Clinical trials: Functional Insufficiency
Immunosuppression, Renal Failure
Conversion to Everolimus From Calcineurin Inhibitor With Mycophenolic Acid: Impact on Long Term Renal Function in Liver Transplantation.
This study will examine the renal sparing impact of implementing a strategy of conversion to everolimus from a calcineurin inhibitor based immunosuppressive protocol at 3 months post liver transplant
- Trial name
- NCT01936519
- Testing
- Arm A: Everolimus, Calcineurin Inhibitor
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Milton S. Hershey Medical Center
Functional Insufficiency, Aging
Therapeutic Exercise Training in the Elderly
In adulthood, limited mobility and pain are very common and often the first clear sign of functional decline. The loss of independent mobility is related to higher rates of functional disability and mortality; however, it is also…
- Trial name
- NCT02487667
- Testing
- Therapeutic exercise by fitness machines
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Hepatic Encephalopathy, Coenzyme Q10
Coenzyme Q10 and Meclofenoxate in Hepatic Encephalopathy
Hepatic encephalopathy is a syndrome occurs in patients with liver cirrhosis and is defined as neuropsychiatric abnormalities in patients with liver impairment, characterized by personality changes, intellectual impairment, and…
- Conditions
- Hepatic Encephalopathy, Coenzyme Q10, Intellectual Functioning Disability
- Trial name
- EH (NCT03961087)
- Testing
- Coenzyme Q10, MECLOFENOXATE
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Zagazig University
Renal Impairment
A Study to Evaluate the Pharmacokinetics of VI-0521 Subjects With Renal Impairment
VI-0521, a fixed dose combination of immediate-release (IR) phentermine and controlled-release (CR) topiramate, is in Phase III clinical development as a potential therapy for obesity.
- Trial name
- NCT00768404
- Testing
- Topirmate and Phentermine
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC
Multiple Myeloma
A Study of Belantamab Mafodotin Monotherapy in Multiple Myeloma Participants With Normal and Varying Degree of Impaired Renal Function
Belantamab mafodotin is an antibody-drug conjugate (ADC) containing humanized anti- B-cell maturation antigen (BCMA) monoclonal antibody (mAb).
- Trial name
- DREAMM12 (NCT04398745)
- Testing
- Belantamab mafodotin
- Where
- 4 sites in Greece, South Korea
- Volunteers
- 36 people
- Sponsor
- GlaxoSmithKline
Tear Film Insufficiency, Dry Eye
Correlation of Noninvasive Tear Film Function and the Optical Quality in Mild and Moderate Dry Eye
2017 International Dry Eye Workshop (DEWS) defines dry eye as a multifactorial ocular surface disease characterized by tear film instability with disturbed visual function.
- Trial name
- NCT03815539
- Testing
- 0.1% sodium hyaluronate
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jin Yuan
Postoperative Pulmonary Complications, Respiratory Insufficiency
The PROtective Ventilation Using Open Lung Approach Or Not Trial
Postoperative Pulmonary Complications (PPC) are very common. It severely affects postoperative recovery, particularly in the abdominal surgery.
- Trial name
- PROVOLON (NCT03160144)
- Testing
- open lung approach
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Mitral Regurgitation
Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease)
The investigators hypothesize that beta-1 receptor blockade (ß1-RB) attenuates extracellular matrix (ECM) degradation and progressive adverse Left Ventricular (LV) remodeling and failure in the volume overload of mitral…
- Trial name
- P1A1 (NCT01052428)
- Testing
- metoprolol succinate (Toprol XL)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy Volunteer, Renal Impairment
Renal Impairment Study of PF-06700841
The purpose of this study is to characterize the effect of kidney impairment on the blood concentrations of PF-06700841 and its major metabolite.
- Trial name
- NCT04260464
- Testing
- PF-06700841
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pfizer
Hyperplasia, Chronic Renal Failure
Prevention of Vascular Access Graft Failure in Patients With Chronic Renal Failure Requiring Hemodialysis
The purpose of this study is to determine the effect of recipient vein pretreatment of edifoligide (E2F Decoy), compared to placebo, on graft/recipient vein stenosis in polytetrafluoroethylene (PTFE) vascular access grafts placed…
- Trial name
- NCT00086164
- Testing
- edifoligide (E2F Decoy)
- Where
- 21 sites in United States
- Sponsor
- Anesiva, Inc.
End-Stage Renal Disease
Effect of Different Hemodialysis Modality on Adiponectin,Vascular Function and Clinical Prognosis
Adiponectin, an adipose tissue derived protein, with anti-inflammatory properties that is secreted from adipose tissue, is associated with insulin resistance.
- Trial name
- NCT00155363
- Testing
- conventional artificial kidney (AK) vs. high flux AK
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Intestinal Failure
Effect of Vitamin D on Skeletal Muscle Function and Qol in Patients With Chronic Intestinal Failure/Insufficiency
Eligible patients were randomized into two groups: Vitamin D group and Control group. Control group: received placebo plus standard care, no additional vitamin D intervention therapy.
- Trial name
- NCT06283615
- Testing
- Vitamin D
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Jinling Hospital, China
Chronic Kidney Disease, Chronic Hepatitis C
Viekira Pak or Mavyret Treatment for Patient With Chronic Kidney Disease and Hepatitis C
Open-label experimental trial of 12 weeks of Viekira Pak treatment ± ribavirin or Mavyret for adults with chronic kidney disease and hepatitis C.
- Trial name
- NCT02946034
- Testing
- Viekira Pak ± ribavirin, Mavyret
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Arterial Hypertension
Fetuin A as a Predictor of Deterioration of Renal Function in Hypertonic Patients
Commonly used parameters (creatinine, estimated glomerular filtration rate, and urine albumin/creatinine ratio) for prediction of decline of renal function are sensitive for advanced kidney impairment.
- Trial name
- NCT05963126
- Testing
- No intervention.
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital Ostrava
Aortic Valve Insufficiency
Effect of Beta Blockade on Left Ventricular Remodeling and Function in Moderate to Severe Asymptomatic Aortic Regurgitation
The primary objective of this study is to evaluate the effect of beta-blocker on left ventricular (LV) remodeling in asymptomatic patients with moderate to severe aortic regurgitation.
- Trial name
- BAR (NCT01157572)
- Testing
- Metoprolol
- Volunteers
- 75 people
- Sponsor
- Oslo University Hospital
Sepsis, Septic Shock
The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients
The high chloride content of 0.9%sodium chloride (0.9%NaCl) leads to adverse pathophysiological effects in both animals and healthy human volunteers.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT03277677
- Testing
- Normal saline, Ringer's Acetate
- Where
- Thailand
- Volunteers
- 116 people
- Sponsor
- Chulalongkorn University
Chronic Kidney Diseases
Skeletal Muscle Oxygenation in Patients With Chronic Kidney Disease Stage 2, 3 and 4
Endothelial dysfunction occurs early in chronic kidney disease (CKD) and is associated with target organ damage, progression of renal injury, cardiovascular events, and mortality.
- Trial name
- NCT05250167
- Where
- Greece
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
End Stage Renal Disease, Hemodialysis-Induced Symptom
Integrated Patient Care Intradialysis Programme in Hemodialysis Through a Virtual Health Platform
There is wide evidence regarding the weak points of end-stage Chronic kidney disease (CKD) patients in hemodialysis, and they include three intervention aspects: exercise, nutrition and psychological support.
- Conditions
- End Stage Renal Disease, Hemodialysis-Induced Symptom, Chronic Kidney Diseases
- Trial name
- GoodRENal (NCT04823286)
- Testing
- Virtual reality health platform during hemodialysis
- Where
- 8 sites in Belgium, Greece and 2 more
- Volunteers
- 70 people
- Sponsor
- Cardenal Herrera University
Thyroid Diseases, Respiratory Failure
Respiratory Muscle Function After Thyroid Hormone Replacement Therapy in Nonthyroidal Illness Syndrome
Although it is now recognized that a variety of respiratory abnormalities, such as diaphragmatic dysfunction, can be present in primary hypothyroidism and reverse with adequate hormone treatment, the role of thyroid hormone…
- Trial name
- NCT03157466
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Chronic Kidney Disease
Endothelial Function and Arterio-Venous Fistula Maturation
An arterio-venous fistula is a surgical procedure that supports access for people undergoing hemodialysis (HD) for End Stage Renal Disease (ESRD).
- Trial name
- EFAVF (NCT01604473)
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- University of California, San Francisco
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