Clinical trials: GASTROINTESTINAL NEOPLASMS
Pancreas Cancer
A Decision Support Tool for Pancreatic Cancer Screening -Aim 2
Pancreatic cancer has a rising incidence and poor survival. Early detection in high-risk individuals may substantially improve outcomes.
- Trial name
- NCT07808671
- Testing
- Electronic Decision Support Tool
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Colorectal Cancer, Adenomatous Polyps
Liquid Biopsy Based Multiomics Study for Colorectal Cancer Early Screening
The primary objective is to determine the diagnostic sensitivity and specificity of the newly developed liquid biopsy based multiomics Colorectal Cancer (CRC) screening test (CRC-Appareo) for detecting advanced neoplasia…
- Conditions
- Colorectal Cancer, Adenomatous Polyps, Adenoma, Advanced Adenoma
- Trial name
- COLO-LIMULOID (NCT06258434)
- Testing
- multiomics Colorectal Cancer (CRC) screening test (CRC-Appareo)
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Stomach Neoplasms, Stomach Cancer
Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer
Background: Gastric cancers are cancers of the stomach. Hereditary ones are passed from parent to child. Researchers want to gather data about hereditary gastric cancers.
- Conditions
- Stomach Neoplasms, Stomach Cancer, Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS), Hereditary Diffuse Gastric Cancer (HDGC)
- Trial name
- NCT03030404
- Where
- United States
- Volunteers
- 733 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer
Colorectal Cancer Screening French Organizations for the Follow-up After Colonoscopy
France is one of the European countries where the incidence of colorectal cancer is the highest among cancers for both sexes. Fecal occult blood screening has been implemented since 2008.
- Trial name
- Tempo-colo (NCT03383367)
- Testing
- Tempo Colo
- Where
- France
- Volunteers
- 33,000 people, healthy volunteers welcome
- Sponsor
- Association pour le Dépistage Organisé des Cancers dans le Rhône
Colonic Neoplasms
Yoga and Bolus Lukewarm Saline as Rapid Colonoscopy Preparation
A quality colonoscopy examination remains as the gold standard for colorectal cancer screening, but effective large bowel cleansing prior to colonoscopy is still not achieved in all cases that undergo the procedure.
- Trial name
- NCT01547130
- Testing
- Normal (0.9%) saline, HalfLytely
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Arya, Vijaypal, M.D., P.C.
Quality of Life
Impact of Different Carbohydrate Feedings on a Hydrogen Breath Curve and Self-reported Gastrointestinal Complaints
GI distress is widely prevalent among athletes, ranging from 30 to 90% in recreationally and professionally active athletes. As the recipient of nutrients, the gastrointestinal (GI) tract plays an important role in athleticism.
- Trial name
- NCT06648967
- Testing
- Supplementation with a multi-ingredient whey supplement
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Liver Neoplasms, Hepatitis B
Lay Health Worker Model to Reduce Liver Cancer Disparities in Asian Americans
The study was conducted between April 2013 and October 2014. In the parent study, 600 foreign-born Asian American adults 18 years of age and older were drawn from the community in the Baltimore Washington Metropolitan Area.
- Trial name
- LHWAA (NCT02760537)
- Testing
- Lay Health Worker Intervention
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Colon Cancer
TVB 2640 for Resectable Colon Cancer Other Resectable Cancers; a Window Trial.
Primary Objective To evaluate the pharmacodynamic effects on metabolic endpoints (malonyl carnitine and tripalmitin levels) following short-term treatment with TVB-2640 in patients with resectable cancers Secondary Objectives To…
- Trial name
- NCT02980029
- Testing
- TVB-2640
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Mark Evers
Colorectal Cancer, Advanced Adenocarcinoma
A Prospective, Multi-center, Observational Study for Signal-C Test Evaluation
To evaluate the performance characteristics of Signal-C™ a plasma circulating free-DNA test, to detect colorectal cancer and advanced precancerous lesions (APL) in an average risk screening population for 45 and over.
- Trial name
- NCT06059963
- Testing
- Signal-C™
- Where
- United States
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Universal Diagnostics
Esophageal Neoplasms
Pronase Improves Efficacy of Chromoendoscopy Screening on Esophageal Cancer
Lugol's solution staining was regarded as a gold standard to detect early superficial lesion during esophageal cancer screening using endoscopy.
- Trial name
- NCT02030769
- Testing
- Pronase, Control
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Lung Cancer, Breast Cancer
Large Language Models Assist in Tumor MDT
Multidisciplinary teams (MDTs) represent the gold standard for personalized tumor treatment, but they are limited by medical resources and accessibility Limitation.
- Conditions
- Lung Cancer, Breast Cancer, Colorectal Cancer, Stomach Cancer
- Trial name
- NCT07504367
- Testing
- LLM assists in MDT report writing
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Gastrointestinal Neoplasms
Intervention to Motivate Standing &Walking in Gastrointestinal Cancer Surgical Patients
Observational research has linked physical activity with faster recovery, improved quality of life, and greater survival; however, little is known about the effects of physical activity in pre-operative, peri-operative, or…
- Trial name
- NCT01982994
- Testing
- Education/Daily Planning
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Colon Cancer
A Prospective Study of a New Immunochemical Fecal Occult Blood Test in U.S. Veteran Patients Undergoing Colonoscopy
The purpose of our study is to evaluate the diagnostic validity of a new immunofecal occult blood test (IFOBT) (Teco Diagnostics) in U.S. veterans and to compare it with the guaiac based FOBT.
- Trial name
- NCT00533975
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Metastatic Cancer, Foregut Carcinoid Tumor
Study Comparing Standard of Care Chemotherapy With/ Without Sequential Cytoreductive Surgery for Patients With Metastatic Foregut Cancer and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid Levels
This study is designed for participants who have cancer of the upper gastrointestinal (GI) tract such as cancer of the esophagus, stomach, duodenum (the initial portion of your small intestine), pancreas, bile duct…
- Conditions
- Metastatic Cancer, Foregut Carcinoid Tumor, Gastric Adenocarcinoma, Gallbladder Adenocarcinoma
- Trial name
- NCT04931420
- Testing
- Standard of Care Chemotherapy, Video-Assisted Thoracic Surgery (VATS), Lobectomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Metastatic Pancreatic Cancer
Nab-paclitaxel and Gemcitabine in Metastatic Pancreatic Cancer
This is a single arm, open-label Phase II clinical trial to Evaluate the Efficacy and Safety of the Combination of Nab-paclitaxel and Gemcitabine in Treating Patients with metastatic pancreatic cancer.
- Trial name
- NCT03929094
- Testing
- Paclitaxel for Injection（Albumin Bound）, Gemcitabine
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fudan University
Chronic Pancreatitis, Pancreatic Cancer
Immune Repertoire Decoding for Chronic Pancreatitis-to-Pancreatic Cancer Risk Stratification
This study will follow people with chronic pancreatitis, people with pancreatic cancer, and healthy volunteers. The goal is to better understand why some people with chronic pancreatitis may later develop pancreatic cancer.
- Trial name
- NCT07612566
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Cirrhosis of the Liver
Composition for Treating Cirrhosis and Liver Cancer (SB-1121)
The composition treats cirrhosis and hepatocellular carcinoma (Hcc) at an early stage. The product is extracted from herbs, including Adenosma glutinosum extract, Eclipta prostrata extract, Phyllanthus urinaria extract, Impatiens…
- Trial name
- SB-1121 (NCT05178303)
- Testing
- SB-1121(1), SB-1121(2)
- Where
- 2 sites in United States, Vietnam
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Nguyen Thi Trieu, MD
Colonic Polyp, Colonic Diseases
Optical Polyp Testing for In Vivo Classification
Small growths detected in the colon (polyps) during a colonoscopy may or may not have the potential to develop into cancer. However, since visual inspection alone cannot separate all potentially harmful polyps from harmless ones…
- Conditions
- Colonic Polyp, Colonic Diseases, Colonic Neoplasms, Colonic Adenoma
- Trial name
- OPTIC (NCT03139942)
- Testing
- Optical spectral reflectance and autofluorescence imaging
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Gastric Cancer
Study on the Value of Three DWI Scanning Sequences in Staging of Gastric Cancer
Accurate staging is critical for effective gastric cancer treatment planning. Conventional DWI (C-DWI) has limitations in image quality due to magnetic field inhomogeneity, which hampers precise T staging.
- Trial name
- NCT06735105
- Testing
- Scanning parameter
- Where
- China
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Yunnan Cancer Hospital
GERD, Barretts Esophagus
In Vivo Anatomy, Physiology, Mechanics and Function of the Lower Esophageal Sphincter
The purpose of this study is: To study the components of the gastroesophageal junction high-pressure zone individually and as a group, by pharmacologically eliminating or accentuating the pressure profile generated by the smooth…
- Trial name
- NCT00737802
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Northwell Health
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