Clinical trials: Functional Outcomes
Total Hip Replacement
Randomized Clinical Trial of Ceramic Bearing Primary Total Hip Arthroplasty
Primary total hip arthroplasty (THA) has been a very successful surgical intervention in the geriatric population. Numerous studies have reported good mid and long term results of THA in patients over the age of 60 years.
- Trial name
- NCT01522014
- Testing
- Secure-Fit™ arc-deposited Hydroxylapatite (HA) shell - surface ceramic and an Alumina Bearing Couple (ABC) ceramic insert and Ceramic C-taper head, Secure-Fit™ arc-deposited hydroxylapatite shell, a Crossfire® insert and a Ceramic C-taper head
- Where
- 2 sites in Canada
- Volunteers
- 92 people
- Sponsor
- University of Alberta
Rectal Cancer, Radiotherapy
PRediction of Outcomes and PERsonalized Radiotherapy by Biomarkers and Functional Imaging
This is a study focused on analyses of peripheral blood (tissue study). The aim of the trial is to determine whether it is possible to predict early clinical and/or pathological responses after radiotherapy in the setting of…
- Trial name
- NCT06730035
- Testing
- Blood analysis
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Deceased Donor Kidney Transplant, Acute Kidney Injury
Deceased Donor Biomarkers and Recipient Outcomes
Compared to chronic dialysis, kidney transplantation provides recipients with longer survival and better quality of life at a lower cost.
- Conditions
- Deceased Donor Kidney Transplant, Acute Kidney Injury, Delayed Graft Function, End Stage Renal Disease
- Trial name
- DDS (NCT01848249)
- Where
- 17 sites in United States
- Volunteers
- 1,679 people
- Sponsor
- Yale University
Malunion of Fracture of Clavicle, Delayed Union of Fracture of Clavicle
A Prospective Cohort of Displaced Adolescent Midshaft Clavicle Fractures
Outcomes for displaced midshaft clavicle fractures in adolescents are not defined. The current method of treatment for these fractures is non-operative management.
- Trial name
- NCT03415958
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Psychological Distress, Impaired Social Functioning
A Scalable Psychological Intervention for Earthquake Survivors in Türkiye
This will be the first pilot randomized controlled trial (RCT) study that investigate the potential effectiveness of individual PM+ among earthquake survivors residing in container cities in Türkiye.
- Conditions
- Psychological Distress, Impaired Social Functioning, Depressive Symptoms
- Trial name
- NCT06026306
- Testing
- Problem Management Plus (PM+)
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Koç University
Abdominal Pain, Gallstone; Colic
RELIEF-pathway in Patients With Upper Abdominal Pain
Upper abdominal pain (UAP) is a common symptom and frequently the reason to visit the hospital. The prevalence of epigastric pain in the Dutch population is estimated to be as high as 37%.
- Conditions
- Abdominal Pain, Gallstone; Colic, Dyspepsia, Irritable Bowel Syndrome
- Trial name
- RELIEF (NCT06002516)
- Testing
- RELIEF-pathway
- Where
- Netherlands
- Volunteers
- 471 people
- Sponsor
- Radboud University Medical Center
Arthoplasty, Nutrition
Effects of Preoperative Whey Protein and Exercise Support on Recovery After Total Hip Arthroplasty
Objective: The aim of this project is to evaluate the effects of preoperative whey protein supplementation and a physical exercise program on postoperative recovery outcomes in patients undergoing total hip arthroplasty (THA).
- Conditions
- Arthoplasty, Nutrition, Geriatric Assessment, Exercise Training
- Trial name
- THA (NCT07329010)
- Testing
- Preoperative Whey Protein and Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- TC Erciyes University
Frailty, Stroke
Body Composition, Frailty, and Function in Rehabilitation
The investigators are investigating if body composition measures - in particular muscle mass, body fat, and something called the phase angle - are able to reliably predict functional outcomes for patients who are in an acute…
- Conditions
- Frailty, Stroke, Debility Due to Disease
- Trial name
- NCT06527742
- Where
- Singapore
- Volunteers
- 345 people
- Sponsor
- Changi General Hospital
Mitral Regurgitation Functional, Heart Failure
Optimizing Clinical Outcomes in Patients Undergoing Mitral Transcatheter Edge-to-edge Repair (M-TEER) for Severe Functional Mitral Regurgitation Towards Improved Guideline-directed Medical Therapy
A multi-centre, prospective, observational pilot registry in patients undergoing mitral valve repair for severe functional mitral regurgitation to report the heart failure drug therapy and dosing before the mitral valve procedure…
- Conditions
- Mitral Regurgitation Functional, Heart Failure, M-TEER
- Trial name
- MOTOR (NCT06702527)
- Testing
- Mitral transcatheter edge-to-edge repair
- Where
- 2 sites in Germany
- Volunteers
- 9 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Menopause, Sleep Disturbance
Radicle Revive 24: A Study of Health and Wellness Products on Menopausal Health and Related Health Outcomes
A randomized, double-blind, placebo-controlled, direct-to-consumer trial assessing the impact of health and wellness products on hormonal health and associated health outcomes in women with menopausal health issues
- Conditions
- Menopause, Sleep Disturbance, Anxiety, Depression
- Trial name
- NCT06749288
- Testing
- Radicle Revive Active Study Product 4.1 Usage
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Pain, Physical Function
Osteoarthritis Outcomes in Different Ages
We aim to study if there are differences in outcomes between different age groups for persons with knee or hip osteoarthritis during treatment in digitally delivered exercise and education treatment.
- Conditions
- Pain, Physical Function, Age
- Trial name
- NCT05208463
- Testing
- Joint Academy
- Where
- Sweden
- Volunteers
- 14,610 people
- Sponsor
- Joint Academy
Dyspepsia
Symptoms and Physiological Effects of Amara in Functional Dyspepsia
The primary aim of this investigator-initiated, prospective, open-label study is to assess perceived changes in symptom burden reported by in patients with functional dyspepsia treated with Amara.
- Trial name
- NCT05553587
- Testing
- Amara drops
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Mark Fox
Muscle Weakness
Lower Limb Resistance Training in Older Inpatients
The primary aim of this feasibility study is to evaluate the feasibility of delivering a PRT programme in an inpatient older person rehabilitation setting and to describe changes in lower limb strength and physical function…
- Trial name
- NCT02141126
- Testing
- Resistance training, Usual care
- Where
- Ireland
- Volunteers
- 60 people
- Sponsor
- Royal College of Surgeons, Ireland
Total Knee Anthroplasty, Total Knee Arthroplasty Recovery
The Effects of Mir Shakeel Teleintegrated Therapy Plan in Patients Undergoing Total Knee Arthroplasty
This randomized controlled trial aims to evaluate the effectiveness of a newly developed Modified Structured Telerehabilitation Intervention Protocol (MSTITP) compared with conventional in-person physical therapy in patients…
- Trial name
- RCT (NCT07239258)
- Testing
- Mir Shakeel Teleintegrated Therapy plan, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Lincoln University College Malaysia
Post-Lung Transplantation Bronchiectasis
Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes After Lung Transplant
The purpose of this research is to study the effect of training the inspiratory muscles (i.e. the muscle that allow you to breath-in) on exercise capacity, quality of life, and short-term clinical outcomes in patients post lung…
- Trial name
- NCT04783155
- Testing
- POWERBreathe Plus®, Cardiopulmonary rehabilitation post lung transplant
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Dysfunctional Breathing, Breathing Pattern Disorder
OptiMuscle - Improving Respiration by Optimising Muscle Function
The primary aim will be to understand whether a digital breathing biofeedback system can improve the outcomes of physiotherapist guided breathing retraining.
- Trial name
- OptiMuscle (NCT06103955)
- Testing
- Digital Breathing Biofeedback system
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Salford
Rectal Cancer, Quality of Life
Quality of Life After Transanal Total Mesorectal Excision Compared to Traditional Total Mesorectal Excision
The improvement in prognosis of rectal cancer through modern therapy modalities rises questions regarding quality of life (QoL) and functional outcomes.
- Conditions
- Rectal Cancer, Quality of Life, Functional Outcome, Surgery
- Trial name
- NCT06505863
- Testing
- Transanal total mesorectal excision, Abdominal total mesorectal excision
- Where
- Switzerland
- Volunteers
- 249 people
- Sponsor
- Cantonal Hospital of St. Gallen
Heart Failure, Heart Failure NYHA Class IV
Association Between the Sit-To-Stand Test and the Prognosis of Patients With Heart Failure
Introduction: Heart failure (HF), among cardiovascular diseases, is the disease that has been increasing its incidence and prevalence the most in recent years in the world population, due to the aging of the population.
- Conditions
- Heart Failure, Heart Failure NYHA Class IV, Heart Failure; With Decompensation, Heart Failure NYHA Class III
- Trial name
- NCT07045649
- Testing
- 1-minute sit-to-stand test
- Where
- Brazil
- Volunteers
- 68 people
- Sponsor
- Centro Universitário Augusto Motta
Covid19
Respiratory Muscle Function, Dyspnea, Exercise Capacity and Quality of Life in Severe COVID19 Patients
Further knowledge regarding sequelae in severe COVID-19 patients who have required ICU admission for invasive mechanical ventilation is still needed.
- Trial name
- NCT04853940
- Testing
- Data collection and clinical testing of subjects
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Functional Constipation (FC), Accidental Falls
Functional Constipation and Fall-Related Outcomes in Older Adults
This retrospective cross-sectional observational study aims to examine the relationship between Rome IV functional constipation and fall history, functional capacity, and physical activity in older adults.
- Conditions
- Functional Constipation (FC), Accidental Falls, Physical Functional Performance
- Trial name
- FC-FALLS (NCT07630740)
- Where
- Turkey (Türkiye)
- Volunteers
- 208 people
- Sponsor
- Izmir Bakircay University
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