Clinical trials: Functional Insufficiency
Right Ventricular Dysfunction
Right Ventricular Contractility Reserve Following Repair of Tetralogy of Fallot
Background: Residual pulmonary regurgitation following repair of tetralogy of Fallot, in particular the use of a transannular patch, has been shown to correlate with the development of right ventricular dysfunction.
- Trial name
- TOF-Cond (NCT00557934)
- Testing
- dobutamine
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- University Hospital Tuebingen
Preeclampsia, Hypertension
Collection of Samples From Pregnant Women for the Evaluation of Preeclampsia (Pre-E) Biomarkers
Preeclampsia (Pre-E) is a hypertensive disease of pregnancy with multi-system involvement that usually occurs in the second half of pregnancy. Pre-E occurs in 5% to 7% of U.S. pregnancies, and is the third-leading cause of U.S.
- Conditions
- Preeclampsia, Hypertension, Proteinuria, Thrombocytopenia
- Trial name
- NCT02780414
- Where
- 20 sites in United States
- Volunteers
- 1,730 people
- Sponsor
- Progenity, Inc.
Renal Insufficiency, Kidney Diseases
A Study to Evaluate the Pharmacokinetics and Safety of INCB161734 in Participants With Impaired Renal Function and Participants on Hemodialysis
This study is conducted to evaluate the pharmacokinetics and safety of INCB161734 in participants with impaired renal function and participants on hemodialysis.
- Trial name
- NCT07854249
- Testing
- INCB161734
- Volunteers
- 24 people
- Sponsor
- Incyte Corporation
Acute Kidney Injury, Shock
Normal Saline Versus Balance Salt Solution Resuscitation on Kidney Function
The purpose of this study is to determine Acute kidney injury incidence between sterofundin and normal saline ; Resuscitation shock patients
- Trial name
- NCT02520804
- Testing
- sterofundin, normal saline
- Where
- Thailand
- Volunteers
- 107 people
- Sponsor
- Mahidol University
Mitral Regurgitation, Coronary Artery Disease
Randomised Ischaemic Mitral Evaluation (RIME) Trial
The study is a randomised controlled trial comparing two treatment strategies for patients with moderate functional ischaemic mitral regurgitation undergoing coronary artery bypass grafting (CABG).
- Trial name
- RIME (NCT00413998)
- Testing
- CABG + Mitral valve annuloplasty, CABG
- Where
- 9 sites in Poland, United Kingdom
- Volunteers
- 73 people
- Sponsor
- Imperial College London
Diabetes Mellitus, Type 2, Chronic Kidney Diseases
REGROUP: Renohemodynamic Effects empaGliflozin in vaRiOUs Populations
Worldwide, diabetic kidney disease (DKD) is the most common cause of chronic and end stage kidney disease. Large-sized prospective randomized clinical trials indicate that intensified glucose and blood pressure control, the…
- Trial name
- REGROUP (NCT04243850)
- Testing
- Empagliflozin 10 MG, Caffeine
- Sponsor
- Amsterdam UMC, location VUmc
Renal Insufficiency, Acute Kidney Injury
Influence of Perioperative Kidney Function on Postoperative Outcome
This study investigates the influence of perioperative changes in serum creatinine on hospital length of stay and mortality.
- Trial name
- NEPHRANEST (NCT01522313)
- Where
- Germany
- Volunteers
- 39,369 people
- Sponsor
- Charite University, Berlin, Germany
Renal Insufficiency
Effects of Creatine Supplementation on Renal Function
Creatine (CR) supplementation is commonly used by athletes. However, its effects on renal function remain controversial. The aim of this study was to evaluate the effects of creatine supplementation on renal function and…
- Trial name
- NCT00465140
- Testing
- creatine supplementation, aerobic exercise training
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pancreatic Neoplasm Malignant Head Primary, Pancreatic Exocrine Insufficiency
Impact of Pancreatic Endoscopic Drainage on Exocrine Pancreatic Function in Unresectable Pancreatic Cancer
Background: exocrine pancreatic insufficiency (IPE), frequent in patients with pancreatic cancer, plays a major role in malnutrition and cachexia with a significant impact on survival, quality of life and tumor progression.
- Trial name
- DEPARA (NCT05244174)
- Testing
- Pancreatic stent
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- Hospital Clinico Universitario de Santiago
End Stage Renal Disease, Reperfusion Injury
Intra-graft Coagulation Events in Clinical Renal Transplantation and Delayed Graft Function
The purpose of this study is to investigate local activation of the coagulation system in the kidney graft during organ preservation and during early reperfusion in adult kidney transplantation.
- Conditions
- End Stage Renal Disease, Reperfusion Injury, Delayed Graft Function, Kidney Transplantation
- Trial name
- KTX (NCT02568696)
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Helsinki University Central Hospital
Renal Impairment
Pharmacokinetics Of CP-690,550 In Patients With Impaired Renal Function
A study to evaluate the pharmacokinetics of CP-690,550 in subjects with mild, moderate or severe renal impairment, who do not require hemodialysis, compared to healthy controls.
- Trial name
- NCT01740362
- Testing
- CP-690,550
- Where
- 4 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Kidney Function Issue, Acute Kidney Injury
N-Acetylcysteine Roles in Preserving Renal Function Measured by Urinary KIM-1 (Kidney Injury Molecule-1) and Serum Creatinine on Cancer Patients With Cisplatin Based Chemotherapy: A Randomized Placebo-Controlled Trial
The goal of this clinical trial is to learn if N-Acetylcysteine drug works to protect kidney function in adults patient with cancer.
- Conditions
- Kidney Function Issue, Acute Kidney Injury, Cancer (Solid Tumors), Kidney Function Tests
- Trial name
- NCT07156786
- Testing
- N-acetylcysteine (NAC)
- Volunteers
- 72 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Renal Impairment
A Study to Evaluate the Pharmacokinetics of HSK7653 in Subjects With Renal Impairment
This is an open-label, single-dose study to evaluate the pharmacokinetics, pharmacodynamics and safety of HSK7653 in subjects with mild, moderate, severe renal impairment and subjects with kidney failure compared to the matched…
- Trial name
- NCT05497297
- Testing
- HSK7653 tablets
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Chronic Venous Insufficiency
Study to Assess the Efficacy and Safety of Endolex Forte VErsus Diosmin and Hesperidin in Reducing VeNous Insufficiency
The trial is designed as a randomized, multicenter, open label, comparative, 6 months, clinical study.
- Trial name
- EVELINE (NCT02927483)
- Testing
- Endolex Forte®, A combination of diosmin and hesperidin
- Volunteers
- 120 people
- Sponsor
- SunWave Pharma
Renal Impairment
A Study to Investigate the Effect of Renal Function and Hemodialysis on the Pharmacokinetics (PK) of RO7079901
This is a multi-center, non-randomized, open-label, two-part study to investigate the effect of renal function and hemodialysis on PK of RO7079901.
- Trial name
- NCT02975388
- Testing
- RO7079901
- Where
- 5 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Impaired Renal Function
Longterm Follow-up After Remote Ischemic Preconditioning for Prevention of Contrast-induced Nephropathy
Remote ischemic preconditioning reduces the incidence of contrast-induced acute kidney injury in patients undergoing elective coronary angiography.
- Trial name
- RenProLong (NCT01760031)
- Testing
- Ischemic preconditioning
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- University of Cologne
Erectile Dysfunction Due to Arterial Insufficiency
Platelet-rich Plasma (PRP) Injection for Treatment of Erectile Function
The primary objective of the present study is to investigate and compare the treatment efficacy of PRP injection vs placebo treatment in men with mild-moderate vasculogenic ED, as measured by IIEF.The secondary objective of the…
- Trial name
- NCT04050020
- Testing
- Platelet-Rich Plasma (PRP), Normal saline injection
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Institute for the Study of Urological Diseases, Greece
Tear Film Insufficiency, Dry Eye
Correlation of Noninvasive Tear Film Function and the Optical Quality in Mild and Moderate Dry Eye
2017 International Dry Eye Workshop (DEWS) defines dry eye as a multifactorial ocular surface disease characterized by tear film instability with disturbed visual function.
- Trial name
- NCT03815539
- Testing
- 0.1% sodium hyaluronate
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jin Yuan
Chronic Kidney Disease
Mechanisms of Muscle Blood Flow Dysregulation and Exercise Intolerance in Chronic Kidney Disease
Patients with chronic kidney disease (CKD) experience fatigue and exercise intolerance. Increased oxidative stress in CKD may be a contributing factor.
- Trial name
- NCT02664519
- Testing
- Forearm exercise training
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Renal Transplant
A Study of the Correlation Between Donor UDP-Glc and Transplanted Kidney Function
Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD), however, organ shortage is the primary bottleneck restricting the progression of organ transplantation.1 Organs from Expanded Criteria Donors…
- Trial name
- NCT06707272
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Qianghua Leng
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