Clinical trials: Functionality, open to volunteers
Achondroplasia
Extension Study of Infigratinib in Children With Achondroplasia (ACH)
This is a Phase 2, multicenter, open-label, extension (OLE) study to evaluate the long-term safety, tolerability, and efficacy of infigratinib, an FGFR 1-3-selective tyrosine kinase inhibitor, in participants with ACH who…
- Trial name
- NCT05145010
- Testing
- Infigratinib
- Where
- 31 sites in United States, Argentina and 8 more
- Volunteers
- 325 people
- Sponsor
- QED Therapeutics, a BridgeBio company
Aged, Aged Subject
CREM - Clinical and Functional Outcomes in a Controlled Clinical Trial with Older Adults
To evaluate and compare the effects of different types of physical exercise on clinical and functional outcomes in the elderly. 240 community-dwelling elderly individuals of both sexes, sedentary, will be recruited for twelve…
- Trial name
- CREM (NCT06638697)
- Testing
- Free walking, Nordic walking, Dance
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Acute Myeloid Leukemia
Harnessing the Immunosuppressive Leukemic Microenvironment to Engineer T Cells With Enhanced Anti-tumor Functionality
This is a monocentric, retrospective and prospective study aimed to underline the potential of T-cell receptor (TCR)-mediated Ab recognition from the post transplant setting in acute myeloid leukemia (AML).
- Trial name
- SynT (NCT07743047)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Stroke
Investigation of the Effects of Visual-Motor Based Training on Upper Extremity Functions in Individuals With Stroke
The purpose of this study is to investigate the effects of visual-motor based training and physiotherapy program on upper extremity functions in individuals with stroke and to compare with physiotherapy program.
- Trial name
- NCT07055945
- Testing
- Experimental group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Baskent University
Sarcopenia
Multicomponent Training and Muscle Quality in Older Women
This study aims to evlauate the effect os a 32-week multicomponent training (MT) program on muscle architecture and muscle quality (assessed by ultrasound) in womer over 60 years.
- Trial name
- NCT07359495
- Testing
- Multicomponent training
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Functionality, Cognition
Impact of Creatine Monohydrate Micronized Supplementation With or Without Multicomponent Training in Older Adults.
The goal of this clinical trial is to study and evaluate whether a protocol of creatine supplementation, with or without multicomponent training, improves functional and cognitive capacity in individuals over 75 years old.
- Conditions
- Functionality, Cognition, Strength Training Effects
- Trial name
- CREAGED (NCT06677359)
- Testing
- Creatine Group, Multicomponent Training
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Amputation, Surgical
Improving Prosthetic Arms for Amputee: A Better Fit and More Functionality
This research and development will improve upon and investigate the potential validity of an innovative new transradial socket and harness design (the KSH system) that offers an alternative to standard hard sockets and rubber…
- Trial name
- KSH (NCT05990062)
- Testing
- K-Socket-Harness
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Achilles Tendon Rupture, Strength Training Adaptations
Effects of Strength Training on the Plantar Flexors' Properties After Achilles Tendon Rupture
Among the injuries that affect the Achilles tendon, rupture is one of the most frequent. This injury can generate functional, neuromuscular, and tendon deficits that can last for long periods or even be permanent.
- Conditions
- Achilles Tendon Rupture, Strength Training Adaptations, Neuromuscular Adaptations
- Trial name
- NCT06912269
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Endometriosis, Chronic Pain
Therapeutic-educational Physiotherapy on Pain, Physical-functionality and Quality of Life in Women With Endometriosis.
This is a randomized clinical trial that will be carried out in women with endometriosis divided into two groups: the experimental group (EG) that will receive therapeutic-educational physiotherapy, which will combine therapeutic…
- Conditions
- Endometriosis, Chronic Pain, Women's Health
- Trial name
- PHYSIO_ENDOM (NCT06212349)
- Testing
- therapeutic-educational physiotherapy and pain education program, pain education program
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- University of Valencia
Quadriplegia, Amputations
A Study on the Safety and Functionality of the Implantable Wireless Brain-Computer Interfaces for Motor Rehabilitation
The objective of this study is to evaluate the safety and efficacy of minimally invasive, wireless brain-machine interface system (WRS) in patients with paralysis (resulting from spinal cord injuries, brainstem strokes…
- Conditions
- Quadriplegia, Amputations, Spinal Cord Injuries (SCI), Brainstem Stroke
- Trial name
- STAIR (NCT06944834)
- Testing
- Implant
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shanghai StairMed Technology Co., Ltd.
Healthy Adults
Pilot Study of the Entarik System With Advanced Functionality in Health Adults
In this single-site study, data will be recorded during nasogastric or orogastric placement (and post-pyloric placement) and removal of the Entarik Feeding Tube.
- Trial name
- NCT06660758
- Testing
- Feeding tube (Entarik)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gravitas Medical, Inc.
Fibromyalgia, Neck Pain Musculoskeletal
VALIDITY AND RELIABILITY OF THE TURKISH VERSION OF THE SEX PAIN QUESTIONNAIRE
Although there are many questionnaires used in the literature regarding sexual function and satisfaction, these questionnaires evaluate sexual problems regardless of the chronic pain condition and have not been validated for…
- Conditions
- Fibromyalgia, Neck Pain Musculoskeletal, Back Pain Lower Back Chronic, Musculoskeletal Diseases
- Trial name
- SPQ (NCT07536672)
- Testing
- surveys
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Pregnant Women
The Effect of Haptonomy Practice on Body Functionality Appreciation and Childbirth Self-Efficacy in Pregnant Women
Study Type and Aim: This clinical study aims to examine the effects of haptonomy practices on appreciation of bodily functionality and childbirth self-efficacy among healthy pregnant women.
- Trial name
- HAP-Func-Eff (NCT07199140)
- Testing
- Haptonomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Obesity, Metabolic Syndrome
Rutazyme Lemon Fermented Product Capsules for Metabolic Function in Adults With Obesity
This study evaluates whether a fruit- and vegetable-based fermented product (Rutazyme® lemon fermented product) taken as a capsule can improve metabolic health in adults with obesity.
- Trial name
- NCT07540949
- Testing
- Rutazyme® Lemon Fermented Product Capsule
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan Sport University
Cerebral Palsy (CP), Spasticity Due to Cerebral Palsy
Effect of Botulinum Toxin Type A on Motor Function in Children With Cerebral Palsy
Project Identification and Researchers Title: "Changes in functionality and quality of life when applying the botulinum toxin type A infiltration protocol in children and adolescents with cerebral palsy of the spastic hemiparesis…
- Conditions
- Cerebral Palsy (CP), Spasticity Due to Cerebral Palsy, Hemiparesis
- Trial name
- NCT07034547
- Testing
- Botulinum toxin infiltration
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Instituto Teletón Chile
Poor Response to Ovulation Induction, Infertility, Female
Autologous Platelet Rich Plasma Intraovarian Infusion for Poor Responders
Autologous platelet rich plasma (PRP) intraovarian infusion may improve ovarian response to controlled ovarian stimulation as well as the hormonal profile of poor ovarian response infertile women subjected to intracytoplasmic…
- Conditions
- Poor Response to Ovulation Induction, Infertility, Female, Ovarian Insufficiency, Ovarian Failure
- Trial name
- PRPPOR (NCT05181748)
- Testing
- Autologous platelet rich plasma
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Major Depressive Disorder (MDD)
Effect of TMS Treatment on Defense Mechanisms and Functionality in Patients With Depression
This prospective observational study aims to evaluate changes in psychological defense mechanisms in patients with non-psychotic major depressive disorder (MDD) undergoing repetitive Transcranial Magnetic Stimulation (rTMS)…
- Trial name
- NCT07853989
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Namik Kemal University
Stellate Ganglion Block
Stellate Ganglion Block in Complex Regional Pain Syndrome
The aim was to investigate the effect of Stellate Ganglion Blockade, which will be applied in addition to conventional physical therapy, on pain and functionality in patients with poststroke complex regional pain syndrome.
- Trial name
- NCT07129811
- Testing
- Stellate Ganglion Block
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Ankara City Hospital Bilkent
Rotator Cuff Tears
Effect of Motor Imagery Training on Pain, Functionality, Proprioception and Kinesiophobia in Partial Rotator Cuff Tear
The aim of this study is to investigate the effects of motor imagery training on pain, functionality, proprioception and kinesiophobia in patients with partial rotator cuff tears.
- Trial name
- NCT06875895
- Testing
- Traditional Physiotherapy, Motor Imagery Training
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kutahya Health Sciences University
Diabetes Type 2, Frail Elderly Syndrome
Involvement of Muscle Mitochondrial Dysfunction in Frailty in Older Adults. Role of Exercise
This study aims to investigate the role of skeletal muscle mitochondrial dysfunction in the development of frailty in older adults and to evaluate whether a short-term, supervised resistance training intervention can improve…
- Conditions
- Diabetes Type 2, Frail Elderly Syndrome, Mitochondrial Function, Bioenergetics, Functionality
- Trial name
- MITOSTRENGTH (NCT07828847)
- Testing
- Short-duration resistance training
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia