Clinical trials: Functional Outcomes
Ischemic Stroke, Acute, Treatment Outcome
Effect of Early Versus Late Initiation of Edaravone Dexborneol on Neural Function in Patients With Acute Ischemic Stroke
The primary objective of this study was to evaluate the efficacy and safety of initiation of edaravone dextivel therapy compared with placebo in patients with acute ischaemic stroke (early and late) and to explore the optimal…
- Trial name
- EARLYS (NCT05885919)
- Testing
- Edaravone Dexborneol Concentrated Solution for injection
- Where
- 3 sites in China
- Volunteers
- 212 people
- Sponsor
- Xiangya Hospital of Central South University
Renal Cell Carcinoma
Oncological and Functional Outcomes of Laparoscopic Partial Nephrectomy in Renal Cell Carcinoma Stages T1 Versus T2a: Prospective Comparative Study.
RCC represents around 3% of all cancers, with the highest incidence occurring in Western countries . Within the several RCC risk factors identified, smoking, obesity, and hypertension are most strongly associated with RCC .
- Trial name
- NCT05486871
- Testing
- laparoscopic partial nephrectomy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Knee Replacement
Biomechanical Assessment of a High Congruency Knee Bearing
The aim of the project is to compare the biomechanics of three different bearing designs used in total knee replacement (TKR) implants.
- Trial name
- NCT02422251
- Testing
- Mobile high congruency bearing (Columbus), Fixed high congruency bearing (Columbus)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Golden Jubilee National Hospital
Stroke
Environmental-perturbation Balance Training Improves Functional Outcomes in Patients With Subacute Stroke
This study innovatively proposes an "environment-perturbation balance training (E-PBT)" intervention, which delivers stable, graded environmental perturbations to keep the challenges within the manageable range.
- Trial name
- E-PBT (NCT07697794)
- Testing
- Environmental-perturbation balance training, Conventional rehabilitation training
- Where
- China
- Sponsor
- First People's Hospital of Shenyang
Balance Impairment in Peripheral Diabetic Neuropathy
" Effects of Task Oriented Training on Balance With or Without Textured Insoles in Patient With Peripheral Diabetic Neuropathy."
Introduction Peripheral diabetic neuropathy (PDN) is a common complication of diabetes that can cause sensory impairment, poor balance, and increased risk of falls.
- Trial name
- NCT07830173
- Testing
- Task oriented balance training, task oriented training with textured insoles
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Superior University
Varicella Zoster, Varicella Meningitis
Clinical Features and Outcomes of VZV CNS Infections
The goal of this observational study is to learn about the clinical characteristics, risk factors, and long-term outcomes of varicella zoster virus (VZV)-related central nervous system (CNS) infections in adults.
- Conditions
- Varicella Zoster, Varicella Meningitis, Varicella Encephalitis, Varicella Neurological
- Trial name
- NCT07554261
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Kocaeli University
Healthy
Punicalagin and Hydroxytyrosol Mixture on Different Inflammatory Markers
A crossover trial was carried out in healthy volunteers aged 45-70 years and BMI <30 kg/m2. Subjects consumed a Antioxidant Supplement (AS) containing 65 mg of punicalagin mixed with 3.3 mg of hydroxytyrosol 3 times daily or a…
- Trial name
- PROBELTEII (NCT02042742)
- Testing
- punicalagin and hydroxytyrosol mixture, Control supplement (maltodextrin)
- Where
- Spain
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Peripheral Arterial Occlusive Disease
Activity To Improve Outcomes in Peripheral Arterial Disease
Peripheral artery disease (PAD) results in blockages of arteries (blood vessels) in the legs and decreased blood flow to the legs. This may cause difficulty or pain with walking or other activities that use leg muscles.
- Trial name
- ACTION (NCT02189018)
- Testing
- Active Exercise, Neuromuscular electrical stimulation, Weight loss and active exercise
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Baltimore VA Medical Center
Lymphedema, Oropharyngeal Cancer
Complete Decongestive Therapy (CDT) for Treatment of Head and Neck Lymphedema
Objectives: Specific Aim 1: Estimate the prevalence of head and neck lymphedema in patients who have been treated with surgery and/or radiation therapy (± chemotherapy) for oral cavity and oropharyngeal cancer.
- Conditions
- Lymphedema, Oropharyngeal Cancer, Head and Neck Cancer, Oral Cancer
- Trial name
- NCT00951470
- Testing
- Follow -Up Visits, Full CDT, Modified CDT Program
- Sponsor
- M.D. Anderson Cancer Center
Hallux Valgus Correction, Hallux Valgus
Comparing Outcomes Using 1 Versus 2 Kirshner Wire Fixation in Patients With Severe Hallux Valgus
Comparing the radiographic and functional outcomes by using a Minimal invasive procedure to treat Hallux Valgus ; Distal linear Metatarsal Osteotomy - 1 Kirshner wire fixation versus two Kirshner wire fixation
- Conditions
- Hallux Valgus Correction, Hallux Valgus, Hallux Valgus Deformity, Minimal Invasive Surgery
- Trial name
- NCT07344077
- Testing
- 2 Kirshner wire fixation
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Myopic Traction Maculopathy
Predictors of Vitrectomy Outcomes in Myopic Foveoschisis
This prospective pilot study evaluates factors that predict outcomes after vitrectomy for myopic foveoschisis (MFS), a sight-threatening complication of high myopia that can lead to progressive visual loss, foveal detachment…
- Trial name
- NCT07774637
- Testing
- pars plana vitrectomy
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore National Eye Centre
Recurrent Anterior Shoulder Instability
Surgical Stabilization of Anterior Shoulder Instability Using the Open Latarjet Procedure, With or Without Anterior Capsuloplasty Using the Coracoacromial Ligament.
This pilot study aims to explore the feasibility and relevance of comparing the open Latarjet procedure performed with and without capsular repair (via coracoacromial ligament transfer) in patients with recurrent anterior…
- Trial name
- SCIFI-L (NCT07756827)
- Testing
- Capsuloplasty, No capsuloplasty
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Clinique Générale dAnnecy
Healthy Volunteers
Effects of Massage on the Short-term Post-exercise Recovery
Objectives: To analyze the behavior of the effects of massage on clinical, metabolic and functional variables in different scenarios: i) under no stress or massage application; ii) after massage; iii) after exhaustion protocol…
- Trial name
- NCT03057210
- Testing
- Stress Protocol, Massage Protocol
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- São Paulo State University
Cancer, Cancer in Pregnancy
ProspectiveFemaleAYA - Late Effects of Cancer Therapies on Gonadal Function, Fertility, Efficiency of Fertility Preservation Procedures and Pregnancy Outcomes
In the past two decades, the evidence-based knowledge on the prevalence and risk factors for gonads impairment, including infertility, following cancer and numerous cancer treatment regimen has significantly increased.
- Conditions
- Cancer, Cancer in Pregnancy, Infertility, In Vitro Fertilisation (IVF) Treatment
- Trial name
- FemFertilAYA (NCT07622420)
- Volunteers
- 3,000 people
- Sponsor
- Karolinska Institutet
Fabry Disease
Natural History and Structural Functional Relationships in Fabry Renal Disease Treatment Outcomes(Changes)in Fabry Renal Disease Study
The investigators will perform a study with two major components. The first is a natural history study of untreated Fabry patients.
- Trial name
- LDN6702 (NCT01581424)
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Tuberculosis, Inflammation Biomarkers
Effects of Adjunct Omega-3 Long Chain Polyunsaturated Fatty Acids in Pulmonary Tuberculosis Patient: an Early Bactericidal Activity and Inflammatory Trial
The goal of this randomized controlled trial is to evaluate the early bactericidal activity, early inflammatory response, and safety of omega-3 long chain polyunsaturated fatty acid (n-3 PUFA) supplementation in adult patients…
- Conditions
- Tuberculosis, Inflammation Biomarkers, Liver Function Tests, Iron Status
- Trial name
- TREAT 3 (NCT07118059)
- Testing
- Omega-3 (EPA+DHA)
- Where
- South Africa
- Volunteers
- 40 people
- Sponsor
- North-West University, South Africa
Covid19_rehabilitation
Recovery Profiles in Patients With SARS-CoV-2 Outcomes Undergoing Rehabilitation
COVID19 patients survivors, after discharge from hospital show reduced lung function and reduced ability to exercise. Furthermore, mental health problems including stress, anxiety and depression and a low quality of life were…
- Trial name
- NCT04615390
- Testing
- Early rehabilitation, Subacute rehabilitation, Mindfulness training
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Heart Failure With Preserved Ejection Fraction, Obesity
Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity.
- Trial name
- NCT05723679
- Testing
- HeO2 gas mixture, Room air gas mixture
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hirschsprung Disease
Minimally Invasive Surgical Intervention for Hirschsprung Disease
Hirschsprung's disease (HD) is one of the most common congenital conditions, with a global incidence of 1/5000 newborns; the prevalence in the Vietnamese population is even higher.
- Trial name
- NCT06880666
- Testing
- Minimally invasive laparoscopic pull-through surgery
- Where
- Vietnam
- Volunteers
- 23 people
- Sponsor
- National Children's Hospital, Vietnam
Multiple Sclerosis
Effects of Sleep Quality on Functional and Cognitive Outcomes in Multiple Sclerosis
The goal of this observational study is to investigate the effects of sleep quality on cognitive flexibility, physical activity level, body awareness, and reaction time in individuals with Multiple Sclerosis.
- Trial name
- NCT07536503
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Büşra Seçkinoğulları Korkusuz
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.