Clinical trials: Functional Insufficiency
COPD, OSA
Efficacy of CPAP Therapy on Pulmonary Function Test in Patients With COPD-OSA Overlap Syndrome
To evaluate efficacy of CPAP Therapy on Pulmonary Function Test in Patients With COPD-OSA Overlap Syndrome
- Conditions
- COPD, OSA, Lung Function Decreased
- Trial name
- NCT05857475
- Testing
- CPAP therapy, Control
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Mahidol University
Kidney Failure
RUCONEST® as a Therapeutic Strategy to Reduce the Incidence of Delayed Graft Function
An unmet medical need exists for therapeutic regimens in transplantation that allow immediate postoperative graft function, thereby improving graft survival.
- Trial name
- NCT03791476
- Testing
- rhC1INH, Saline Solution
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Cleft Palate, Tube Disorders Eustachian
Exercises for Improving Soft Palate and Eustachian Tube Function in Children With Ear Tubes With or Without Cleft Palate
Elevation of the soft palate (the soft part of the roof of the mouth) during swallowing helps the Eustachian tube to open and keep the ear healthy.
- Conditions
- Cleft Palate, Tube Disorders Eustachian, Velopharyngeal Incompetence Due to Cleft Palate, Velopharyngeal Insufficiency
- Trial name
- NCT03868891
- Testing
- EMST150
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Noel Jabbour
Acute Renal Failure, Acute Kidney Tubular Necrosis
Predictive Value of PIIINP and Urinary NGAL in Renal Function Recovery
Acute Renal Failure (ARF) is defined by a severe, and usually reversible, glomerular filtration rate decreasing. Acute Tubular Necrosis (ATN) remain the major cause of ARF involving distress and destruction of tubular cells.
- Conditions
- Acute Renal Failure, Acute Kidney Tubular Necrosis, Chronic Kidney Failure
- Trial name
- PIIINP-NGAL (NCT02889575)
- Where
- France
- Volunteers
- 287 people
- Sponsor
- Nantes University Hospital
Renal Impairment
Glasdegib Renal Impairment Study
The goal of this study is to administer single dose (100 mg) glasdegib tablet to subjects with normal, moderate and severe renal impairment and estimate the effect, if any, of this renal impairment on glasdegib pharmacokinetics.
- Trial name
- NCT03596567
- Testing
- Glasdegib single 100 mg dose in normal healthy subjects, Glasdegib single 100 mg dose in moderate renal impairment subjects, Glasdegib single 100 mg dose in severe renal impairment subjects
- Where
- 3 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
End-Stage Renal Disease
Vitamin D3 Supplementation in Dialysis Patients
Vitamin D deficiency is highly prevalent among dialysis patients, and has been associated with cardiovascular risk factors such as increased aortic pulse wave velocity, blood pressure, inflammation, and brain natriuretic peptide.
- Trial name
- NCT01312714
- Testing
- Cholecalciferol
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Regional Hospital Holstebro
Vitamin D 25-Hydroxylase Deficiency, Vitamin D Deficiency/Insufficiency
Effects of High-Dose Vitamin D on Hormones, Neuromuscular Function, Cognition, and Body Composition in Athletes
This study aims to evaluate the effects of high-dose vitamin D3 supplementation on selected physiological, neuromuscular, and cognitive parameters in athletes.
- Trial name
- NCT07641075
- Testing
- Vitamin D supplementation
- Where
- Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Peripheral Artery Disease, End Stage Renal Disease on Dialysis
A Cross-Sectional Study to Assess Walking Performance in Subjects With Peripheral Artery and End Stage Kidney Disease
A cross-sectional, non-interventional study to assess walking performance, vascular function, and lower limb calcification in subjects with peripheral artery disease and end-stage kidney disease (PAD-ESKD) receiving hemodialysis.
- Trial name
- NCT04487301
- Where
- 7 sites in United States
- Volunteers
- 36 people
- Sponsor
- Sanifit Therapeutics S. A.
Pulmonary Regurgitation, Congenital Heart Disease
Right Ventricular Diastolic Function in Chronic Adverse RV Loading And Congenital Heart Disease
The aim of the study is to assess the characteristics, incidence and predictors of load-independent right ventricle (RV) diastolic dysfunction in patients with congenital heart disease (CHD) and adverse RV loading conditions by…
- Trial name
- RaDICAL-CHD (NCT03471936)
- Testing
- Acquisition of pressure-volume-loops
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Heart Center Leipzig - University Hospital
Chronic Renal Disease
Kidney Graft Function Under the Immunosuppression Strategies
To demonstrate that cyclosporine-sparing immunosuppressions with the standard dose of Enteric-Coated Mycophenolate Sodium would preserve renal graft function after transplantation without an increase of incidences of adverse…
- Trial name
- MyLowCsA (NCT01817322)
- Testing
- Standard Dose of Myfortic and Reduced Dose of Myfortic, Prednisolone OR methylprednisolone OR deflazacort injected both control group and experimental group, Basiliximab injected both control group and experimental group
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Renal Impairment
Renal Impairment Study of PF-07321332 Boosted With Ritonavir in Adult Participants With Renal Impairment and in Healthy Participants With Normal Renal Function.
This is a Phase 1, non-randomized, open-label, 2-part study to investigate the effect of renal impairment on the pharmacokinetics (PK), safety and tolerability of a single oral dose of PF-07321332 in combination with the PK…
- Trial name
- NCT04909853
- Testing
- PF-07321332/ritonavir
- Where
- 5 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Pfizer
End Stage Renal Disease
Dehydr8 and Deactiv8
Managing fluid status is a complex but fundamental part of the clinical care of people receiving haemodialysis (HD). Day-to-day fluid management is usually based on the concept of 'target weight' - the weight used to determine…
- Trial name
- NCT03179072
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Portsmouth
Symptomatic Functional MR 3 or Greater
AMEND TS Early Feasibility Study
Valcare Medical AMEND Trans-Septal System is a mitral valve repair annuloplasty ring implanted in a trans-catheter method intended for correction of mitral regurgitation.
- Trial name
- NCT06951672
- Testing
- This study will evaluate the safety and functionality of the AMEND™ Trans-Septal System for annuloplasty as a therapy for mitral regurgitation.
- Where
- 11 sites in United States
- Volunteers
- 15 people
- Sponsor
- Valcare Medical Ltd.
Chronic Kidney Diseases, Cardio-Renal Syndrome
Left Ventricular Fibrosis in Chronic Kidney Disease
This study aims to understand the onset an functional consequences of left ventricular interstitial fibrosis in patients with chronic kidney disease (stage 2 to 5), as well as assess whether transplantation results in a…
- Conditions
- Chronic Kidney Diseases, Cardio-Renal Syndrome, Myocardial Fibrosis, Uraemic Cardiomyopathy
- Trial name
- FibroCKD (NCT03176862)
- Testing
- cardiac magnetic resonance scan, Cardiopulmonary exercise test with stress echocardiogram, 24-hour ECG holter monitor
- Where
- United Kingdom
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Dr Manvir Kaur Hayer
Renal Impairment
A Study to Evaluate Pharmacokinetic and Safety Trial of Emraclidine in Participants With Renal Impairment Compared With Participants With Normal Renal Function
The primary purpose of this study is to assess the effect of renal impairment on the pharmacokinetics (PK) of emraclidine following administration of a single oral dose in participants with mild, moderate, and severe renal…
- Trial name
- NCT05940402
- Testing
- Emraclidine
- Where
- 5 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- AbbVie
Atrial Fibrillation, Elderly Patients
Glomerular Filtration Rate-Estimating Equations During Use of Direct Oral Anticoagulants in Elderly Patients
Atrial fibrillation in the elderly is a complex condition due to the high number of frequently associated comorbidities such kidney disease.
- Conditions
- Atrial Fibrillation, Elderly Patients, Chronic Kidney Disease
- Trial name
- REINACO (NCT02964546)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 116 people
- Sponsor
- University Hospital, Montpellier
Hyperparathyroidism, Secondary, Kidney Failure, Chronic
How Vitamin D Analogues Affect Endothelial Cells in Patients on Dialysis
Patients with chronic kidney disease and end stage renal disease have greater cardiovascular risk than the general population. Vitamin D analogues have been shown in observational studies to have mortality benefit for these…
- Trial name
- NCT00528788
- Testing
- doxercalciferol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Respiratory Failure
The Use of Vibrational Methods of Influencing the Lungs to Restore Their Functional State
There will be formed of groups for application of vibration methods on the lungs: the method of vibroacoustic lung massage using the "BARK VibroLUNG" device; the method of oscillating PEP therapy using Acapella DH Green; the…
- Trial name
- NCT05159401
- Testing
- prevention of respiratory failure
- Where
- Russia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Petrovsky National Research Centre of Surgery
Impaired Renal Function
Computer Prescribing System and Impaired Renal Function
To evaluate the quality of orders for target drugs in old patients with impaired renal function, hospitalized or living in long stay units, and to improve these practices by means of a counselling system coupled to a computer…
- Trial name
- Ordoclic-IR (NCT00784381)
- Testing
- computer-assisted counselling about target drugs
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cognitive Impairment, RRSO
IMProving Executive Function Study
This is a double-blind, placebo-controlled, crossover study testing whether Vyvanse (lisdexamfetamine; LDX) improves executive functioning (EF) in 100 postmenopausal women who report onset of EF difficulties after oophorectomy.
- Trial name
- IMPRES (NCT03187353)
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
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