Clinical trials: Functioning
Stroke
Hybrid Robot+FES Stroke Rehabilitation
The investigators have developed a novel robot-guided stretching under intelligent control and combine it with active movement training, which helped increase joint ROM, reduce spasticity and joint stiffness, increase muscle…
- Trial name
- NCT04550728
- Testing
- Ankle robot training group, Ankle robot training and functional electrical stimulation(FES) group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Major Injury
Perioperative Research Into Memory: Cognitive Outcome Following Major Burns
The long term survival of patients who require admission to critical care (CC) following a major burn injury (MBI) continues to improve with advanced clinical management.
- Trial name
- PRiMe (NCT03470844)
- Testing
- Face-to-face neurocognitive tests, Psychological screening, fMRI
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Stroke
Effects of Cerebrolysin Combined With Rehabilitation on Motor Recovery in Stroke
This study, E-COMPASSII is a phase IV clinical trial designed as a multicenter, randomized, double-blind, placebo-controlled, parallel-group study. This study will enroll 80 subacute stroke patients with severe motor involvement.
- Trial name
- NCT02768571
- Testing
- Cerebrolysin
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
Covid19
Balance Function in Patients Post Corona Virus Disease 2019 (COVID-19)
The purpose of this study is to describe balance deficits in patients post COVID-19. The information the investigators learn may help influence balance training exercises for patients post-COVID-19.
- Trial name
- NCT04914364
- Testing
- Balance assessments
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Pulmonary Disease, Chronic Obstructive
A Study to Evaluate the Efficacy and Safety of Umeclidinium Bromide/Vilanterol Compared With Fluticasone Propionate/Salmeterol Over 12 Weeks in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
This is a multicenter, randomized, double-blind, double-dummy, parallel group study. The purpose of this study is to compare the efficacy and safety of umeclidinium/vilanterol (UMEC/VI) and fluticasone propionate/salmeterol (FSC)…
- Trial name
- NCT01822899
- Testing
- Umeclidinium bromide/Vilanterol, Fluticasone propionate/Salmeterol
- Where
- 78 sites in Czechia, Denmark and 6 more
- Volunteers
- 717 people
- Sponsor
- GlaxoSmithKline
Childhood Cancers
Cardiovascular Function in Adult Survivors of Childhood Malignancies
Anthracyclines have been used commonly to treat children with solid tumours and haematological malignancies and have led to their increased survival. Nonetheless, anthracycline has the side effect of cardiotoxicity.
- Trial name
- NCT01415999
- Where
- China
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Sickle Cell Disease
Assessment of Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People With Sickle Cell Disease
Background: Sickle cell disease (SCD) is a blood disease. The drug hydroxyurea (HU) is approved to prevent pain crises in people with SCD. Researchers want to see how higher doses of HU affect the blood.
- Trial name
- NCT02225132
- Testing
- Hydroxyurea
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myasthenia Gravis, Depression
Depressive Tendency and Counseling Outcomes in Thymoma-Associated MG
This study aimed to examine whether baseline depressive tendency independently predicts post-counseling clinical outcomes in patients with thymoma-associated MG.
- Conditions
- Myasthenia Gravis, Depression, Thymoma, Depression and Quality of Life
- Trial name
- NCT07649187
- Testing
- Psychological counseling intervention
- Where
- Taiwan
- Volunteers
- 19 people
- Sponsor
- Ming-Hsing Chang
Opioid-use Disorder
Using Combined EEG and Non-invasive Brain Stimulation to Examine and Improve Reward Functioning in Opioid Use Disorder
The primary aims of this study are to identify impaired cognitive control in opioid use disorder (OUD) and subsequently to examine the effects of transcranial magnetic stimulation (TMS) on reward processing, as measured by the…
- Trial name
- NCT04432493
- Testing
- Active repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Overweight, Obesity
The Effects of Exercise Snacks on Endothelial Function and Body Composition in Overweight Individuals
This randomized controlled trial investigates the effects of two types of stair-climbing exercise snacks versus moderate-intensity continuous training on vascular health, body composition, and blood lipids in overweight or obese…
- Trial name
- NCT07558421
- Testing
- Short-term stair climbing exercise snack group, Long-duration stair climbing exercise snack group, Moderate-intensity continuous exercise（MICT）
- Volunteers
- 60 people
- Sponsor
- Weifang Medical University
Neuromuscular Control, Functional Training
Comparison of Lower Limb COP and Muscle Activation During Single-Leg Deadlift Using Elastic and Inelastic Barbells
This study aims to investigate the effects of barbell type (elastic vs. inelastic) and lifting speed on lower limb balance and muscle activation during the Single-Leg Deadlift (SLDL) exercise.
- Conditions
- Neuromuscular Control, Functional Training, Lower Limb Stability
- Trial name
- NCT07061314
- Testing
- Elastic Barbell, Inelastic Barbell
- Where
- South Korea
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Busan University of Foreign Studies
Parkinson's Disease
Exercise and Cognitive Training in Parkinson's Disease
This study compares the effects treadmill exercise, computerized cognitive training, or the combination of the two on executive function, dual-task performance, and performance on several Instrumental Activities of Daily Living…
- Trial name
- NCT01156714
- Testing
- Treadmill training with aerobic exercise, Memory training with computerized memory program, Combination of treadmill training and computerized memory
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Functional Movement Disorders
Brain Activity in People With Functional Movement Disorders
This study will use functional MRI (fMRI, a technique that shows what areas of the brain are active when performing different mental tasks), to examine how the brain in people with functional movement disorders (FMD) may differ…
- Trial name
- NCT00448084
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Anterior Cruciate Ligament Injuries, Knee Injuries
Graft Type and Outcomes After ACL Reconstruction in Female Athletes
This prospective multicenter cohort study aims to compare clinical and functional outcomes between hamstring tendon and quadriceps tendon autografts in anterior cruciate ligament (ACL) reconstruction in female athletes.
- Trial name
- LCA-WOMEN (NCT07722104)
- Testing
- Hamstring tendon autograft ACL reconstruction, Quadriceps tendon autograft ACL reconstruction
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Obesity, Sarcopenia
Biological Effects of Weight Loss In Older, Obese Women
Obesity and sedentary lifestyle are associated with physical impairments and biological changes in older adults. Weight loss combined with exercise may reduce inflammation and may improve physical functioning in older adults who…
- Trial name
- WL+E (NCT01032733)
- Testing
- Lifestyle Counseling, Educational Control
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Muscle Oxygenation
Evaluation of Muscle Oxygen With MRI
Demonstration of soft tissue hypoxia on MRI using external compression and muscle contraction.
- Trial name
- NCT07638384
- Testing
- Compression and Contraction
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Depression, Anxiety
Modulating Default Mode Network Function: A Transcranial Direct Current Stimulation (TDCS) Pilot Study
The primary purpose of this research is to gather scientific information about how different people's brains work when they look at different types of pictures.
- Trial name
- MDMN (NCT04598152)
- Testing
- TDCS - transcranial direct current stimulation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jay Fournier
Respiratory Physiological Phenomena
Functional Residual Capacity Measured by Capnography in Ventilated Patients
Changes in body position during anesthesia can alter functional residual capacity and gas exchange. The monitoring of such changes in functional residual capacity is difficult at the bedside.
- Trial name
- NCT03693352
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
Muscle Weakness
Effects of Creatine Supplementation on Muscle Mass and Function Among Older Women Subjected to Resistance Training
To determine, in a double blind trial, the effects of creatine supplementation during 12 weeks on muscle mass and function of community living older women subjected to resistance training.
- Trial name
- NCT02188849
- Testing
- Resistance exercise training, Creatine
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Chile
Neurologic Manifestations, Neurobehavioral Manifestations
Training Cognitive Control Processes in Older Adults
Control processes are classes of brain activity that initiate, coordinate, synchronize, and regulate elemental cognitive functions for the conduct of goal-directed behavior.
- Trial name
- NCT00586638
- Testing
- Video game based training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Columbia University