Clinical trials: Functional Immune Response, active
Multiple Sclerosis, Cognitive Impairment
MODAFIMS: A Trial to Evaluate Predictors of Response to MODAFinil in Patients With Multiple Sclerosis
This is a phase II/exploratory clinical trial with a single-center, open-label design to evaluate the effect of modafinil on cognitive deficits in adult patients with multiple sclerosis and identify predictors of response using…
- Trial name
- MODAFIMS (NCT06592352)
- Testing
- Modafinil Generis 100 mg
- Where
- Portugal
- Volunteers
- 64 people
- Sponsor
- Clinical Academic Center (2CA-Braga)
Asthma
GINA-P and ACT-P Scores for Assessing Asthma Control
The goal of this observational study is to determine the accuracy of GINA-P and ACT-P scores in assessing asthma control levels among adults with asthma.
- Trial name
- NCT07548827
- Testing
- Spirometry, Global Initiative for Asthma (GINA), Asthma Control Test (ACT)
- Where
- 2 sites in Thailand
- Volunteers
- 144 people
- Sponsor
- Thammasat University
Functional Gastrointestinal Disorders
Functionally Enhanced Limosilactobacillus Reuteri Probiotic Preparation in Elderly Patients With Functional Bowel Disorders
This is a single-center, open-label, single-arm interventional study designed to evaluate the effects of a functionally enhanced Limosilactobacillus reuteri probiotic preparation on intestinal immunity, gut microbiota balance…
- Trial name
- NCT07624656
- Testing
- Functionally Enhanced Limosilactobacillus reuteri Probiotic Preparation
- Volunteers
- 30 people
- Sponsor
- Maanshan Shiqiye Hospital
Asthma (Diagnosis)
Respiratory Admittance by Oscillometry in Children
Oscillometry is a pulmonary function testing technique suited for children because it does not require specific respiratory maneuvers like spirometry.
- Trial name
- ArsEIB (NCT07771608)
- Volunteers
- 144 people
- Sponsor
- Central Hospital, Nancy, France
T Cell Response to Dried Plum, Vitamin D Influence on Immune Response
Prebiotics (Dried Plum) and Immune Function in Postmenopausal Women
Prior studies have shown that dietary supplementation with dried plums (also known as prunes) reduces bone loss in postmenopausal women.
- Conditions
- T Cell Response to Dried Plum, Vitamin D Influence on Immune Response, Dried Plum and Immune Function
- Trial name
- NCT07222111
- Testing
- Dried plums
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Chronic Granulomatous Disease (CGD), X-Linked Severe Combined Immune Deficiency (XSCID)
Evaluation of Patients With Immune Function Abnormalities
This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation.
- Conditions
- Chronic Granulomatous Disease (CGD), X-Linked Severe Combined Immune Deficiency (XSCID), Leukocyte Adhesion Deficiency 1 (LAD), Graft Versus Host Disease (cGvHD)
- Trial name
- NCT00128973
- Where
- United States
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hepatitis A, Hepatitis A Virus
Immunity With Acute Hepatits A
Hepatitis A Virus (HAV) is a public health concern in Egypt, especially among children. Historically highly endemic, recent studies suggest a changing epidemiology.
- Trial name
- Hepatitis A (NCT06942962)
- Volunteers
- 50 people
- Sponsor
- Assiut University
Constipation - Functional
Breath Gases, Gut Flora, and Immunity in Children With Constipation
Constipation is a common problem in children that can affect their daily life, school performance, and social activities. Researchers have found that the bacteria living in our intestines (called "gut microbiome") may play an…
- Trial name
- NCT07797491
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Microbial Composition, Immune Function
Gut Microbiome Response to Long-Haul Travel in Elite Football Players
The goal of this randomised control trial is to measure the gut microbiome response to long-haul travel alongside the demands of pre-season amongst elite football players.
- Trial name
- NCT07585474
- Testing
- Probiotic Capsule
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Inflammation, Immune System
Design and Development of a Functional Plant-based Beverage to Improve Nutritional Status and Immunity for the Early Elderly People to Get Well-healthy Ageing
In 2018, for the first time, the number of people aged 65 and over exceeded the number of children under the age of 5. A rise in ageing societies is coming, and new efforts are needed to ensure that this increase in life…
- Trial name
- Immugold (NCT07409480)
- Testing
- Functional plant-based beverage, Control Beverage
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
COVID-19
Characterization of the IFN-I Response in Subjects Who Experienced Severe or Mild Forms of COVID-19
Type I interferon (IFN-I) production is triggered by the detection of viral molecules, such as strands of viral RNA or DNA, by receptors known as PRRs (Pattern Recognition Receptors) present on many cell types.
- Trial name
- CARE-IF-COVID (NCT06703034)
- Testing
- Biological Sampling
- Where
- France
- Volunteers
- 134 people
- Sponsor
- Hospices Civils de Lyon
Stress, Physiological, Stress, Psychological
Daoist Zhanzhuang and Human Flourishing
This project investigates the impact of Daoist Zhanzhuang (sometimes spelled as Chan Chuang) on human flourishing, and explores the physiological, psychological, and spiritual mechanisms.
- Conditions
- Stress, Physiological, Stress, Psychological, Inflammatory Response, Well-Being, Psychological
- Trial name
- Z-Flo (NCT06573034)
- Testing
- Daoist Zhanzhuang
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Charlotte
Melanoma
Profiling of Circulating Immune Cells to Uncover Response Signatures to Anti-PD1 Immunotherapy in Melanoma Patients
Despite being standard of care, there are still many medical requirements related to immune checkpoint blocker based therapies such as identify patients susceptible to respond with the less adverse events, evaluate the clinical…
- Trial name
- PHENOMENAL (NCT06154668)
- Where
- France
- Volunteers
- 707 people
- Sponsor
- University Hospital, Grenoble
Glycemic and Insulinemic Response, Type 1 Diabetes (T1D)
Glycemic Response to Carbob-Enriched Pasta in Healthy and With Type 1 Diabetes People
Carob (Ceratonia siliqua) is a fruit traditionally used in various Mediterranean countries for the preparation of sweets and beverages.
- Trial name
- GR-CEP (NCT06994403)
- Testing
- Durum wheat pasta enriched with carob flour, Standard durum wheat pasta, White bread reference meal
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Federico II University
Eosinophilic Esophagitis (EoE)
Local Clinical and Immunological Responses in Eosinophilic Esophagitis (EoE) Patients, Role of Mucosal Barrier Function and Type II Inflammation
Eosinophilic esophagitis (EoE) is an allergic inflammation of the esophagus. If not treated properly, inflammation and narrowing of the esophagus can occur. This can eventually lead to food impaction.
- Trial name
- SINFONIA (NCT07012928)
- Where
- Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Preterm, Surgery
An Exploratory Study of Arginine Supplementation and the Postoperative Immune REsponse
ASPIRE is a nutrition study focusing on the effect of arginine supplementation on immune function in postoperative infants. The investigators will explore the effect of current intravenous feeding (parenteral nutrition (PN))…
- Conditions
- Preterm, Surgery, Nutritional Deficiency, Immune System and Related Disorders
- Trial name
- ASPIRE (NCT05306925)
- Testing
- Arginine
- Where
- 2 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Liverpool
Liver Diseases
Characterization of the Intrahepatic Inflammatory Microenvironment in Patients With Non-alcoholic Steatohepatitis
Non-alcoholic fatty liver disease (NAFLD) is a nosological entity that groups together non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH).
- Trial name
- Profil-NASH (NCT06152250)
- Testing
- Liver Fine-Needle Aspiration
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Achilles Tendinopathy (AT), Achilles Tendon
Achilles Tendinopathy; the Effect of Shockwave Treatment
BACKGROUND Achilles tendinopathy-pain in the Achilles tendon-is a common and often long-lasting condition that limits physical activity and performance, and also affects work capacity and quality of life.
- Conditions
- Achilles Tendinopathy (AT), Achilles Tendon, Achilles Tendon Pain
- Trial name
- NCT07685509
- Testing
- individually tailored exercises and Radial Shockwave, Individually tailored exercises
- Volunteers
- 200 people
- Sponsor
- Vastra Gotaland Region
Oncology
Promoting Response to IMmunotherapy by Exercise in Patients With Advanced Renal Cell Carcinoma
The primary aim of this study is to evaluate the feasibility of a supervised high intensity interval training (HIIT) program during first-line dual immune checkpoint inhibitor (ICI) therapy (nivolumab plus ipilimumab) in patients…
- Trial name
- PRIMER (NCT07680556)
- Testing
- HIIT
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Immune Responses, Post Operative Recovery
Comparative Study Between the Effects of Deep Versus Moderate Neuromuscular Blockade on Postoperative Recovery and Immune Function in Patients Undergoing Total Hip Replacement Surgery.
. The investigators hypothesized that DNMB ( Deep NeuroMuscular Block) would yield superior postoperative recovery quality and attenuate the surgery-induced immune suppression compared to MNMB ( Moderate NeuroMuscular Block)in…
- Trial name
- NCT07870954
- Testing
- ToF ( Train of Four) Scan
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University