Clinical trials: Fungal Keratitis
Corneal Ulcer, Infectious Keratitis
Cross-linking for Corneal Ulcers Treatment Trial
The primary purpose of this study is to determine if patients randomized to corneal collagen cross-linking plus medical therapy will have a lower prevalence of positive bacterial or fungal cultures immediately after the procedure…
- Conditions
- Corneal Ulcer, Infectious Keratitis, Bacterial Ulcer, Fungal Ulcer
- Trial name
- CLAIR (NCT02570321)
- Testing
- Corneal Cross-linking, Anti Fungal Drug
- Where
- 2 sites in United States, India
- Volunteers
- 147 people
- Sponsor
- University of California, San Francisco
Corneal Ulcer, Fungal Keratitis
Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers
Mycotic Antimicrobial Localized Injection (MALIN) is a randomized, masked, two-arm clinical trial investigating intrastromal voriconazole in the treatment of fungal corneal ulcers.
- Trial name
- MALIN (NCT02731638)
- Testing
- Intrastromal voriconazole, Natamycin
- Where
- 2 sites in United States, India
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Fungal Keratitis, Corneal Ulcer
Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A
The goal of this clinical trial is to learn if adjunctive topical Cyclosporine A eye drops combined with standard of care topical Natamycin treatment improves vision outcomes in patients with fungal keratitis.
- Trial name
- FANCY (NCT06658002)
- Testing
- Cyclosporine A
- Where
- 2 sites in United States, India
- Volunteers
- 150 people
- Sponsor
- University of California, San Francisco
Keratitis, Automatic Judgement
Deep Learning for the Discrimination Among Different Types of Keratits: a Nationwide Study
Detecting the cause of keratitis fast is the premise of providing targeted therapy for reducing vision loss and preventing severe complications.
- Conditions
- Keratitis, Automatic Judgement, Image
- Trial name
- NCT05538793
- Where
- 2 sites in China
- Volunteers
- 10,369 people
- Sponsor
- Ningbo Eye Hospital
Corneal Ulcer, Eye Infections, Fungal
Mycotic Ulcer Treatment Trial I
The purpose of this study is to determine if natamycin or voriconazole results in better visual outcomes in fungal corneal ulcers, especially visual acuity.
- Trial name
- MUTT I (NCT00996736)
- Testing
- Natamycin, Voriconazole
- Where
- 3 sites in United States, India
- Volunteers
- 323 people
- Sponsor
- University of California, San Francisco
Infection, Fungal
Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis
OBJECTIVE To evaluate the efficacy and safety of the concurrent treatment of 5% Natamycin and 1% Voriconazole in patients affected by fungal keratitis METHODS AND MATERIALS STUDY POPULATION Patients with smear and or culture…
- Trial name
- NATA_VORI (NCT03230058)
- Testing
- Group 1 Natamycin 5% Suspension + voriconazole 1% eye drops; Group 2 Natamycin 5% Suspension + Vehicle eye drops
- Where
- India
- Volunteers
- 55 people
- Sponsor
- L.V. Prasad Eye Institute
Safety, Efficacy
Intrastromal Injection of Fluconazole in Treatment of Fungal Keratitis
This study aimed to evaluate the Safety and the Effectiveness of Intrastromal Injection of Fluconazole in The Treatment of Fungal Keratitis.
- Conditions
- Safety, Efficacy, Intrastromal Injection, Fluconazole
- Trial name
- NCT07557966
- Testing
- Topical fluconazole eye drops, Intrastromal injection of fluconazole
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Acanthamoeba Keratitis, Fungal Keratitis
Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction
Rose Bengal Electromagnetic Activation with Green light for Infection Reduction (REAGIR ) is an international, randomized, doubled masked, clinical trial.
- Trial name
- REAGIR (NCT05110001)
- Testing
- Moxifloxacin Ophthalmic, Chlorhexidine Gluconate, Natamycin
- Where
- 2 sites in Brazil, India
- Volunteers
- 330 people
- Sponsor
- University of California, San Francisco
Bacterial Keratitis, Fungal Keratitis
The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study
This study is an observational prospective cohort study which aims to generate an antibiogram and to assess the clinical responses and outcomes of microbial keratitis patients, treated with empiric topical antimicrobial…
- Conditions
- Bacterial Keratitis, Fungal Keratitis, Mixed Bacterial and Fungal Keratitis, Microbial Keratitis
- Trial name
- NCT05655689
- Testing
- Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Ceftazidime 5% + vancomycin 5%, Gentamicin 1.4% + vancomycin 5%
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Alexandria University
Infective Keratitis
Microbial Keratitis in Cairo University Hospitals
The aim of the study was to identify the incidence of infective keratitis presenting to the ophthalmology emergency department at Cairo University hospital, the risk factors and the bacterial/fungal spectrum causing the ulcers…
- Trial name
- NCT05387993
- Where
- Egypt
- Volunteers
- 85 people
- Sponsor
- Kasr El Aini Hospital
Fungal Keratitis
A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine
The purpose of this study is to determine the effectiveness of 1.25% povidone-iodine ophthalmic solution for the treatment of small to medium sized fungal corneal ulcers compared with an antifungal antibiotic.
- Trial name
- NCT00516399
- Testing
- povidone-iodine 1.25% ophthalmic solution, natamycin ophthalmic suspension, USP 5%
- Volunteers
- 78 people
- Sponsor
- University of California, Los Angeles
Fungal Keratitis
Trial to Evaluate the Efficacy And Safety of IVIEW-1201 In the Treatment of Fungal Keratitis
A Phase II, Multi-center, Randomized, Masked, Parallel-Control Study to Evaluate the Clinical Efficacy and Safety of IVIEW-1201 (1.0% PVP-Iodine) Gel Forming Ophthalmic Solution in the Treatment of Fungal Keratitis.
- Trial name
- NCT06463678
- Testing
- IVIEW-1201, NATACYN®
- Volunteers
- 60 people
- Sponsor
- IVIEW Therapeutics Inc.
Infectious Keratitis, Bacterial Keratitis
Collagen Cross-linking in Infectious Keratitis Trial
The purpose of this study is to evaluate the efficacy of collagen cross-linking for treatment of infectious keratitis.
- Conditions
- Infectious Keratitis, Bacterial Keratitis, Fungal Keratitis
- Trial name
- NCT01831206
- Testing
- Collagen cross-linking
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Keratitis Bacterial, Keratitis Fungal
Validation of Interleukins and Other Cytokines Together With OCT Imaging for Rapid Infectious Keratitis Assessment
As conventional corneal scraping with bacterial culturing has several disadvantages such as long duration until diagnosis, invasiveness and lacks alternatives, there is demand for a novel non-invasive, rapid test in keratitis…
- Trial name
- VICTORIA (NCT05620264)
- Testing
- Tear Sample Probe
- Where
- Austria
- Volunteers
- 392 people
- Sponsor
- Johannes Kepler University of Linz
Corneal Ulcer, Eye Infections, Fungal
The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo
The purpose of this study is to determine if the addition of oral voriconazole to topical treatment regimens results in lower rates of perforation in severe fungal corneal ulcers.
- Trial name
- MUTTII (NCT00997035)
- Testing
- Voriconazole
- Where
- 7 sites in United States, India and 1 more
- Volunteers
- 240 people
- Sponsor
- University of California, San Francisco
Bacterial Keratitis, Fungal Keratitis
Safety and Efficacity of Corneal Collagen Crosslinking in Infectious Keratitis (Bacterial and Fungal ): Randomized,Controlled, Prospective Study. (CXL)
The corneal collagen cross linking is currently used in the treatment of keratoconus but this procedure has also a sterilizing non-specific effect on bacteria and fungus.
- Trial name
- CXL (NCT02088970)
- Testing
- Crosslinking, antibiotic treatment
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Nantes University Hospital
Infective Keratitis
Infective Keratitis in Minia Governate
The purpose of the study is to determine the microbiological aetiology, epidemiological factors, and clinical profile and treatment outcomes of infective keratitis in Ophthalmology department, Minia University. Egypt
- Trial name
- NCT04894630
- Testing
- antimicrobial treatment
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Minia University
Mycotic Corneal Ulcer
Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis
The study is a randomised control trial to assess the visual and clinical outcomes of collagen cross linking in fungal keratitis.
- Trial name
- NCT02328053
- Testing
- collagen crosslinking group, Topical anti-fungal therapy
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Aravind Eye Care System
Keratitis
Efficacy of Mutilayered Fresh Amnoitic Membrane Transplantation in Resistant Fungal Keratitis
Corneal infection or infectious keratitis (IK) is the most common cause of corneal blindness worldwide, particu-larly in the developing countries1. The incidence was estimated at 2.5-799 per 100,000 population/year.
- Trial name
- NCT06070883
- Testing
- Amniotic membrane transplantation
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Al-Azhar University
Treatment
UVX as an Adjuvant in the Treatment of Fungal Keratitis
In this study, investigators want to find the effect of adjuvant collagen cross-linking in the treatment of fungal keratitis
- Trial name
- NCT03138785
- Testing
- topical voriconazole / levofloxacin systemic itraconazole, CXL
- Volunteers
- 20 people
- Sponsor
- Farabi Eye Hospital