Clinical trials: Fungal Infections
Invasive Aspergillosis
Caspofungin Maximum Tolerated Dose in Patients With Invasive Aspergillosis
This study investigates the safety and tolerability as well as the efficacy and pharmacokinetics of caspofungin in four escalating dosages in adult patients with hematologic malignancies and proven or probable invasive…
- Trial name
- NCT00404092
- Testing
- caspofungin
- Where
- 4 sites in Belgium, Germany
- Volunteers
- 46 people
- Sponsor
- University of Cologne
Tuberculosis
Safety and Immunogenicity of Nyaditum Resae® Probiotic to Protect From Tuberculosis
This is a double-blind, masked, compared with placebo clinical trial in healthy volunteers with or without tuberculosis infection.
- Trial name
- NCT02076139
- Testing
- Nyaditum resae® 10e4, Nyaditum resae® 10e5, Distilled water
- Where
- Spain
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Manresana de Micobacteriologia, SL
HIV Infections
A Phase I Study of Safety and Immunogenicity of the WRAIR HIV-1 Vaccine
To evaluate the safety of LFn-p24 administered at three different doses with Alhydrogel given intramuscularly To evaluate immune responses to LFn-p24 with Alhydrogel at three different doses given intramuscularly
- Trial name
- NCT00412477
- Testing
- HIV LFn-p24
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Infections, Streptococcal
Primary Vaccination Course in Children Receiving the Pneumococcal Vaccine GSK 1024850A, Zilbrix™ Hib and Polio Sabin™
The purpose of this study is to assess the immunogenicity in terms of antibody response and the safety/reactogenicity in terms of solicited and unsolicited symptoms and serious adverse events following primary vaccination of…
- Trial name
- NCT00678301
- Testing
- GSK Biologicals' Synflorix™, GSK Biologicals' Polio Sabin™, GSK Biologicals' Zilbrix™ Hib
- Where
- 2 sites in Mali, Nigeria
- Volunteers
- 365 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
RSV, Tdap - Tetanus, Diphtheria and Acellular Pertussis Vaccination
Concurrent Versus Sequential Administration of Tdap and RSV Vaccines in Pregnancy
The goal of this clinical trial is to learn if the RSV vaccine (protects against respiratory syncytial virus) and Tdap vaccine (protects against pertussis) are most effective in pregnant individuals when taken together at the…
- Conditions
- RSV, Tdap - Tetanus, Diphtheria and Acellular Pertussis Vaccination, Pregnancy, Healthy
- Trial name
- CosTaR (NCT07097012)
- Testing
- Tdap Vaccine Administration, RSV Vaccine
- Where
- 4 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Canadian Immunization Research Network
Hidradenitis Suppurativa
Efficacy, Safety, and Tolerability of HB0043 in Hidradenitis Suppurativa Patients.
The purpose of this study is to assess efficacy safety and tolerability of HB0043 in adult patients with moderate to severe HS.
- Trial name
- HB0043-HS-0-01 (NCT06895499)
- Testing
- HB0043
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Shanghai Huaota Biopharmaceutical Co., Ltd.
Group A Streptococcal Infection
A Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-A1 in Healthy Young Adults
This is a phase 1, first-in-human, randomized, double-blind, placebo-controlled, dose-escalation study to evaluate the safety, tolerability, and immunogenicity of VAX-A1 in healthy adults 18-40 years of age.
- Trial name
- NCT07616934
- Testing
- VAX-A1 Low, VAX-A1 Mid, VAX-A1 High
- Where
- Australia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vaxcyte, Inc.
Abscesses, Furunculosis
The Natural History of Community-Associated MRSA Infections and Decolonization Strategies
The purpose of this study is to determine the natural history of community-associated Staphylococcus aureus infections in both adult and pediatric patients by monitoring the rate of recurrent infections in those colonized with S.
- Conditions
- Abscesses, Furunculosis, Staphylococcus Aureus, Staphylococcal Skin Infections
- Trial name
- StLStaRS (NCT00513799)
- Testing
- Mupirocin ointment, Chlorhexidine showers, Bleach baths (dilute)
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine
Clostridium Difficile Infection
SER-262 Versus Placebo in Adults With Primary Clostridium Difficile Infection to Prevent Recurrence
The study will involve administering a single dose of investigational drug or placebo in ascending dose cohorts. This study is designed to evaluate the safety and tolerability of investigational drug as well as the efficacy of…
- Trial name
- NCT02830542
- Testing
- SER-262
- Where
- 22 sites in United States
- Volunteers
- 96 people
- Sponsor
- Seres Therapeutics, Inc.
Buruli Ulcer, Mycobacterium Ulcerans Disease
Pathogenesis and Management of M. Ulcerans Disease, Buruli Ulcer
Buruli ulcer is a neglected tropical disease caused by infection with Mycobacterium ulcerans (Mu) in rural parts of West Africa. It causes large skin ulcers mainly in children aged 5 to 15 years.
- Trial name
- Buruli_Path (NCT02153034)
- Where
- 3 sites in Ghana
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Kwame Nkrumah University of Science and Technology
Mycoses
PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893)
This phase II study will be conducted to: 1. evaluate the pharmacokinetics, safety, tolerance, and efficacy of different dosing schedules of Posaconazole in immunocompromised hosts with a variety of refractory invasive fungal…
- Trial name
- NCT00034671
- Testing
- Posaconazole oral suspension
- Volunteers
- 98 people
- Sponsor
- Merck Sharp & Dohme LLC
Pneumonia
Pneumococcal Adult-dose Ranging Immunization Study
The purpose of this study is to give seniors different doses of a new pneumococcal vaccine called PCV7 to evaluate the safety of the vaccine and compare the immune response to find out which amount gives the best immune response.
- Trial name
- NCT00169234
- Testing
- PCV7, Prevnar®, Pneumovax 23
- Where
- 2 sites in United States
- Volunteers
- 220 people
- Sponsor
- Kaiser Permanente
Fournier Gangrene, Perianal Abscess
The Immunological Differences Between Fournier Gangrene and Perianal Abscess
Although it is rarely observed, necrotizing fasciitis progresses with high mortality and serious complications. Fournier's gangrene is a specific form of necrotizing fasciitis.
- Trial name
- NCT05529628
- Testing
- Cytokine levels
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Bacterial Infections
Prospective Study to Optimize Vancomycin Dosing in Children and Adults Using Computer Software
We will compare the percentage of patients having therapeutic vancomycin serum concentrations after current standard dosing, after dosing with our software. We will also include therapeutic outcomes and costs in the analysis.
- Trial name
- NCT01932034
- Testing
- BestDose Computer Software
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- Children's Hospital Los Angeles
Tuberculosis, Diagnoses Disease
Detection of Lipoarabinomannan in Urine Evaluation of the STANDARDTMF TBLAMFIA and Its Impact on the Initial TB Diagnosis
Evaluation of the performance of an in vitro test, the STANDARDTM F TB LAM Ag FIA (SD BIOSENSOR, INC.) for the early diagnosis of tuberculosis (TB) infection.
- Trial name
- uLAMTBFIA (NCT06306430)
- Testing
- STANDARDTM F TB LAM FIA
- Where
- Italy
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Ospedale San Raffaele
Streptococcal Infections
Rapid Strep Testing in Children With Recent Streptococcal Pharyngitis
The purpose of this study is to determine if the rapid antigen detection test for Group A streptococcal pharyngitis diagnosis might yield higher rates of false positive results in patients who have been treated for GAS…
- Trial name
- NCT03055728
- Testing
- Rapid strep antigen detection test, throat culture
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Georgetown University
HIV Infections, Tuberculosis
Drug Interaction Between Coartem® and Nevirapine, Efavirenz or Rifampicin in HIV Positive Ugandan Patients
There are increasing numbers of HIV-infected patients in sub-Saharan Africa receiving antiretroviral drugs and/or rifampicin based antituberculous therapy. HIV infected patients are at an increased risk of contracting malaria.
- Trial name
- NCT00620438
- Testing
- Lumefantrine-artemether and nevirapine, lumefantrine-artemether and efavirenz, Lumefantrine-artemether and rifampicin
- Where
- Uganda
- Volunteers
- 90 people
- Sponsor
- Makerere University
Mucormycosis
Rehabilitation With an Obturator in Maxillary Defects
During the COVID-19 pandemic, there was a lot of reporting of COVID-19-associated mucormycosis cases. Managing this condition posed a new challenge to clinicians.
- Trial name
- NCT06515743
- Testing
- Obturator Prosthetic Rehabilitation
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Menoufia University
Staphylococcal Infection
Uncomplicated Skin and Soft Tissue Infections Caused by Community-Associated Methicillin-Resistant Staphylococcus Aureus
The purpose of this clinical trial is to evaluate 2 different antibiotics, drugs that fight bacteria, [clindamycin (CLINDA) and trimethoprim-sulfamethoxazole (TMP-SMX)] and wound care for the outpatient management of…
- Trial name
- NCT00730028
- Testing
- Trimethoprim-sulfamethoxazole, Clindamycin
- Where
- 6 sites in United States
- Volunteers
- 1,310 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Febrile Illness, Pneumococcal Infections
Immunogenicity and Safety PCV-20 of the Vaccine Administered During an Acute Febrile Illness in Adults
Streptococcus pneumoniae is responsible for serious infections associated to numerous hospitalizations and high rate of mortality.
- Trial name
- PREV-HOSPIT (NCT06822907)
- Testing
- Early intervention, Delayed intervention
- Where
- 24 sites in France
- Volunteers
- 1,052 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
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