Clinical trials: Functional Neurological Disorder, active
Diplegic Cerebral Palsy
"Immediate Effect of DAFO on Gross Motor Function and Balance in Diplegic Cerebral Palsy
" Study will investigate the immediate effect of DAFO usage on balance and gross motor functions in individuals with spastic diplegic cerebral palsy.
- Trial name
- NCT06343688
- Testing
- "Assessment of Balance and Lower Extremity Gross Motor Function with and without DAFO"
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Stroke, Stroke, Acute
The Enriched Environment as an Integrated Tool in the Ward Setting
The goal of this longitudinal interventional study is to integrate the enriched environment (EE) in the context of the Neurology Clinic ward of the General Hospital - University of Padua, by verifying its effectiveness and impact…
- Trial name
- ENVIRONMENT (NCT06233682)
- Testing
- Enriched environment
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Padova
Aneurysmal Subarachnoid Hemorrhage (aSAH), Delayed Cerebral Ischemia
Early Prophylactic Aspirin for Aneurysmal Subarachnoid Hemorrhage
This study is a multicenter, prospective, double-blind, randomized controlled trial designed to evaluate whether early prophylactic use of aspirin improves functional outcomes in patients with aneurysmal subarachnoid hemorrhage…
- Trial name
- aSAH-ASA (NCT07642427)
- Testing
- Aspirin
- Where
- China
- Volunteers
- 388 people
- Sponsor
- Ganzhou City People's Hospital
Functional Movement Disorder, Functional Neurological Disorder
Tremor Retrainer Software Application for Functional Tremor
The purpose of this clinical trial is to learn about the Tremor Retrainer smartphone application and Simplified Functional Movement Disorder Rating Scale in patients with functional tremor.
- Conditions
- Functional Movement Disorder, Functional Neurological Disorder, Functional Neurological Symptom Disorder
- Trial name
- NCT06257069
- Testing
- Tremor Retrainer Smartphone Application
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Muscle Weakness, Muscle Loss
Physical Activity as Intervention Against Age-related Loss of Muscle Mass and Function
A minimum of 450 healthy individuals (62-70 years old) will be recruited. Each individual will be randomized into one of three groups stratified according to gender (M/F), BMI (≤28/>28), and 30 sec chair stand (≤11/>11).
- Conditions
- Muscle Weakness, Muscle Loss, Sarcopenia, Physical Activity
- Trial name
- LISA (NCT02123641)
- Testing
- Heavy resistance training, Moderate intensity training, Control
- Where
- Denmark
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Hemiplegia, Aphasia
The Effect of Upper Extremity Motor Function, Trunk Control and Motor Imagery Ability on Turkish Language Skills in Individuals With Stroke
A large number of people have a stroke each year and it is a major cause of disability worldwide. Upper limb motor impairments, aphasia, body control problems and decreased motor imagery ability are common after stroke.
- Conditions
- Hemiplegia, Aphasia, Stroke, Trunk
- Trial name
- NCT06946082
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Izmir Bakircay University
Fragile X Syndrome (FXS), Autism Spectrum Disorder
Group CBT in Adolescents With Fragile X Syndrome and in Adolescents With Autism Spectrum Disorder
Fragile X Syndrome (FXS) is a rare genetic syndrome, caused by a mutation in the FMR1 gene located on the X chromosome. It is considered the leading hereditary cause of intellectual disability (ID) and the primary cause of Autism…
- Trial name
- NCT06677866
- Testing
- Cognitive behavioral therapy, Waiting List
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
CVA, Gait, Hemiplegic
Robotic Exoskeleton Assisted Gait Post Stroke
The current investigation takes advantage of both a progressive and adaptive assist-as-needed massed practice and time-sensitive neuroplasticity through exoskeleton assisted walking in order to induce greater recovery-oriented…
- Trial name
- RE-Assist (NCT04309305)
- Testing
- EksoGT™, Ekso Bionics, Berkley, CA, USA, Standard of Care, No Intervention
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Stroke, Hemiplegia
Robot-Assisted Therapy in Chronic Stroke Patients
Considering the paucity of studies on robotic hand therapy, larger-scale and long-term follow-up studies are needed. The aim in this study is to demonstrate the effectiveness of robot-assisted hand therapy in patients with…
- Trial name
- NCT06692829
- Testing
- robotic rehabilitation, conventional rehabilitation
- Volunteers
- 80 people
- Sponsor
- Afyonkarahisar Health Sciences University
Vagus Nerve Diseases, Epilepsy
Electrical Impedance Tomography & Selective Stimulation of Vagus Nerve
Electroceuticals is a new field in which the goal is to treat a wide variety of medical diseases with electrical stimulation of autonomic nerves.
- Conditions
- Vagus Nerve Diseases, Epilepsy, Vagus Nerve Autonomic Disorder
- Trial name
- EITsVNS (NCT05664854)
- Testing
- Nerve cuff electrodes for spatially selective vagus nerve stimulation and electrical impedance tomography
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College, London
Brain Tumor, Metastatic Brain Tumor
A Study of How Proton Beam Radiotherapy (PBRT) Affects Brain Function and Quality of Life in Children and Young Adults Undergoing Treatment for a Brain Tumor
The researchers are doing this study to find out if there are differences in the resting state brain networks of children and young adults (ages 6-25) after treatment with proton beam radiation therapy (PBRT).
- Trial name
- NCT05288439
- Testing
- Resting-state functional connectivity MRI, Neurocognitive battery with quality-of-life assessment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Mucopolysaccharidosis I, Mucopolysaccharidosis II
Study to Evaluate the Safety and Efficacy of Adalimumab in MPS I, II, and VI
Randomized, double-blind, placebo-controlled, parallel-group, single-center study followed by open-label phase, to evaluate the effects of adalimumab compared to placebo on the change from baseline in joint and skeletal disease…
- Conditions
- Mucopolysaccharidosis I, Mucopolysaccharidosis II, Mucopolysaccharidosis VI
- Trial name
- NCT03153319
- Testing
- Adalimumab Injection [Humira], Saline Solution for Injection
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Functional Neurological Disorder
Clinical Evaluation of HRV Biofeedback in Functional Neurological Disorders Compared to Placebo
Evaluation of the clinical effects of the Heart Rate Variability biofeedback training with patients suffering from Functional neurological Disorders compared with placebo.
- Trial name
- HRV_BFB_FND (NCT06422819)
- Testing
- Heart rate variability Biofeedback [HRV-BFB], Pseudo HRV-BFB
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Gastroparesis, Gastroparesis-like Syndrome
GpCRC Pediatric Gastroparesis Registry 2
The objective of the Pediatric Gastroparesis Registry 2 is to create a national prospective registry of children, adolescents, and young adults with gastroparesis and gastroparesis-like syndrome (symptoms of gastroparesis but…
- Trial name
- PGpR2 (NCT05981300)
- Where
- 6 sites in United States
- Volunteers
- 216 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Spinal Cord Injury
Investigation Into Optimal FES Training Characteristics After Spinal Cord Injury
The aim of this study is to investigate two different modalities of functional electrical stimulation (FES) leg exercise in patients with spinal cord injury (SCI). The primary outcomes being compared are 1.
- Trial name
- NCT03621254
- Testing
- [LO-LONG], [HI-SHORT
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Parkinson Disease
Evaluation of Functional and Biochemical Effectiveness of a Strength Training Protocol in Parkinson's Disease
Parkinson's Disease (PD) is a complex neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, which results in a range of motor symptoms such as tremor, rigidity, and bradykinesia, as well as…
- Trial name
- POWER-PD (NCT07095400)
- Testing
- strength training
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Universidad Villanueva
Parkinsons Disease (PD), Anxiety
TMS in Anxiety-Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's dementia. Anxiety in PD is common, has major effects on quality of life and contributes to increased disability.
- Trial name
- NCT06999330
- Testing
- Theta burst stimulation active coil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- HealthPartners Institute
Healthy, Stroke
Influence of Brain Oscillation-Dependent TMS on Motor Function
Background: When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well people with and without stroke can move their arms and hands.
- Conditions
- Healthy, Stroke, Normal Physiology, Aging
- Trial name
- NCT03288220
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Injuries (SCI)
Spatiotemporal tSCS in Spinal Cord Injury
Spinal cord injury leads to long-lasting impairment, and currently, there is no cure for paralysis. Although transcutaneous spinal cord stimulation has shown promising results in recovering lost movements, its poor selectivity in…
- Trial name
- NCT07397559
- Testing
- No Stimulation, Conventional tSCS, Spatiotemporal tSCS
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Washington University School of Medicine
Parkinson Disease
The Effects of Ischemic Conditioning in Individuals With Parkinson's Disease
Ischemic conditioning (IC) is a promising therapy that can mimic the physiological effects of physical exercise. IC consists of using a cuff to measure blood pressure and calibrate 200 mmHg on the upper or lower limb.
- Trial name
- NCT06293118
- Testing
- Ischemic conditioning group
- Volunteers
- 50 people
- Sponsor
- Hospital Israelita Albert Einstein
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