Clinical trials: Functional Immune Response
Immune Response, Cardiometabolic Risk Factors
Effects of Peanuts on Immunity and Cardiometabolic Risk Factors
The aim of the proposed study is two-fold: to determine whether the intake of peanuts (a) enhances immune function and (b) produces a desirable impact on selected cardiometabolic biomarkers and risk factors.
- Trial name
- NCT06159556
- Testing
- Peanut intake
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Healthy Volunteers
The Effects of the Synbiotic Ecologic 825/scFOS on Intestinal Barrier Function and Immune Modulation
In the present pilot study, the investigators will study the effects of a novel synbiotic, which is a mix of probiotics (Ecologic 825) in the presence of a prebiotic (short chain fructo-oligosaccharide (scFOS)), on mucosal…
- Trial name
- CRIB (NCT02018900)
- Testing
- Ecologic 825/scFOS
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Asthma
Lung Function Changes of Induced Asthma Children Treated With Inhaled MgSO4
As a non-selective bronchodilator, magnesium sulfate (MgSO4) is effective when administered intravenously in the treatment of the patients with acute severe asthma not responding to conventional therapy (oxygen, nebulized…
- Trial name
- NCT01856959
- Testing
- Magnesium Sulfate, magnesium sulfate & albuterol, Albuterol
- Where
- China
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
Cell Migration, Cell Invasion
This Repeated Measures Parallel-group Investigation Will Examine the Influence of Short-term Melatonin Supplementation (5mg, 3 x Day for 72 Hours) on Cellular Responses, Functional Performance and Recovery Following an Acute Bout of Dynamic Resistance Exercise in Resistance Trained Men and Women
Oral Melatonin is a commercially available product available alone and as a constituent in a number of supplements. Previous research suggests that short-term supplementation with oral melatonin may amplify the recovery response…
- Conditions
- Cell Migration, Cell Invasion, Exercise Recovery
- Trial name
- NCT06617351
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
COVID-19
COVID Booster in Pregnancy and Lactation
This is a prospective longitudinal cohort study to evaluate the impact of COVID-19 vaccination and booster on maternal and infant immunity against COVID-19 variants over time.
- Trial name
- NCT05543993
- Testing
- Bivalent COVID-19 Booster
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Axial Spondyloarthritis
New Biomarkers in Axial Sypondyloarthropathy; SII and SIRI
investigators aimed to evaluate the relationship between Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) and disease activity in patients with axial spondyloarthropathy (SpA).
- Trial name
- NCT05914532
- Testing
- lab testing
- Where
- Turkey (Türkiye)
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Immune Function
Effect of Fruit and Vegetable Consumption on Immune Function in the Elderly
The immune system undergoes a range of changes as individuals become elderly. These may manifest as an increasing susceptibility to infection or a tendency to develop autoimmune or malignant disease.
- Trial name
- ADIT (NCT00858728)
- Testing
- 5 portions, 2 portions
- Where
- United Kingdom
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Bronchiolitis Obliterans Syndrome (BOS)
Mechanisms and Targeted Therapy of Airway Basal Cell Dysfunction in Bronchiolitis Obliterans Syndrome
This experimental study aims to investigate the pathogenesis of bronchiolitis obliterans syndrome (BOS) and provide a basis for clinical diagnosis and treatment.
- Trial name
- NCT07018804
- Testing
- Bronchoscopic brushing, Single - cell cloning, Cell function identification
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Haikou Affiliated Hospital of Central South University Xiangya School of Medicine
Sepsis, SIRS
Innate Immune Functions of Immature Neutrophils
Polymorphonuclear neutrophils, or granulocytes, are essential effector cells of the innate immune system against bacterial infections.
- Trial name
- NCT01155674
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Immune Response
The Immune Function Intervention Trial
The purpose of the study is to examine whether cardiovascular exercise training improves immune responses to vaccination in previously sedentary older adults.
- Trial name
- ImFIT (NCT00548990)
- Testing
- cardiovascular exercise training, flexibility/balance control
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Healthy
Selenium and Immune Function
The aim of the study is to investigate the relationship between dose and form of selenium on immune function, and to identify functional markers of selenium status.
- Trial name
- NCT00279812
- Testing
- 50ug selenium enriched yeast, 100ug selenium enriched yeast, 200ug selenium enriched yeast
- Where
- United Kingdom
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Healthy Volunteers, Abnormal Phagocyte Function
Inflammatory Responses in Normal Volunteers and Patients With Abnormal Immune Responses
This study will investigate the inflammatory response. People with abnormal regulation of inflammation and immune defects often have an exaggerated or depressed inflammatory response that results in poor healing of recurrent…
- Trial name
- NCT00001257
- Where
- United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Deglutition Disorders
Design and Development of a Functional Plant-based Beverage Formulated According to the Main Nutritional Guides for Early Elderly Requirements to Improve Nutritional Status and Immunity for the Early Elderly People to Get Well-healthy Ageing
Populations around the world are aging and this demographic transition will impact almost every aspect of society. Furthermore, the COVID-19 pandemic has highlighted the seriousness of gaps in policies, systems and services.
- Trial name
- IMMUGOLD (NCT06445309)
- Testing
- Sensory test of functional plant-based drink
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Healthy Volunteers
Consumption of Dairy Yogurt Enhanced Immune Function
To investigate the impact of consumption of dairy yogurt with rhamnogalacturonan (RG) in Korean citrus Hallabong peel polysaccharide on Natural Killer (NK) cell activity and circulating cytokine levels.
- Trial name
- NCT02535663
- Testing
- RG
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Asthma, Obesity
Meal-Exercise Challenge and Physical Activity Reduction Impact on Immunity and Inflammation
In a society where exercise is prescribed by physicians to increase physical condition, improve dietary habits and reduce cardiovascular risk, the impact of exercise, acute or chronic, and diet in inflammation and immunity is…
- Trial name
- MERIIT (NCT02027675)
- Testing
- High fat poor micronutrient meal, Mediterranean meal
- Where
- 3 sites in Portugal
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Colorectal Cancer
Anthocyanin-Rich Berry Supplementation in Patients With Colorectal Cancer
This prospective, open-label interventional study evaluated the effects of short-term supplementation with an anthocyanin-rich freeze-dried black raspberry and strawberry preparation in patients undergoing treatment for…
- Trial name
- NCT07819539
- Testing
- Anthocyanin-Rich Freeze-Dried Berry Supplement
- Where
- Poland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Inflammatory Response, Metabolic Disturbance
Cranberry Ingestion and Cycling Related Immunity and Inflammation
This is a randomized, crossover clinical trial with 25 male and female cyclists. Study participants will ingest polyphenol-rich cranberry juice or placebo juice for 4 weeks under double-blinded procedures, and then crossover to…
- Conditions
- Inflammatory Response, Metabolic Disturbance, Immune Suppression
- Trial name
- NCT05407701
- Testing
- Cranberry Juice
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Appalachian State University