Clinical trials: Functional Near-infrared Spectroscopy
Depression
Accelerated iTBS for Depression: Monitoring Brain Hemodynamics With Simultaneous iTBS/fNIRS
This study will investigate the cortical hemodynamic response variability of an accelerated form of TBS stimulation over left dorsolateral prefrontal cortex (DLPFC) using a concurrent TBS/fNIRS setup.
- Trial name
- NCT06971549
- Testing
- Accelerated iTBS
- Where
- Hong Kong
- Volunteers
- 1 people
- Sponsor
- The Hong Kong Polytechnic University
End-stage Renal Disease (ESRD)
NIRS for the Diagnosis of Residual Renal Function Injury in Hemodialysis Patients
Hemodialysis (HD) is the main renal replacement therapy for patients with end-stage renal disease (ESRD), accounting for approximately 69% of all renal replacement therapies and 89% of all dialysis.
- Trial name
- HDRRFI-NIRS (NCT06243900)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yuanjun Yang
ADHD - Attention Deficit Disorder With Hyperactivity
Brain Stimulation and Attention Control in Children With ADHD
The goal of this clinical trial is to learn if brain stimulation can help children ages 6 to 12 with attention-deficit/hyperactivity disorder (ADHD) improve their attention and self-control.
- Trial name
- NCT07182344
- Testing
- Intermittent Theta Burst Stimulation to Right DLPFC
- Where
- 2 sites in Kazakhstan
- Volunteers
- 40 people
- Sponsor
- Neurolab Plus
Healthy Elderly
Innovative Hand Rehabilitation System With Synchronized Contralateral Haptic Feedback
Previous studies have found that graded motor imagery (GMI) training can provide continuous activation of the cerebral cortex compared to traditional rehabilitation therapy.
- Trial name
- NCT07077460
- Testing
- TIPr, Mirror Visual Feedback Device, Mirror Visual Feedback Device(Blocked mirror)
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
SCI - Spinal Cord Injury, Motor Imagery
Near-Infrared Imaging of Motor Imagery Effects in Spinal Cord Injury
The primary objective of this clinical trial is to investigate the efficacy of motor imagery-based brain-computer interface (MI-BCI) technology in improving motor function among patients with spinal cord injury (SCI), as well as…
- Conditions
- SCI - Spinal Cord Injury, Motor Imagery, Brain-Computer Interfaces
- Trial name
- NCT07106060
- Testing
- EEG-based rehabilitation training device (L-B300), EEG-based rehabilitation training device (L-B300)（Not connected）
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shengjing Hospital
Healthy
Evaluation of the Impact of Laterality on Brain Activation During a Virtual Mirror Therapy Task in Healthy Subjects
The aim of this study is to investigate the differences in brain activation in healthy subjects during virtual mirror therapy tasks, depending on the laterality of the task.
- Trial name
- LARTHEMIRS (NCT05793762)
- Testing
- Left virtual mirror therapy task, Right virtual mirror therapy task
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Stroke
Cortical Reorganization Models for Motor Areas and Inter-hemispheric Equilibrium Post-stroke: a Pilot Study
The main objective is to develop models for the cortical reorganization of motor areas and inter-hemispheric equilibrium in the early phase of post stroke recovery evaluated by the fNIRS technique from day 0 to day 60 (day 0…
- Trial name
- ERASM (NCT02664636)
- Testing
- Physiotherapy, Occupational therapy, Functional near-infrared spectroscopy
- Where
- 2 sites in France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Depression
Neurophysiological RCT of Qigong in Elderly With Depression
Summary of Project: Elderly depression is a common mood disorder and the individuals will have persistent low mood and self-absorption that adversely affect their quality of life.
- Trial name
- NCT05000788
- Testing
- Qigong, Exercise
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Stroke
fNIRS-Driven Visual Feedback Training to Restore Walking After Stroke
The objective of this clinical trial is to investigate whether intelligent visual feedback-based lower limb motor control training is more effective than conventional rehabilitation training in promoting walking ability recovery…
- Trial name
- NCT07014891
- Testing
- Intelligent Visual Feedback Motor Control Training, Bobath Ball Training
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Shengjing Hospital
Iron, Cerebral Blood Flow
16 Weeks' Dietary Supplementation With Iron and Iron + Vitamin C on Cerebral Blood Flow and Energy Expenditure in Women of Reproductive Age
Iron deficiency is the most prevalent nutritional deficiency worldwide with one in four estimated to be affected by iron deficiency anaemia.
- Conditions
- Iron, Cerebral Blood Flow, Energy Metabolism, Cognitive Function
- Trial name
- NCT04477018
- Testing
- Iron bis-glycinate chelate and vitamin C, Iron bis-glycinate chelate
- Where
- United Kingdom
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Hemiparesis
Post-stroke Motor Rehabilitation Using Functional Near-infrared Spectroscopy-based Brain-computer-interface
Chronic stroke survivors suffering from weaknesses or movement difficulties in their hand/arm are provided a system to aid in at-home rehabilitation for 6 weeks.
- Trial name
- fNIRS-PROMOTE (NCT05258591)
- Testing
- Axem Home
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Axem Neurotechnology Inc.
Septic Shock
Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock
This study has been approved as a nested substudy of a multicenter trial (CORVICTES, Clinicaltrials.gov Identifier: NCT03592693).
- Trial name
- CORVICTES-ΥΜ (NCT03649633)
- Testing
- Stress-dose Hydrocortisone plus Vitamin C
- Where
- Greece
- Volunteers
- 26 people
- Sponsor
- University of Athens
Healthy Volunteers, Working Memory Task
Non-invasive Optical Low-frequency Oscillation Study of the Prefrontal Cortex Based on fNIRS
The investigators aimed to investigate the effects of different cognitive load tasks (1-back, 2-back, 3-back) on low-frequency oscillations (LFOs) in the prefrontal cortex of healthy young individuals, analyze the relationship…
- Conditions
- Healthy Volunteers, Working Memory Task, Cognition
- Trial name
- NCT07759648
- Testing
- N-back Visual working memory task
- Where
- China
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College
Healthy
Impact of Dietary Flavanols on Microvascular Function in Young Females During Mental Stress
The aim of this project is to examine whether flavonoids, which are small molecules naturally present in cocoa, as well as fruits and vegetables such as berries, tea, citrus fruits, apple (typically responsible for giving these…
- Trial name
- NCT07864545
- Testing
- High-flavanol cocoa powder, Low-flavanol cocoa powder
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Delirium - Postoperative, Cerebral Oxygenation
Cerebral Oxygen Consumption Response to Increased Oxygen Supply and Postoperative Delirium in Older Surgical Patients
The goal of this observational study is to learn whether the brain's ability to use oxygen during surgery is associated with postoperative delirium in adults aged 65 years and older undergoing general anesthesia.
- Trial name
- NCT07463586
- Testing
- Intraoperative Cerebral Oxygen Utilization Assessment
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Bundang Hospital
Aplastic Anemia, Myelodysplastic Syndromes
Brain Cognitive Network Abnormalities in Anemia Patients Using fNIRS
Anemia is a global public health concern and is closely linked to dysfunction of brain cognitive neural networks, a key mechanism underlying cognitive impairment.
- Conditions
- Aplastic Anemia, Myelodysplastic Syndromes, Autoimmune Hemolytic Anemia, Functional Near-Infrared Spectroscopy
- Trial name
- AN-CNA (NCT07578675)
- Where
- China
- Volunteers
- 323 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Healthy Male and Female Subjects, Healthy Volunteer Study
Near-InfraRed Spectroscopy of Auricular Stimulation
This is a single-visit non-invasive study of healthy volunteer subjects. Brain activity will be measured with infra-red light sensors attached to a cap worn on the head, while both ears are gently stimulated with plastic…
- Trial name
- NIRAS (NCT06825364)
- Testing
- auricular stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Major Depressive Disorder, Bipolar Disorder
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
The purpose of this research is to measure brain activity in individuals with mood disorders and memory problems using a simple, safe, and noninvasive method called functional near-infrared spectroscopy (fNIRS).
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Mild Cognitive Impairment
- Trial name
- NCT06897670
- Testing
- Observational assessment using functional near-infrared spectroscopy (fNIRS), a noninvasive, portable brain imaging tool that measures changes in brain blood flow and oxygen levels.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Transcutaneous Nerve Stimulation
Effect of Transcutaneous Nerve Stimulation on Primary Motor Cortex to Modulate Cortical Excitability and Hemodynamic Response During Implicit Motor Learning: A TMS and NIRS Study
Noninvasive brain stimulation was recently gradually be emphasized. The electrical current applied on scalp can effective modulate cortical excitability.
- Trial name
- NCT02115841
- Testing
- "Enraf-Nonius" Muscle stimulator
- Where
- Taiwan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Heart Failure, Chronic Heart Failure
Wearable Tissue Oximetry During Arm Cuff Occlusion, Walking, and Standing Tests in Outpatients With Chronic Heart Failure
This prospective, single-center, observational pilot study evaluated an investigational wearable tissue oximeter (NIRSense Argus Oximetry System, also called Envello Core) in adult outpatients with chronic heart failure in New…
- Trial name
- NCT07874386
- Testing
- Argus Oximetry System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NIRSense Inc.