Clinical trials: GENE EXPRESSION
Hypoglycemia, Hyperglycemia
Influence of Dietary Fiber-rich Meals on Gene Expression and Postprandial Glucose and Lipid Response
The aim of this study is to Measure the effect on gene expression in leukocytes from a meal rich in oat bran Investigate the postprandial glucose, insulin and triglyceride responses after intake of meals containing fiber from…
- Trial name
- NCT01005342
- Testing
- Oat bran, Spray-dried oat drink, Rye bran
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Lund University
Multiple Sclerosis
Expression of PARP-1 in Multiple Sclerosis Patients
This study will explore the expression of PARP-1 in optic neuritis of multiple sclerosis patients. The data will be collected from Sohag University hospital in the period from the start of August 2021 to the end of December 2021.
- Trial name
- NCT05196425
- Testing
- Blood sampling
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Healthy, Asthma
Study to Examine the Cytokine Levels, Gene Expression and Safety of a Single Nasal Dose of JNJ-43260295, in Healthy Participants, and Atopic Participants With Mild to Mild-Persistent Asthma
The purpose of this study is to investigate the cytokine levels in nasal lavage and gene expression in nasal scraping following a single nasal dose of JNJ-43260295 in healthy participants, and in atopic mild to mild-persistent…
- Trial name
- NCT02243189
- Testing
- JNJ-43260295, Nasal Allergen Challenge
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Pregnancy, Infertility
The Expression of IL-15 and Its Receptor in Decidua
Human decidual tissue appears to play an important role not only in nurturing the implanted embryos, but also in preventing its rejection by the maternal immune system.
- Trial name
- NCT00173758
- Testing
- co-culture of embryos and endometrial cells
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Breast Milk Collection
Factors Influencing the Composition of Human Milk
This study aims for characterization of different maternal, infant and environmental factors (e.g. maternal age, pregnancy duration, lactation period, baby gender, circadian rhythm, Holder pasteurisation, etc.) that influence…
- Trial name
- NCT04382989
- Testing
- Analysis of human milk composition by mid-infrared spectrophotometry
- Where
- Lithuania
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Vilnius University
Parkinson
The Effect of Deep Brain Stimulation on Facial Expressions.
Whether Subthalamic Nucleus (STN) Deep Brain Stimulation (DBS), a treatment commonly used to ameliorate the motor symptoms of Parkinson's disease (PD), affects on facial expressions is unclear.
- Trial name
- STN-DBS (NCT03558568)
- Testing
- Deep Brain Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Healthy Volunteers
A First-In-Human Study With a Single Ascending Dose of UCB7858 in Healthy Volunteers
This study is designed to evaluate the safety and tolerability of UCB7858 when given as single ascending doses administered by intravenous or subcutaneous infusion in healthy subjects.
- Trial name
- NCT02879877
- Testing
- UCB7858
- Where
- United Kingdom
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- UCB Biopharma S.P.R.L.
Overweight and Obesity
Effectiveness of a Precision Diet Based on Gene Expression Versus a Personalized Mediterranean-Style Diet in Weight Loss
The present randomized controlled trial aims to evaluate the relationship between gene expression profiling and the response to a precision diet compared to a personalized Mediterranean-style diet (control diet) in metabolically…
- Trial name
- NCT06435325
- Testing
- Precision diet, Control diet
- Where
- Spain
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Pregnancy Related, Hypothyroidism
TSHβX1 and D2 THR92ALA in Pregnancy
Thyroid diseases are pathologies that frequently affect pregnant women causing serious complications. This current research aims to find out whether the expression of TSHβX1 splice variant and D2 Thr92Ala polymorphism in the DIO2…
- Conditions
- Pregnancy Related, Hypothyroidism, Hyperthyroidism
- Trial name
- NCT03612908
- Where
- Mexico
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Materno-Perinatal Hospital of the State of Mexico
Inflammation, Oxidative Stress
An Evaluation of Zinc Status Biomarkers
The purpose of this study is to determine the effect of a moderate decrease in dietary zinc on DNA strand breaks and other cellular zinc biomarkers.
- Trial name
- NCT02861352
- Testing
- Diet zinc
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Gene Expression, Metabolomics
Gene Expression Monitoring of Mononuclear Cells (MNC) Subpopulations and Immunological Status and Metabolome Defining of Healthy Population
Study on healthy volunteers is focusing on analysis of transcriptome profile fluctuations in healthy population in three mononuclear cell types (CD4+ cells, CD56+ cells and CD4+CD25+ cells)and should provide a reference for…
- Conditions
- Gene Expression, Metabolomics, Immunological Status
- Trial name
- NCT01052649
- Testing
- Blood sampling
- Where
- Slovenia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Blood Transfusion Centre of Slovenia
Pulmonary Disease, Chronic Obstructive
Inert Dusts and Pathology of Chronic Obstructive Pulmonary Disease
The main objective of the study is the exploration of the natural course of COPD and its biological background. To this end, active workers without COPD and workers in functional classes GOLD 0-III are investigated by a combined…
- Trial name
- NCT00618137
- Where
- Austria
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Breast Pumping
Testing of New Method in Sanitizing Breast Pump Equipment in the NICU
This study will evaluate a newly developed device, Q. Basin. The Q. Basin is a multifunctional, single patient use device that can sanitize breast pump parts, bottles, and reusable feeding devices for patients admitted under one…
- Trial name
- NCT05248828
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Healthy
Omega-3 Supplement and Health Markers
The goal of this clinical trial is to learn whether fish oil-based supplements can affect gene expression and serum protein markers in healthy volunteers. The main questions it aims to answer are: 1.
- Trial name
- NCT06492694
- Testing
- Fish oil + wild orange essential oil supplement, Fish oil supplement
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- dōTERRA International
Moderate to Severe Plaque Psoriasis, Psoriatic Arthritis
A Study to Evaluate the Effect of Bimekizumab on Gene Expression Biomarkers in Study Participants With Moderate to Severe Plaque Psoriasis
The purpose of this study is to evaluate the effect of bimekizumab on gene expression biomarkers at Week 48 in a subset of study participants with moderate to severe plaque psoriasis (PSO) and moderate to severe plaque PSO with…
- Trial name
- BE UNIQUE (NCT06506916)
- Testing
- bimekizumab
- Where
- 14 sites in United States, Germany and 1 more
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- UCB Biopharma SRL
Delirium, Confusion
Intelligent Intensive Care Unit
Delirium, as a common complication of hospitalization, poses significant health problems in hospitalized patients. Though about a third of delirium cases can benefit from intervention, detecting and predicting delirium is still…
- Trial name
- ICU_Delirium (NCT02465307)
- Testing
- Confusion Assessment Method, Accelerometer, Commercially available camera
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Florida
Android Obesity, Metabolic Parameters and Adipose Tissue (AT) Gene Expression
Effect of Hula Hooping as Compared to Walking on Adipose Tissue Distribution, Metabolic Parameters and Adipose Tissue Gene Expression
o determine effects of hula-hooping on android obesity, metabolic parameters and adipose tissue (AT) gene expression.
- Trial name
- NCT01913171
- Testing
- Exercise
- Where
- Finland
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Healthy
Pharmacotoxicology of Trichloroethylene Metabolites
This project focuses on the kinetics, metabolism and human toxicology of dichloroacetate (DCA)and tyrosine catabolism. The hypothesis is that tyrosine metabolism will be greatest in subject who harbor the KRT variant for…
- Trial name
- NCT00865514
- Testing
- Dichloroacetate, Genotyping, Leucine
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Florida
Breastfeeding, Breastfeeding, Exclusive
Breastfeed a Better Youngster: the BABY Study
This research will investigate different aspects of the 'signalling' between mother and infant during breastfeeding in a stressful situation following late preterm and early term delivery, when breastfeeding is often challenging.
- Conditions
- Breastfeeding, Breastfeeding, Exclusive, Infant Behavior, Psychological Stress
- Trial name
- BABY (NCT03674632)
- Testing
- Relaxation meditation tape
- Where
- 2 sites in China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University College, London
Colorectal Adenoma, Colorectal Cancer
Novel Blood-based Colorectal Cancer Screening Method Using Natural Killer Cell Activity and Gene Panel Expression
Natural killer cells (NK cells) are cytotoxic lymphocytes that play an important role in the innate immune system. In particular, it plays a very important defense function against host cells or cancer cells infected with a…
- Trial name
- NCT03289988
- Testing
- blood sampling
- Where
- South Korea
- Volunteers
- 964 people, healthy volunteers welcome
- Sponsor
- Yonsei University