Clinical trials: Fungal Disease
Diphtheria, Tetanus
Study of the Tdap Combined Vaccine (ADACEL™) as a Booster Dose in Healthy Adults and Children in China
The aim of the study is to assess the safety profile of ADACEL vaccine in a small number of participants in China. Primary objective: To describe the safety in terms of occurrence of serious adverse reactions and grade 3 adverse…
- Conditions
- Diphtheria, Tetanus, Pertussis
- Trial name
- NCT01933776
- Testing
- Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed Tdap
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Infections, Meningococcal
The Long-term Antibody Persistence of GSK Biologicals' Meningococcal Vaccine GSK134612 in Healthy Adolescents/Adults
In this study, the concentration of antibody to the vaccine one year, three and five years after vaccination in subjects who were vaccinated with GSK Biologicals' meningococcal vaccine GSK134612 and Menactra® in a previous study…
- Trial name
- NCT00715910
- Testing
- Nimenrix, Blood sampling
- Where
- 10 sites in United States
- Volunteers
- 818 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Haemoptysis
The Utility of Radiotherapy in the Management of Haemoptysis Secondary to Aspergillomata and Structural Lung Diseases
The sequelae of tuberculosis are still the commonest causes of haemoptysis in the developing world, where life-threatening haemoptysis remains a common and not infrequently fatal medical emergency.
- Trial name
- NCT02878447
- Testing
- External beam radiotherapy
- Where
- South Africa
- Volunteers
- 40 people
- Sponsor
- University of Stellenbosch
BCG Vaccination Reaction, Tuberculosis
A Study of GC3107(BCG Vaccine) in Healthy Infants
The purpose of this study is to investigate the efficacy and safety of GC3107 in healthy infants
- Trial name
- NCT03947138
- Testing
- GC3107, Intradermal BCG SSI inj.
- Where
- 2 sites in South Korea
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Green Cross Corporation
Cancer
Natural History Study of Fungal Infections of the Blood in Patients With Cancer or in Patients Who Have Undergone a Stem Cell Transplant
RATIONALE: Gathering information about how often fungal infections of the blood occur in patients with cancer or in patients who have undergone stem cell transplant may help doctors learn more about the disease.
- Trial name
- NCT00445952
- Testing
- clinical observation, management of therapy complications
- Where
- 5 sites in Belgium, France and 3 more
- Volunteers
- 304 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Cryptococcal Infection, Cryptococcal Pneumonia
Fungal Infection Susceptibility
The protocol will be carried out in accordance with International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) Good Clinical Practice (GCP) and the following United States Code of…
- Conditions
- Cryptococcal Infection, Cryptococcal Pneumonia, Pulmonary Cryptococcosis, Cryptococcal Meningitis
- Trial name
- NCT00001352
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Subarachnoid Hemorrhage, Pneumonia, Bacterial
Influence of Pneumonia on Delayed Cerebral Ischemia After Subarachnoid Hemorrhage . SAH-CIP (SubArrachnoid Hemorrhage - Cerebral Infarction Pneumonia)
Prognosis of subarachnoid hemorrhage (SAH) is scarce, indeed almost half patients die or become severely disable after SAH. Outcome is related to the severity of the initial bleeding and delayed cerebral infarction (DCI).
- Trial name
- SAH-CIP (NCT05094349)
- Where
- France
- Volunteers
- 224 people
- Sponsor
- University Hospital, Brest
CTCL/ Mycosis Fungoides
Diagnostic Classifier for Cutaneous T-cell Lymphomas
Primary cutaneous T-cell lymphomas (CTCL) are a form of skin cancer that is derived from immune cells. The most common form of CTCL is mycosis fungoides (MF).
- Trial name
- NCT04491825
- Testing
- Skin suction blistering and skin biopsies
- Where
- Austria
- Volunteers
- 160 people
- Sponsor
- Medical University of Vienna
Syphilis
Interventions for Enhancing Adherence to Syphilis Treatment and Follow-up: Study Protocol for the Health Information and Monitoring of Sexually Transmitted Infections (SIM) Randomized Controlled Trial
The SIM study is a single-centre, randomized, controlled trial with a 12-month follow-up period. The aim is to determine which of the 3 methods of follow-up is the most effective in promoting patient treatment compliance.
- Trial name
- SIM (NCT04753125)
- Testing
- follow-up by telephone, follow-up via a game in a smartphone app, conventional follow-up by a health professional
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Hospital Moinhos de Vento
Bacterial Infections
Study Evaluation Tazocin Intervention
This is an antibiotic intervention study to determine the value of using piperacillin/tazobactam in reducing the cases of ESBL producing E. coli or K. pneumoniae colonization and infection.
- Trial name
- NCT00488189
- Testing
- Tazocin (pipercillin/tazobactam)
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Anthrax, Bacillus Infections
Natural History of Anthrax: a Study of Primary Infected, Recovered, and Exposed Individuals (SPoRE); and Evaluation of AVA-Vaccinated Recipients
This study will examine pathophysiology and immune response of anthrax in infected or exposed individuals to learn more about the disease symptoms, prevention and response to treatment.
- Trial name
- NCT00050310
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis
Feasibility and Effectiveness of Community Based Isoniazid Preventive Therapy in Kenya
Isoniazid preventive therapy (IPT) is a well studied clinical intervention for primary and secondary prevention of active tuberculosis (TB) after infection with Mycobacterium tuberculosis.
- Trial name
- IPT (NCT00850915)
- Testing
- community IPT
- Where
- 18 sites in Kenya
- Volunteers
- 1,259 people, healthy volunteers welcome
- Sponsor
- KNCV Tuberculosis Foundation
Mycobacterium Infections, Nontuberculous
Diagnostic Accuracy of Nontuberculous Mycobacterial Lung Disease Based on Chest CT
The aim of this study was to elucidate the accuracy and inter-rater agreement of diagnosis of nontuberculous mycobacterial lung disease based on chest computed tomography findings.
- Trial name
- NCT02340897
- Volunteers
- 132 people
- Sponsor
- Seoul National University Hospital
Hidradenitis Suppurativa (HS)
Canadian Humira Post Marketing Observational Epidemiological Study : Assessing Humira Real-life Effectiveness and Impact on HS Burden of Illness
This study assesses Humira's® real-life effectiveness in the management of dermatological manifestations of moderate to severe Hidradenitis Suppurativa (HS).
- Trial name
- SOLACE (NCT02896920)
- Where
- 22 sites in Canada
- Volunteers
- 165 people
- Sponsor
- AbbVie
Clostridium Difficile Infection
Use of Bismuth Subsalicylate in Clostridium Difficile Colitis
Clostridium difficle infection is the leading cause of hospital acquired infection and infectious diarrhea in hospitalized patients.
- Trial name
- NCT03592082
- Testing
- Bismuth Subsalicylate, standard antibiotic therapy
- Where
- United States
- Sponsor
- Bassett Healthcare
HIV
Multiplex Microarray Chip-Based Diagnosis of Respiratory Infections
Respiratory infections have a high associated morbidity and mortality, especially in immunocompromised patients. To initiate effective treatment of respiratory infections, it is essential that a rapid and thorough laboratory…
- Trial name
- NCT01212042
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumonia, Pneumocystis Carinii, HIV Infections
A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral / Oral Trimethoprim - Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia in AIDS
This is a randomized double-blinded controlled study comparing aerosolized pentamidine with trimethoprim plus sulfamethoxazole (TMP / PurposeX).
- Trial name
- NCT00002056
- Testing
- Pentamidine isethionate
- Where
- United States
- Sponsor
- LyphoMed
Conjunctivitis, Bacterial
Efficacy of the Ophthalmic Pazufloxacin 0.6% for Bacterial Conjunctivitis, Compared to Gatifloxacin 0.3%.
Phase III clinical study of non-inferiority, multicenter, double-blind, with comparative group, of parallel groups and randomized. about a ophthalmic topical antibiotic for the treatment of bacterial conjunctivitis.
- Trial name
- PRO-157 (NCT03696342)
- Testing
- Pazufloxacin, Zymar
- Where
- 6 sites in Mexico
- Volunteers
- 46 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Partner Notification Following STI Diagnosis
Partner Notification Strategies for MSM in Peru
The goal of the proposed research is to assess new strategies for partner management and sexually transmitted infection (STI) control to reduce the spread of HIV-1 among men who have sex with men (MSM) in Latin America.
- Trial name
- NCT01720641
- Testing
- Internet, Referral Card, Internet and Referral Card
- Where
- Peru
- Volunteers
- 370 people
- Sponsor
- University of California, Los Angeles
Drug Resistant Tuberculosis, MDR-TB
Triage Test for All Oral DR-TB Regimen (TRiAD Study)
A Phase 4 operational study to assess the effectiveness, feasibility, acceptability, and cost effectiveness of the GeneXpert MTB/XDR (Xpert XDR; Cepheid) assay for rapid triage-and-treatment of DR-TB-A multi-centre, multi-country…
- Conditions
- Drug Resistant Tuberculosis, MDR-TB, XDR-TB, Tuberculosis
- Trial name
- NCT05175794
- Testing
- Xpert® MTB/XDR
- Where
- 4 sites in Ethiopia, Nigeria and 1 more
- Volunteers
- 786 people
- Sponsor
- Centre for the AIDS Programme of Research in South Africa
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