Clinical trials: Functional Magnetic Resonance Imaging, open to volunteers
Effort Based Decision Making, Prosocial Behavior
Effort and Antidepressant Study Test
The aim of this study is to investigate the behavioural effects and neural correlates of increasing serotonin levels in healthy volunteers, through a 7-day course of the SSRI escitalopram, on an effort-based decision-making task…
- Conditions
- Effort Based Decision Making, Prosocial Behavior, Apathy
- Trial name
- EAST (NCT06696482)
- Testing
- Escitalopram 10mg
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy
Neurofeedback Training of Anterior Insula Activity Based on Unidimensional vs. Multidimensional Interoceptive Regulation Strategies
The purpose of this study is to compare the neural and behavioral effects of real-time functional magnetic resonance imaging (fMRI) neurofeedback training using two different interoceptive strategies: a unidimensional heartbeat…
- Trial name
- NCT07416370
- Testing
- real-time fMRI neurofeedback training
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Nonsuicidal Self Injury, Emotion Regulation
Neuro- and Biofeedback in Nonsuicidal Self-injury
Nonsuicidal self-injury (NSSI) is defined as the direct, deliberate destruction of one's own body tissue without suicidal intent, typically including behaviors such as cutting, burning, or hitting oneself.
- Trial name
- NCT05656001
- Testing
- Real-time functional magnetic resonance imaging Neurofeedback and Real-time Biofeedback
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Östergötland
Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD)
Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder
This study will evaluate whether pregnenolone is an effective treatment for adults with Alcohol Use Disorder (AUD) and Major Depressive Disorder (MDD).
- Trial name
- PREG-AUD-RO1 (NCT07734701)
- Testing
- Pregnenolone
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Sherwood Brown, MD, PhD
Major Depressive Disorder (MDD)
Neurofeedback to Treat Depression - 2
This study tests the efficacy of a new psychotherapeutic strategy for reducing negative attention bias (and therefore depression severity) in participants with MDD.
- Trial name
- NCT07159061
- Testing
- Active Closed Loop Real Time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Primary Progressive Aphasia(PPA)
Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia
This is a monocenter randomized controlled clinical trial with cross-over arm - assessor blinded. The aims is investigating the effects of the speech language therapy (SLT) alone vs SLT + non-invasive brain stimulation (STIM)…
- Trial name
- NCT06921265
- Testing
- Training with Speech Language Therapy, Standard rTMS, Targeted rTMS
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Depression, Treatment Resistant Depression
Neurocardiac Predictors of Treatment Response to RTMS in Depression
Heartbeat is controlled by the brain and is regular but flexible to change in response to environmental and internal stimuli. This feature is known as heart rate variability (HRV).
- Trial name
- NCP (NCT05139862)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Bipolar Disorder, Alcohol Drinking
Acute Alcohol Response In Bipolar Disorder: a Longitudinal Alcohol Administration/fMRI Study
Alcohol use disorders (AUDs) affect up to 60% of individuals with bipolar disorder during their lifetime and is associated with worse illness outcomes, yet few studies have been performed to clarify the causes of this…
- Conditions
- Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder
- Trial name
- Long_BACS (NCT05838274)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Left Ventricle Function, Transcatheter Aortic Valve Replacement (TAVR)
Phenotyping Left Ventricle Failure With Hemodynamic Biomarkers From 4D Flow Magnetic Resonance Imaging
This study aims to enhance and streamline intracardiac 4D Flow magnetic resonance imaging (MRI) processing by increasing automation for the quantitative and systematic assessment of left ventricular (LV) dysfunction.
- Conditions
- Left Ventricle Function, Transcatheter Aortic Valve Replacement (TAVR), Aortic Valve Stenosis
- Trial name
- TRANSLATE (NCT07455292)
- Testing
- Cardiac MRI with 4D Flow acquisition and invasive signal routinely collected during transcatheter aortic valve replacement
- Where
- 2 sites in Italy
- Volunteers
- 190 people
- Sponsor
- IRCCS Policlinico S. Donato
Full PRT, Partial PRT (Non Somtic)
Rewiring Chronic Pain
This study examines the effectiveness of a brief psychological intervention for chronic pain treatment, as well as the psychological and neurophysiological mechanisms associated with changes in pain intensity.
- Conditions
- Full PRT, Partial PRT (Non Somtic), Treatment as Usual
- Trial name
- NCT07724808
- Testing
- Pain Reprocessing Therapy (PRT), TAU
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Ben-Gurion University of the Negev
Acute Ischemic Stroke
Effects of Cerebrospinal Fluid Drainage on Cerebral Hemodynamics
This pilot interventional study investigates whether continuous cerebrospinal fluid (CSF) drainage via lumbar drain can improve cerebrovascular reactivity (CVR) in patients with acute ischemic stroke and hemodynamic failure, as…
- Trial name
- NCT07056907
- Testing
- Lumbar drain placement
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Brain Injuries, Traumatic
Mild TBI Assessment & Rehabilitation
One of the most pressing concerns within the VA currently is the provision of interventions that address the cognitive as well as emotional problems faced by Veterans with mild TBI and comorbid conditions.
- Trial name
- MTAR (NCT02920788)
- Testing
- Goal-Oriented Attentional Self-Regulation (GOALS), Brain Health Education (BHE), fMRI
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- VA Office of Research and Development
Depression Disorder, fMRI Research
Modulatory Effects of Personalized Transcranial Magnetic Stimulation (TMS) on Heart-Brain Coupling in Individuals With Depressive Tendencies
This study focuses on individuals with depressive tendencies and investigates the regulatory effects of Transcranial Magnetic Stimulation (TMS)-guided by personalized functional connectivity mapping-on heart-brain coupling in…
- Conditions
- Depression Disorder, fMRI Research, Heart-Brain Coupling
- Trial name
- NCT07753473
- Testing
- DLPFC-insula TMS, DLPFC-sgACC TMS, 10-20 F3 TMS
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xidian University
Self Injurious Behavior, Suicide
Real-time Examination of Skills and Coping Use in Teen's Everyday Lives
The goal of this clinical trial is to compare two core intervention skills among adolescents with a history of engaging in at least 3 lifetime incidents of self-inflicted injury (SII), at least one of which was a suicide attempt…
- Trial name
- RESCUE (NCT06720753)
- Testing
- Opposite to emotion action, GIVE
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Utah
Coma, Cardiac Arrest
Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac Arrest
To assess the performance of a predictive model resulting from the analysis of sMRI/fMRI/contrast-enhanced MRI-derived personalized connectomic data, as compared with standard predictors (clinical examination, electrophysiology…
- Conditions
- Coma, Cardiac Arrest, Disorder of Consciousness, Neurologic Disorder
- Trial name
- ARISE (NCT06617377)
- Testing
- advanced whole-brain sMRI/fMRI/contrast-enhanced MRI scan
- Where
- France
- Volunteers
- 263 people
- Sponsor
- University Hospital, Toulouse
Healthy
Neurofeedback to Reduce Spontaneous Recovery of Threat Expectancy
This study tests the efficacy of a new behavioral intervention with the goal of reducing spontaneous recovery of threat expectancy in healthy adults.
- Trial name
- NCT07122739
- Testing
- Active Real-time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Trustees of Princeton University
Amputation, Congenital, Upper Limb; Amelia
CNS Changes Following Upper Limb Loss
The objective of this study is to better understand the structural and functional changes that the central nervous system (CNS) undergoes following congenital upper limb loss.
- Trial name
- NCT06043518
- Testing
- MRI
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Repetitive Negative Thinking, Neurofeedback
Effect of Mindfulness-based Neurofeedback for Adolescents With Elevated Repetitive Negative Thinking
This study will test the hypotheses that adolescent with repetitive negative thinking who at at-risk for serious mental illness will show greater default mode network (DMN) connectivity than healthy controls, at-risk adolescents…
- Trial name
- CHARMS (NCT07055217)
- Testing
- Mindfulness Training, Mindfulness-based Neurofeedback (Real mbNF)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Type 2 Diabetes Mellitus (T2DM), Mild Cognitive Impairment (MCI)
The Cognitive Protective Effect of VR-based Cognitive Training in Type 2 Diabetes Patients With Mild Cognitive Impairment
A multi-center prospective, open-label, parallel-group randomized controlled trial is conducted to investigate the cognitive-protective efficacy of a novel, diabetes-specific virtual reality (VR)-based cognitive training system…
- Trial name
- NCT07650318
- Testing
- VR-Based Cognitive Training Plus Standard Diabetes Care, Traditional Paper-and-Pencil Cognitive Training Plus Standard Diabetes Care
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Brain Health, Longevity
L-serine and Strength Training in the Elderly
This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older…
- Conditions
- Brain Health, Longevity, Cognitive Performance, Strength Training Effects
- Trial name
- AAAging (NCT07466290)
- Testing
- Strength training, L-serine supplementation, Control (cornstarch)
- Where
- Austria
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Vienna