Clinical trials: GAD
Secondary Progressive Multiple Sclerosis
Comparison of Clinical Effects of Rituximab and Glatiramer Acetate in Secondary Progressive Multiple Sclerosis Patients
The purpose of this study is to compare expanded disability status scale, annualized relapse rate, Gad-enhanced brain lesions, and side effects after administration of rituximab and glatiramer acetate among patients with active…
- Trial name
- NCT03315923
- Testing
- Rituximab, Glatiramer Acetate
- Where
- Iran
- Volunteers
- 84 people
- Sponsor
- Isfahan University of Medical Sciences
Anxiety
Probiotics for Anxiety Study
The purpose of this study is to observe the effect of a consumer-grade probiotic capsule called GABA (gamma-aminobutyric acid ) Probiotic ("Study Product"), a probiotic capsule containing Lactiplantibacillus plantarum 815, on…
- Trial name
- NCT06466603
- Testing
- GABA Probiotic Dose 1, GABA Probiotic Dose 2
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Verb Biotics LLC
Generalized Anxiety Disorder
A Study to Evaluate Efficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained-release Tablets in Generalized Anxiety Disorder.
The study aims to evaluate the efficacy and safety of Toludesvenlafaxine Hydrochloride Sustained-release Tablets compared to placebo in adults participants with generalized anxiety disorder over a period of 8 weeks.
- Trial name
- NCT05970510
- Testing
- Toludesvenlafaxine Hydrochloride Sustained-release Tablet 80mg, Toludesvenlafaxine Hydrochloride Sustained-release Tablet 160mg
- Where
- China
- Volunteers
- 555 people
- Sponsor
- Luye Pharma Group Ltd.
Depression, Generalized Anxiety
The Impact of Information Sources on Mental Health During the COVID-19 Pandemic
Study description: The present study seeks to investigate the impact of various sources of information on psychopathology, and specifically health anxiety, depression, and general anxiety, during the COVID-19 pandemic.
- Conditions
- Depression, Generalized Anxiety, Health Anxiety
- Trial name
- NCT04442360
- Testing
- Prospective study with two measurement points investigating the impact of viral mitigation protocols on mental health
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Generalized Anxiety Disorder, Panic Disorder
Treatment of Late-life Anxiety in Primary Care Settings
The research study proposed is designed to examine the outcomes of a cognitive behavioral guided self-care intervention with older adults diagnosed with generalized anxiety disorder and recruited from a primary care setting.
- Conditions
- Generalized Anxiety Disorder, Panic Disorder, Anxiety Disorder Not Otherwise Specified
- Trial name
- NCT00938093
- Testing
- Cognitive behavioral therapy, Enhanced usual care
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
Anxiety Disorders
Effectiveness of Long-Term Versus Short-Term Treatment of Generalized Anxiety Disorder With Venlafaxine XR
This study will assess the effectiveness of venlafaxine XR, randomized to either venlafaxine XR or placebo in preventing the relapse of generalized anxiety disorder after 6 months of treatment versus 12 months of treatment.
- Trial name
- NCT00183274
- Testing
- Venlafaxine XR
- Where
- United States
- Volunteers
- 268 people
- Sponsor
- University of Pennsylvania
Anxiety Generalized, Quality of Life
A Problem Solving Intervention for Hospice Caregivers
Hospice care is conceptualized as quality compassionate care for people facing a life-limiting illness, with services that cover clinical care, pain management, and emotional and spiritual support tailored to patients' and…
- Conditions
- Anxiety Generalized, Quality of Life, Depression
- Trial name
- NCT03712410
- Testing
- PISCES
- Where
- United States
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- George Demiris, PhD
Generalized Anxiety Disorder, Oxygenation Sensitive CMR
BreathinG-induced Myocardial and Cerebral Perfusion in Anxiety Disorders
This study aims to view variations in MRI measurements of the heart and the brain in people with anxiety versus healthy volunteers.
- Trial name
- B-GLAD (NCT05574140)
- Testing
- Cardiac MRI
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Generalized Anxiety Disorder
A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (2)
This is a 10-week trial that evaluates the efficacy and safety of PD 0332334 in subjects, ages 18 to 65, with generalized anxiety disorder.
- Trial name
- NCT00658372
- Testing
- PD 0332334, Paroxetine
- Where
- 33 sites in United States, Hungary and 2 more
- Volunteers
- 360 people
- Sponsor
- Pfizer
Generalized Anxiety Disorder, Panic Disorder
Neural Functioning Underlying Anxiety and Its Treatment (The INSULA Study)
This study will examine the effects of cognitive behavioral therapy on brain function in people with anxiety disorders.
- Conditions
- Generalized Anxiety Disorder, Panic Disorder, Anxiety Disorders
- Trial name
- NCT00947570
- Testing
- Cognitive behavioral therapy for anxiety
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obsessive-Compulsive Disorder, Generalized Anxiety Disorder
Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive Thoughts
The investigators are conducting this study to learn more about the cognitive and attentional processes among individuals with three types of repetitive negative thinking (RNT): mental rituals (as seen in obsessive compulsive…
- Conditions
- Obsessive-Compulsive Disorder, Generalized Anxiety Disorder, Major Depressive Disorder
- Trial name
- NCT04225624
- Testing
- Emotion Regulation Therapy - Attention Regulation (AR-ERT), Supportive Psychotherapy (SPT)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital
Acute Coronary Syndrome, Heart Failure
Pragmatic Collaborative Care for Cardiac Inpatients With Depression or Anxiety
The investigators will complete a pragmatic randomized trial (N=260 randomized participants) of the 26-week blended collaborative care (CC) intervention compared to enhanced usual care (eUC) in patients admitted for acute…
- Conditions
- Acute Coronary Syndrome, Heart Failure, Depression, Generalized Anxiety Disorder
- Trial name
- NCT03118752
- Testing
- Collaborative Care
- Where
- 3 sites in United States
- Volunteers
- 290 people
- Sponsor
- Massachusetts General Hospital
Anxiety, Depression
Community Applications of the MindShift App
Despite considerable, replicated evidence of the efficacy and effectiveness of cognitive behavioural therapy, there is an insufficient number of professionals (e.g., psychologists, psychiatrists) in North America to provide…
- Conditions
- Anxiety, Depression, Anxiety Generalized, Anxiety Disorders and Symptoms
- Trial name
- NCT04562948
- Where
- Canada
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of Windsor
Bipolar Disorder, Panic Disorder
Quetiapine SR and Divalproex Sodium ER in the Treatment of Anxiety in Bipolar Disorder With Panic Disorder and/or GAD
The specific aim of this study is to evaluate the efficacy, tolerability, and safety of quetiapine SR monotherapy and divalproex sodium ER monotherapy in comparison to placebo in the treatment of ambulatory bipolar disorder with…
- Conditions
- Bipolar Disorder, Panic Disorder, Generalized Anxiety Disorder
- Trial name
- NCT00579280
- Testing
- quetiapine SR, divalproex sodium ER
- Where
- 3 sites in United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Mental Disorders, Mood Disorders
Group Transdiagnostic Cognitive Behavioural Therapy for Intolerance of Uncertainty Versus Applied Relaxation
Many people find uncertainty distressing, but for some, it may become overwhelming and drive persistent anxiety, worry, and avoidance.
- Conditions
- Mental Disorders, Mood Disorders, Anxiety Disorders, Generalized Anxiety Disorder
- Trial name
- OBSCURA (NCT07866794)
- Testing
- Group Transdiagnostic Cognitive Behavioural Therapy for Intolerance of Uncertainty (CBT-IU), Group Transdiagnostic Applied Relaxation (AR)
- Where
- United Kingdom
- Volunteers
- 135 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Generalized Anxiety Disorder
Therapeutic Massage for Generalized Anxiety Disorder
The purpose of this study is to compare the relative effectiveness of three relaxation treatments (therapeutic massage, thermotherapy, and time in a relaxing environment) in reducing anxiety in persons with Generalized Anxiety…
- Trial name
- CALM (NCT00515242)
- Testing
- massage, thermotherapy, relaxing environment
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Kaiser Permanente
Anxiety Disorder
Experimental Medication For the Treatment of Generalized Anxiety Disorder
The purpose of this study is to determine whether an experimental anti-anxiety medication is effective in the treatment of Generalized Anxiety Disorder.
- Trial name
- NCT00097708
- Testing
- experimental anti-anxiety drug
- Where
- 50 sites in United States
- Volunteers
- 511 people
- Sponsor
- Jazz Pharmaceuticals
Generalized Anxiety Disorder
Locating Regions of Interest in Generalized Anxiety Disorder Using Function Magnetic Resonance Imaging (fMRI)
The investigators are seeking to locate the brain regions of interest in generalized anxiety disorder (GAD) using both structural (sMRI) and functional magnetic resonance imaging (fMRI).
- Trial name
- fMRI (NCT01607710)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Generalized Anxiety Disorder
Pharmacokinetic Study of Buagafuran Capsules in Participants With Hepatic Impairment and Normal Hepatic Function
This study adopts a non-randomized, open label, parallel, single-dose design to evaluate the safety and pharmacokinetic characteristics of Buagafuran capsules in participants with hepatic impairment.
- Trial name
- NCT07457190
- Testing
- Buagafuran
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Beijing Union Pharmaceutical Factory Ltd
Anxiety Disorder
A Long-Term Study Continuing on From Study 04-001-01 of an Experimental Medication in Adults With Anxiety Disorder
The purpose of the study is to assess the safety and effectiveness of the experimental drug, a benzodiazepine drug, in long-term use and the effects on quality of life, social and occupational functioning, sleep, and daytime…
- Trial name
- NCT00106860
- Testing
- a benzodiazepine drug
- Where
- 13 sites in United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Jazz Pharmaceuticals