, 100ug selenium enriched yeast, 200ug selenium enriched yeast
- Where
- United Kingdom
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Eosinophilic Esophagitis (EoE)
Local Clinical and Immunological Responses in Eosinophilic Esophagitis (EoE) Patients, Role of Mucosal Barrier Function and Type II Inflammation
Eosinophilic esophagitis (EoE) is an allergic inflammation of the esophagus. If not treated properly, inflammation and narrowing of the esophagus can occur. This can eventually lead to food impaction.
- Trial name
- SINFONIA (NCT07012928)
- Where
- Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)