Clinical trials: Functional Vision Changes
Healthy
Effect of Simvastatin Withdrawal on Ocular Endothelial Function
Statins are drugs representing the most commonly prescribed medication for the treatment of hypercholesterolemia. In a recently published study, discontinuation of statin therapy in patients after acute myocardial infarction was…
- Trial name
- NCT02533141
- Testing
- Dynamic Vessel Analyzer (DVA), Laser Doppler Velocimetry (LDV), Simvastatin
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Vision Disorders
Modification in Cortical Activation in Pseudophakic Patients With Visual Difficulties After a Multifocal Implantation
This study will highlight differences in cortical activation between asymptomatic and symptomatic patients.
- Trial name
- PlainteIMF (NCT02529098)
- Testing
- fMRI
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Optic Glioma, Pediatric Brain Tumor, Optic Nerve Glioma
Modified CV Regimen in Optic Pathway Glioma
Optic pathway glioma (OPG) can result in visual deterioration. Symptomatic patients often report deficits in visual acuity (VA), visual field, visual-evoked potentials (VEPs), strabismus, proptosis, disc swelling, and other…
- Trial name
- NCT05278715
- Testing
- Carboplatin, Vincristine, Recombinant human endostatin
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Beijing Sanbo Brain Hospital
Glaucoma, Ocular Hypertension
Long-term Vascular, Functional and Morphological Changes in Glaucoma and Ocular Hypertensive Patients
This is an observational study involving patients with glaucoma, those with ocular hypertension and healthy subjects. The aim of the study is the long term evaluation of functional, vascular and morphological changes in glaucoma…
- Trial name
- Ippocrate (NCT06827535)
- Where
- 5 sites in Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Mario Stirpe
Visual Impairment, Amblyopia
Developing Better Computerised Vision Tests (CVTV)
Clinical vision measurements usually involve printed charts with an eye care professional interpreting patient responses to generate a score. Those scores determine the need for or outcome of treatment.
- Conditions
- Visual Impairment, Amblyopia, Macular Degeneration, Ophthalmic Disease
- Trial name
- CVTV (NCT06224751)
- Testing
- Near logMAR letter acuity, Near LogMAR word acuity, Red Green Stereoacuity
- Where
- United Kingdom
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Glaucoma
Does Glaucoma Cause Loss of Brain Function?
The purpose of the study is to determine if glaucoma is associated with neurodegenerative changes in areas of the brain other than the occipital lobe.
- Trial name
- NCT01303939
- Testing
- magnetic resonance imaging (MRI) of the brain
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Age Related Macular Degeneration (AMD)
A 16 Week Evaluation of the Novartis Health Management Tool (HMT) in Age Related Macular Degeneration (AMD)
This is a prospective pilot study to evaluate the usability and applicability of a self monitoring test of visual function with the handheld Health Management Tool (HMT) to remotely monitor neovascular Age Related Macular…
- Trial name
- NCT01542866
- Testing
- Health Management Tool (HMT)
- Where
- 23 sites in United States
- Volunteers
- 160 people
- Sponsor
- Novartis Pharmaceuticals
Spaceflight Associated Neuro-Ocular Syndrome, SANS
The Eye in Orbit: UCF Adaption
The goal of this study is to understand the impact of space travel on the eyes. Space flight impacts numerous aspects of ocular anatomy and physiology.
- Trial name
- NCT06092359
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Central Florida
Age-Related Macular Degeneration
Visual Function Change in Wet Age-related Macular Degeneration Patients With Better Baseline Visual Acuity
Although the number of wet AMD patients with the better visual acuity is increasing, the visual improvement in patients with the better vision may not be so significant after anti-vascular endothelial growth factor (VEGF)…
- Trial name
- NCT06330220
- Testing
- Aflibercept Injection [Eylea]
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Seoul National University Hospital
Dry Eye Syndrome, Photophobia
Functional MRI Study of Cortical Modifications to Light Stimulation in Patients With Photophobia
Photophobia is a common and disabling symptom in patient with dry eye syndrome. The aim of this study is tried to better understand this complain analyzing brain activation during a luminous stimulation to highlight modification…
- Trial name
- NCT03464357
- Testing
- fMRI
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Toulouse
Glaucoma
Visual Function Changes After Intraocular Pressure Reduction
During the glaucomatous disease process, subpopulations of cells may be dead, damaged or healthy. Visual function changes could be observed due to a recovering of the suffering ganglion cells after the intraocular pressure…
- Trial name
- NCT00435058
- Testing
- timolol maleate 0,5%, brimonidine tartrate 0,2%, travoprost 0,004%
- Volunteers
- 54 people
- Sponsor
- University of Sao Paulo
Vision, Ocular
Determine Functions of Pinhole Glasses on the Eyes
Pinhole glasses which is using pinhole effect may induce a functional change on the eyes, including Distance and near visual acuity(DVA, NVA), Pupil size, DOF, Accomodative amplitude, CS, Visual field(VF), Stereopsis.
- Trial name
- PH001 (NCT02111356)
- Testing
- Phinhole glasses
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chung-Ang University Hospital
Dry AMD
Morpho-functional Changes After Oral Supplementation of Antioxidants and Anti-inflammatory Treatment in Age-Related Macular Degeneration.
In patients with AMD a deterioration of the antioxidant mechanisms of the retina is observed and therefore an increase in the production of free radicals responsible for tissue damage.
- Trial name
- MACUPREV (NCT03919019)
- Testing
- Macuprev Group
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Cataract Bilateral, Astigmatism Bilateral
Vision and Balance Changes After Bilateral Implantation of Toric IOLs
Cataracts are the major cause of blindness in the world. Cataract surgery, being the most performed surgery in the world today, provide correction by extracting the natural lens from its capsular bag and replaced by an artificial…
- Trial name
- NCT05629078
- Testing
- Toric intraocular lens Zeiss AT TORBI
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- University of Plymouth
Ocular Surface Disease, Keratoconus
Changes of Visual Function, Ocular Surface Structures and Physiology After Long-Termed Contact Lens Wear
Our study is aimed to observe the long termed effect of contact lens wear on ocular surface, especially focused on visual function and ocular inflammation mediators.
- Conditions
- Ocular Surface Disease, Keratoconus, Irregular Astigmatism
- Trial name
- NCT02894489
- Testing
- corneal lenses, large diameter lenses
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Choroideremia
The Dark-Adapted Retinal Function Response in Choroideremia (DARC) Study
Choroideremia (CHM) is an inherited retinal disorder that causes progressive vision loss, ultimately leading to complete blindness.
- Trial name
- DARC (NCT05045703)
- Testing
- Vitamin A palmitate
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Adult Refractory Complex Partial Seizures
A Study of the Structure and Function of the Retina in Adult Patients With Refractory Complex Partial Seizures Treated With Vigabatrin (Sabril®)
The purpose of the study is to evaluate the change in visual fields by means of automated static perimetry and to evaluate the change in retinal structure by means of spectral domain optical coherence tomography (SD-OCT) in adult…
- Trial name
- NCT01278173
- Testing
- Sabril
- Where
- 22 sites in United States
- Volunteers
- 65 people
- Sponsor
- Lundbeck LLC
Healthy
Aqueous Outflow Facility Changes With Posture
Intraocular pressure (IOP) varies with body position, with a significant increase occurring from the seated to the supine position.
- Trial name
- NCT00571012
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
High Myopia
The Relationship Between Structure and Visual Function in Myopia Foveoschisis
Macular foveoschisis (MF) is a common complication of pathological myopia, which is characterized by choroid-retinal degeneration and vision impairment.
- Trial name
- NCT02915133
- Testing
- macular buckling surgery
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-sen University