Clinical trials: Fungal Keratitis
Corneal Ulcer, Infectious Keratitis
Cross-linking for Corneal Ulcers Treatment Trial
The primary purpose of this study is to determine if patients randomized to corneal collagen cross-linking plus medical therapy will have a lower prevalence of positive bacterial or fungal cultures immediately after the procedure…
- Conditions
- Corneal Ulcer, Infectious Keratitis, Bacterial Ulcer, Fungal Ulcer
- Trial name
- CLAIR (NCT02570321)
- Testing
- Corneal Cross-linking, Anti Fungal Drug
- Where
- 2 sites in United States, India
- Volunteers
- 147 people
- Sponsor
- University of California, San Francisco
Corneal Ulcer, Fungal Keratitis
Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers
Mycotic Antimicrobial Localized Injection (MALIN) is a randomized, masked, two-arm clinical trial investigating intrastromal voriconazole in the treatment of fungal corneal ulcers.
- Trial name
- MALIN (NCT02731638)
- Testing
- Intrastromal voriconazole, Natamycin
- Where
- 2 sites in United States, India
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Corneal Ulcer, Eye Infections, Fungal
Mycotic Ulcer Treatment Trial I
The purpose of this study is to determine if natamycin or voriconazole results in better visual outcomes in fungal corneal ulcers, especially visual acuity.
- Trial name
- MUTT I (NCT00996736)
- Testing
- Natamycin, Voriconazole
- Where
- 3 sites in United States, India
- Volunteers
- 323 people
- Sponsor
- University of California, San Francisco
Acanthamoeba Keratitis, Fungal Keratitis
Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction
Rose Bengal Electromagnetic Activation with Green light for Infection Reduction (REAGIR ) is an international, randomized, doubled masked, clinical trial.
- Trial name
- REAGIR (NCT05110001)
- Testing
- Moxifloxacin Ophthalmic, Chlorhexidine Gluconate, Natamycin
- Where
- 2 sites in Brazil, India
- Volunteers
- 330 people
- Sponsor
- University of California, San Francisco
Corneal Ulcer, Eye Infections, Fungal
The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo
The purpose of this study is to determine if the addition of oral voriconazole to topical treatment regimens results in lower rates of perforation in severe fungal corneal ulcers.
- Trial name
- MUTTII (NCT00997035)
- Testing
- Voriconazole
- Where
- 7 sites in United States, India and 1 more
- Volunteers
- 240 people
- Sponsor
- University of California, San Francisco
Fungal Keratitis
Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer
We evaluated whether voriconazole is a superior treatment to natamycin for filamentous fungal keratitis in a randomized, masked, controlled trial.
- Trial name
- MUTT_TE (NCT00557362)
- Testing
- Natamycin 5%, Voriconazole, Corneal de-epithelialization
- Where
- 2 sites in India
- Volunteers
- 120 people
- Sponsor
- University of California, San Francisco