Clinical trials: Fungal Disease
Pneumococcal Infections
Immunogenicity and Safety Study of NBP606 in Healthy Toddlers
This study will assess the immunogenicity and safety of booster vaccination with NBP606 compared to the existing commercial vaccine, when given concomitantly with routine pediatric vaccinations.
- Trial name
- NCT02927444
- Testing
- NBP606, Prevnar13
- Where
- South Korea
- Volunteers
- 462 people, healthy volunteers welcome
- Sponsor
- SK Chemicals Co., Ltd.
Latent Tuberculosis, Diabetes Mellitus
Evaluation of Diabetes Control and Effect on Transmission and Development of Tuberculosis
Clinical test (essay) randomized to evaluate the toxicity adherence and efficiency of the chemoprophylaxis of tuberculosis (TB) in subjects with Diabetes Mellitus (DM) and latent TB.
- Trial name
- NCT03498534
- Testing
- Isoniazid 300Mg Tab, Isoniazid 300 MG
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Opioid Use Disorder, HIV Infections
Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washington
The investigators will implement a non-randomized observational clinical trial that will include a pop-up clinic for women who inject drugs (WWID) near venues for exchange sex and drug use in north Seattle.
- Conditions
- Opioid Use Disorder, HIV Infections, Chlamydia, Gonorrhea
- Trial name
- NCT06187064
- Testing
- Mobile Van Clinic
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Washington
Healthy Participants
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of AZD5148 in Healthy Adults
The purpose of this study is to measure safety, tolerability, and pharmacokinetics (PK) of a single dose of AZD5148 administered via intravenous (IV) bolus or intramuscular (IM) injection in healthy participants
- Trial name
- NCT06469151
- Testing
- AZD5148
- Where
- 4 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Tuberculosis Infection
Evaluation of Immune Cell Markers in Diagnosis of Tuberculosis
Diagnosis of active and latent pulmonary tuberculosis, as well as extrapulmonary tuberculosis, is still a major challenge of TB control in China.
- Trial name
- NCT04148053
- Testing
- TB-antigen responsive T cell markers
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tongji University
Tuberculosis
Population Pharmacokinetics of Anti-tuberculosis Drugs in Children With Tuberculosis
This study is based on the hypothesis that the pharmacokinetics of anti-tuberculosis drugs in TB children are different from adults.
- Trial name
- NCT03625739
- Testing
- anti-tuberculosis drug
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Beijing Children's Hospital
Leptospirosis
Immune Response After Leptospirosis Infection
Leptospirosis is a zoonotic infection induced by pathogen bacteria (genus: Leptospira) growing in water polluted by animal fluids.
- Trial name
- SERO7LEPTO (NCT02898519)
- Testing
- cohort
- Volunteers
- 175 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Infections Nervous System
Molecular Panel Evaluation for Diagnosis of Infections of the Central Nervosous System
Infections involving the central nervous system (CNS), such as meningitis/encephalitis (ME), are serious clinical conditions associated with high morbidity and mortality rates, as well as significant long-term consequences.
- Trial name
- NCT06720519
- Testing
- QIAstat-Dx®Meningitis/Encephalite Panel
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Hidradenitis Suppurativa
LTX-109 as Treatment for Hidradenitis Suppurativa
An Open label Phase II//proof of concept-study to demonstrate if percutaneous application of LTX-109 in a gel vehicle is a safe treatment of Hidradenitis suppurativa and to identify clinical response to intervention, as well to…
- Trial name
- NCT04756336
- Testing
- LTX-109 gel, 3% w/w
- Where
- Norway
- Volunteers
- 11 people
- Sponsor
- Pharma Holdings AS
Staphylococcus Aureus Infection
Study of the Nasal Decolonisation of Staphylococcus Aureus (SA) and the Safety and Tolerability of XF-73 Nasal Gel in Healthy Subjects
Study to determine the efficacy, safety and tolerability of two concentrations of XF-73 nasal gel in combination with body and face washing with chlorhexidine gluconate cloths in eradicating nasal carriage of Staphylococcus…
- Trial name
- NCT02282605
- Testing
- XF-73 nasal gel, Chlorhexidine gluconate 2% topical cloths
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Destiny Pharma Plc
Pneumococcal Infections
A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Adults Infected With Human Immunodeficiency Virus (HIV) (V114-018)
This study is designed to 1) describe the safety, tolerability, and immunogenicity of V114 and Prevnar 13™ in pneumococcal vaccine-naïve adults infected with HIV and to 2) describe the safety, tolerability, and immunogenicity of…
- Trial name
- PNEU-WAY (NCT03480802)
- Testing
- V114, Prevnar 13™, PNEUMOVAX™23
- Where
- 13 sites in United States, France and 3 more
- Volunteers
- 302 people
- Sponsor
- Merck Sharp & Dohme LLC
Community-Acquired Infections
Community Acquired Bacteremic Syndromes in Young Nigerian Children
To define the etiologic agents of community acquired bacteremic syndromes (defined as septicemia, bacteremia, pneumonia and/or meningitis) in a malaria endemic setting.
- Trial name
- CABSYNC (NCT02946775)
- Where
- Nigeria
- Volunteers
- 29,146 people
- Sponsor
- University of Nebraska
Shigellosis
A Human Challenge Study to Assess Protection of a Shigella Tetravalent Bioconjugate Vaccine
In this challenge study, the bioconjugate candidate vaccine Shigella4V2 will be tested for its ability to induce an immune response that protects healthy adult volunteers from infection with a wild-type Shigella sonnei strain…
- Trial name
- S4V03 (NCT06615375)
- Testing
- Shigella4V2
- Where
- 3 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- LimmaTech Biologics AG
Infection, Bacterial, Pacemaker Complication
Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome
Background: Infection of cardiac implantable electronic device including wound and pouch infection, bacteraemia and endocarditis is a common complication of device insertion.
- Trial name
- NCT03148444
- Testing
- cefalexin 500 mg qid or roxithromycin 150 mg bid
- Volunteers
- 400 people
- Sponsor
- Kaplan Medical Center
Hemodialysis
HeRO Vascular Access Device Bacteremia Study
The purpose of this study is to compare the safety and effectiveness of the HeRO Vascular Access Device in access challenged (e.g., catheter-dependent) hemodialysis patients.
- Trial name
- NCT00889564
- Testing
- HeRO Vascular Access Device
- Where
- 7 sites in United States
- Volunteers
- 38 people
- Sponsor
- Merit Medical Systems, Inc.
Tuberculosis, Pediatric Infectious Disease
Evaluation of Xpert MTB/RIF Ultra in Stools and Urine to Improve Tuberculosis Diagnosis in Children
Tuberculosis (TB) diagnosis in children is challenging in low and middle-income countries where access to TB culture and X-ray is limited. More than half cases of childhood TB remain undiagnosed every year.
- Trial name
- NCT06239337
- Testing
- Xpert MTB/RIF Ultra in stools and urine
- Where
- 2 sites in Guinea-Bissau, South Sudan
- Volunteers
- 563 people
- Sponsor
- Medecins Sans Frontieres, Spain
Hidradenitis Suppurativa (HS)
1726-nm Laser for Acne Inversa (Hidradenitis Suppurativa)
Hidradenitis suppurativa (HS) is a long-lasting skin condition that causes painful lumps, abscesses, and tunnels in areas such as the armpits and groin.
- Trial name
- WMCREI (NCT07155239)
- Testing
- AviClear Lase Treatment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wynn Medical Center
HIV, Malaria
Impact of Cotrimoxazole Prophylaxis for HIV-Infected Adults on Antifolate Resistance
At least three studies in sub-Saharan Africa have demonstrated a decrease in morbidity or mortality among HIV-infected adults who took daily cotrimoxazole (trimethoprim sulfamethoxazole) [CTX] prophylaxis.
- Conditions
- HIV, Malaria, Diarrhea, Pneumonia
- Trial name
- NCT00137657
- Testing
- Cotrimoxazole (trimethoprim sulfamethoxazole)
- Where
- Kenya
- Volunteers
- 1,478 people
- Sponsor
- Centers for Disease Control and Prevention
Clostridium Difficile Infection
Bezlotoxumab (MK-6072) Versus Placebo in Children With Clostridium Difficile Infection (CDI) (MK-6072-001)
The primary objectives of this study are to evaluate the pharmacokinetics (PK), safety, and tolerability of bezlotoxumab (MK-6072) in children aged 1 to <18 years of age with a confirmed diagnosis of Clostridium difficile…
- Trial name
- MODIFY III (NCT03182907)
- Testing
- Bezlotoxumab, Antibacterial drug treatment (ABD)
- Where
- 75 sites in United States, Argentina and 15 more
- Volunteers
- 148 people
- Sponsor
- Merck Sharp & Dohme LLC
Meningitis, Meningococcemia
Antibody Responses Following Meningococcal Tetravalent (A, C, Y, and W-135) Conjugate Vaccination in Healthy Adults
This study was designed to generate data for the assessment of Meningococcal Polysaccharide Diphtheria Toxoid Conjugate vaccine (Menactra®) when given to adults aged 18 to 55 years.
- Trial name
- NCT00772629
- Testing
- Meningococcal Polysaccharide Diphtheria Toxoid Conjugate
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
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